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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | 定量和定性评价髂总动脉及下肢动脉CT血管成像过程中不同的进床速率对外周血管显影的影响显示文摘回顾性研究不同进床速度(TF)对周围动脉闭塞性疾病(PAOD)、急性缺血(AI)或腹主动脉瘤(AAA)合并PAOD病人下肢流出性CTA血管增强与影像质量的影响O185例病人(PAOD132例,A140例,AAAl3例)以不同的TF(30mm/s25例,40mm/s91例,48mm/s36例,56mm/s33例)行16层CT流出性CTA(120kV;140mAs,0.5s,准直器宽16×1.5mm)检查。在上腹部至脚趾的范围内,沿身体长轴每隔10cm测量主干动脉的强化程度。应用方差分析法(Bonferroni posttest)对下肢远侧动脉的强化行对照分析, | B.C. Meyerl A. Oldenburg B.B. Frericks C. Ribbe W. Hopfenmüller K.J. Wolf 赵艳萍(译) 刘文亚(校) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 8 |
| 3 | Initial experience from a combination of systemic and regional chemotherapy in the treatment of patients with nonresectable cholangiocellular carcinoma in the liver显示文摘AIM: In nonresectable cholangiocellular carcinoma (CCC)therapeutic options are limited. Recently, systemic chemotherapy has shown response rates of up to 30%.Additional regional therapy of the arterially hyper vascularized hepatic tumors might represent a rational approach in an attempt to further improve response and palliation. Hence, a protocol combining transarterial chemoembolization and systemic chemotherapy was applied in patients with CCC limited to the liver.METHODS: Eight patients (6 women, 2 men, mean age 62 years) with nonresectable CCC received systemic chemotherapy (gemcitabine 1 000 mg/m2) and additional transarterial chemoembolization procedures (50 mg/m2cisplatin, 50 mg/m2 doxorubicin, up to 600 mg degradable starch microspheres). Clinical follow-up of patients, tumor markers, CT and ultrasound were performed to evaluate maximum response and toxicity.RESULTS: Both systemic and regional therapies were tolerated well; no severe toxicity (WHO Ⅲ/Ⅳ) was encountered. Nausea and fever were the most commonly observed side effects. A progressive rarefication of the intrahepatic arteries limited the maximum number of chemoembolization procedures in 4 patients. A median of 2 chemoembolization cycles (range, 1-3) and a median of 6.5 gemcitabine cycles (range, 4-11) were administered.Complete responses were not achieved. As maximum response, partial responses were achieved in 3 cases,stable diseases in 5 cases. Two patients died from progressive disease after 9 and 10 mo. Six patients are still alive. The current median survival is 12 mo (range, 9-18); the median time to tumor progression is 7 mo (range, 3-18). Seven patients suffered from tumor-related symptoms prior to therapy, 3 of these experienced a treatment-related clinical relief. In one patient the tumor became resectable under therapy and was successfully removed after 10 mo.CONCLUSION: The present results indicate that a combination of systemic gemcitabine therapy and repeated regional chemoembolizations is well tolerated and may enhance the effect of palliation in a selected group of patients with intrahepatic nonresectable CCC. | Timm Kirchhoff Lars Zender Sonja Merkesdal Bernd Frericks Nisar Malek Joerg Bleck Stefan Kubicka Stefan Baus Ajay Chavan Michael P.Manns Michael Galanski | 2005 | World Journal of Gastroenterology2005，11，8： | 3 |
| 4 | Pathways to Nursing:an innovative program to encourage high shcool students to enter nursing显示文摘 | Cormley DK Frerick JA Dean A | | 0，，04： | 1 |
