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| 1 | Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis显示文摘AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress. | Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden Bur(?)ak | 2005 | World Journal of Gastroenterology2005，11，15： | 18 |
| 2 | Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer显示文摘AIM: To assess the incidence of MLH1 (the human MutL homologue) and MSH2 (the human MutS homologue) protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS: We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis: p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability (MSI). RESULTS: Our analysis showed that 29 (39.2%) had loss of MLH1 expression, 5 (6.8%) had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival (71.7 ± 8.65 mo vs 47.08 ± 5.26 mo) for the patients with MLH1-negative versus MLH1-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION: Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas. | Sibel Erdamar Esra Ucaryilmaz Gokhan Demir Tayfun Karahasanoglu Gulen Dogusoy Ahmet Dirican Suha Goksel | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 4 | 土耳其中医药发展现状与分析显示文摘土耳其是位于亚欧大陆交界处的总统共和制国家。2003年医疗改革后,该国医疗保险几乎覆盖全民。导致土耳其居民死亡的主要疾病是缺血性心脏病、脑卒中和肺癌,且下呼吸道感染、慢性肾脏病、高血压心脏病等疾病的致死率增长较快。1991年《针灸实施条例》的颁布标志着针灸正式获得土耳其政府的认可。2014年至今,《传统与补充医疗实践法规》明确规定,只有经过培训的全科医生及牙医方可进行针灸治疗。目前,土耳其针灸治疗应用相对简单;中药在土耳其仍受农业部管辖,尚不能作为药品进入土耳其。建议在针灸推广过程中加强中医理论的学习,明确两国中药质量标准的差异,以当地高发病入手突出中医优势,加强中医药在土耳其的推广力度。 | 王哲 梁宁 Kanat Tayfun 石晗 赵静 杨龙会 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，4： | 4 |
| 5 | Horizontal transmission of hepatitis B virus in children with chronic hepatitis B显示文摘AIM: To determine the possible routes of intrafamilial transmission pattern in pediatric cases of chronic hepatitis B virus (HBV) infection.METHODS: In this descriptive retrospective study, 302 children with chronic HBV infection from 251 families and their parents attending the Social Security Children's Hospital and Doctor Sami Ulus Children's Hopsital in Ankara between December 1998 and May 2000, were enrolled in. Screenings and diagnosis of chronic HBV infections were established according to the Consensus 2000.RESULTS: In the studied 302 children with chronic HBV infection, mothers of 38% and fathers of 23% were HBsAg positive. The HBsAg positivity in at least two siblings of the same family was 61% when both parents were HBsAg positive.CONCLUSION: It is well known that horizontal transmission is quite common in countries where Hepatitis B Virus is moderately endemic. To our best knowledge, this is the largest series observed regarding the horizontal transmission in pediatric chronic HBV infection in Turkey. It is necessary to expand the preventive programs to target not only the newborn period but also all stages of childhood. | Tumay Doganci Gulnar Uysal Tayfun Kir Arzu Bakirtas Necdet Kuyucu Levent Doganci | 2005 | World Journal of Gastroenterology2005，11，3： | 2 |
| 6 | Evaluation of Diverting Ileostomy in Laparoscopic Low Anterior Resection for Rectal Cancer显示文摘 | Tayfun Karahasanoglu Ismail Hamzaoglu Bilgi Baca Erman Aytac Ilknur Erenler Sibel Erdamar | 2011 | Asian Journal of Surgery2011，，2： | 2 |
| 7 | Beyond 11% Efficiency: Characteristics of State‐of‐the‐Art Cu2ZnSn(S,Se)4 Solar Cells显示文摘 | Teodor K. Todorov Jiang Tang Santanu Bag Oki Gunawan Tayfun Gokmen Yu Zhu David B. Mitzi | 2012 | Adv. Energy Mater2012，，： | 2 |
| 8 | A compari- son of shock wave lithotripsy, semirigid and flexible ure- teroscopy in the'management of proximal ureteral calculi显示文摘 | FARUK Y KEMAL S TAYFUN G | 2009 | Turkish Journal of Urology2009，35，： | 1 |
| 9 | Transvaginal ultrasound‐guided local methotrexate administration as the first‐line treatment for cesarean scar pregnancy: Follow‐up of 18 cases显示文摘 | Tayfun Cok Hakan Kalayci Halis Ozdemir Bulent Haydardedeoglu Ayse H. Parlakgumus Ebru Tarim | 2015 | J Obstet Gynaecol Res2015，，： | 1 |
| 10 | Analysis of stress distribution in amaxillary central inciscr subjected to various post and core application显示文摘 | Sis DY Tayfun A Yavuz Y | 1998 | J Endodon1998，24，： | 1 |
| 11 | Strategic pricing of horizontally differ- entiated services with switching costs: A pricing model for cloud computing 显示文摘 | Tayfun K Nazim T | 2015 | International Journal of Electronic Commerce2015，19，3： | 1 |
| 12 | Failure analysis of woven laminated glass-vinylester composites with pin-loaded hole 显示文摘 | Ramazan Karakuzu Tayfun G u lem B u lent Murat Icten | 2006 | Composite Structures2006，72，： | 1 |
| 13 | Effects of different land reallocation models on the success of land consolidation projects:Social and economic approaches显示文摘 | TAYFUN CAY TURGUT AYTEN FATIH ISCAN | 2010 | Land Use Policy2010，，27： | 1 |
| 14 | Selection of proper enhanced oil recovery fluid for efficient matrix recovery in fractured oil reservoirs 显示文摘 | Tayfun Babadagli | 2003 | Colloid Surface A: Physieoehem Eng Aspects2003，223，13： | 1 |
| 15 | A low-cost rate-grade nickel microgyroscope显示文摘 | Said E A Kanber M S Tayfun A | 2006 | Sensors and Actuators A2006，132，： | 1 |
| 16 | Symmetrical and Decoupled nickel Microgyroscope Oil Insulating Substrate显示文摘 | Said Emre Alper Tayfun Akin | 2004 | Sensors and Actuators2004，115，： | 1 |
| 17 | A comparison of shock wave lithotripsy,semirigid and flexible ureteroscopy in the management of proximal ureteral calchli显示文摘 | Faruk Y Kemal S Tayfun G | 2009 | Turkish J Urol2009，35，2： | 1 |
| 18 | Prognostic value of tissue Doppler imaging in patients with chronic congestive heart failure显示文摘 | Tayfun Acila Thomas Wichtera Jfrg Stypmanna | 2004 | International Journal of Cardiology2004，5，10： | 1 |
| 19 | Effect of diesel–microalgae biodiesel–butanol blends on performance and emissions of diesel engine显示文摘 | G?khan Tüccar Tayfun ?zgür Kadir Ayd?n | 2014 | Fuel2014，，： | 1 |
| 20 | Determination of efficiency of flat-plate solar collectors using neural network approach 显示文摘 | ADNAN S TAYFUN M SINAN U | 2008 | Expert Systems with Applications2008，35，4： | 1 |
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