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| 1 | Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice显示文摘瞄准:在 Kupffer 房间的功能上检验 adiponectin 的效果,脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法:D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间,从 Sprague-Dawley 孤立老鼠,是 preincubated 与或没有 adiponectin,然后与 LPS 对待。结果:在猛烈老鼠, GalN/LPS 注射显著地降低了幸存率,显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间, LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次,与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论:Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产,并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。 | Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 2 | Strategies for gastric cancer in the modern era显示文摘Gastric cancer is one of the most common neoplasms in Japan, and it is also the second leading cause of cancer-related deaths worldwide. Nowadays, infection with Helicobacter pylori (H. pylori) is a known risk factor for the development of gastric cancer. Therefore, gastric cancer should be considered as an infectious disease, and in fact, prophylactic eradication of H. pylori may prevent the development of metachronous gastric carcinoma. Before the role of H. pylori was understood, a different approach was used. Recently even after the cancer has developed, some newer therapeutic approaches have been pursued. These newer treatments have been summarized as 'minimally invasive therapies' and use endoscopic or laparoscopic techniques. In addition, robotic approaches are being developed that seem to hold a great potential to change the surgical approach. Since basic understanding and treatment of the disease have both changed signif icantly over the last decade, we present a review of current advances in gastric cancer research and therapy. | Satoru Takayama Takehiro Wakasugi Hitoshi Funahashi Hiromitsu Takeyama | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 5 |
| 3 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 4 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 5 | Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model显示文摘 | Yoshihiro Kamada Hitoshi Matsumoto Shinji Tamura Juichi Fukushima Shinichi Kiso KojiFukui Takumi Igura Norikazu Maeda $hinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2007 | Journal of Hepatology2007，，4： | 1 |
| 6 | Relationship between the Serum Uric Acid Level,Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men显示文摘 | Achiko Tamba Hitoshi Nishizawa Tohuru Funahashi | 2008 | Inter Med2008，47，： | 1 |
| 7 | Expression and Prognostic Roles of Integrins and Interleukin-1 Receptor Type I in Patients with Ductal Adenocarcinoma of the Pancreas显示文摘 | Hirozumi Sawai Hitoshi Funahashi Yoichi Matsuo Minoru Yamamoto Yuji Okada Tetsushi Hayakawa Tadao Manabe | 2003 | Digestive Diseases and Sciences2003，，7： | 1 |
| 8 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 1 |
| 9 | Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin显示文摘 | Yoshihiro Kamada Shinji Tamura Shinichi Kiso Hitoshi Matsumoto Yukiko Saji Yuichi Yoshida Koji Fukui Norikazu Maeda Hitoshi Nishizawa Hiroyuki Nagaretani Yoshihisa Okamoto Shinji Kihara Jun-ichiro Miyagawa Yasuhisa Shinomura Tohru Funahashi Yuji Matsuzawa | 2003 | Gastroenterology2003，，6： | 1 |
| 10 | Uric Acid Secretion from Adipose Tissue and Its Increase in Obesity显示文摘 | Yu Tsushima Hitoshi Nishizawa Yoshihiro Tochino Hideaki Nakatsuji Ryohei Sekimoto Hirofumi Nagao Takashi Shirakura Kenta Kato Keiichiro Imaizumi Hiroyuki Takahashi Mizuho Tamura Norikazu Maeda Tohru Funahashi Iichiro Shimomura | 2013 | Journal of Biological Chemistry2013，，38： | 1 |
| 11 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 1 |
| 12 | Dipeptidyl peptidase‐4 inhibitors are effective in J apanese type 2 diabetic patients with sustained endogenous insulin‐secreting capacity, a higher body mass index and insulin resistance显示文摘 | Junji Kozawa Tetsuhiro Kitamura Hitoshi Nishizawa Tetsuyuki Yasuda Norikazu Maeda Michio Otsuki Kohei Okita Hiromi Iwahashi Hideaki Kaneto Tohru Funahashi Akihisa Imagawa Iichiro Shimomura | 2012 | J Diabetes Invest2012，，2： | 1 |
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