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| 1 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 2 | First Report LA-ICP-MS Zircon U-Pb Age of Early Jurassic Volcanic Rocks from Rencha Volcanic Basin, Northeast Guangdong Province, Southeastern China显示文摘Objective Most scholars agreed that the tectonic setting of South China block(SBC)changed from Tethys during the Indosinian to Pacific tectonic regime in the Yanshanian.However,the specific change time for the transition is still in debate and the Triassic to Jurassic magmatic activity will provide a clue to better understanding the transition.The Rencha volcanic basin,located at the conjunction | YU Yushuai LOU Feng DAI Pingyun GUO Fusheng YANG Qidi | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 3 |
| 3 | AncestryPainter:A Graphic Program for Displaying Ancestry Composition of Populations and Individuals显示文摘Ancestry composition of populations and individuals has been extensively investigated in recent years due to advances in the genotyping and sequencing technologies. As the number of populations and individuals used for ancestry inference increases remarkably, say more than 100 populations or 1000 individuals, it is usually challenging to present the ancestry composition in a traditional way using a rectangular graph. To address this issue, we developed a program,AncestryPainter, which can illustrate the ancestry composition of populations and individuals with a rounded and nice-looking graph to save space. Individuals are depicted as length-fixed bars partitioned into colored segments representing different ancestries, and the population of interest can be highlighted as a pie chart in the center of the circle plot. In addition, AncestryPainter can also be applied to display personal ancestry in a way similar to that for displaying population ancestry.AncestryPainter is publicly available at http://gffzz6effa043a78a4d2dhpovw56qbnofx6pvw.ffgz.tsg.suse.edu.cn/PGG/resource.php. | Qidi Feng Dongsheng Lu Shuhua Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，5： | 1 |
| 4 | IMPULSIVE CONTROL IN MICROORGANISMS CONTINUOUS FERMENTATION显示文摘 | LIJUAN SHEN ENMIN FENG QIDI WU | 2012 | International Journal of Biomathematics2012，5，2： | 0 |
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