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| 1 | Total thyroidectomy is safer with identification of recurrent laryngeal nerve显示文摘Objective:To investigate the effect of recurrent laryngeal nerve(RLN)identification on the complications after total thyroidectomy and lobectomy.Methods:Total 134 consecutive patients undergoing total thyroidectomy or thyroid lobectomy from January 2003 to November 2004 were investigated retrospectively.Patients were divided into two groups:RLN identified (Group A)or not(Group B).The two groups were compared for RLN injury and hypocalcaemia.Results:The numbers of patients and nerves at risk were 71 and 129 in Group A,and 63 and 121 in Group B,respectively.RLN injury in Group A(0)was sig- nificantly lower than that in Group B(57.9%)patients,75.8%nerves)for the numbers of patients(P=0.016)and nerves at risk (P=0.006).Temporary hypocalcaemia was significantly higher in Group A than in Group B(1424.1%vs 610.3%,P=0.049). Permanent complications in Group B were significantly higher than those in Group A(1320.6%vs 45.6%,P=0.009).Con- clusion:RLN injury was prevented and permanent complications were decreased by identifying the whole course and branches of the recurrent laryngeal nerve during total thyroidectomy. | Hakan CANBAZ Musa DIRLIK Tahsin COLAK Koray OCAL Tamer AKCA Oner BILGIN Bahar TASDELEN Suha AYDIN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，6： | 20 |
| 2 | Drainage after total thyroidectomy or lobectomy for benign thyroidal disorders显示文摘Objective: This prospective randomized clinical trial was conducted to evaluate the necessity of drainage after total thyroidectomy or lobectomy for benign thyroidal disorders. Methods: A total of 116 patients who underwent total thyroidectomy or lobectomy for benign thyroidal disorders were randomly allocated to be drained or not. Operative and postoperative outcomes including operating time, postoperative pain assessed by visual analogue scale (VAS), total amount of intramuscular analgesic administration, hospital stay, complications, necessity for re-operation and satisfaction of patients were all assessed. Results: The mean operating time was similar between two groups (the drained and non-drained groups). The mean VAS score was found to be significantly low in the non-drained group patients in postoperative day (POD) 0 and POD 1. The mean amount of intramuscular analgesic requirement was significantly less in the non-drained group. One case of hematoma, two cases of seroma and three cases of transient hypoparathyroidism occurred in the non-drained group, whereas one case of hematoma, two cases of seroma, two cases of wound infections and two cases of transient hypoparathyroidism occurred in the drained group. No patient needed re-operation for any complication. The mean hospital stay was significantly shorter and the satisfaction of patients was superior in the non-drained group. Conclusion: These findings suggest that postoperative complications cannot be prevented by using drains after total thyroidectomy or lobectomy for benign thyroid disorders. Furthermore, the use of drains may increase postoperative pain and the analgesic requirement, and prolong the hospital stay. In the light of these findings, the routine use of drains might not be necessary after thyroid surgery for benign disorders. | Tahsin COLAK Tamer AKCA Ozgur TURKMENOGLU Hakan CANBAZ Bora USTUNSOY Arzu KANIK Suha AYDIN1 | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，4： | 12 |
| 3 | Synergistic effect of multiple predisposing risk factors on the development of bezoars显示文摘AIM:To describe the clinical characteristics of patients with gastric or intestinal bezoars recently treated in our hospital.METHODS:In this study,a retrospective chart review of consecutive patients with gastrointestinal bezoars,who were treated at the Samsun Education and Research Hospital between January 2006 and March 2011,was conducted.Data on demographic characteristics,clinical presentation,history of risk factors,diagnostic procedures,localization of bezoars,treatment interventions,and postoperative morbidity and mortality rates were collected and evaluated.RESULTS:Forty-two patients [26 (61.9%) males and 16 (31.1%) females] with a mean±SD (range) age of 55.8±10.5 (37-74) years were enrolled in this study.Thirty-six patients (85.7%) had one or more predisposing risk factors for