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| 1 | Magnesium lithospermate B possesses inhibitory activity on Na^+,K^+-ATPase and neuroprotective effects against ischemic stroke显示文摘瞄准:如果镁 lithospermate B (MLB ) 从 Danshen 提取了,检验,鼠尾草植物 miltiorrhiza 的弄干的根,当为经由一样的分子的机制的这繁体中文植物的 cardiactherapeutic 效果负责的一个活跃部件触发了 bycardiac glycosides,可以行动,例如 ouabain 和异羟基洋地黄毒苷。而且,如果,我们想要测试 MLB 对 ischemic 的 provideneuroprotection 可以是为心脏的 glycosides 观察了摸。方法:在 MLB 和 ouabain 之间的类似 inthe 化学药品结构和分子的配置被分析。Na+ 上的 MLB 和 ouabain 的 Theinhibition 力量,一个商业产品的 K+-ATPase 活动,也, asin 从老鼠大脑和心纸巾净化了膜部分,被检验,对 ischemic 击的 MLB 的 compared.Neuroprotective 效果也用一个外皮的基于 brainslice 的试金模型被评估。结果:商业 Na+ 上的剂量依赖者抑制,为 ouabain 的到那的 K+-ATPaseequivalent 为 MLB 被观察近似由重量的半剂量。ouabain 和 MLB 的 Thisrelative 力量也在 Na+ 上为他们的抑制被观察,从老鼠纸巾净化的 K+-ATPase activityof 血浆膜,尽管这 2 个禁止者有点在这些粗略的摘录展出了 lowercompetence。在 ischemic 沙鼠大脑,与 MLB significantlyreduced 处理以后梗塞尺寸,由 2,3,5-triphenyltetrazolium 氯化物染色设想了, byapproximately 55% 什么时候与控制组相比。结论:这些结果显然 suggestthat Danshen 的心脏的治疗学的效果应该部分至少被归因于 Na+ ,由 MLB 的 K+-ATPase,和那 MLB 的 effectiveinhibition 在 gerbilssubjected 提供 anti-ischemic neuroprotection 给焦点的局部缺血和灌注。 | Jason TC TZEN Tzyy-rong JINN Yi-ching CHEN Feng-yin LI Fu-chou CHENG Li-shian SHI Hank KH SHE Balance CM CHEN Vic HSIEH Mu-lin TU | 2007 | Acta Pharmacologica Sinica2007，28，5： | 25 |
| 2 | 用最小量冷却液法钻削航空铝-钛多层复合板显示文摘介绍了汉堡工业大学采用最小冷却液法钻削多种复合板的研究结果。研究表明,在钻削铝-钛多层复合板时,钻削钛板切屑的摩擦磨损作用,会导致铝板的孔呈喇叭形,孔径波动幅度和平均孔径值增大并可能超出允差。试验采用了最小量冷却液技术,所用的3种冷却液对钻削孔径影响不大。使用涂层刀具加工时,钻削孔径同进给速度呈正比。钻头顶角越大,铝板的孔径越大,但钛板的孔径不变。为保证加工孔径质量,采用退刀排屑和扩孔方式加工,减小刃带宽度,增大进给前角和使用阶梯钻头。 | 王成勇 Clausen Rolf Hanke Harald | 2002 | 机械工程学报2002，38，6： | 7 |
| 3 | Effect of welding parameters on the heat-affected zone of AISI409 ferritic stainless steel显示文摘One of the main problems during the welding of ferritic stainless steels is severe grain growth within the heat-affected zone(HAZ).In the present study,the microstructural characteristics of tungsten inert gas(TIG) welded AISI409 ferritic stainless steel were investigated by electron backscattered diffraction(EBSD),and the effects of welding parameters on the grain size,local misorientation,and low-angle grain boundaries were studied.A 3-D finite element model(FEM) was developed to predict the effects of welding parameters on the holding time of the HAZ above the critical temperature of grain growth.It is found that the base metal is not fully recrystallized.During the welding,complete recrystallization is followed by severe grain growth.A decrease in the number of low-angle grain boundaries is observed within the HAZ.FEM results show that the final state of residual strains is caused by competition between welding plastic strains and their release by recrystallization.Still,the decisive factor for grain growth is heat input. | Eslam Ranjbarnodeh Stefanie Hanke Sabine Weiss Alfons Fischer | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，10： | 6 |
| 4 | Progressive loss of striatal dopamine terminals in MPTP-induced acute parkinsonism in cynomolgus monkeys using vesicular monoamine transporter type 2 PET imaging([^(18)F]AV-133)显示文摘The 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine(MPTP)-induced parkinsonism model, particularly in non-human primates, remains the gold-standard for studying the pathogenesis and assessing novel therapies for Parkinson's disease. However, whether the loss of dopaminergic neurons in this model is progressive remains controversial, mostly due to the lack of objective in vivo assessment of changes in the integrity of these neurons. In