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| 1 | 非酒精性脂肪性肝病患者肝脏脂联素的表达与病理改变的关系显示文摘目的探讨脂肪细胞因子脂联素在肝脏的表达与非酒精性脂肪性肝病病理改变程度的关系。方法对30例做胃旁路减肥手术的重度肥胖患者进行肝穿刺活检,进行常规肝脏组织学检查,免疫组化法测定脂联素在肝脏的表达,根据临床和病理表现,将病人分为两组,18例为非酒精性脂肪性肝炎(NASH),12例为单纯性脂肪肝。两组病人的体重指数、年龄和性别分布匹配。两组相比,NASH组脂联素在肝脏的表达明显下降,两组脂联素表达强度分别为1.61±0.70和2.25±0.75(P=0.028)。结果脂联素在肝脏的表达强度与肝脏病理变化的炎症程度(r=-0.368,P=0.045)和纤维化程度(r=-0.380,P=0.038)呈负相关。结论脂联素可能在非酒精性脂肪性肝病的疾病进展,特别是从单纯性脂肪肝到脂肪性肝炎的发展过程中起一定作用。 | 马红 郭春花 杨香玖 | 2014 | 中国老年学杂志2014，34，16： | 6 |
| 2 | Adipokines as a novel link between obesity and atherosclerosis显示文摘The traditional perception of adipose tissue as a storage organ of fatty acids has been replaced by the notion that adipose tissue is an active endocrine organ, releasing various adipokines that are involved in the pathogenesis of obesity-related metabolic disturbances. Obesity is a well-known risk factor for atherosclerosis, and accelerates atherosclerosis by many mechanisms such as increase in blood pressure and glucose level, abnormal lipid profiles, and systemic inflammation. Furthermore, growing evidence suggests that some adipokines directly mediate the process of atherosclerosis by influencing the function of endothelial cells, arterial smooth muscle cells, and macrophages in vessel walls. In obese patients, the secretion and coordination of such adipokines is abnormal, and the secretion of specific adipokines increases or decreases. Accordingly, the discovery of new adipokines and elucidation of their functions might lead to a new treatment strategy for metabolic disorders related to obesity, including cardiovascular diseases. | Hye Jin Yoo Kyung Mook Choi | 2014 | World Journal of Diabetes2014，5，3： | 3 |
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