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| 1 | 中国乙型肝炎和非肝炎男性间的精液质量和辅助生殖技术治疗结果的比较显示文摘本研究旨在确定乙型肝炎病毒(HBV)感染对精子质量和辅助生殖技术治疗结局的影响。分析2008年1月至2009年12月于浙江大学附属妇产科医院寻求辅助生育治疗的916例男性(457例乙型肝炎病毒携带者和459例阴性对照男性)的精液参数;将2004年1月至2009年12月期间的男性乙肝病毒携带的587个常规体外受精(In vitro fertilisation,IVF)周期和325个单精子卵细胞浆内注射(Intracytoplasmic sperm injection,ICSI)周期作为阳性观察组,根据取卵日期、女方年龄及ART受精方式通过统计软件以1:1比例匹配,设立夫妇双方均为HBsAg阴性的对照组(587个IVF周期,324个ICSI周期),分析两组间的辅助生殖治疗结局。与对照组相比,乙肝携带者表现有较低的精液体积、精子总数以及较差的精子活动力和形态学表现(P〈0.05);乙肝男性夫妇接受ICSI治疗后,双原核(2PN)受精率、优质胚胎率、胚胎着床率以及临床妊娠率均显著性降低俨〈0.05);而两组病人间的IVF治疗结局差异无显著性(P〉0.05)。通过Logistic回归分析发现乙肝病毒感染作为一个独立的因素增加少弱精子症的发生以及降低ICSI治疗周期的胚胎着床率和临床妊娠率(P〈0.05)。我们的研究结果提示了男性乙型肝炎病毒感染与较差的精子质量和ICSI治疗结局有关,而对IVF治疗结局没有明显的影响。 | Xu-Ping Zhou Xiao-Ling Hu Yi-Min Zhu Fan Qu Sai-lun Sun Yu-Li Qian | 2011 | Asian Journal of Andrology2011，13，3： | 27 |
| 2 | 电针和经皮穴位电刺激技术在生殖医学中的应用:专家共识(英文)显示文摘本文从传统针刺治疗不孕症的选穴依据与现代电针/经皮穴位电刺激技术的相关原理着手,从最优刺激参数选择、穴位辨证、疗程与治疗次数的确定及基本原理等方面阐述了电针/经皮穴位电刺激技术在多囊卵巢综合症、取卵镇痛、卵巢储备功能降低、胚胎移植以及男性少/弱精症等生殖领域中的具体应用。首次对电针/经皮穴位电刺激技术在生殖领域优势病种中的应用进行了系统的分析和总结,在最优刺激参数选择、穴位辨证、疗程与治疗次数的确定等方面提出了一系列专家共识,并为临床实践提供了指导意见和理论依据。 | Fan QU Rong LI Wei SUN Ge LIN Rong ZHANG Jing YANG Li TIAN Guo-gang XING Hui JIANG Fei GONG Xiao-yan LIANG Yan MENG Jia-yin LIU Li-ying ZHOU Shu-yu WANG Yan WU Yi-jing HE Jia-yu YE Song-ping HAN Ji-sheng HAN | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 24 |
| 3 | Isotopic Chronological Study of the Huangsha-Tieshanlong Quartz Vein-Type Tungsten Deposit and Timescale of Molybdenum Mineralization in Southern Jiangxi Province,China显示文摘Huangsha-Tieshanlong 石英静脉钨 polymetallic 矿石沉积物,在勘探 Yushan metallogenic 带的区域的东方 Ganxian-Yudu 在北 Pangushan-Tieshanlong 钨矿石地里定位了,是在南部的江西省的著名的钨沉积物,中国。从 Tieshanlong 花岗石的锆石的虾坚定的标明日期产出 168.1 | HUANG Fan FENG Chengyou CHEN Yuchuan YING Lijuan CHEN Zhenghui1 ZENG Zailin QU Wenjun | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 18 |
| 4 | 关于美国、欧洲和中国的多囊卵巢综合征临床指南或共识的比较分析(英文)显示文摘通过比较欧洲人类生殖和胚胎学会和美国生殖医学协会联合发表的鹿特丹共识、中国的多囊卵巢综合征诊治标准专家共识和美国内分泌学会的临床实践指南,分析了不同指南对育龄期、青春期和围绝经期多囊卵巢综合症诊断标准的差异,概括了多囊卵巢综合征临床治疗的主要方面,同时提出了一些诊治方面的新进展及今后需要进一步关注的问题。在多囊卵巢综合征的诊断上,对育龄期女性的标准三大指南略有不同,而对青春期和围绝经期女性的标准尚待完善。多囊卵巢综合征的治疗主要围绕肥胖、月经失调、高雄激素血症、胰岛素抵抗、不孕、青春期、心理干预等来进行,各大指南各有侧重。由于不同种族的多囊卵巢综合征的临床表现差异较大,需要尽早建立具有种族特异性的指南来改善诊疗过度或不足的情况。 | Fang-fang WANG Jie-xue PAN Yan WU Yu-hang ZHU Paul J.HARDIMAN Fan QU | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，5： | 17 |
| 5 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 6 | Lake sediment resuspension and caused phosphate release——a simulation study显示文摘Intact sediment cores and wet/dried surficial sediments sampled from the two sublakes in Taihu Lake, Meiliang Bay and Wuli Lake, were incubated in the laboratory to determine the effects of resuspension on internal phosphorus loading by simulating different resuspension events. Soluble reactive phosphorus (SRP) release from undisturbed core sediment sampled in the Meiliang Bay and Wuli Lake in July 1998 was 1 53 mg/m 2 and 2 24 mg/m 2 within 4 days, respectively. However during one hour experimental