the present study, parkinsonism was induced in cynomolgus monkeys by intravenous administration of MPTP(0.2 mg/kg) for 15 days; stable parkinsonism developed over 90 days, when the symptoms were stable. Noninvasive positron emission tomographic neuroimaging of vesicular monoamine transporter 2 with 9-[18F]fluoropropyl-(+)-dihydrotetrabenazine([18F]AV-133) was used before, and 15 and 90 days after the beginning of acute MPTP treatment. The imaging showed evident progressive loss of striatal uptake of [18F]AV-133. The dopaminergic denervation severity had a significant linear correlation with the clinical rating scores and the bradykinesia subscores. Thesefindings demonstrated that [18F]AV-133 PET imaging is a useful tool to noninvasively evaluate the evolution of monoaminergic terminal loss in a monkey model of MPTP-induced parkinsonism. | Yajing Liu Feng Yue Rongping Tang Guoxian Tao Xiaomei Pan Lin Zhu Hank F.Kung Piu Chan | 2014 | Neuroscience Bulletin2014，30，3： | 6 |
| 5 | 《词汇学:语言学中的关键概念》述介显示文摘 | Patrick Hanks 汪榕培 周福娟 | 2008 | 外语教学与研究2008，40，5： | 4 |
| 6 | The Plastid-Localized NAD-Dependent Malate Dehydrogenase Is Crucial for Energy Homeostasis in Developing Arabidopsis thaliana Seeds显示文摘当光合作用不在时, ATP 被 ATP/ADP transporters 进口进叶绿体和非绿的质体或在 glycolysis 期间形成了,要求 NAD+ 的连续新生的后者,由 NADMDH 的 plastidial isoform 供应了。在在 Arabidopsis 的 plNADMDH 基因为 T-DNA 插入异种屏蔽期间,仅仅异质接合的植物能被孤立,同型结合的猛烈异种仅仅在互补以后成长了。这些异质接合的植物显示出其他的改革 NAD+ 酶的更高的抄本层次, NADHGOGAT,并且,显著地,当铵是唯一的 N 来源时,改进了生长。在 situ,杂交并且 GUS 组织化学的染色表明 plNADMDH 特别地充满男、女的配偶体。猛烈 plNADMDH 花粉展览在 vitro 损害了试管生长,它能被增加 NADHGOGAT 的底层克服。在 vivo,猛烈花粉能使肥沃卵房间。异质接合的植物包含的 selfed 的年轻 siliques 相应于 wild-type/heterozygous (绿色) 和同型结合的猛烈异种(白色) 在的绿、白的种子一(1:2 ): 1 比率。同型结合的猛烈种子的胚胎仅仅到达了球状的阶段,绿,并且发展了到微小的起皱的种子。有在本国的倡导者下面的基因的互补救了作为野类型开发的这个缺点,和所有种子。这建议在 plNADMDH 异种的一个堵住的主要生理的过程停止胚胎和内乳开发,因此避免在损害后代吸收投资。 | Jennifer Selinski Nicolas Konig Benedikt Wellmeyer Guy T. Hanke Vera Linke H. Ekkehard Neuhaus Renate Scheibe | 2014 | Molecular Plant2014，7，1： | 4 |
| 7 | Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia显示文摘AIM: To test for the association between genome-wide methylation and myopia in human and mice. METHODS: Long interspersed nucleotide element 1(LINE-1) methylation levels were used to surrogate genome-wide methylation level. We first tested for the association between high myopia(<-6 D) and LINE-1 methylation in leukocytes in 220 cases and 220 control subjects. Secondly, we validated the results of LINE-1 methylation in eyes from the form deprivation myopia(FDM) mice. Furthermore,we calculated the correlation of LINE-1 methylation levels between leukocyte DNA and ocular DNA in the mice. We also tested whether dopamine can alter LINE-1 methylation levels. RESULTS: The LINE-1 methylation level was significantly higher in the myopic human subjects than controls. The upper and middle tertiles of the methylation levels increased an approximately 2-fold(P≤0.002) risk for myopia than the lower tertile. Similarly, FDM mice had high LINE-1 methylation levels in the leukocyte, retina and sclera, and furthermore the methylation levels detected from these three tissues were significantly correlated. Immunohistochemical staining revealed higher levels of homocysteine and methionine in the rodent myopic eyes than normal eyes. Dopamine treatment to the cells reduced both LINE-1 methylation and DNA methyltransferase levels. CONCLUSION: LINE-1 hypermethylation may be associated with high myopia in human and mice. Homocysteine and methionine are accumulated in myopic eyes, which may provide excess methyl group for genome-wide methylation. | Edward Hsi Yung-Song Wang Chia-Wei Huang Ming-Lung Yu Suh-Hang Hank Juo Chung-Ling Liang | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 4 |
