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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Mechanisms for the intracellular manipulation of organelles by conventional electroporation显示文摘 | Esser A T Smith K C Gowrishankar T R | 2010 | Biophysical Journal2010，98，11： | 1 |
| 3 | Towards solid tumor treatment by irreversible electroporation: intrinsic redistribution of fields and currents in tissue显示文摘 | Esser A T Smith K C Gowrishankar T R | 2007 | Technology in Cancer Research and Treatment2007，6，4： | 1 |
| 4 | Plasma-MIG welding developed by philips显示文摘 | Essers W G hietfkens A C | 1972 | Machinery and Production Engineering1972，121，3129： | 1 |
| 5 | Nuclear dynamics of PCNA in DNA replication and repair显示文摘 | Essers T Thiel AF Baldeyron C | 2005 | Mol Cell Biol2005，25，21： | 1 |
| 6 | A new approach to power supplies for robots 显示文摘 | Esser A Skudelny H C | 1991 | IEEE Transactions on Industry Applications1991，27，5： | 1 |
| 7 | Plasma-MIG welding developed hy philips显示文摘 | Esser W G Liefkens A C | 1972 | Macllinery and Production Engineering1972，1，11： | 1 |
| 8 | Bone development in dairy heifers fed diets with and without supplemental phosphorus显示文摘 | Esser N M P C Hoffman W K Coblentz | | Anita Sci Vol 86 E-Suppl 2/J Dairy Sei Vol 91 E-Suppl10，481，： | 1 |
| 9 | Immunoglobulin class switching:molecular and cellular analysis显示文摘 | Esser C Gunn B David F | 1990 | Annu Rev Immunol1990，8，： | 1 |
| 10 | 显示文摘 | ESSERS M MUCK-LICHTENFELD C HAUFE G | 2002 | J Org Chem2002，67，： | 1 |
| 11 | The psychometric properties of the St George's Respiratory Questionnaire(SGRQ)in patients with idiopathic pulmonary fibrosis:a literature review显示文摘 | Swigris J J Esser D Conoscenti C S | 2014 | Health Qual Life Outcomes2014，12，1： | 1 |
| 12 | Vector design for liver-specific expression of multiple interfering RNAs that target hepatitis B virus transcripts显示文摘 | Snyder L L Esser J M Pachuk C J | 2008 | AntiviraI Research2008，80，1： | 1 |
| 13 | Nuclear dynamics of PCNA in DNA replication and repair显示文摘 | Essers J Theil AF Baldeyron C van Cappellen WA Houtsmuller AB Kanaar R Vermeulen W | 2005 | Mol Cell Biol2005，5，21： | 1 |
| 14 | Early mother-infant interaction as a precursor to childhood social withdrawal显示文摘 | Gerhold M Laucht M Texdorf C Schmidt M.H Esser G | | 0，，： | 1 |
| 15 | The effect of dietary phosphorus on bone development in dairy heifers显示文摘 | Esser N M P C Hoffman W K Coblentz | 2009 | J Dairy Sci2009，92，4： | 1 |
| 16 | Ultraviolet B radiation-induced immunosuppression : molecular mechanisms and cellular alterations Photochem 显示文摘 | Schade N Esser C Krutmann J | 2005 | Photobiol Sci2005，4，： | 1 |
| 17 | Plasma-MIG welding developped by Philips 显示文摘 | Essers W G Liefkens A C | 1972 | Machinery and Production Engineering1972，1，11： | 1 |
| 18 | Beta 2- microglobulin stimulates osteoclast formation显示文摘 | Menaa C Esser E Sprague S | 2008 | Kidney Int2008，73，11： | 1 |
| 19 | Chemical warfare in the First World War: reflections 100 years later 显示文摘 | Mangerich A Esser C | 2014 | Arch Toxicol2014，88，11： | 1 |
| 20 | The chaperone - associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation显示文摘 | Esser C Scheffner M Hohfeld J | 2005 | J Biol Chem2005，280，27： | 1 |
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