|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells显示文摘 | Liu Yang Ying Wang Hua Mao Susanne Fleig Alessia Omenetti Kevin D. Brown Jason K. Sicklick Yin-Xiong Li Anna Mae Diehl | 2007 | Journal of Hepatology2007，，： | 2 |
| 2 | Waixenicin A,a marine-derived TRPM7 inhibitor:a promising CNS drug lead显示文摘Ion channels are the third largest class of targets for therapeutic drugs.The pharmacology of ion channels is an important research area for identifying new treatment options for human diseases.The past decade or so has seen increasing interest in an ion channel protein belonging to the transient receptor potential(TRP)family,namely the melastatin subfamily member 7(TRPM7),as an emerging drug target.TRPM7 is a bifunctional protein with a magnesium and calcium-conducting divalent ion channel fused with an active kinase domain.TRPM7 is ubiquitously expressed in human tissues,including the brain,and regulates various cell biology processes such as magnesium and calcium homeostasis,cell growth and proliferation,and embryonic development.TRPM7 provides a link between cellular metabolic status and intracellular calcium homeostasis in neurons due to TRPM7’s unique sensitivity to fluctuating intracellular Mg·ATP levels.Thus,the protein plays a key role in ischemic and hypoxic neuronal cell death and brain injury,and is one of the key nonglutamate mechanisms in cerebral ischemia and stroke.Currently,the most potent and specific TRPM7 inhibitor is waixenicin A,a xenicane diterpenoid from the Hawaiian soft coral Sarcothelia edmondsoni.Using waixenicin A as a pharmacological tool,we demonstrated that TRPM7 is involved in promoting neurite outgrowth in vitro.Most recently,we found that waixenicin A reduced hypoxic-ischemic brain injury and preserved long-term behavioral outcomes in mouse neonates.We here suggest that TRPM7 is an emerging drug target for CNS diseases and disorders,and waixenicin A is a viable drug lead for these disorders. | Hong-Shuo Sun F.David Horgen Daniel Romo Kenneth G.Hull Sigrid A.Kiledal Andrea Fleig Zhong-Ping Feng | 2020 | Acta Pharmacologica Sinica2020，41，12： | 2 |
| 3 | Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR显示文摘 | Simone Fleige Vanessa Walf Silvia Huch Christian Prgomet Julia Sehm Michael W. Pfaffl | 2006 | Biotechnology Letters2006，，19： | 2 |
| 4 | RNA integrity and the effect on the real-time qRT-PCR performance显示文摘 | Simone Fleige Michael W. Pfaffl | 2005 | Molecular Aspects of Medicine2005，，2： | 2 |
| 5 | Ofloxacin and Ursodeoxycholic Acid Versus Ursodeoxycholic Acid Alone to Prevent Occlusion of Biliary Stents: A Prospective, Randomized Trial显示文摘 | U. Halm I. Schiefke W. Fleig J. M?ssner V. Keim | 2001 | Endoscopy2001，，06： | 2 |
| 6 | Identification of novel hradyzoite-specific Toxoplasma gondii genes with domains for protein-protein interactions by suppression subtractive hybridization 显示文摘 | FRIESEN J FLEIGE T GROSS U | 2008 | Mol Biochem Parasitol2008，157，2： | 1 |
| 7 | Carbohydrate metabolism in the Toxoplasma gondii apicoplast:localization of three glycolytic isoenzymes,the single pyruvate dehydrogenase complex,and a plastid phosphate translocator显示文摘 | Fleige T Fischer K Ferguson DJ | 2007 | Eukaryotic Cell2007，6，6： | 1 |
| 8 | On the width of the electrochemically active region in mixed conducting solid oxide fuel cell cathodes 显示文摘 | FLeig J | 2002 | Journal of Power Sources2002，105，： | 1 |
| 9 | Measurement of conductivity profiles in acceptor doped Strontium Titanatte显示文摘 | RODEWALD S FLEIG J MAIER J | 1999 | J Eur Ceram SOc1999，19，： | 1 |
| 10 | Stitching interferometry: a flexible solution for surface metrology 显示文摘 | Murphy P Forbes G Fleig J | 2003 | Optics and Photonics News2003，14，： | 1 |
| 11 | Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice显示文摘 | Fleig S V Choi S S Yang L | 2007 | Lab Invest2007，87，12： | 1 |
| 12 | Futterb Gauffutterbereit显示文摘 | Fleig | 1938 | Natura Bresciana1938，2，： | 1 |
| 13 | Regulation of TRPM2 by extra-and intracellular calcium显示文摘 | Starkus J Beck A Fleig A | 2007 | J Gen Physiol2007，130，4： | 1 |
| 14 | Carbohydrate metabolism in the Toxoplasma gondii apicoplast , localization of three glycolytic isoenzymes, the single pyruvate dehydrogenase complex, and a plastid phosphate translocator 显示文摘 | Fleige T Fischer K Ferguson D J | 2007 | Eukaryot Cell2007，6，6： | 1 |
| 15 | Imped- ance spectroscopic study on well - defined ( La, Sr) ( Co, Fe) 03_a model electrodes显示文摘 | Baumann F S Fleig J Habermeier H U | 2006 | Solid State Ionics2006，177，： | 1 |
| 16 | Wind Turbine Blade Tip Flow and Noise Prediction by Large-Eddy Simulation 显示文摘 | Fleig O Iida M Arakawa C | 2004 | Journal of Solar Energy Engineering2004，126，4： | 1 |
| 17 | Hepatocellular Carcinoma (HCC): A Global Perspective显示文摘 | Peter Ferenci Michael Fried Douglas Labrecque Jordi Bruix Morris Sherman Masao Omata Jenny Heathcote Teehra Piratsivuth Mike Kew Jesse A. Otegbayo S.S. Zheng S. Sarin Saeed S. Hamid Salma Barakat Modawi Wolfgang Fleig Suliman Fedail Alan Thomson Aamir Kha | 2010 | Journal of Clinical Gastroenterology2010，，4： | 1 |
| 18 | Achieving sub-pixel geolocation accuracy in support of MODIS land science显示文摘 | Wolfe R E Nishihama M Fleig A J Kuyper J A Roy D P Storey J C and Patt F S | | 0，，1： | 1 |
| 19 | “Zebrafishing” for Novel Genes Relevant to the Glomerular Filtration Barrier显示文摘 | Nils Hanke Lynne Staggs Patricia Schroder Jennifer Litteral Susanne Fleig Jessica Kaufeld Cornelius Pauli Hermann Haller Mario Schiffer Richard Tucker | 2013 | BioMed Research International2013，，： | 1 |
| 20 | The TRPM ion channel subfamily:molecular,biophysical and functional features显示文摘 | Fleig A Penner R | 2004 | Trends Pharmacol Sci2004，25，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员