| 8 | G-Quadruplex(G4) Motifs in the Maize(Zea mays L.) Genome Are Enriched at Specific Locations in Thousands of Genes Coupled to Energy Status,Hypoxia,Low Sugar,and Nutrient Deprivation显示文摘The G-quadruplex(G4) elements comprise a class of nucleic acid structures formed by stacking of guanine base quartets in a quadruple helix.This G4 DNA can form within or across single-stranded DNA molecules and is mutually exclusive with duplex B-form DNA.The reversibility and structural diversity of G4 s make them highly versatile genetic structures,as demonstrated by their roles in various functions including telomere metabolism,genome maintenance,immunoglobulin gene diversification,transcription,and translation.Sequence motifs capable of forming G4 DNA are typically located in telomere repeat DNA and other non-telomeric genomic loci.To investigate their potential roles in a large-genome model plant species,we computationally identified 149,988 non-telomeric G4 motifs in maize(Zea mays L.,B73 AGPv2),29%of which were in non-repetitive genomic regions.G4 motif hotspots exhibited non-random enrichment in genes at two locations on the antisense strand,one in the 5'UTR and the other at the 5'end of the first intron.Several genic G4 motifs were shown to adopt sequence-specific and potassium-dependent G4 DNA structures in vitro.The G4 motifs were prevalent in key regulatory genes associated with hypoxia(group VII ERFs),oxidative stress(DJ-1/GATase1),and energy status(AMPK/SnRK) pathways.They also showed statistical enrichment for genes in metabolic pathways that function in glycolysis,sugar degradation,inositol metabolism,and base excision repair.Collectively,the maize G4 motifs may represent conditional regulatory elements that can aid in energy status gene responses.Such a network of elements could provide a mechanistic basis for linking energy status signals to gene regulation in maize,a model genetic system and major world crop species for feed,food,and fuel. | Carson M.Andorf Mykhailo Kopylov Drena Dobbs Karen E.Koch M.Elizabeth Stroupe Carolyn J.Lawrence Hank W.Bass | 2014 | Journal of Genetics and Genomics2014，41，12： | 2 |
| 9 | 人们如何用语词来表达意义——语义类型与句法配价的交合显示文摘在过去的半个世纪中,语言学研究因没有充分重视语言使用的实际情况而走了一些弯路。因此,现在有必要根据语词使用的实证对这些已被普遍接受的语言学理论的核心部分重新进行评判。句法结构对意义表征起着重要的作用,但它过于笼统,难以表述日常语言使用中普遍存在的语义差别。许多语词的语义十分含混;语词的各个意义之间似乎没有很明显的界限。单靠句法或语词都无法解构说话人或作者想要表达的意思。但如果我们把二者结合起来,通过甄别语词的组合模式和优先搭配结构,其歧义就会大大减小。近年来,语料库模式分析表明,每个语词通常只参与为数不多的几个模式,而这些模式在意义表征上大多数都没有歧义。语词的模式通常含有两大要素:相对稳定的句法配价和灵活多变的词汇搭配。语料库模式分析是建立在之前一些理论上的一个崭新的语言学理论,语言使用受两套规则的支配:一是语词的常态用法规则,二是创造性地拓展常态用法的规则。文章将详细介绍该理论的核心部分——常态与拓展理论,并概述这两套系统或规则相互作用的方式。 | Patrick Hanks 夏立新 庾小美 | 2015 | 辞书研究2015，，1： | 2 |
| 10 | Surface modification of silicon nitride powder with alumina 显示文摘 | HANK R LIM C S HONG M J | 1996 | J Am Ceram Soc1996，79，2： | 2 |
| 11 | Pediatric obesity prevention:From na?ve examination of energy imbalance towards strategies that influence the competition for nutrient resources among tissues显示文摘Current pediatric obesity interventions have collectively yielded relatively unsuccessful results. In this Field of Vision, we present plausible physiologic underpinnings fostering ineffectiveness of conventional strategies grounded in requisite induction of negative energy imbalance. Moreover, such recommendations exacerbate the underlying metabolic dysfunction by further