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| 1 | Changing trends in the mortality rate at 1-year post hip fracture-a systematic review显示文摘BACKGROUND Traditionally, the mortality rate at 1-year post hip fracture was quoted as approximately 30% of all hip fractures. There have been recent improvements in hip fracture care in the main driven by national hip fracture registries with reductions in 30-d mortality rates reported.AIM To address recent 1-year post hip fracture mortality rates in the literature.METHODS Systematic literature review, national hip fracture registries/databases, local studies on hip fracture mortality, 5 years limitation(2013-2017), cohorts > 100,studies in English. Outcome measure: Mortality rate at 1-year post hip fracture.RESULTS Recent 1-year mortality rates were reviewed using the literature from 8 National Registries and 36 different countries. Recently published 1-year mortality rates appear lower than traditional figures and may represent a downward trend.CONCLUSION There appears to be a consistent worldwide reduction in mortality at 1-year post hip fracture compared to previously published research. Globally, those which suffer hip fractures may currently be benefiting from the results of approximately 30 years of national registries, rigorous audit processes and international collaboration. The previously quoted mortality rates of 10% at 1-mo and 30% at 1-year may be outdated. | Colum Downey Martin Kelly John F Quinlan | 2019 | World Journal of Orthopedics2019，10，3： | 17 |
| 2 | Kevlar对位芳纶浆粕增强橡胶的研究显示文摘研究Kevlar对位芳纶浆粕和精切短纤维对天然橡胶胶料的补强效果。结果表明:随着纤维用量的增大,Kevlar对位芳纶浆粕补强的胶料储能模量增加幅度大于损耗模量增加幅度,损耗角和损耗因子随着浆粕用量的增大而降低,这种效果有利于低滚动阻力轮胎或其他轮胎部件的胶料配方设计,在提高胶料定伸模量的同时不会增加滞后生热;Kevlar对位芳纶浆粕表现出的一种独特手风琴效应可能是低滞后生热的原因。 | Jeffery S. Downey Constantine W. Tsimpris Andrew L. Pollard Chloe F. Wilson Jocelyn Willis-Papi Christiane K. Hohenwarter Qin Lin 黎学东 | 2012 | 轮胎工业2012，32，7： | 11 |
| 3 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 4 | 采用轧辊分段冷却控制带钢的平直度和板形显示文摘通过精确使用冷却液冷却轧辊,可以校正轧辊的不对称热瓢曲,并因此提高带钢的平直度。需要采用V形平口喷嘴以准确地将冷却液喷到轧辊的指定部位。 | Downey,G 邓超 | 1997 | 国外钢铁1997，22，9： | 3 |
| 5 | Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning’s success显示文摘 | Michael V. Cohen MD Xi-Ming Yang James M. Downey | 2008 | Basic Research in Cardiology2008，，5： | 2 |
| 6 | Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits 显示文摘 | Miki T Cohen M Downey J | 1998 | Mol Cell Biochem1998，186，1： | 2 |
| 7 | Recent technological advances for the determination of food authenticity显示文摘 | Linda M. Reid Colm P. O’Donnell Gerard Downey | 2006 | Trends in Food Science & Technology2006，，7： | 2 |
| 8 | A comparison of model-based and regression classification techniques applied to near infrared spectroscopic data in food authentication studies显示文摘 | TOHER D DOWNEY G MURPHY T B | 2007 | Chemometrics and Intelligent Laboratory Systems2007，89，2： | 1 |
| 9 | Regulation of neutrophil activation in acute lung injury显示文摘 | Downey GP Dong Q Kruger J | 1999 | Chest1999，116，1： | 1 |
| 10 | Oxygen radicals released during isehemic preconditioning contribute to cardioprotection in the rabbit myocardium显示文摘 | Baines CP Goto M Downey JM | 1997 | J Mol Cell Cardiol1997，29，1： | 1 |
| 11 | A new model for broad-band waveguide-to-microstrip transition design显示文摘 | PONCHAK G E DOWNEY A N | 1988 | Microwave Journal1988，5，： | 1 |
| 12 | Back to the future:testing in disseminated intravascular coagulation显示文摘 | Toh CH Downey C | 2005 | Blood Coagulation Fibrinolysis2005，16，8： | 1 |
| 13 | Reversal of the TCR stop signal by CTLA-4显示文摘 | Schneider H Downey J Smith A | 2006 | Science2006，313，： | 1 |
| 14 | Exploiting process lifetime distributions for load balaeing显示文摘 | Harchol-Balter M Downey A | 1997 | ACM transaction on Computer Systems1997，3，31： | 1 |
| 15 | High volume hemofiltration in septic shock显示文摘 | Romero CM Downey P Hernandez G | 2010 | Med Intensiva2010，34，5： | 1 |
| 16 | Unsupervised named-entity extraction from the web: An experimental study 显示文摘 | Etzioni M Cafarella D Downey S | 2005 | Artificial Intelligence2005，165，1： | 1 |
| 17 | 3 Dultrasound imaging: Applications in image-guided therapy and biopsy显示文摘 | Fenster A Surrya K Smitha W GiUa J Downey D B | 2002 | Computers & Graphics2002，26，4： | 1 |
| 18 | Primary and secondary malignancies of the sternum显示文摘 | Downey RJ Huvos AG Martini N | 1999 | Semin Thorac Cardiovasc Surg1999，11，3： | 1 |
| 19 | Antibiotic pharmacokinetics in the inflamed prostate显示文摘 | Nickel JC Downey J Clark J | 1995 | J Uro11995，153，5： | 1 |
| 20 | Use of partially missmatched related donors extends acess to allogeneic marrow transplant 显示文摘 | Henslee - Downey PJ Abhyankar SH Raffish RS | 1997 | Bloed1997，89，10： | 1 |
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