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| 1 | Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis显示文摘AIM: To report 13 patients with benign esophageal stenosis treated with the biodegradable stent. METHODS: We developed a Ultraflex-type stent by knitting poly-l-lactic acid monofilaments. RESULTS: Two cases were esophageal stenosis caused by drinking of caustic liquid, 4 cases were due to surgical resection of esophageal cancers, and 7 cases were patients with esophageal cancer who received the preventive placement of biodegradable stents for post- endoscopic mucosal dissection (ESD) stenosis. The preventive placement was performed within 2 to 3 d after ESD. In 10 of the 13 cases, spontaneous migration of the stents occurred between 10 to 21 d after placement. In these cases, the migrated stents were excreted with the feces, and no obstructive complications were experienced. In 3 cases, the stents remained at the proper location on d 21 after placement. No symptoms of re-stenosis were observed within the follow-up period of 7 mo to 2 years. Further treatment with balloon dilatation or replacement of the biodegradable stent was not required. CONCLUSION: Biodegradable stents were useful for the treatment of benign esophageal stenosis, particularly for the prevention of post-ESD stenosis. | Yasuharu Saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama | 2007 | World Journal of Gastroenterology2007，13，29： | 30 |
| 2 | Mucosal cytokine network in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved. The chronic in-flammatory process leads to disruption of the epithelial barrier, and the formation of epithelial ulceration. This permits easy access for the luminal microbiota and dietary antigens to cells resident in the lamina pro-pria, and stimulates further pathological immune cell responses. Cytokines are essential mediators of the interactions between activated immune cells and non-immune cells, including epithelial and mesenchymal cells. The clinical efficacy of targeting TNF-α clearly indicates that cytokines are the therapeutic targets in IBD patients. In this manuscript, we focus on the bio-logical activities of recently-reported cytokines [Inter-leukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-α in the pathophysiology of IBD. | Akira Andoh Yuhki Yagi Makoto Shioya Atsushi Nishida Tomoyuki Tsujikawa Yoshihide Fujiyama | 2008 | World Journal of Gastroenterology2008，14，33： | 21 |
| 3 | Usefulness of bispectral monitoring of conscious sedation during endoscopic mucosal dissection显示文摘AIM: To assess the usefulness of bispectral index (BIS) monitoring in order to carry out endoscopic submucosal dissection (ESD) safely and with patients' satisfaction. METHODS: Three hundred sixty-six patients with an early-stage neoplasm of the digestive tract were enrolled. The BIS monitor (A-1050: Aspect medical systems/NIHON KOHDEN, Tokyo, Japan) was used. The appropriate sedative condition was set at 55 to 75 BIS levels (BIS value) during the endoscopic procedures. RESULTS: Among 366 cases, 13 were accompanied by adverse events during and/or after ESD. All episodes occurred in cases with BIS value between 56 and 65. Hypotension was observed in four cases, and bradycardia in six. Respiratory distress was observed in two cases with chronic pulmonary obstructive disease. All patients with adverse events were able to leave the hospital without extension of the hospitalization. CONCLUSION: BIS monitoring is useful to safely perform ESD. A BIS value of 70 to 75 is suitable for ESD. | Kazunori Hata Akira Andoh Kiyoyuki Hayafuji Atsuhiro Ogawa Tamio Nakahara Tomoyuki Tsujikawa Yoshihide Fujiyama Yasuharu Saito | 2009 | World Journal of Gastroenterology2009，15，5： | 9 |