limiting metabolic fuel availability, lowering energy expenditure, and increasing hunger(recapitulating the starvation response amid apparent nutritional adequacy) which precede and promote obesity during growth and development. The qualitative aspects of musculoskeletal system(i.e., endocrine response, muscle functional capacity) are likely to improve metabolic function and increase nutrient delivery and utilization. An intricate and complex system including multiple feedback mechanisms operates to homeostatically regulate energy balance and support optimal body composition trajectories and metabolic health, during growth and development. Thus, ignoring the interdependencies of regulatory growth processes initiates a nuanced understanding of energy regulation and thus misguided attempts at preventive strategies. Importantly, these gains are not dependent upon weight-loss, rather we suggest can be achieved through resistance training. Collectively, optimizing musculoskeletal health via resistance training elicits augmentation of competitive capacity across systems. Further, substantial gains can be achieved in skeletal muscle mass, strength, and functional capacity through resistance training in a relatively short period of time. | Lynae J Hanks Tina Simpson Kenneth McCormick Krista Casazza | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 2 |
| 12 | Prostate Cancer Radiotherapy Dose Response: An Update of the Fox Chase Experience显示文摘 | ALAN POLLACK ALEXANDRA L. HANLON ERIC M. HORWITZ STEVEN J. FEIGENBERG ROBERT G. UZZO GERALD E. HANKS | 2004 | The Journal of Urology2004，，3： | 2 |
| 13 | Dynamics of liquefaction during the 1987 Superstition Hills, California, Earthquake显示文摘 | Holzer T L Youd T L Hanks T C | 1989 | Science1989，244，： | 2 |
| 14 | Analysis of perfluorooctanoate (PFOA) and other perfluorinated compounds (PFCs) in the River Po watershed in N-Italy显示文摘 | Robert Loos Giovanni Locoro Tania Huber Jan Wollgast Eugen H. Christoph Alfred de Jager Bernd Manfred Gawlik Georg Hanke Gunther Umlauf José-Manuel Zaldívar | 2007 | Chemosphere2007，，2： | 2 |
| 15 | Inhibition of autophagy rescues HT22 hippocampal neurons from erastin-induced ferroptosis显示文摘Ferroptosis is a regulated form of cell death which is considered an oxidative iron-dependent process.The lipid hydroperoxidase glutathione peroxidase 4 prevents the iron(Fe2+)-dependent formation of toxic lipid reactive oxygen species.While emerging evidence indicates that inhibition of glutathione peroxidase 4 as a hallmark of ferroptosis in many cancer cell lines,the involvement of this biochemical pathway in neuronal death remains largely unclear.Here,we investigate,first whether the ferroptosis key players are involved in the neuronal cell death induced by erastin.The second objective was to examine whether there is a cross talk between ferroptosis and autophagy.The third main was to address neuron response to erastin,with a special focus on ferritin and nuclear receptor coactivator 4-mediated ferritinophagy.To test this in neurons,erastin(0.5-8μM)was applied to hippocampal HT22 neurons for 16 hours.In addition,cells were cultured with the autophagy inhibitor,3-methyladenin(10 mM)and/or ferroptosis inhibitors,ferrostatin 1(10-20μM)or deferoxamine(10-200μM)before exposure to erastin.In this study,we demonstrated by immunofluorescence and western blot analysis,that erastin downregulates dramatically the expression of glutathione peroxidase 4,the sodium-independent cystine-glutamate antiporter and nuclear receptor coactivator 4.The