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	题名	作者	年代	出处	被引量
1	克罗恩病患者使用低聚果糖的临床、微生物学和免疫学效果显示文摘Background and aims: The intestinal microbiota play a pivotal role in the inflammation associated with Crohn’s disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL- 10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn’s disease. Patients and methods: Ten patients with active ileocolonic Crohn’s disease received 15 g of FOS for three weeks. Disease activity was measured using the Harvey Bradshaw index. Faecal and mucosal bifidobacteria were quantified by fluorescence in situ hybridisation, and mucosal dendritic cell IL- 10 and Toll-like receptor (TLR) expression were assessed by flow cytometry of dissociated rectal biopsies. Results: FOS induced a significant reduction in the Harvey Bradshaw index from 9.8 (SD 3.1) to 0.9 (3.4) (p < 0.01). There was a significant increase in faecal bifidobacteria concentration from 8.8 (0.9) log10 to 9.4 (0.9)- log10 cells/g dry faeces (p < 0.001). The percentage of IL- 10 positive dendritic cells increased from 30 (12)% to 53 (10)% (p = 0.06). Finally, the percentage of dendritic cells expressing TLR2 and TLR4 increased from 1.7 (1.7)% to 36.8 (15.9)% (p = 0.08) and from 3.6 (3.6)% to 75.4 (3.4)% (p < 0.001), respectively. Conclusions: FOS supplementation increases faecal bifidobacteria concentrations and modifies mucosal dendritic cell function. This novel therapeutic strategy appears to decrease Crohn’s disease activity in a small open label trial and therefore warrants further investigation.	Lindsay J.O. Whelan K. Stagg A.J. 程妍	2006	世界核心医学期刊文摘(胃肠病学分册)2006，2，8：	2
2	炎症性肠病患者肠道树突状细胞的特性	Hart A.L. Al- Hassi H.O. Rigby R.J. A.J. Stagg 王志宇	2005	世界核心医学期刊文摘(胃肠病学分册)2005，0，12：	2
3	A randomized,trial of continuous intravenous versus hepatic intraarterial floxaridine in patients with colorectal cancer metastatic to the liver:Northern California Oncology Group trial显示文摘	Hohn DC Stagg RJ Friedman MA	1989	J Clin Oncol1989，7，11：	1
4	In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors 显示文摘	Duguay D Mercier F Stagg J	2002	Cancer Res2002，62，：	1
5	A new model to understand the career choice and practice location decisions of medical graduates 显示文摘	Stagg P Greenhill J Worley PS	2009	Rural and Remote Health 9 (online)2009，15，9：	1
6	Review article:the role of the gut ffo-ra in health and disease and its modification as therapy显示文摘	Hart AL Stagg AJ Frame M	2002	Aliment Phar-macol Ther2002，16，8：	1
7	lmmunotherapeutic approaches in triple- negative breast cancer: latest research and clinical prospects 显示文摘	Stagg J Allard B	2013	Ther Adv Med Oncol2013，5，3：	1
8	Laser Raster Conditioning of KDP and DKDP Crystals Using XeC1 and Nd: YAG Lasers显示文摘	Staggs M Yan M Runkel M	2000	SPIE Proceedings2000，4347，：	1
9	Short communication: Approximate solutions for the pyrolysis of char forming and filled polymers under thermally thick conditions 显示文摘	Staggs J E J	2000	Fire and Materials2000，24，：	1
10	The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria显示文摘	Stagg A J Hart AL Knight SC	2003	Gut2003，52，10：	1
11	Interferon-gamma- stimulated marrow stromal cells: a new type of nonhematopoi- etic antigen presenting cell显示文摘	Stagg J Pommey S Eliopoulos N	2006	Blood2006，107，：	1
12	Vaccines against Chlamydia :approaches and progress显示文摘	Stagg AJ	1998	Mol Med Today1998，4，4：	1
13	Physiological Basis of Transcranial Direct Current Stimulation 显示文摘	Stagg b C J Nitsche MA	2011	Neuroscientist2011，17，1：	1
14	Allogeneic marrow stromat cells are immune rejected by MHC class Ⅰ and Ⅱ mis- matched recipient mice显示文摘	Eliopoulos N Stagg J Lejeune L	2005	Blood2005，106，：	1
15	A phase Ⅲ trial of high dose cytosine arabinoside with or without etoposide in relapsed and refractory acute myelogenous leukemia显示文摘	VOGLER W R MCCARLEY D H STAGG M	1994	Leukemia1994，8，11：	1
16	Direct effects of apelin on cardiommol/Lmmol/Lol/Lyocyte contractility and electrophysiology 显示文摘	Farkasfalvi K Stagg MA Coppen SR	2007	Biochem Biophys Res Comun2007，357，11：	1
17	Physiological responses to handling in the turbot 显示文摘	Waring C E Stagg R M Poxton M G	1996	Journal of Fish Biology1996，48，2：	1
18	Large area laser conditioning of dielectric thin film mirrors显示文摘	Kozlowski M R Wolfe C R Staggs M C		0，，：	1
19	Relationships between functional and structural corticospinal tract integrity and walk- ing post stroke 显示文摘	Jayaram G Stagg CJ Esser P	2012	Clin Neurophysiol2012，123，12：	1
20	Investigation of optically active defect clusters in KH2PO4 under laser photoexcitation显示文摘	Demos S G Staggs M Yan M	1999	J Appl Phys1999，85，：	1

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