| 4 | Hepatitis B virus reactivation associated with antirheumatic therapy: risk and prophylaxis recommendations显示文摘Accompanying the increased use of biological and non-biological antirheumatic drugs,a greater number of cases of hepatitis B virus(HBV) reactivation have been reported in inactive hepatitis B surface antigen(HBs Ag) carriers and also in HBs Ag-negative patients who have resolved HBV infection. The prevalence of resolved infection varies in rheumatic disease patients,ranging from 7.3% to 66%. Through an electronic search of the Pub Med database,we found that among 712 patients with resolved infection in 17 observational cohort studies,12 experienced HBV reactivation(1.7%) during biological antirheumatic therapy. Reactivation rates were 2.4% for etanercept therapy,0.6% for adalimumab,0% for infliximab,8.6% for tocilizumab,and 3.3% for rituximab. Regarding non-biological antirheumatic drugs,HBV reactivation was observed in 10 out of 327 patients with resolved infection from five cohort studies(3.2%). Most of these patients received steroids concomitantly. Outcomes were favorable in rheumatic disease patients. A number of recommendations have been established,but most of the supporting evidence was derived from the oncology and transplantation fields. Compared with patients in these fields,rheumatic disease patients continue treatment with multiple immunosuppressants for longer periods. Optimal frequency and duration of HBV-DNA monitoring and reliable markers for discontinuation of nucleoside analogues should be clarified for rheumatic disease patients with resolved HBV infection. | Shunsuke Mori Shigetoshi Fujiyama | 2015 | World Journal of Gastroenterology2015，21，36： | 9 |
| 5 | Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease显示文摘煽动性的肠疾病, ulcerative,和 Crohn 是疾病,是在的未知病原学的长期的肠的混乱在遗传上易受影响的个人,,粘膜免疫系统向共栖的细菌显示出异常回答。胃肠道开发了机灵的机制与它的自体同源的微植物群共存,但是在病原的感染被清除以后,很快对与它的共栖的细菌入侵病原体然后回来到动态平衡作出回应。在这紧调整的动态平衡的混乱的情况下,长期的肠的发炎可以被导致。当其它也没有影响或有一个保护的行动时,以前的研究证明一些共栖的细菌是有害的。另外,每位主人有遗传上坚定的回答到有害、保护的细菌的种类。这些建议微植物群的不平衡的那治疗学的操作能影响健康和疾病。这评论处于内脏健康和疾病集中于新卓见进共栖的细菌的角色,并且在天生、适应的有免疫力的相互作用介绍最近的调查结果。调制肠的微植物群的平衡和他们行动的潜在的机制的治疗学的途径也被讨论。 | Akira Andoh Yoshihide Fujiyama | 2006 | World Journal of Gastroenterology2006，12，28： | 9 |
| 6 | Some Physiological Responses of Chinese Iris to Salt Stress显示文摘Chinese iris (Iris lactea Pall. var. chinensis (Fisch) Koidz.), a robust iridaceous plant, is widespread in arid and semiarid regions with high salinity. However, the mechanism of its salt tolerance is not well understood. In this study, plant growth, water status, content and distribution of inorganic ions, cell membrane permeability, and proline content of I. lactea under salt stress were investigated using nutrient solutions with six NaCl concentrations ranging from 0 to 350 mmol L-1. The results indicated that the biomass, height, fresh weight, K+ content, and K+/Na+ and Ca2+/Na+ ratios decreased with increasing NaCl stress, whereas plant water deficit and contents of Na+ and Cl-increased with increasing NaCl stress. In all salt treatments, water deficit of shoots was found to be higher than that of roots and had a positive correlation with salt concentration. When the NaCl concentration was less than 280 mmol L-1, the ion absorption selectivity ratio and the transportation selectivity ratio sharply increased with increasing NaCl stress. Under medium salt stress, I. lactea exhibited a strong K+ selective absorption and the transportation of K+ from roots to shoots increased, whereas Na+ was not transported and was mostly retained in roots. The plants were able to maintain osmotic adjustment through the accumulation of Na+, Cl-, and proline. On the basis of its biomass production under salt stress, I. lactea could be considered as a facultative halophyte. | BAI Wen-Bo LI Pin-Fang LI Bao-Guo H. FUJIYAMA FAN Fen-Cheng | 2008 | Pedosphere2008，18，4： | 7 |