simulation of resuspension, SRP increased by 0 041 mg/L and 0 077 mg/L in the above cores, which indicate that a typical resuspension event in the lake would be accompanied by the release of 10 77 mgSRP/m 2 and 23 1 mgSRP/m 2, respectively. The internal phosphorus loading induced by resuspension is estimated to be 8-10 times greater than the release from undisturbed sediment. SRP release from the dried sediments during simulation of resuspension was mainly dependent on the disturbing intensity. Only when the wind strength gets to certain level, the influence of wind speed on phosphorus release appears significant, indicating that an exchangeable P pool, capable of altering equilibrium conditions in the lake areas, is built up under strongly wind exposed resuspension events. | Fan, CX Zhang, L Qu, TC | 2001 | Journal of Environmental Sciences2001，13，4： | 14 |
| 7 | Ligustrazine alleviates gastric mucosal injury in a rat model of acute necrotizing pancreatitis显示文摘BACKGROUND: Acute necrotizing pancreatitis (ANP) leads to a systemic inflammatory response characterized by widespread leukocyte activation and, as a consequence, distant organ injury. The aim of this study was to explore the relationship between gastric microcirculatory impairment and inflammatory mediators released in rats and to evaluate the therapeutic effect of ligustrazine extracted from Rhizoma ligusticum wallichii on gastric mucosa injury in a rat model of ANP. METHODS: Ninety-six Sprague-Dawley rats were randomly divided into three groups: normal control (group C); ANP without treatment (group P); and ANP treated with ligustrazine (group T). The ANP model was induced by injection of 50 g/L sodium taurocholate under the pancreatic membrane (4 ml/kg). Group C was given isovolumetric injection of 9 g/L physiological saline by the same route. Group T was injected with ligustrazine (10 ml/kg) via the portal vein. The radioactive biomicrosphere technique was used to measure the blood flow 2 and 12 hours after the induction of ANP. Samples of the pancreas and stomach were taken to assess pathological changes by a validated histology score; meanwhile, the levels of serum interleukin-1β (IL-1β) were determined. Gastric tissues were also used to measure the level of myeloperoxidase (MPO), which is expressed intracellularly in the azurophilic granules of neutrophils. RESULTS: Blood flow in group P was significantly lower than that in group C (P<0.01). Pathological changes were significantly aggravated in group P. The gastric MPO activity in group P was significantly higher than that in group C (P<0.01). The level of serum IL-1β in group P increased more significantly than that in group C (P<0.01). Blood flow of the stomach in group T was significantlyhigher than that in group P after 2 hours (P<0.01). The pathological changes were significantly alleviated in group T. The MPO activity of group T was significantly lower than that of group P (P<0.01). Although serum IL-1β level of group T, was higher than of group C (P<0.01), it was lower than that of group P (P<0.01). There was a negative correlation between gastric blood flow and MPO activity (r=-0.983, P<0.01), and between gastric blood flow and pathological score (r=-0.917, P<0.05). CONCLUSIONS: Decreased gastric blood flow and increased inflammatory mediators can be seen early in ANP, and both are important factors for gastric and mucosal injury. Ligustrazine can ameliorate microcirculatory disorder and alleviate the damage to the pancreas and stomach. | Dang, Sheng-Chun Zhang, Jian-Xin Qu, Jian-Guo Wang, Xue-Qing Fan, Xin | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，2： | 13 |
| 8 | Removal of tetracycline from water by Fe-Mn binary oxide显示文摘Significant concerns have been raised over the presence of antibiotics including tetracyclines in aquatic environments.A series of FeMn binary oxide with different Fe:Mn molar ratios was synthesized by a simultaneous oxidation and coprecipitation process for TC removal.Results showed that Fe-Mn binary oxide had higher removal efficiency than that of hydrous iron oxide and hydrous manganese oxide,and that the oxide with a Fe:Mn molar ratio of 5:1 was the best in removal than other molar ratios.The tetracycline removal was highly pH dependent.The removal of tetracycline decreased with the increase of initial concentration,but the absolute removal quantity was more at high concentration.The presence of cations and anions such as Ca2+,Mg2+,CO32-and SO42-had no significant effect on the tetracycline removal in our experimental conditions,while SiO32-and PO43-had hindered the adsorption of tetracycline.The mechanism investigation found that tetracycline removal was mainly achieved by the replacement of surface hydroxyl groups by the tetracycline species and formation of surface complexes at the water/oxide interface.This primary study suggests that Fe-Mn binary oxide with a proper Fe:Mn molar ratio will be a very promising material for the removal of tetracycline from aqueous solutions. | Huijuan Liu Yang Yang Jin Kang Maohong Fan Jiuhui Qu | 2012 | Journal of Environmental Sciences2012，24，2： | 13 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 11 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 12 | Over-expression of an Arabi-dopsisd δ-OAT gene enhances salt and drought tolerance in transgenic rice显示文摘d-OAT, ornithine--aminotransferase, is the key enzyme involved in proline biosynthesis. In this study the Arabidopsis d -OAT gene was transferred into rice (Oryza sativa L. ssp japonica cv. Zhongzuo 321), whose successful integration was demonstrated by PCR and Southern blot analysis. The over-expression of the gene in transgenic rice was also confirmed. Biochemical analysis showed that, under salt or drought stress conditions, proline contents in the leaves and roots in transgenic rice plants were 5- to 15-fold of those in non-transgenic controls. Under stress conditions, germinating rate of transgenic lines is higher than that of controls. Although the growth of rice plants