protein levels of ferritin and mitochondrial ferritin in HT22 hippocampal neurons did not remarkably change following erastin treatment.In addition,we demonstrated that not only the ferroptosis inhibitor,ferrostatin1/deferoxamine abrogated the ferroptotic cell death induced by erastin in hippocampal HT22 neurons,but also the potent autophagy inhibitor,3-methyladenin.We conclude that(1)erastin-induced ferroptosis in hippocampal HT22 neurons,despite reduced nuclear receptor coactivator 4 levels,(2)that either nuclear receptor coactivator 4-mediated ferritinophagy does not occur or is of secondary importance in this model,(3)that ferroptosis seems to share some features of the autophagic cell death process. | Nora Hanke Abdelhaq Rami | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 16 | REFLECTION OF RADIANT ENERGY FROM SOILS显示文摘 | S. A. BOWERS R. J. HANKS | 1965 | Soil Science1965，，2： | 2 |
| 17 | Preparation method of submicrometer sized α alumina by surface modification of γ-alumina with aluminasol显示文摘 | HANK R LIM C S | 2000 | J Am Ceram Soc2000，83，4： | 2 |
| 18 | 范式未成?再论社会网络研究的动态稳定性显示文摘本文提倡基于关系优先、普遍的嵌入性、网络连结的社会效用以及社会生活结构模式构成的一组核心概念(Lakatos,1970)来渐进式地发展理论,而非统一范式。组织网络研究可以捕捉个体和网络在相互建构与变化方面的复杂性和区别性。本文的目标不是描述已预设结果的细微难题,而是勾画一些与新兴现象相关的大胆设想。 | Martin Kilduff Wenpin Tsai Ralph Hanke 李永强(译) 车瑜(译) 曾媛媛(译) | 2013 | 经济管理2013，39，6： | 2 |
| 19 | Compliant Mechanism Synthesis by Using Elastic Similitude显示文摘Compliant mechanisms have several advantages, especially smaller number of elements and therefore less movable joints. The flexural members furthermore allow an integration of special functions like balancing or locking. Especially fiber reinforced materials exhibit a wide range of function integration considering their compliance in passive as well active applications. To take advantage of compliant elements in applications a robust synthesis tool is needed. The synthesis based on topology optimization method or the pseudo rigid body approach leads to complex structures. Considering the use of fiber reinforced material a synthesis approach which leads to less complex structures is more suitable. For building up simple structures, with only one cantilever beam as compliant element(B) a graphical approach using the elastic similitude is the most efficient method. A step-by-step synthesis procedure is presented to synthesize compliant mechanisms with rotatory joints(R) and prismatic joints(P) to develop RRB/PRB- and RPB-linkages. Using the elastic similitude to implement these results into a graphical synthesis algorithm is the innovation part of this paper. It can be shown that this approach leads to a comfortable handling of beam elements during the synthesis, where the two free parameters can be directly coupled to scale and fix the orientation of the beam element. This advantage inherently shortens the development process. In giving an example the focus lies of the experimental approach, which also shows that the simple BERNOULLI beam model is valid and so the synthesis by using the elastic similitude. The method is presented and discussed by using an application for a cup holder mechanism made of fiber reinforced material. | HANKE Uwe HAMPEL Peter COMSA Andrei MODLER Niels MODLER Karl-Heinz | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 2 |
| 20 | Market Attractiveness, Resource- based Capabilities, Venture Strategies, and Venture Performance 显示文摘 | Clumdler G N Hanks S H | 1994 | Journal of Business Venturing1994，9，4： | 1 |
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