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| 1 | Suppression of experimental osteoarthritis by adenovirus-mediated double gene transfer显示文摘背景骨关节炎(OA ) 是一长期并且不治之症,缺乏的有效处理。基因治疗把一条激进的不同途径提供给关节炎的处理。尽管 OA 的病原学仍然保持不清楚,现在有可观的证据建议 thatinterleukin-1 (IL-1 ) 和肿瘤坏死因素 -- α(TNF- α) 是在 OA 的致病的主要调停人。这研究的目标是决定本地表示 ofinterleukin-1 受体对手(IL-1Ra ) 和可溶的肿瘤坏死因素的功效 -- α受体类型(sTNF-RI ) 我骨关节炎由在兔子的直接调停 adenoviral 的 intra 关节的基因交货当模特儿。包含 IL-1Ra 或 sTNF-RI 基因的方法 Adenoviral 向量被构造。中间的并行的系带的切除加中间的 meniscectomy 在 12 只新西兰白兔子的两后部的膝导致的 OAwas。在外科以后的五天,果汁饮料的约 1 x 10 个 ~8plaque 形式单位(pfu ) 没有病毒通过膝盖骨的腱被注入膝的联合空间。12 只操作兔子的一个总数被划分成四个组。三个试验性的兔子组收到了 1 X 10 ~ 编码任何一个 IL-1Ra (3 只兔子) 的侵入人体气管粘膜的病菌的 8 pfu, sTNF-RI (3rabbits ) 和在联合(3 只兔子) 的 sTNF-RI,进两个膝关节分别地。3 只兔子的 Aninflamed 控制组收到了进两个的 Ad-GFP 的 8 pfu 连接的约 1 x 10 ~ 。在侵入人体气管粘膜的病菌的注射以后的三天,每只兔子的两膝是通过膝盖骨的腱与盐溶液的 1 ml 变老的洗室。在白天 7 点,兔子被牺牲,并且膝是为 transgene 表示的效果变老,把并且分析的洗室。在恢复洗室年龄液体的 IL-1Ra andsTNF-RI 表示的层次用一个 cytokine ELISA 工具包被测量。Cartilagefrom 中间的大腿骨的髁和 synovium 的损害区域被修理,嵌入, sectioned 并且与 hematoxylin 和曙红和 toluidine 蓝色(软骨)( 软骨和 synovium ) 染色了。Thesamples 被评估的轻显微镜学和份量上检验。IL-1Ra 的结果 Intra-articulardelivery 导致了软骨降级的重要抑制,但是 affectsynovial 变化。相反,独自收到 sTNF-RI 的兔子膝关节没在软骨降级显示出更可检测的引出。然而, IL-1Ra 和 sTNF-RI 的两倍基因转移在滑膜炎导致了软骨降级和可见减小的更高的抑制。Thesedata 增加并且证实 IL-1Ra 有好 chondroprotective 性质,而是 TNF- α封锁在联合破坏上有小效果。在联合的两个对手的提高的治疗学的效果建议多重煽动性的 cytokines 的抑制的结论可能在对待 OA 独自是比任何一个 cytokine 的封锁更有效的。 | WANG Hai-jun YU Chang-long Kishi Hiroyuki Motoki Kazumi MAO Ze-bin Muraguchi Atsushi | 2006 | Chinese Medical Journal2006，，16： | 19 |
| 2 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 3 | A chimeric antigen receptor for TRAIL-receptor 1 induces apoptosis in various types of tumor cells显示文摘 | Eiji Kobayashi Hiroyuki Kishi Tatsuhiko Ozawa Hiroshi Hamana Hidetoshi Nakagawa Aishun Jin Zhezhu Lin Atsushi Muraguchi | 2014 | Biochemical and Biophysical Research Communications2014，，： | 2 |
| 4 | Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Yoshihisa Okamoto Kazuhisa Maeda Hiroshi Kuriyama Kikuko Hotta Makoto Nishida Masahiko Takahashi Masahiro Muraguchi Yasukazu Ohmoto Tadashi Nakamura Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2000 | Circulation: Journal of the American Heart Association2000，，11： | 2 |
| 5 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 6 | A novel screen usingthe reck tumor suppressor gene promoter detects both conven-tional and metastasis -suppressing anticancer drugs显示文摘 | Murai R? Yoshida Y Muraguchi T | 2010 | Oncotar-get2010，1，4： | 1 |
| 7 | RECK modulates Notch signaling during cortical neurogenesis by regulating ADAMlO activi- ty显示文摘 | Muraguchi T Takegami Y Ohtsuka T | 2007 | Nat Neurosci2007，10，7： | 1 |
| 8 | Correlation between salivary secretion and salivary AQP5 levels in health and disease显示文摘 | Wang D Iwata F Muraguchi M | 2009 | J Med Invest2009，56，： | 1 |
| 9 | Involvcment of IL -6 in mcsangial proliferative glomerulonephritis显示文摘 | Muraguchi A Iwano M | 1998 | J Immunol1998，143，： | 1 |
| 10 | Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3显示文摘 | Matsuda T Yamamoto T Muraguchi A | 2001 | J Biol Chem2001，276，42： | 1 |
| 11 | The essential role of B cell stimulatory factor2 (BSF-2/L-6) for the terminal dif- ferentiation of B eell显示文摘 | Muraguchi A Hirano T Tang B | 1998 | EXP Med1998，1667，： | 1 |
| 12 | 显示文摘 | Matsuda T Yamamoto T Muraguchi A | 2001 | J Biol Chem2001，276，42： | 1 |
| 13 | An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls显示文摘 | Okamoto Y Arita Y Nishida M Muraguchi M Ouchi N Takahashi M | 2000 | Horm Metab Res2000，32，2： | 1 |
| 14 | TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia显示文摘 | Naka K Hoshii T Muraguchi T | 2010 | Nature2010，463，7281： | 1 |
| 15 | TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia显示文摘 | Naka K Hoshii T Muraguchi T | 2010 | Nature2010，463，7281： | 1 |
| 16 | The essential of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells显示文摘 | Muraguchi A Hirano T Tang B | 1998 | J Exp Med1998，167，： | 1 |
| 17 | TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia显示文摘 | Naka K Hoshii T Muraguchi T | 2010 | Nature2010，463，7281： | 1 |
| 18 | Prohibitin protects against hypoxia-induced H9c2 cardiomyocyte cell death显示文摘 | Muraguchi T Kawawa A Kubota S | | 0，，： | 1 |
| 19 | The ichl gene of the mushroom Coprinus cinereus is essential for pileus formation in fruiting 显示文摘 | Muraguchi H Kamada T | 1998 | Development1998，125，16： | 1 |
| 20 | RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity显示文摘 | Muraguchi T Takegami Y Ohtsuka T | | 0，，： | 1 |
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