tested were more and more retarded with the increasing of NaCl concentration, the transgenic plants grow faster compared to the controls under the same stress condition. Meanwhile, the resistance to KCl and MgSO4 stresses was also found enhanced in trans-genic rice. Furthermore, the over-expression of d -OAT also improved the yield of transgenic plants under stress condi-tions. The average yield per plant of transgenic lines in-creases about 12%—41% more than that of control lines under 0.1 mol/L NaCl stress. These data indicated that the over-expression of d -OAT, with the accumulation of proline, resulted in the enhancement of salt and drought tolerance and an increase of rice yield, which is of significance in agri-culture. | WU Liangqi, FAN Zhanmin, GUO Lei, LI Yongqing, ZHANG Wenjing, QU Li-Jia & CHEN Zhangliang The National Laboratory of Protein Engineering and Plant Genetic En-gineering, College of Life Sciences, Peking University, Beijing 100871, China Correspondence should be addressed to Qu Li-Jia (e-mail: qulj@pku. edu.cn) | 2003 | Chinese Science Bulletin2003，48，23： | 11 |
| 13 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 14 | Intestinal Metrnl released into the gut lumen acts as a local regulator for gut antimicrobial peptides显示文摘Metrnl 是新奇分泌蛋白质,但是它的生理的角色留下逃犯。在这研究,我们在人调查了 Metrnl 的织物表示模式并且与最高度表示的 levels.Methods 在纸巾探索了它的可能的生理的角色:从 69 个施主包含纸巾的 19 种类型的人的织物 microarray 被用来检验 Metrnl,和表示模式的织物表示模式进一步在新鲜的人和老鼠纸巾被验证。肠的上皮的房间特定的 Metrnl 猛烈老鼠被产生,它被用来分析 Metrnl.Results 的生理的角色:Metrnl 是高度在人的胃肠的道表示的大多数,并且明确地在肠的上皮被表示。与这一致, Metrnl mRNA 最高度也在在 14 之中的胃肠的道测试的纸巾打的老鼠被表示。在肠的上皮的房间特定的 Metrnl 猛烈老鼠,而 Metrnl 浆液层次向减小显示出一个趋势,在内脏液体的 Metrnl 层次显著地被减少,但是这个变化不是统计上重要的。Metrnl 的这房间特定的删除没影响身体重量,食物吸入,血葡萄糖,结肠长度和组织学,肠的渗透,粘液内容或粘蛋白在生理的条件下面的 2 表示,但是统计上减少了抗菌剂肽的表示,例如再生导出小岛 3 gamma (Reg3g ) 和 lactotransferrin.Conclusion:Metrnl 高度在人和老鼠的肠的上皮的房间被表示,它主要贡献本地内脏 Metrnl 层次并且影响浆液 Metrnl 水平到更小的程度。Metrnl 在维持内脏抗菌剂肽起一个作用。 | Zhi-yong LI Mao-bing FAN Sai-long ZHANG Yi QU Si-li ZHENG Jie SONG Chao-yu MIAO | 2016 | Acta Pharmacologica Sinica2016，37，11： | 11 |
| 15 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 16 | LOW TEMPERATURE THERMAL DEBINDING BEHAVIOR OF WAX-BASED MULTI-COMPONENT BINDER FOR TUNGSTEN HEAVY ALLOY显示文摘1INTRODUCTIONPowderinjectionmoulding(PIM)isanewprocessformanufacturingnearnetshapepartswithadvantagesoflowcost,highperformanc... | Fan, Jinglian Huang, Baiyun Qu, Xuanhui Li, Yiming | 1999 | 中国有色金属学会会刊:英文版1999，9，1： | 10 |
| 17 | Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer显示文摘Innate lymphoid cells(ILCs)reside in mucosal surfaces to potentiate immune responses,sustain mucosal integrity and maintain tissue homeostasis.However,how tumor infiltrating ILCs modulate tumor development and progression is unclear.Here we profiled tumor infiltrating ILCs during colorectal cancer(CRC)progression by single-cell RNA sequencing.We identified six clusters of tumor infiltrating ILCs with unique features.ILC1s expressed inhibitory receptors and underwent inhibitory functional conversion at the late stage of