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| 1 | Treatment of sepsis: What is the antibiotic choice in bacteremia due to carbapenem resistant Enterobacteriaceae?显示文摘Sepsis is one of the major challenges of today. Although gram-positive bacteria related infections are more prevalent in hospital setting, the highest mortality rate is associated with gram-negative microorganisms especially Enterobacteriaceae. Enterobacteriaceae, including Escherichia coli, Klebsiella spp., Proteus spp., Enterobacter spp. and Serratia spp. Resistance to β-lactams in Enterobacteriaceae is primarily attributed to the production of B-lactamase enzymes with subsequent antibiotic hydrolysis and to a lesser extent by alteration of efflux pump or porins expression. Carbapenem resistant Enterobacteriaceae(CRE) and Acinetobacter baumannii are the most notorious pathogens due to the high incidence of morbidity and mortality especially in the immunocompromised patients in the intensive care unit. The most appropriate antimicrobial therapy to treat CRE is still controversial. Combination therapy is preferred over monotherapy due to its broad-spectrum coverage of micro-organisms, due to its synergetic effect and to prevent development of further resistance. Current suggested therapies for CRE resistance as well as promising antibiotics that are currently under investigation for winning the war against the emerging CRE resistance are reviewed and discussed. | Fatema Alhashem Nicolette Leonie Tiren-Verbeet Emine Alp Mehmet Doganay | 2017 | World Journal of Clinical Cases2017，5，8： | 6 |
| 2 | Endoscopic retrograde cholangiopancreatography in elderly patients: Difficult cannulation and adverse events显示文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is a valuable therapeutic technique for pancreatobiliary diseases,and its application in the elderly is no longer limited.However,a higher incidence of procedure difficulty and periprocedural adverse events might be expected in elderly patients due to the presence of other medical disorders and the poor general condition of this population.AIM To evaluate the incidence,causes,and management of difficult biliary cannulation during ERCP in elderly patients and the role of difficult cannulation as a risk factor for adverse events.METHODS A total of 614 patients who underwent ERCP during the study period were prospectively studied and divided into two groups based on their age.One hundred and forty-six patients were aged 80 years or older and 468 patients were aged less than 80 years.The primary outcome measurements were cannulation difficulty,cannulation success rate,ERCP procedure time,and related adverse events.RESULTS There was no difference in the incidence of difficult cannulation among the two groups(32.9%vs 34.4%,P=0.765),as well as in the cannulation success rate(96.6%vs 96.8%,P=0.54).The cannulation techniques were shown to be safe and efficient in achieving successful cannulation.Logistic regression analysis showed that patients aged 80 years or older were not associated with increased adverse events;however,difficult cannulation cases[adjusted odds ratio(AOR)=3.478;95%confidence interval(CI):1.877-6.442;P<0.001]and patients with Charlson Comorbidity Index≥2(AOR=1.824;95%CI:0.993-3.349;P=0.045)were more likely to develop adverse events.In contrast,other factors including age≤65(AOR=3.460;95%CI:1.511-7.922;P=0.003),female gender(AOR=2.362;95%CI=1.089-5.124;P=0.030),difficult cannulation(AOR=4.527;95%CI:2.078-9.860;P<0.001),and patients with cholangitis(AOR=3.261;95%CI:1.204-8.832;P=0.020)were strongly associated with a higher rate of post-ERCP pancreatitis.CONCLUSION Advanced age has not been proved to be a risk factor for difficult cannulation,and secondary cannulation techniques can be safely and efficaciously utilized in this group.Patients with a Charlson Comorbidity Index≥2 and difficult cannulation are associated with an increased overall adverse events rate,while age≥80 years is not. | Fatema Tabak Hui-Shan Wang Quan-Peng Li Xian-Xiu Ge Fei Wang Guo-Zhong Ji Lin Miao | 2020 | World Journal of Clinical Cases2020，8，14： | 2 |
| 3 | Tissue culture independent transformation for Corchorus olitorius显示文摘 | Abu Ashfaqur Sajib Md. Shahidul Islam Md. Shamim Reza Arpita Bhowmik Layla Fatema Haseena Khan | 2008 | Plant Cell, Tissue and Organ Culture2008，，3： | 1 |
| 4 | Hemodialysis improves myocardial interstitial edema and left ventricular diastolic function in patients with end-stage renal disease:noninvasive assessment by ultrasonic tissue characterization显示文摘 | Fatema K Hirono O Takeishi Y | 2002 | Heart Vessels2002，16，： | 1 |
| 5 | Role of intraoperative transesophageal echocardiography in patients having coronary artery bypass graft surgery显示文摘 | Fatema E Qaddoura MD Martin D | 2004 | Ann Thorac Surg2004，78，： | 1 |
| 6 | Predictive valueof normal left atrial volume in stress echocardiography显示文摘 | Alsaileek AA Osranek M Fatema K | 2006 | AmColl Cardiol2006，47，5： | 1 |
