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| 1 | Mechanical microenvironments of living cells: a critical frontier in mechanobiology显示文摘The fields of biomechanics and mechanobiology have long been predicated on the premise that mechanics governs cell behavior. However, over the past few years, a growing body of evidence has suggested that the mechanical environment very close to cells–the cell microenvironment–plays the most important role in determining what a cell feels and how it responds to tissue-level stimuli. To complicate matters further, cells can actively manipulate their microenvironments through pathways of recursive mechanobiological feedback. Harnessing this recursive behavior to understand and control cell physiology and pathophysiology is a critical frontier in the field of mechanobiology. Recent results suggest that the key to opening this scientific frontier to investigation and engineering application is understanding a different frontier: the physical frontier that cells face when probing their mechanical microenvironments. | Guoyou Huang Feng Xu Guy M. Genin Tian Jian Lu | 2019 | Acta Mechanica Sinica2019，35，2： | 5 |
| 2 | Volumetric response of an ellipsoidal liquid inclusion: implications for cell mechanobiology显示文摘Elastic composites containing liquid inclusions exist widely in nature and engineering fields. The volumetric response of liquid inclusions is important in many cases, such as an isolated cell embedded in an extracellular matrix and an oil pocket embedded within shale. In this study, we developed a model for describing the volumetric response of an ellipsoidal liquid inclusion. Specifically, we investigated the volumetric response of an ellipsoidal liquid inclusion embedded in a three-dimensional (3D) matrix through an analytical expression of the volumetric response. We performed parametric analysis and found that loading along the shortest axis can induce the most volume change, while loading along the longest axis can induce the least volume change. We also found that the volumetric response decreases with increasing Poisson ratio of the matrix. These results could be used to understand some cell behavior in a 3D matrix, for example, cell alignment under mechanical load. | Xin Chen Wei He Shaobao Liu Moxiao Li Guy M. Genin Feng Xu Tian Jian Lu | 2019 | Acta Mechanica Sinica2019，35，2： | 2 |
| 3 | Clinical and molecular genetic features of ARC syndrome显示文摘 | Paul Gissen Louise Tee Colin A. Johnson Emmanuelle Genin Almuth Caliebe David Chitayat Carol Clericuzio Jonas Denecke Maja Rocco Bj?rn Fischler David FitzPatrick Angeles García-Cazorla Delphine Guyot Sebastien Jacquemont Sibylle Koletzko Bruno Leheup Hann | 2006 | Human Genetics2006，，3： | 2 |
| 4 | Interferon regulatory factors: the next generation显示文摘 | Mamane Y Heylbroeck C Genin P | 1999 | Gene1999，237，1： | 1 |
| 5 | Functional grading of mineral and collagen in the attachment of tendon to bone 显示文摘 | Genin GM Kent A Birman V | 2009 | Biophys J2009，97，： | 1 |
| 6 | APOE and Alzheimer disease: a major gene with semi-dominant inheritance 显示文摘 | Genin E Hannequin D Wallon D | 2011 | Mol Psychiatry2011，16，9： | 1 |
| 7 | Lessons learned from the genome analysis of Ralstonia solanacearum显示文摘 | Genin S Boucher C | | 0，，42： | 1 |
| 8 | Hypogonadotropie hy- pogonadism due to loss of function of the Kissl-derived peptide receptor GPR54 显示文摘 | De Roux N Genin E Carel J C | 2003 | Proe Natl Acad Sei USA2003，100，10： | 1 |
| 9 | Pregnancy-associat- ed breast cancers: Do they differ from other breast cancers in young women显示文摘 | Genin AS Lesieur B Gligorov J | 2012 | Breast2012，21，4： | 1 |
| 10 | Cloning, Human Chromosomal Assignment, and Adipose and Hepatic Expression of the CL-6/INSIG1 Gene显示文摘 | Yong Peng Emily J. Schwarz Mitchell A. Lazar Anna Genin Nancy B. Spinner Rebecca Taub | 1997 | Genomics1997，，3： | 1 |
| 11 | Interferon regulatory factor: the next generation 显示文摘 | Mamane Y Heylbroeck C Genin P | 1999 | Gene1999，237，： | 1 |
| 12 | Recent progress with oxazolidinone antibacterial agents显示文摘 | Genin MJ | 2000 | Expert Opinion on Therapeutic Patents2000，10，： | 1 |
| 13 | Secreted proteins from Ralstonia solanace-arum :a hundred tricks to kill a plant 显示文摘 | Poueymiro M Genin S | 2009 | Current Opinion inMicrobiology2009，12，1： | 1 |
| 14 | Hostile take overs: viral appropriation of the NF B pathway显示文摘 | HISCOTT J KWON H GENIN P | 2001 | J Clin Invest2001，107，： | 1 |
| 15 | Bio-physical coupling in the formation of zooplankton and fish aggregations over abrupt topographies显示文摘 | Genin A | 2004 | Journal of Marine Systems2004，50，1： | 1 |
| 16 | Catastrophic failure of contaminated fused silica optics at 355 nm显示文摘 | Genin F Y Kozlowski M R Brusasco R | | 0，，： | 1 |
| 17 | Ralstonia solanacearum: secrets of a major pathogen unveiled by analysis of its genome 显示文摘 | Genin S Boucher C | 2002 | Mol Plant Pathol2002，3，3： | 1 |
| 18 | APOE and Alzheimer disease: a major gene with semi-dominant inheritance 显示文摘 | Genin E Hannequin D Wallon D | 2011 | Mol Psychiatry2011，16，： | 1 |
| 19 | Lessons learned from the genome analysis of ralstonia solanacearum显示文摘 | Genin S Boucher C | 2004 | Annu Rev Phytopatho12004，42，： | 1 |
| 20 | Characterization of the eisaeting regulatory element controlling HrpB- mediated activation of the type III secretion system and effeetor genes in Ralstonia solanaccm'um 显示文摘 | Cunnac S Boucher C Genin S | 2004 | Bacteriol2004，18，： | 1 |
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