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| 1 | A chronic ulcerative colitis model in rats显示文摘INTRODUCTIONIn recent years,there have been many reports aboutanimal model to investigate drugs for inflammatorybowel diseases (IBD).The experimental animalmodel often used is acetic acid-induced damage ofcolonic muscosa.In the present study,this animalmodel was investigated by administering variousconcentrations of TNBS. | Zheng L Gao ZQ Wang SX | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 2 | Inhibitory effect of recombinant adenovirus carrying melittin gene on hepatocellular carcinoma显示文摘 | Ling CQ Li B Zhang C Zhu DZ Huang XQ Gu W Li SX | 2005 | 第二军医大学学报2005，26，10： | 30 |
| 3 | In vitro and in vivo effects of hydrolysates from conglycinin on intestinal microbial community of mice after Escherichia coli infection显示文摘 | Shen CL Chen WH Zou SX | 2007 | 中国生物学文摘2007，21，7： | 7 |
| 4 | 非选择性β受体阻滞剂可能促进肝硬化患者门静脉血栓的进展显示文摘【据《Adv Ther》2020年2月报道】题:非选择性β受体阻滞剂可能加重肝硬化患者门静脉血栓的进展:一项回顾性观察性研究(作者Xu XB等)阻塞性门静脉血栓(PVT)显著影响肝硬化患者预后。非选择性β受体阻滞剂(NSBBs)可能与PVT形成有关,但目前尚不清楚NSBBs是否会加重PVT进展。来自北部战区总医院的Xu等纳入了43例既往曾行两次增强CT和/或MRI且具有服用NSBBs详细信息的患者。其中,NSBBs组包括16例患者,非NSBBs组包括27例患者。血栓进展的定义为一个复合性终点,包括既往无PVT的患者发生PVT和既往有PVT的患者PVT加重。采用logistic回归分析明确NSBBs对PVT进展的影响。 | 许向波 祁兴顺 XU SX PRIMIGNANI M | 2020 | 临床肝胆病杂志2020，36，5： | 6 |
| 5 | Interleukin-1α, 6 regulate the secretion of vascular endothelial growth factor A, C in pancreatic cancer显示文摘Vascular endothelial growth factor (VEGF, namely VEGF-A) is an angiogenic polypeptide and VEGF-C is a lymphangiogenic polypeptide that has been implicated in cancer growth, invasion and metastasis. Several cytokines and growth factors play an important part in cancer progression. These cytokines and growth factors are the principal mediators of cancer cells-stromal cell interaction , which is critical for invasion of cancer cells to the surrounding tissues and metastatic dissemination to distant organs. In this study, we studied VEGF-A, C expression in cultured human pancreatic cancer cell lines and whether the presence of VEGF-A, C in the cell lines is regulated by cytokines interleukin-lct (EL-1α), and interleukin-6 (IL-6). METHODS: We used Northern blot and Western blot methods to analyze expression of the gene and protein of VEGF-A, C in all 6 tested cell lines (ASPC-1, CAPAN-1, MIA-PaCa-2, PANC-1, COLO-357 and T3M4) respectively. To analyze what is the regulator for this VEGF-A, C expression in pancreatic cancer,we used the reverse transcription -polymerase chain reaction (RT-PCR) method to analyze VEGF-A, C expression in cultured human pancreatic cancer cell lines (CAPAN-1 and COLO-357) under the stimulation with IL-1α (10μg/L) or IL-6 (100 μg/L). RESULTS:Northern blot analysis revealed the presence of the 4.1-kb VEGF-A mRNA transcript and 2.4-kb VEGF-C mRNA transcript in all 6 tested cell lines. Immunoblotting with highly specific anti-VEGF-A, anti-VEGF-C antibody revealed the presence of a molecular weight of 43-kDa VEGF-A protein and 55-kDa VEGF-C protein in all the cell lines. RT-PCR analysis revealed the levels of the VEGF-A and VEGF-C gene were 1-2 fold and a 1-fold increase in the COLO-357 cell line by stimulation with IL-la, however, no effect was found in the CAPAN-1 cell line. The levels of the VEGF-A and VEGF-C gene were 2-5 fold and a 1-fold increase in the CAPAN-1 cell line by stimulation with IL-6, but, no effect was found in the COLO-357 cell line. CONCLUSION:These findings suggested that the expression of VEGF-A, C and their regulation by IL-1α, IL-6 in pancreatic cancer contributes to the lymphatic and distant metastasis and the disease progression. | Department of Hepatobiliary Surgery (Tang RF, Zhang FR, Peng L, Wang SX, Xiao Y and Zhang M) and Department of Dermatology (Wang SX), 4th Hospital, Hebei Medical University, Shijiazhuang 050011, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 6 |
