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| 1 | Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer显示文摘AIM: To assess the incidence of MLH1 (the human MutL homologue) and MSH2 (the human MutS homologue) protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS: We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis: p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability (MSI). RESULTS: Our analysis showed that 29 (39.2%) had loss of MLH1 expression, 5 (6.8%) had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival (71.7 ± 8.65 mo vs 47.08 ± 5.26 mo) for the patients with MLH1-negative versus MLH1-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION: Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas. | Sibel Erdamar Esra Ucaryilmaz Gokhan Demir Tayfun Karahasanoglu Gulen Dogusoy Ahmet Dirican Suha Goksel | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer显示文摘AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gas- trointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibo- dies using an enzyme-linked immunosorbent assay (ELI- SA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies aga- inst CagA and VacA proteins. The χ2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS: Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositi- vity for anti-CagA was detected in 51 of 62 (82%), andin 55 of 63 (87%) patients with NUD and DU, respec- tively (p = no significance), and seropositivity for anti- VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION: These findings suggest that none of the- se virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia. | Yusuf Erzin Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Ahmet Dirican Murat Tuncer Bekir Kocazeybek | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 3 | Evaluation of Diverting Ileostomy in Laparoscopic Low Anterior Resection for Rectal Cancer显示文摘 | Tayfun Karahasanoglu Ismail Hamzaoglu Bilgi Baca Erman Aytac Ilknur Erenler Sibel Erdamar | 2011 | Asian Journal of Surgery2011，，2： | 2 |
| 4 | Increased lipid peroxidation and impaired enzymatic antioxidant defense mechanism in thyroid tissue with multinodular goiter and papillary carcinoma显示文摘 | Erdamar H Cimen B Giilcemal H | 2010 | Clin Biochem2010，43，78： | 1 |
| 5 | Protective effect of taurine on respiratory burst activity of polymorphonuclear leu kocytes in endotoxemia显示文摘 | EKREMOGLU M TURKOZKAN N ERDAMAR H | 2007 | Amino Acids2007，32，3： | 1 |
| 6 | Expression of the the cyclin-kinaso inhibitors P21 ( WAF1 ) and P27 (Kipl) and the P53 tumor suppressor genes in adult-onset laryngeal papillomas显示文摘 | Erdamar B Keles N Kaur A | 2002 | Eur Arch Otorhinolaryngol2002，259，10： | 1 |
| 7 | Synthesis and characterization of poly(acrylic acid) stabilized cadmium sulfide quantum dots显示文摘 | CELEBI S ERDAMAR A J | 2007 | J Phys Chem B2007，111，12： | 1 |
| 8 | Role of host interleukin 1β gene ( IL-1B ) and interleukin 1 receptor antagonist gene ( IL-1RN ) polymorphisms in clinical outcomes in Helicobacter pylori -positive Turkish patients with dyspepsia显示文摘 | Yusuf Erzin Vedat Koksal Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Süha Goksel Ahmet Dirican Bekir Kocazeybek | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 9 | Cilostazol Attenuates Spinal Cord Ischemia-Reperfusion Injury in Rabbits显示文摘 | Yunus Nazli Necmettin Colak Mehmet Namuslu Husamettin Erdamar Hacer Haltas Mehmet Fatih Alpay Omer Nuri Aksoy Ismail Olgun Akkaya Omer Cakir | 2015 | Journal of Cardiothoracic and Vascular Anesthesia2015，，： | 1 |
| 10 | Cytoplasmic accumulation of glycogen synthase kinase-3beta is associated with aggressive clinicopathological features in human prostate cancer 显示文摘 | Li R Erdamar S Dai H | 2009 | Anticancer Research2009，29，6： | 1 |
| 11 | Extracapsular spread in ipsilateral neck and contralateral neck metastasis in laryngeal cancer显示文摘 | SUOGLU Y ERDAMAR B KATIRCIOGLU O S | 2002 | Ann Otol Laryngol2002，111，： | 1 |
| 12 | Role of host interleukin 1β gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia显示文摘 | Yusuf Erzin Vedat Koksal Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Süha Goksel Ahmet Dirican Bekir Kocazeybek | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 13 | A wavelet and Teager energy operator based method for automatic detection of K-complex in sleep EEG显示文摘 | Erdamar A Duman F Yetkin S | 2012 | Expert Systems with Applications2012，39，1： | 1 |
| 14 | Levels of expression of p27kipl protein in human prostate and prostate cancer:an immunohistochemical analysis显示文摘 | Erdamar S Yang G Harper JW | 1999 | Mod Pathol1999，12，8： | 1 |
| 15 | Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis显示文摘 | Erdamar S Yang G Harper JW | 1999 | Mod Pathol1999，12，8： | 1 |
| 16 | Association KRAS G13D tumor mutated outcome in patients with chemotherapy refractory metastatic colorectal cancer treated with cetuximab显示文摘 | Tural D Selcukbiricik F Erdamar S | 2013 | Hepatogastroenterology2013，60，125： | 1 |
| 17 | Penile blood cyclic guanosin monophosphate level is associated with penile Doppler ultrasound findings 显示文摘 | Serefoglu EC Erdamar H O2 demir AT | 2009 | Int J ImpotRes2009，21，1： | 1 |
| 18 | Detection of clinically significant,occult prostate cancer metastases in lymph nodes using a splice variant-specific RT-PCR assay for human glandular kallikrein显示文摘 | Shariat SF Kattan MW Erdamar S | 2003 | J Clin Oncol2003，21，： | 1 |
| 19 | The effect of hypothyroidism,hyperthyroidism,and their treatment on parameters of oxidative stress and antioxidant status显示文摘 | Erdamar H Demirci H Yaman H | | 0，，： | 1 |
| 20 | Expression of the Cyclin-kinase Inhibitors p21(WAF1)and p27(Kip1) and the p53 Tumor Suppresser Genes in Adult-onset Larynpeal Papillomas显示文摘 | Erdamar B Keles N Kaur A | 2002 | Eur Arch Otorhinolaryngol2002，259，10： | 1 |
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