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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 4 | Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials显示文摘 | Gilles R Dagenais Janice Pogue Kim Fox Marteen L Simoons Salim Yusuf | 2006 | The Lancet2006，，9535： | 2 |
| 5 | Synthesis,characterization and ctalytic applications of a palladlum-nanoparticle-cored dendrlmer显示文摘 | Gopidas K R Whitesell J K Fox M A | 2003 | Nano Lett2003，3，12： | 1 |
| 6 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 7 | The serine/ threonine kinase Pim-2 is a transcriptionally regulated apopotot-ic inhibitor显示文摘 | FOX C J HAMMERMAN P S CINALLI R M | 2003 | Genes Dev2003，17，15： | 1 |
| 8 | The role of manipulation following total knee replacement显示文摘 | Fox J L Poss R | 1981 | J Bone Joint Surg Am1981，63，3： | 1 |
| 9 | Detection and quantification of intraperitonealfluid using electrical impedance tomography显示文摘 | Sadleir R J Fox R A | 2001 | IEEE Trans BiomedEng2001，48，4： | 1 |
| 10 | Antibodies to endothelial cells显示文摘 | Fox R | 1991 | Lancet1991，337，： | 1 |
| 11 | Controlling cryptosporidium using conventional treatment 显示文摘 | Dugan N R Fox K R Owens J H | 2001 | J AWWA2001，93，12： | 1 |
| 12 | Monoclonal autibody to the glycoprotein of VSV显示文摘 | Bricker B J Snyder R W Fox J W | 1997 | Virology1997，161，2： | 1 |
| 13 | Prediction of ruminal volatile fatty acids and pH within the net carbohydrate and protein system显示文摘 | Pitt R E Van KesselJ S Fox D G | 1996 | J Anita Sci1996，74，： | 1 |
| 14 | Wind tunnel evaluation of a computer program to model spray drift 显示文摘 | Zhu H Reichard D L Fox R D | 1992 | Transactions of the ASAE1992，35，3： | 1 |
| 15 | A theoretical model of solar radiation transfer in a row-crop canopy显示文摘 | Yang X Shot T H Fox R D | 1990 | Transaction of the ASAE1990，，33： | 1 |
| 16 | Helicobacter canis isolated from a dog liver with multifocal necrotizing hepatitis 显示文摘 | Fox J G Drolet R Higgins R | 1996 | J Clin Microbiol1996，34，10： | 1 |
| 17 | A view of cloud computing显示文摘 | ARMBRUST M FOX A GRIFFITH R | 2010 | Communications of the ACM2010，53，4： | 1 |
| 18 | Recurrence of primary breast lymphoma in contralateral breast:case report and review of the literature显示文摘 | Earnest R E Downey D M Fox J P | | 0，，05： | 1 |
| 19 | Molecular dynamics simulations of a supercooled monatomic liquid and glass显示文摘 | Fox J R Andersen H C | | 0，，18： | 1 |
| 20 | A view of cloud computing显示文摘 | Armbrust M Fox A Griffith R | 2010 | Communications of the ACM2010，53，4： | 1 |
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