gastrointestinal bezoars.The most common predisposing risk factor was a history of previous gastric surgery which was identified in 18 patients (42.8%).Twenty three patients (54.8%) had multiple predisposing risk factors.Phytobezoars were identified in all patients except one who had a trichobezoar in the stomach.Non-operative endoscopic fragmentation was performed either initially or after unsuccessful medical treatment in 14 patients with gastric bezoars and was completely successful in 10 patients (71.5%).Surgery was the most frequent treatment method in our study,which was required in 28 patients (66.7%).Intestinal obstruction secondary to bezoars was the most common complication (n=18,42.8%) in our study.CONCLUSION:The presence of multiple predisposing factors may create a synergistic effect in the development of bezoars. | Metin Kement Nuraydin Ozlem Elif Colak Sadik Kesmer Cem Gezen Selahattin Vural | 2012 | World Journal of Gastroenterology2012，18，9： | 11 |
| 4 | Falls from height: A retrospective analysis显示文摘BACKGROUND: Emergency services manage trauma patients frequently and falls from height comprise the main cause of emergency service admissions. In this study, we aimed to analyse the demographic characteristics of falls from height and their relationship to the mortality.METHODS: A total of 460 patients, who admitted to the Emergency Department of Inonu University between November 2011 and November 2014 with a history of fall from height, were examined retrospectively. Demographic parameters, fall characteristics and their effect to mortality were evaluated statistically. RESULTS: The study comprised of 292(63.5%) men and 168(36.5%) women patients. The mean age of all patients was 27±24.99 years. Twenty-six(5.6%) patients died and the majority of them were in ≥62 years old group. The highest percentage of falls was at 0–5 years age group(28.3%). People fell mainly from 1.1–4 metres(m) level(46.1%). The causes of falls were ordered as unintentional(92.2%), workplace(8.1%) and suicidal(1.7%). Skin and soft tissue injuries(37.4%) were the main traumatic lesions. CONCLUSION: Age, fall height, fall place, linear skull fracture, subarachnoidal hemorrhage, cervical fracture, thoracic vertebra fracture and trauma scores had statistically significant effect on mortality. The casualties died because of subarachnoid hemorrhage mostly. | Kasim Turgut Mehmet Ediz Sarihan Cemil Colak Taner Giiven Ali Gur Sukru Gurbuz | 2018 | World Journal of Emergency Medicine2018，9，1： | 5 |
| 5 | Leucocyte-and platelet-rich fibrin as a rescue therapy for small-to-medium-sized complex wounds of the lower extremities显示文摘Background:Generally,advanced wound care resources are applied for complex wounds that pose a challenge to the medical and nursing teams.In this report,the use of leukocyte-and platelet-rich fibrin(L-PRF)is emphasized for complex wounds as an alternative,simple,inexpensive,time-saving process that does not require hospitalization and has a healing potential over that of bare soft tissue,including bone,tendon,and ligaments.The aim of this study is to extend the use of L-PRF in small-to-moderate-sized complex wounds of lower extremities in which L-PRF maintains the sensitive structures viable.Methods:Between January 2016 and December 2017,17 small-to-moderate-sized complex wounds of lower extremities treated with L-PRF were recruited from the plastic and reconstructive surgery clinic in Aydin State Hospital,Turkey.The treatment was administered twice per week in the outpatient clinic.Depending on the size and extension of the complex wound,two to five blood samples were collected into 8.5 ml dry,glass vacuum tubes with no anticoagulant,and samples were immediately centrifuged at 1630×g for 5 min to obtain L-PRF.Complete healing was defined as the day of complete wound epithelialization.Results:The median values of the initial wound size and wound duration were 12 cm^(2)(interquartile range,6 to 23 cm^(2))and 8 months before first admission(interquartile range,4 to 18 months),respectively.All wounds showed significant improvements after L-PRF therapy and full closure after a median of 18months,with an interquartile range of 11 to 34 months of L-PRF applications.There were recurrences of wounds during the first 6 months after therapy.No adverse events were observed.Conclusions:Our results add to the growing evidence that L-PRF treatments protect and maintain bare soft tissue structures viable,facilitate the formation of granulation tissue and epithelization,and remarkably reduce the need for additional soft tissue surgeries in small-to-medium-sized complex wounds. | Kadri Ozer Ozlem Colak | 2019 | Burns & Trauma2019，7，1： | 4 |