| 7 | Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct显示文摘A carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as a lymphoepithelioma-like carcinoma(LEC),and some of LEC is associated with Epstein-Barr virus(EBV).All of the 13 previously reported cases of LEC of the biliary system were intrahepatic in location.Herein,we describe the first case of LEC of the inferior common bile duct.A 68-year-old Japanese man,who had been previously treated for hepatocellular carcinoma using microwave coagulation therapy,was found to have tumors of the common bile duct and pancreas head.Histopathological study of the resected tumor showed solid or cohesive nests of large undifferentiated cells with irregular large vesicular nuclei and nucleoli.Around the tumor cell nests,dense lymphoplasmacytic infiltration was observed.Focal glandular differentiation(approximately 5%) was also present.These histopathological features corresponded morphologically to LEC.Immunohistochemically,the tumor cells were positive for cytokeratin(CK) 7,CK 19 and CA19-9,but negative for CK 20 and Hep Par 1.In situ hybridization for Epstein Barr virus early small RNAs disclosed no nuclear signal in tumor cells.Therefore,a diagnosis of non-EBV-associated LEC of the inferior common bile duct was made.Although the prognosis of the biliary LEC is thought to be better than that of conventional cholangiocarcinoma,the differences in prognosis between EBV-positive and-negative cases have not yet been established.Therefore,additional case studies will be needed to clarify the clinicopathological features of LEC of the biliary tract. | Mitsuaki Ishida Tsuyoshi Mori Hisanori Shiomi Shigeyuki Naka Tomoyuki Tsujikawa Akira Andoh Yasuharu Saito Yoshimasa Kurumi Fumiyoshi Kojima Machiko Hotta Tohru Tani Yoshihide Fujiyama Hidetoshi Okabe | 2011 | World Journal of Gastrointestinal Oncology2011，3，7： | 5 |
| 8 | 基于AFC数据和RF模型的城轨车站服务功能分类显示文摘城轨线网上服务不同类型客流车站的分布能反映城市结构特征,本文基于多年的城轨AFC数据,应用随机森林模型(RF),分析了全网车站服务客流类型的时空演变.对于传统RF在选择训练集时过于依靠主观经验的问题,本文首先利用传统随机森林度量车站之间的相似性,再采用Partitioning Around Medoid(PAM)方法对度量结果进行聚类,结果表明无监督随机森林方法拥有更好的准确性;最后采用无监督随机森林对北京市2014—2017年的车站服务客流属性的时空变化情况进行分析,结果显示,北京市近4年来城市职住结构在大的空间尺度上基本保持不变,但城市内部各功能区正经历缓慢变化,而服务于居住与工作混合类客流的车站所处区域将是今后城市结构演变中热点区域.本文的研究结果可以为城市轨道交通与城市结构互动关系的认识提供新视角. | 王子甲 刘海旭 TAKU Fujiyama | 2018 | 交通运输系统工程与信息2018，18，4： | 5 |
| 9 | Novel Biodegradable Stents for Benign Esophageal Strictures Following Endoscopic Submucosal Dissection显示文摘 | Yasuharu Saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama | 2008 | Digestive Diseases and Sciences2008，，2： | 4 |
| 10 | Responses of Halophyte Salicornia bigelovii to Different Forms of Nitrogen Source显示文摘Salt-affected soils are agricultural and environmental problems on a global scale. Plants suffer from saline stresses in these soils and show nitrogen (N) deficiency symptoms. However, halophytes grow soundly under saline conditions. In order to clarify the N nutrition of the halophyte Salicornia bigelovii, it was grown at several N levels (1, 2, 3, and 4 mmol L-1), supplied in the form of NO3- or ammonium (NH4+ ), under high NaCl conditions (200 mmol L-1). NH4+- fed plants showed better growth than NO3- -fed plants at 1-3 mmol L-1 N, and plants in both treatments showed the same growth at 4 mmol L-1 N. Nitrogen contents in NO3- -fed plants increased with the N concentrations in solution; competitive inhibition of NO3- absorption by Cl- was observed under lower N conditions. In addition, shoot dry weight was significantly correlated only with shoot N content. Therefore, growth of NO3- -fed plants was regulated by N absorption. Inc ontrast, N contents of shoots in NH+4 -fed plants did not change with N concentration. Shoot Na content decreased with increasing N concentration, while K content increased. Dry weight was highly correlated only with K content in NH+4 -fed plants. These observations indicated that growth of NH4+ -fed plants was mainly regulated by K absorption. | N. KUDO H. FUJIYAMA | 2010 | Pedosphere2010，20，3： | 4 |
