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| 1 | Targeting the insulin-like growth factor pathway in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the third leading cause of cancer-related deaths worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments, which include surgical resection as the first option, liver transplantation and percutaneous ablation. Unfortunately, there is a high frequency of tumor recurrence after surgical resection and most HCC seem resistant to conventional chemotherapy and radiotherapy. Sorafenib, a multi-tyrosine kinase inhibitor, is the only chemotherapeutic option for patients with advanced hepatocellular carcinoma. Patients treated with Sorafenib have a significant increase in overall survival of about three months. Therefore, there is an urgent need to develop alternative treatments. Due to its role in cell growth and development, the insulin-like growth factor system is commonly deregulated in many cancers. Indeed, the insulin-like growth factor(IGF) axis has recently emerged as a potential target for hepatocellular carcinoma treatment. To this aim, several inhibitors of the pathway have been developed suchas monoclonal antibodies, small molecules, antisense oligonucleotides or small interfering RNAs. However recent studies suggest that, unlike most tumors, HCC development requires increased signaling through insulin growth factor Ⅱ rather than insulin growth factor Ⅰ. This may have great implications in the future treatment of HCC. This review summarizes the role of the IGF axis in liver carcinogenesis and the current status of the strategies designed to target the IGF-Ⅰ signaling pathway for hepatocellular carcinoma treatment. | Mónica Enguita-Germán Puri Fortes | 2014 | World Journal of Hepatology2014，6，10： | 10 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | 实体器官移植患者中热带病和地方性感染病的流行状况显示文摘 | Martín-Dávila P Fortún J López-Vélez R 康悦 吴菊芳 | 2010 | 中国感染与化疗杂志2010，10，3： | 3 |
| 4 | Up Close: Family Therapy Challenges and Innovations Around the World显示文摘 | Janine Roberts Khawla Abu‐Baker Cristina Diez Fernández Nelly Chong Garcia Glenda Fredman Hugo Kamya Yolanda Martín Higarza Jacqueline Fortes de Leff Philip Messent Shin‐Ichi Nakamura Fatma Torun Reid Timothy Sim Chitra Subrahmanian Roxana Zevallos Vega | 2014 | Fam. Proc2014，，： | 2 |
| 5 | Porcine circovirus type 2 (PCV2) Cap and Rep proteins are involved in the development of cell-mediated immunity upon PCV2 infection显示文摘 | Maria Fort Marina Sibila Miquel Nofrarías Eva Pérez-Martín Alex Olvera Enric Mateu Joaquim Segalés | 2010 | Veterinary Immunology and Immunopathology2010，，3： | 2 |
| 6 | Analysis of mortality and risk factors associated with native valve endocarditis in drug users: The importance of vegetation size显示文摘 | Pilar Martín-Dávila Enrique Navas Jesús Fortún Jose Luis Moya Javier Cobo Vicente Pintado Carmen Quereda Manuel Jiménez-Mena Santiago Moreno | 2005 | American Heart Journal2005，，5： | 1 |
| 7 | Reduced beta-catenin and peroxisome proliferator- activated receptorgamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome 显示文摘 | Pancione M Forte N Sabatino L | 2009 | Hum Pathol2009，40，5： | 1 |
| 8 | Study of plasma jet capabilities to produce uniform ignition of propellants, ballis tic gain, and significant decrease of the temperature gradient显示文摘 | Zoler D Shafir N Forte D | 2007 | IEEE Transactions on Magnetics2007，43，1： | 1 |
| 9 | Barriers andfacilitating factors for disease self - management : a qualitativeanalysis of perceptions of patients receiving care for type 2 diabetesand/or hypertension in San Jos6,Costa Rica and Tuxtla Gutierrez,Mexico 显示文摘 | Fort MP Alvarado 一 Molina N Pefta L | 2013 | BMC Family Practice2013，14，1： | 1 |
| 10 | Simultaneous application of microbial transglutaminase and high hydrostatic pressure to improve heat induced gelation of pork plasma显示文摘 | FORT N LANIER T C AMATO P M | 2008 | Meat Science2008，80，3： | 1 |
| 11 | Oxidative stress status in rats after intermittent exposure to hypobaric hy- poxia 显示文摘 | ESTEVA S PEDRET R FORT N | 2010 | Wilderness Environ Med2010，21，4： | 1 |
| 12 | Bacterial urinary tract infection after solid organ transplantation in the RESITRA cohort显示文摘 | E. Vidal J. Torre‐Cisneros M. Blanes M. Montejo C. Cervera J.M. Aguado O. Len J. Carratalá E. Cordero G. Bou P. Mu?oz A. Ramos M. Gurguí N. Borrell J. Fortún | 2012 | Transpl Infect Dis2012，，6： | 1 |
| 13 | Analysis ofmortality and risk factors associated with native valve en-docarditis in drug users:the importance of vegetationsize显示文摘 | Martín-Dávila P Navas E Fortún J | 2005 | Am Heart J2005，150，5： | 1 |
| 14 | Listeria monocytogenes isolates from foods and humans form distinct but ovordapping populations显示文摘 | GRAY M J ZADOKS R N FORTES E D | 2004 | Applied and Environment Microbiology2004，70，10： | 1 |
| 15 | Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma:Protective effects of ascorbic acid显示文摘 | FREI B FORTE T M AMES B N | 1991 | Biochem J1991，277，： | 1 |
| 16 | Simultaneous application of microbial transglutaminase and high hydrostatic pressure to improve heat induced gelation of pork plasma显示文摘 | FORT N LANIER T C AMATO P M | 2008 | Meat Science2008，80，3： | 1 |
| 17 | Listeria monocytogenes isolates from foods and humans form distinct but overlapping populations显示文摘 | Gray M J Zadoks R N Fortes E D | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 18 | I5- S1 Aeh- romobaeter xylosoxidans infection secondary to oxygen-ozone therapy for the treatment of lumbosacral dise herniation: a ease report and review of the literature 显示文摘 | FORT N M AICHMAIR A MILLER A O | 2014 | Spine2014，39，6： | 1 |
| 19 | IL-4 exacerbates disease in a Thl cell transfer model of colitis 显示文摘 | Fort M Lesley R Davidson N | 2001 | J Immunol2001，166，4： | 1 |
| 20 | IL-4 exacerbates disease in a Th1 cell transfer model of colitis显示文摘 | LESLEY R DAVIDSON N | 2001 | J Immunol2001，166，4： | 1 |
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