| 6 | Noble gas isotopic compositions of deep carbonate rocks from the Tarim Basin显示文摘Abundances and isotopic compositions of noble gases (He, Ne, Ar, Kr) with various existence states in carbonate rocks from the Tacanl Well have been investigated by means of the stepwise heating technique. The elemental abundance patterns of noble gases in the samples show the enrichment of heavy noble gases and depletion of 20Ne relative to the atmosphere, which are designated as type-I and are similar to that observed in water, natural gases and sedimentary rocks. The 3He/4He ratios of deep carbonate samples at lower and medium temperature (300-700°C) and a majority of samples at higher temperature (1100-1500°C) steps are very similar to those of natural gases in the same strata in this area, this feature of radiogenic crustal helium shows that the Tazhong Uplift is relatively stable. However, significant helium and argon isotopic anomalies are found at the 1100°C step in the Middle-Upper Ordovi-cian carbonate rock, suggesting the incorporation of mantle-derived volatiles, this may be due to minor | Zhou, SX Ye, XR | 2002 | Chinese Science Bulletin2002，47，9： | 4 |
| 7 | Self-organization of Gold Nanoparticles Protected by 9-(5-Thiopentyl)-carbazole显示文摘Through the reduction of [AuCl4]- by aqueous sodium borohydride in the presence of 9-(5-thiopentyl)-carbazole, the gold nanoparticles has been prepared and characterized. | Wang, S Li, YL Du, CM Shi, ZQ Xiao, SX Fang, HJ Zhu, DB | 2001 | Chinese Chemical Letters2001，12，12： | 4 |
| 8 | Effect of electro-acupuntureon c-fos expression in gerbil hippcampus during transient global ischemia显示文摘 | Ying SX Cheng JS | 1994 | Acupuncture Electro-therapeutics Res1994，19，： | 2 |
| 9 | Molecular mechanism of damage and repair of mouse thymus lymphocytes induced by radiation显示文摘 | Cui YF Yang H Wu SX | 2002 | CMJ2002，115，7： | 2 |
| 10 | New experiments on shear modulus of elasticity of arteries显示文摘 | DENG SX Tomioka J Debes JC | 1994 | Am J Physiol1994，266，： | 2 |
| 11 | Differences in the incidence of the CYP2C19 polymorphism affecting the S-Mephenytoin phenotype in Chinese han and bai population and identification of a new rare CYP2C19 Mutant Allele 显示文摘 | Zhou SX Goldstein JA Xie HG | 1997 | J Pharmacol Exp Ther1997，28，1： | 2 |
| 12 | Intravenous iron sucrose in peritoneal dialysis patients with renal anemia显示文摘 | Li H Wang SX | 2008 | Perit Dial Int2008，28，2： | 1 |
| 13 | Unique physiological and pathogenic features of Leptospira interrogans revealed by whole genome sequencing显示文摘 | Fu G Jiang XG | 2003 | Nature2003，422，24： | 1 |
| 14 | Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke显示文摘 | Zhang SX PolissarNL | 2002 | Circulation2002，105，： | 1 |
| 15 | Dissemination of the CDC's Hand Hygiene Guideline and impact on infection rates显示文摘 | Larson EL Quiros D Lin SX | 2007 | Am J Infect Control2007，35，10： | 1 |
| 16 | Generalized system of imposex and reproductive failure of females in gastropods along the coastal waters of mainland China 显示文摘 | Shi HH Huang CJ Zhu SX | 2005 | Mar Ecol Prog Ser2005，304，： | 1 |
| 17 | Creation of the Chinese visible human data set显示文摘 | Zhang SX Heng PA Liu Zj | 2003 | Anat Rec B New Anat2003，275，1： | 1 |
| 18 | Seroprevalence of hepatitis E virus infection, rural southern people's republic of China显示文摘 | Li RC Ge SX Li YP | 2006 | Emerging Infectious Diseases2006，12，11： | 1 |
| 19 | Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion显示文摘 | Bao L Jin SX Zhang C | 2003 | Neuron2003，37，： | 1 |
| 20 | Active constituents against HIV-1 protease from Garcinia mangostana显示文摘 | Chen SX Wan M Loh BN | 1996 | Planta med1996，62，4： | 1 |
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