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| 1 | Endoscopic ultrasonography can diagnose distal biliary strictures without a mass on computed tomography显示文摘AIM:To assess the diagnostic ability of endoscopic ultrasonography(EUS)for evaluating causes of dista biliary strictures shown on endoscopic retrograde chol angiopancreatography(ERCP)or magnetic resonance cholangiopancreatography(MRCP),even without iden tifiable mass on computed tomography(CT). METHODS:The diagnostic ability of EUS was retro spectively analyzed and compared with that of routine cytology(RC)and tumor markers in 34 patients with distal biliary strictures detected by ERCP or MRCP a Dokkyo Medical School Hospital from December 2005 to December 2008,without any adjacent mass or ec centric thickening of the bile duct on CT that could cause biliary strictures.Findings considered as benign strictures on EUS included preservation of the normasonographic layers of the bile duct wall,irrespective of the presence of a mass lesion.Other strictures were considered malignant.Final diagnosis of underlying diseases was made by pathological examination in 18 cases after surgical removal of the samples,and by clinical follow-up for>10 mo in 16 cases. RESULTS:Seventeen patients(50%)were finally di- agnosed with benign conditions,including 6'normal' subjects,while 17 patients(50%)were diagnosed with malignant disease.In terms of diagnostic ability,EUS showed 94.1%sensitivity,82.3%specificity,84.2% positive predictive value,93.3%negative predictive value(NPV)and 88.2%accuracy for identifying ma- lignant and benign strictures.EUS was more sensi- tive than RC(94.1%vs 62.5%,P=0.039).NPV was also better for EUS than for RC(93.3%vs 57.5%,P= 0.035).In addition,EUS provided significantly higher sensitivity than tumor markers using 100 U/mL as the cutoff level of carbohydrate antigen 19-9(94.1%vs 53%,P=0.017).On EUS,biliary stricture that was fi- nally diagnosed as malignant showed as a hypoechoic, irregular mass,with obstruction of the biliary duct and invasion to surrounding tissues. CONCLUSION:EUS can diagnose biliary strictures caused by malignant tumors that are undetectable on CT.Earlier detection by EUS would provide more therapeutic options for patients with early-stage pancreaticobiliary cancer. | Yasuyuki Saifuku Michiko Yamagata Takero Koike Genyo Hitomi Kazunari Kanke Hidetaka Watanabe Toshimitsu Murohisa Masaya Tamano Makoto Iijima Keiichi Kubota Hideyuki Hiraishi | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 2 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 2 |
| 3 | Clinical evaluation of lens culinaris agglufinin-reacdve alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States显示文摘 | Carr BI Kanke F Wise M | 2007 | Dig Dis Sci2007，52，3： | 1 |
| 4 | Clinical evaluation of lens culi-naris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxyprothrombin in histologically proven hepatocellular carcinoma in theUnited States显示文摘 | Carr B I Kanke F Wise M | 2007 | Dig Dis Sci2007，52，3： | 1 |
| 5 | Isolation and particular expression of a new β-tubulin gene in wing discs during meta morphosis of Bombyxmori显示文摘 | Quan G X Kanke E Kawasaki H | 1998 | J Seric Sci Jpn1998，67，： | 1 |
| 6 | Peptidomics:identification of pathogenic and marker peptides显示文摘 | Xiang Y Kurokawa MS Kanke M | 2010 | Methods Mol Biol2010，615，15： | 1 |
| 7 | Treatment of gastric tumors by endoscopic mucosal resection with a ligating device显示文摘 | Suzuke Y Hiraishi H Kanke K | 1999 | Gastrointest Endosc1999，49，： | 1 |
| 8 | Clinical evaluation of granulocyte/monocyte apheresis therapy for active ulcerative co-litis显示文摘 | Kanke K Nakano M Hiraishi H | 2004 | Dig Liver Dis2004，36，12： | 1 |
| 9 | Effects of HM-GB1 on ischemia-reperfusion injury in the rat heart显示文摘 | Oozawa S Mori S Kanke T | 2008 | Circ J2008，72，7： | 1 |
| 10 | Proteinase-Activated Receptors显示文摘 | Macfarlane SR Seatter MJ KANKE T | 2001 | Pharmacol Rev2001，53，2： | 1 |
| 11 | Proteinase-activated receptors显示文摘 | Macfarlane S R Seatter M J Kanke T | 2001 | Pharmacol Rev2001，53，： | 1 |
| 12 | Effects of HMGB1 onischemia-reperfusion injury in the rat heart显示文摘 | Oozawa S Mori S Kanke T | 2008 | Circ J2008，72，7： | 1 |
| 13 | The Performance of the Dry Roots Pump 'DRYMAC' in LP-CVD Silicon Nitride Process显示文摘 | Yukio Kanke Tomonari Tanaka | 2001 | Applied Surface Science2001，，： | 1 |
| 14 | Clearance of ^141Celabeled microspheres from blood and distribution in specific organs following intravenous and intra arterial administration in beagle dog显示文摘 | Kanke M Simmons G H Weiss D L | 1980 | J Pharm Sci1980，69，7： | 1 |
| 15 | Reference change values for lens culinaris agglutinin-reactive α-fetoprotein and des-γ-carboxy prothrombin in patients with chronic hepatitis C 显示文摘 | Kanke F Kumacla T Toyoda H | 2012 | Clin Chem Lab Med2012，50，5： | 1 |
| 16 | Adsorptive granulocyte and monocyte apheresis for refractory Crohn’s disease: an open multicenter prospective study显示文摘 | Yoshihiro Fukuda Toshiyuki Matsui Yasuo Suzuki Kazunari Kanke Takayuki Matsumoto Masakazu Takazoe Takayuki Matsumoto Satoshi Motoya Terasu Honma Koji Sawada Tsuneyoshi Yao Takashi Shimoyama Toshifumi Hibi | 2004 | Journal of Gastroenterology2004，，12： | 1 |
| 17 | Proteinase-activated receptors显示文摘 | Macfarlane S R Seatter M J Kanke J | 2002 | Pharmacol Rev2002，53，2： | 1 |
| 18 | Role of CD44 variant exon 6 in invasion of head and neck squamous cell carcinoma显示文摘 | Kanke M Fujii M Kameyama K | 2002 | Arch Otolaryngol Head Neck Surg2002，126，10： | 1 |
| 19 | Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy显示文摘 | Makino J Yoshiyama Y Kanke M | 2002 | Japan J Antibiot2002，1，55： | 1 |
| 20 | Reference change values for lens culinaris agglutinin-reactive t-fetopretein and des-/-carboxy pro- thrombin in patients with chronic hepatitis C显示文摘 | Kanke F Kumada T Toyoda H | 2012 | Clin Chem Lab Med2012，50，5： | 1 |
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