| 5 | The Global Monitoring for Environment and Security (GMES) Sentinel-3 mission显示文摘 | C. Donlon B. Berruti A. Buongiorno M.-H. Ferreira P. Féménias J. Frerick P. Goryl U. Klein H. Laur C. Mavrocordatos J. Nieke H. Rebhan B. Seitz J. Stroede R. Sciarra | 2012 | Remote Sensing of Environment2012，，： | 1 |
| 6 | 3D CT modeling of hepatic vessel architecture and volume calculations in living donated liver transplantation显示文摘 | Frericks BB Caldorone FC Nashan B | 2004 | Eur Radiol2004，14，： | 1 |
| 7 | Qualitative and quantitative evaluation of hepatocellular carci- noma and cirrhotic liver enhancement using Gd -EOB -DT- PA显示文摘 | FRERICKS BB LODDENKEMPER C HUPPERTZ A | 2009 | A JR Am J Roentgenol2009，193，4： | 1 |
| 8 | The value of combined soft tissue and vessel visualisation before transarterial chemoembolisation of the liver using C arm computed tomography显示文摘 | Meyer BC Witschel M Frericks BB | 2009 | Eur Radiol2009，19，23： | 1 |
| 9 | CT-based liver volumetry in a porcine model: Impact on clinical volumetry prior to living donated liver transplantation显示文摘 | Frericks BB Kiene T Stamm G | 2004 | Rofo2004，176，2： | 1 |
| 10 | Angiodysplasia of the colon combined with portal hypertension and recurrent gastrointestinal bleeding显示文摘 | Lehner F Becker T Frericks B | | 0，，12： | 1 |
| 11 | Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits显示文摘 | Lindsberg PJ Yue TL Frericks KU | 1990 | Stroke1990，21，10： | 1 |
| 12 | A toolbox of novel murine house-keeping genes identified by meta-analysis of large scale gene expression profiles 显示文摘 | Frericks M Esser C | 2005 | Biochim Biophys Acta2005，1779，12： | 1 |
| 13 | Advances in uroradiological imaging显示文摘 | Wefer AE Wefer J Frericks B | 2002 | BJU Int2002，89，5： | 1 |
| 14 | Visualization of hypervascular liver lesions during TACE: comparison of angiographic C-arm CT and MDCT显示文摘 | Meyer BC Frericks BB Voges M | 2008 | AJR2008，190，： | 1 |
| 15 | 查看详情显示文摘 | Bovensmann H Burrows J P Buchwitz M Frerick J Noel S Rozanov V V Chance K V Goede A P H | | 0，，： | 1 |
| 16 | Intraarterial calcium stimulation (ASVS) for pancreatic insulinoma:comparison of preoperative localization procedures 显示文摘 | Kirchhoff TD Merkesdal S Frericks B | 2003 | Radiologe2003，43，4： | 1 |
| 17 | Multipolar radiofrequency ablation of hepatic tumors:initial experience显示文摘 | Frericks BB Ritz JP Roggan A | 2005 | Radiology2005，237，3： | 1 |
| 18 | 3D CT modelingof hepatic vessel architecture and volume calculation in livingdonated liver transplantation显示文摘 | Frericks BB Caldarone FC Nashan B | 2004 | Eur Radiol2004，14，2： | 1 |
| 19 | Hepatic transit time analysis using contrast enhanced MRI with Gd‐BOPTA: A prospective study comparing patients with liver metastases from colorectal cancer and healthy volunteers显示文摘 | Joachim Hohmann Caroline Newerla Anja Müller Christine Reinicke Jan Skrok Bernd B. Frericks Thomas Albrecht | 2012 | J Magn Reson Imaging2012，，6： | 1 |
| 20 | Hepatic Transit Time Analysis Using Contrast-Enhanced Ultrasound with BR1: A Prospective Study Comparing Patients with Liver Metastases from Colorectal Cancer with Healthy Volunteers显示文摘 | Joachim Hohmann Christine Müller Anja Oldenburg Jan Skrok Bernd B. Frericks Karl-Jürgen Wolf Thomas Albrecht | 2009 | Ultrasound in Medicine & Biology2009，，9： | 1 |
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