| 7 | 数据可视化能讲的故事显示文摘数据驱动的故事使决策者们有可能作出高效、明智的决策,这是仅凭文本数据方式无法实现的。为推动企业数字化转型,财会专业人士要有能力探索新的方法去管理、分析数据并从中提取价值,运用分析及批判性思维技能应对战略问题,尤其要能够有效地传递数据背后的“故事”。而通过数据可视化技能,管理会计师可以讲述推动业务增长、转变产品与服务供应以及确保企业长期可持续发展所需的故事。 | Fatema El—Wakeel Loreal Jiles Raef Lawson | 2021 | 新理财(公司理财)2021，，4： | 1 |
| 8 | The distribution and habitat preferences of the zebrafish in Bangladesh显示文摘 | SPENCE R FATEMA M K REICHARD M | 2006 | Journal of Fish Biology2006，69，5： | 1 |
| 9 | Predictive value of normal left atrial volume in stress echocardiography显示文摘 | Alsailcek AA Osranek M Fatema K | | 0，，5： | 1 |
| 10 | Comparative efficiencies of the degradation of crystal violet using UV/hydrogen peroxide and Fenton's reagent显示文摘 | Fatema A Alshamsi Amna S Albadwawi Maitha M Alnuaimi | 2007 | Dyes and Pigments2007，74，： | 1 |
| 11 | Tailored nanocarriers and bioconjugates for combating glioblastoma and other brain tumors显示文摘Worldwide,the incidence of primary brain tumors is on the rise.Unfortunately,noninvasive drug therapy is hampered by poor access of most drugs to the brain due to the insurmountable blood-brain barrier(BBB).Nanotechnology holds great promise for noninvasive therapy of severe brain diseases.Furthermore,recent bioconjugation strategies have enabled the invasion of the BBB via tailored-designed bioconjugates either with targeting moieties or alterations in the physicochemical and/or the pharmacokinetic parameters of central nervous system(CNS)active pharmaceutical ingredients.Multifunctional systems and new entities are being developed to target brain cells and tumor cells to resist the progression of brain tumors.Direct conjugation of an FDA-approved drug with a targeting moiety,diagnostic moiety,or pharmacokinetic-modifying moiety represents another current approach in combating brain tumors and metastases.Finally,genetic engineering,stem cells,and vaccinations are innovative nontraditional approaches described in different patents for the management of brain tumors and metastases.This review summarizes the recent technologies and patent applications in the past five years for the noninvasive treatment of glioblastoma and other brain tumors.Till now,there has been no optimal strategy to deliver therapeutic agents to the CNS for the treatment of brain tumors and metastases.Intensive research efforts are ongoing to bring novel CNS delivery systems to potential clinical application. | Fatema ELAmrawy Amr A.Othman Chris Adkins Aliaa Helmy Mohamed I.Nounou | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 1 |
| 12 | Sheehan’s syndrome with reversible dilated cardiomyopathy: A case report and brief overview显示文摘 | A.K.M. Monwarul Islam Mohammad A. Hasnat Fatema Doza Humayra Jesmin | 2014 | Journal of the Saudi Heart Association2014，，： | 1 |
| 13 | Return of the Prodigal显示文摘 | Ahmed Fatema | | 0，，： | 1 |
| 14 | Effects of Sofosbuvir-based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C显示文摘 | Zobair M. Younossi Maria Stepanova Linda Henry Edward Gane Ira M. Jacobson Eric Lawitz David Nelson Lynn Gerber Fatema Nader Sharon Hunt | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 15 | A privacy preserving authorisation system for the cloud 显示文摘 | DAVID W Chadwick KANIZ Fatema | 2012 | Journal of Computer and System Sciences2012，78，5： | 1 |
| 16 | Dynamic Assessment of Myocardial Involvement in Patients with End-stage Renal Disease by Ultrasonic Tissue Characterization and Serum Markers of Collagen Metabolism显示文摘 | Fatema K Hirono O Masakane I | 2004 | Clin Cardiol2004，27，4： | 1 |
| 17 | Left atrial volume predicts the risk of atrial fibrillation after cardiac surgery:a prospective study显示文摘 | Osranek M Fatema K Qaddoura F | 2006 | J Am Coll Cardiol2006，48，3： | 1 |
| 18 | Left atrial volume pre- dicts the risk of atrial fibrillation after cardiac surgery : a prospec- tive study显示文摘 | Osranek M Fatema K Qaddoura F | 2006 | J Am Coil Cardiol2006，48，4： | 1 |
| 19 | Australian Hajj pilgrims' knowledge about MERS-CoV and other respiratory infections显示文摘Dear Editor,With the intense crowding in mass gatherings such as Hajj,there is a high risk of acquisition of airborne in-fections with the potential for its transmission in the pilgrims’country of origin(Memish Z A,et al.,2014).The risk of importing serious infections from Hajj has escalated since the emergence of the Middle East respiratory syndrome coronavirus(MERS-CoV)in Saudi Arabia and other neighbouring countries from September2012.Active surveillance of Hajj pilgrims in 2012 and | Mohamed Tashani Mohammad Alfelali Osamah Barasheed Fayeza Nusrat Fatema Amani Alqahtani Harunor Rashid Robert Booy | 2014 | Virologica Sinica2014，29，5： | 1 |
| 20 | Dynamic assessment of myocardial involvement in patients with endstage renal disease by ultrasonic tissue characterization and serum markers of collagen metabolism显示文摘 | FATEMA K HIRONO O MASAKANE I | 2004 | Clin Cardio2004，27，4： | 1 |
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