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| 1 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 2 | Effective and simple recovery of 1,3-propanediol from a fermented medium by liquid–liquid extraction system with ethanol and K_3PO_4显示文摘1,3-Propanediol,traditionally obtained from fossils,has numerous industrial applications,including use in the production of high performance polymers.The microbial production of 1,3-propanediol presents several opportunities,and the final purity grade determines its price and commercial viability.The development of novel separation technology could improve the economic viability of the bioproduction of 1,3-propanediol.Thus,we investigated salting-out extraction as a novel process for 1,3-propanediol recovery from fermentation broth.Initially,a screening for the best salt/solvent combination was conducted and then optimized using the response surface methodology.The solvents studied were methanol,ethanol,isopropanol and acetone,and the salts examined were K_2HPO_4,Na_2CO_3,K_2CO_3,(NH_4)_2SO_4,NaHPO_4,K_3PO_4 and C_6H_5NaO_7.The optimal extraction system consisted of 34 wt%K_3PO_4,28 wt% ethanol,and 38 wt% fermentation broth containing 23.0 g·L^(-1)1,3-propanediol,which gave the highest partition coefficient of 33 and recovery yield of 97%.The results demonstrated that salting-out extraction was a promising method for 1,3-propanediol recovery from fermentation broth. | Daiana Wischral Hongxin Fu Fernando L.Pellegrini Pessoa Nei Pereira Jr Shang-Tian Yang | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 2 |
| 3 | The advanced glycation end product, Nξ-(carboxymethyl)-lysine, is a product of both lipid peroxidation and glycoxidation reaction 显示文摘 | Fu MX Requena JR Jenkins AR | 1996 | J Biol Chem1996，271，17： | 1 |
| 4 | Screening and cloning of multi-drug resistant genes in HL-60/MDR cells显示文摘 | Zheng GH Fu JR Xu YH | 2009 | Leuk Res2009，33，8： | 1 |
| 5 | Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass 显示文摘 | Fu C Mielenz JR Xiao X Ge Y hamilton CY Rodriguez M Chen F Foston M Ragauskas A Bouton J Dixon RA Wang ZY | 2011 | Proc Natl Acad Sci USA2011，108，9： | 1 |
| 6 | Gene overexpression/suppression analysis of candidate virulence factors of Candida albicans 显示文摘 | Fu Y Luo G Spellberg BJ Edwards JE Jr Ibrahim AS | 2008 | Eukaryot Cell2008，7，3： | 1 |
| 7 | Postharvest browning of litchi fruit by water loss and its prevenxion by controlled atmosphere storage at high relative humidity显示文摘 | Jiang YM Fu JR | 1999 | Food Science and Technology1999，32，5： | 1 |
| 8 | New prognostic factors in nasopharyngeal carcinoma: tuomor angiogenesis and C-erbB-2 expression显示文摘 | Roychowdhury DF Tseng A Jr Fu KK | 1996 | Cancer1996，77，8： | 1 |
| 9 | Anatomic single-bundle anterior cruciate ligament reconstruction 显示文摘 | Van Eck CF Romanowski JR Fu FH | 2009 | Arthroscopy2009，25，9： | 1 |
| 10 | Anatomic single-bundle anterior cruciate ligament reconstruction显示文摘 | Van Eck CF Romanowski JR Fu FH | 2009 | Arthroscopy2009，25，9： | 1 |
| 11 | Ovarian cycle and sympatho- excitation in premenopausal women显示文摘 | Carter JR Fu Q Minson CT | 2013 | Hypertension2013，61，2： | 1 |
| 12 | Effect ofU-995,a potent shark cartilage-derived angiogenesis inhibitor,on anti-angioigensis and anti-tumor activities显示文摘 | Sheu JR Fu CC Tsai ML | 1998 | Anticancer Res1998，18，8： | 1 |
| 13 | Anticoagulation with warfarin in vitreoretinal surgery显示文摘 | Fu AD McDonald HR Williams DF Cantrill HL Ryan EH Jr Johnson RN | 2007 | Retina2007，27，3： | 1 |
| 14 | Aging and cancer related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate显示文摘 | Fu VX Dobosy JR Desotelle JA | 2008 | Cancer Res2008，68，16： | 1 |
| 15 | Effect of four anticorrosive dips on the cutting efficiency of dental carbide burs显示文摘 | Johnson GK Perry FU Pelleu GB Jr | 1987 | J Am Dent Assoc1987，114，5： | 1 |
| 16 | Porosity and permeability variations in fractured and liesegang-banded Breathirr sandstones(middle Pennsylvanian),eastern Kentucky:diagenetic controls and implications for modeling dual-porosity systems显示文摘 | Fu L Milliken K.L Sharp Jr J.M | | 0，，： | 1 |
| 17 | Micellar bile salt mobile phases for the liquid chromatographic separation of routine compounds and optical, geometrical, and structural isomer 显示文摘 | Fu ZS Hinze WL | 1990 | J Chromatogr Sci1990，28，6： | 1 |
| 18 | Combination therapywith amphotericin B lipid complex and caspofungin acetate ofdisseminated zygomycosis in diabetic ketoacidotic mice显示文摘 | Spellberg B Fu Y Edwards JE Jr | 2005 | Antimicrob Agents Chemother2005，49，2： | 1 |
| 19 | Identification of tumor-associated proteins in laryngeal squamous cell carcinoma by proteomics显示文摘 | Zhou JR Fu ZX Wei LZ | 2007 | Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi2007，42，： | 1 |
| 20 | T-cell depletion and graft survival induced by anti-human CD3 immunotoxins in human CD3 epsilon transgenic mice 显示文摘 | Weetall M Digan ME Hugo R Mathew S Hopf C Tart-Risher N Zhang J Shi V Fu F Hammond-McKibben D West S Brack R Brinkmann V Bergman R Neville D Jr Lake P | 2002 | Transplantation2002，73，10： | 1 |
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