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	题名	作者	年代	出处	被引量
1	Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.	ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu	2003	Asian Journal of Andrology2003，5，1：	38
2	Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.显示文摘	Jiang YM Mo XA Du FQ Fu X Zhu XY Gao HY Xie JL Liao FL Pira E Zheng W	2006	中国生物学文摘2006，20，8：	23
3	The allele frequencies of HPA1-16 determined by PCR-SSP in Chinese Cantonese donors显示文摘	Nie YM Zhou HJ Fu YS	2010	Transfusion Med2010，20，6：	1
4	Angle analysis of Haglund syndrome and its relationship with osseous variations and Achilles tendon calcification显示文摘	Lu CC Cheng YM Fu YC		0，，02：	1
5	The antifibrogenic effect of (-)- epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells 显示文摘	Fu YM Zhou Y J Zheng SZ	2006	Lab Inves2006，86，7：	1
6	Postharvest browning of litchi fruit by water loss and its prevenxion by controlled atmosphere storage at high relative humidity显示文摘	Jiang YM Fu JR	1999	Food Science and Technology1999，32，5：	1
7	The allele frequencies of HPA 1-16 determined by PCR-SSP in Chinese Cantonese donors显示文摘	Nie YM Zhou HI Fu YS	2010	Transfus Meal2010，20，6：	1
8	Ultrasound-guided minimally invasive percutaneous nephrolithotomy in flank position for management of complex renal calculi 显示文摘	Fu YM Chen QY Zhao ZS	2011	Urology2011，77，1：	1
9	Ultrasound-guided minimally invasive percutaneous nephrolithotomy in flank position for management of complex renal calculi 显示文摘	FU YM CHEN QY ZHAO ZS	2011	Urol2011，77，1：	1
10	A rationale for procedure selec-tion to repair female urethral stricture associated with ure-throvaginal fistulas显示文摘	Xu YM Sa YL Fu Q	2013	J Urol2013，189，1：	1
11	U0126, a mitogen-activated protein ki- nase kinase inhibitor, inhibits the invasion of human A375 melanoma cells显示文摘	Ge X Fu YM Meadows GG	2002	Cancer Letters2002，179，2：	1
12	Manganese-induced single strand breaks of mitochondrial DNA in vitro and in vivo 显示文摘	Jiao J Qi YM Fu JL	2008	Environmental Toxicology and Pharmacology2008，26，2：	1
13	Ultrasound-guided minimally invasive percutaneous nephrolithotomy in flank position for management of complex renal calculi显示文摘	Fu YM Chen QY Zhao ZS	2011	Urology2011，77，1：	1
14	The antifibrogenic effect of(-)-epigellocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells显示文摘	Fu YM Zhou YJ Zheng SZ	2006	Lab Invest2006，86，：	1
15	Elevation of plasma soluble human leukocyte antigen-G in patients with chronic hepatitis C virus infection显示文摘	Weng PJ Fu YM Ding SX		0，，：	1
16	Impacted mandibular second molars 显示文摘	Fu PS Wang JC Wu YM	2012	Angle Orthod2012，82，：	1
17	Ultrasound-guided mini- mally invasive percutaneous nephrolithotomy in flank position for management of complex renal calculi 显示文摘	Chinese FU YM CHEN QY ZHAO ZS	2011	Urology2011，77，1：	1
18	Multidrug resistance of tumor cellswasreversed by tetrandrine in vitro and in xenograft derived from humanbreast cancer MCF -7/adr cells显示文摘	Fu LW Zhang YM Liang YJ	2002	Eur J Cancer2002，38，3：	1
19	Curcumin protects the rat liver from cc14 - caused injury and fibrogenesis by attenuating oxida- tive stress and suppressing inflammation 显示文摘	Fu YM Zheng SZ Lin JG	2008	Mol Pharmacol2008，73，2：	1
20	Surgical treatment of 31 complex traumatic posterior urethral strictures associated with urethrorectal fistulas显示文摘	Xu YM Sa YL Fu Q		0，，：	1

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