| 11 | N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer显示文摘AIM:To investigate the possible association between meat intake,cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS:Patients with CRC were matched for gender and age to healthy controls.Meat intake and cigarette smoking were assessed using a specific frequency questionnaire.DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism.Five NAT2 alleles were studied (WT,M1,M2,M3 and M4) using specific digestion enzymes.RESULTS:A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied.The mean age of the two groups was 62 years.More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators.The odds ratio for colorectal cancer was 1.38 (95% CI:0.90-2.12) in slow acetylators.Although the number of women was small (n=76 in the case group),the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR):0.55,95% confidence interval (95% CI):0.29-1.02].This difference was not observed in men (OR:0.56,95% CI:0.16-2.00).Among NAT2 fast acetylators (W/W or W/Mx),meat consumption more than 3 times a week increased the risk of colorectal cancer (OR:2.05,95% CI:1.01-4.16).In contrast,cigarette smoking increased the risk of CRC among slow acetylators (OR:1.97,95% CI:1.02-3.79).CONCLUSION:The risk of CRC was higher among fast acetylators who reported a higher meat intake.Slow NAT2 acetylation was associated with an increased risk of CRC. | Tiago Donizetti da Silva Aledson Vitor Felipe Jacqueline Miranda de Lima Celina Tizuko Fujiyama Oshima Nora Manoukian Forones | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 12 | Epithelial expression of interleukin‐37b in inflammatory bowel disease显示文摘 | H. Imaeda K. Takahashi T. Fujimoto E. Kasumi H. Ban S. Bamba H. Sonoda T. Shimizu Y. Fujiyama A. Andoh | 2013 | Clin Exp Immunol2013，，3： | 2 |
| 13 | Phase II Trial of Intra-Arterial Chemotherapy using a Novel Lipophilic Platinum Derivative (SM-11355) in Patients with Hepatocellular Carcinoma显示文摘 | Takuji Okusaka Shuichi Okada Toshio Nakanishi Shigetoshi Fujiyama Yasuhiko Kubo | 2004 | Investigational New Drugs2004，，2： | 2 |
| 14 | Budd-Chiari syndrome: A case with a combination of hepatic vein and superior vena cava occlusion显示文摘We here report a recent, rare case of Budd-Chiari syndrome, associated with a combination of hepatic vein and superior vena cava occlusion. A young female, who had been ingood health, was admitted to our hospital because of massive ascites. The patient had used no oral contraceptives. Tests for coagulation disorders, hematological disorders, and antiphospholipid syndrome were all negative. BuddChiari syndrome was diagnosed by radiographic examination. The patient was suffering from a combination of hepatic vein and superior vena cava occlusion. In particular, the venous flow returned from the liver mainly through a right accessory hepatic vein, and stenosis was recognized at the orifice of this collateral vein into the vena cava.Subsequently, the patient underwent percutaneous balloon dilatation therapy for this stenosis. After this treatment, the massive ascites was gradually reduced, and she was discharged from our hospital. It has now been one year since discharge, and the patient has been doing well. If deteriorating liver function or intractable ascites occur again, a liver transplantation may be anticipated. This is the first case report of Budd-Chiari syndrome associated with a superior vena cava occlusion. | Yoshio Araki Chikara Sakaguchi Izumi Ishizuka Masaya Sasaki Tomoyuki Tsujikawa Shigeki Koyama Akira Furukawa Yoshihide Fujiyama | 2005 | World Journal of Gastroenterology2005，11，24： | 2 |