CRC.ILC2s were classified into three subsets(called ILC2-A,-B,-C),of which ILC2-C subset could facilitate tumor progression.HS3ST1 and PD1 were highly expressed in ILC2s of late stage CRC tumors and deficiency of HS3ST1 or PD1 in ILC2s suppressed tumor growth.Moreover,ILC3s transdifferentiated into ILCregs during CRC progression and ILCregs promoted tumor growth.Of note,TGF-βsignaling initiated the conversion of ILC3s to ILCregs and blockade of TGF-βsignaling could disrupt the ILCreg transdifferentiation and inhibited tumor growth.Thus,intervention of ILC conversions might be a potential strategy for CRC immunotherapy. | Shuo Wang Yuan Qu Pengyan Xia Yi Chen Xiaoxiao Zhu Jing Zhang Guan Wang Yong Tian Jianming Ying Zusen Fan | 2020 | Cell Research2020，30，7： | 9 |
| 18 | Management of Cesarean Scar Pregnancy: A Case Series显示文摘Objective To survey effective treatment strategies for cesarean scar pregnancy(CSP). Methods The clinical data of 78 patients diagnosed with CSP from January 2010 to December 2013 were reviewed. Results Among these patients, 17 patients were first treated at our hospital; of them, 2 were misdiagnosed. The other 61 patients were referred from other hospitals; of them, 21 were initially misdiagnosed. There were 9 patients who were treated with laparotomy, 50 patients with curettage after uterine artery embolization(UAE) with or without local methotrexate(MTX) infusion, 10 patients with dilatation and curettage, 6 patients with transvaginal sonographic guided local intragestational MTX injection, and 3 patients with systemic MTX injection. All patients finally recovered. Patients with excessive vaginal hemorrhage underwent either emergency UAE treatment or laparotomy. These two treatments had similar success rates(81.82% vs. 100%, χ2 =0.289, P>0.05). Conclusions The accurate diagnosis of CSP is important. Curettage after UAE with or without local MTX infusion is a safe and effective method. | Min-hui Guo Mei-fen Wang Man-man Liu Feng Qi Fan Qu Jian-hong Zhou | 2015 | Chinese Medical Sciences Journal2015，30，4： | 9 |
| 19 | Clinical features of multiple myeloma invasion of the central nervous system in Chinese patients显示文摘背景尽管神经表明经常与多重骨髓瘤复杂化病人的功课,直接中央的神经系统侵略是稀罕的。这研究与中央神经系统骨髓瘤 invasion.Methods 探索了中国病人的神经症状,符号,临床的特征,治疗和预后诊断,治疗和预后从在 Changzheng 医院被对待的 625 个病人的一个总数与中央神经系统渗入在 11 个中国多重骨髓瘤病人回顾地被分析(上海,中国)在1993年1月和2009年5月之间。幸存曲线与在那里的 Kaplan-Meier estimates.Results 的使用被构造是有从 625 个多重骨髓瘤病人的中央神经系统参与的 11 个病人。出现率是 1.8% 。11 个病人中的十个有另外的 extramedullary 疾病。症状包括了服的症状,头部的神经麻痹,和针的绳索或针的神经根 symptoms.Cerebrospinal 液体在 7 个病人,通常展出的 pleocytosis 和提高的蛋白质内容是反常的,加积极 cytologic 调查结果。中央神经系统侵略暗示的特定的磁性的回声成像调查结果在 9 个病人被发现。在 19 个月的中部的后续以后, 3 个病人是活着的。为所有病人的中部的全面幸存是 23 个月,当为在中央神经系统侵略以后的病人的中部的全面幸存仅仅是它是的 6 months.Conclusions 时为极其稀罕在那里是在多重骨髓瘤病人的中央神经系统渗入。当它发生时,尽管有好攻击的本地、全身的治疗的使用,预后是极其差的。 | QU Xiao-yan FU Wei-jun XI Hao ZHOU Fan WEI Wei HOU Jian | 2010 | Chinese Medical Journal2010，，11： | 9 |
| 20 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
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