| 15 | Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines显示文摘AIM: To investigate the effects of butyrate on interleukin (IL)-32α expression in epithelial cell lines. METHODS: The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL- 32α was determined by Western blotting analyses. IL- 32α mRNA expression was analyzed by real-time poly-merase chain reaction. RESULTS: Acetate and propionate had no effects on IL-32α mRNA expression. Butyrate significantly enhanced IL-32α expression in all cell lines. Butyrate also up-regulated IL-1β-induced IL-32α mRNA expression. Butyrate did not modulate the activation of phosphatidylinositol 3-kinase (PI3K), a mediator of IL- 32α expression. Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1β-induced IL- 32α mRNA expression.CONCLUSION: Butyrate stimulated IL-32α expression in epithelial cell lines. An epigenetic mechanism, such as histone hyperacetylation, might be involved in the action of butyrate on IL-32α expression. | Ayako Kobori Shigeki Bamba Hirotsugu Imaeda Hiromitsu Ban Tomoyuki Tsujikawa Yasuharu Saito Yoshihide Fujiyama Akira Andoh | 2010 | World Journal of Gastroenterology2010，16，19： | 2 |
| 16 | Effectiveness of combined anticoagulant therapy for extending portal vein thrombosis in Crohn’s disease显示文摘 | Dr. Tomoyuki Tsujikawa M.D. Ph.D. Takashi Ihara M.D. Masaya Sasaki M.D. Ph.D. Hisayuki Inoue M.D. Ph.D. Yoshihide Fujiyama M.D. Ph.D. Tadao Bamba M.D. Ph.D | 1996 | Diseases of the Colon & Rectum1996，，7： | 2 |
| 17 | Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice显示文摘 | Atsuhiro Ogawa Akira Andoh Yoshio Araki Tadao Bamba Yoshihide Fujiyama | 2003 | Clinical Immunology2003，，： | 2 |
| 18 | Hepatic reactive lymphoid hyperplasia in a patient with primary biliary cirrhosis显示文摘Reactive lymphoid hyperplasia(RLH) of the liver is an extremely rare lesion characterized by the proliferation of non-neoplastic lymphocytes forming follicles.Hepatic RLH is known to be associated with gastrointestinal carc inoma and autoimmune diseases including primary biliary cirrhosis(PBC).We report a case of hepatic RLH in a patient with PBC and gastric cancer.A 68 year old Japanese woman with a 10 year history of liver enzyme abnormality was admitted.Laboratory testing revealed that her anti-mitochondrial antibody was markedly elev ated.Five mo after the diagnosis of PBC,she was foun d to have gastric cancer.Abdominal computed tom og raphy disclosed a liver nodule in S8,suggesting metas tatic gastric carcinoma.Histopathologically,the resected liver lesion comprised of a nodular proliferation of small lym phocytes with lymphoid follicles.This is the first reported case of hepatic RLH in a patient with both PBC and gastric cancer.Pre-operative diagnosis of hepatic RLH by clinical imaging is extremely difficult.Therefore,a need le biopsy could be useful to make a diagnosis of hepat ic RLH,especially to differentiate from metastatic gastroin t estinal carcinoma. | Mitsuaki Ishida Tamio Nakahara Yousuke Mochizuki Tomoyuki Tsujikawa Akira Andoh Yasuharu Saito Hiroshi Yamamoto Fumiyoshi Kojima Machiko Hotta Tohru Tani Yoshihide Fujiyama Hidetoshi Okabe | 2010 | World Journal of Hepatology2010，2，10： | 2 |
| 19 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 2 |
| 20 | Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis显示文摘 | Ayako Kobori Yuhki Yagi Hirotsugu Imaeda Hiromitsu Ban Shigeki Bamba Tomoyuki Tsujikawa Yasuharu Saito Yoshihide Fujiyama Akira Andoh | 2010 | Journal of Gastroenterology2010，，10： | 2 |
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