| 6 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 7 | Comparison of Goldmann applanation tonometry,rebound tonometry and dynamic contour tonometry in normal and glaucomatous eyes显示文摘AIM: To compare the intraocular pressure(IOP)measurements obtained with the rebound tonometry(RT), dynamic contour tonometry(DCT) and Goldmann applanation tonometry(GAT) in normal and glaucomatous eyes and investigate the effects of central corneal thickness(CCT) and corneal curvature(CC) on IOP measurements.METHODS: One hundred and twenty-four eyes of 124 subjects were enrolled in this cross-sectional study.Fifty-six of participants were healthy individuals and 68 of them were glaucomatous patients. IOP was measured on each subject always in the same order, ICare RT-Pascal DCT-GAT, after a minimum interval of 10 min between measurements. CCT and CC were measured using a rotating Scheimpflug camera before the IOP measurements in all subjects. One way repeated measures ANOVA, Pearson correlation coefficient and regression analysis, and Bland-Altman analysis was used for the statistical assessment.RESULTS: Mean IOP for all enrolled eyes was 16.00±3.80 mm Hg for GAT, 16.99 ±4.91 mm Hg for RT, and20.40 ±4.44 mm Hg for DCT. Mean differences between GAT and RT was-1.75±3.41 mm Hg in normal(P <0.001)and-0.37 ±3.00 mm Hg in glaucomatous eyes(P =0.563).Mean differences between GAT and DCT was-4.06 ±3.42 mm Hg in normal(P < 0.001) and-4.67 ±3.12 mm Hg in glaucomatous eyes(P <0.001). GAT and RT were significantly positive correlated with CCT in normal(r2=0.101, P =0.017 and r2=0.331, P <0.001, respectively) and glaucomatous eyes(r2=0.084, P =0.016 and r2=0.123,P =0.003, respectively). DCT was also significantly positive correlated with CCT in normal eyes( r2=0.179,P =0.001) but not in glaucomatous eyes(r2=0.029, P =0.165).All tonometers were unaffected by CC.CONCLUSION: IOP measurements by RT and DCT were significantly higher than GAT. DCT has highest IOP measurements among these tonometers. RT was most influenced tonometer from CCT although all tonometers were significantly positive correlated with CCT except DCT in glaucomatous eyes. CC did not influence IOP measurements. | Fatih Ozcura Nilgün Yildirim Afsun Sahin Ertugrul Colak | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 8 | Tm-doped ZnO nanorods as a TCO for PV applications显示文摘In photovoltaic(PV) devices, a transparent conducting oxide(TCO) film is used as a transparent electrode which permits sun rays to reach to the photoactive semiconducting layers and also to collect the photogenerated electrons. Due to their electrical and optical properties zinc oxide(ZnO) based thin films and nanostructures are considered as an abundant and safer option for TCOs. In this study, undoped and thulium(Tm)-doped ZnO nanorods(NRs) were produced on glass substrates via spin coating and hydrothermal methods. The ZnO samples were described by X-ray diffractometry(XRD). Morphological features of the ZnO samples were investigated with scanning electron microscopy(SEM). It is observed that the all ZnO samples have nanorod shape. The average rods diameter is between 75 and 100 nm. Also,the rods length is found to be between 0.96 and 1.62 μm. Electrical properties of the ZnO samples were performed via four probe method. The conductivity increases with measurement temperature and Tm doping. Optical spectra of the ZnO samples were measured in UV-Vis range and the band gap(E_g) is found to be 3.35 eV. | Hakan Colak Ercan Karakose | 2018 | Journal of Rare Earths2018，36，10： | 3 |
| 9 | Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors显示文摘 | Tuba Kara Ebru Serinsoz Rabia Bozdogan Arpaci Ozlem Gubur Gulhan Orekici Alper Ata Tahsin Colak Ali Arican | 2013 | Pathology - Research and Practice2013，，7： | 2 |
| 10 | Assessment of endothelial function in patients with nonalcoholic fatty liver disease显示文摘 | Yasar Colak Ebubekir Senates Atakan Yesil Yusuf Yilmaz Oguzhan Ozturk Levent Doganay Ender Coskunpinar Ozlem Timirci Kahraman Banu Mesci Celal Ulasoglu Ilyas Tuncer | 2013 | Endocrine2013，，1： | 2 |
| 11 | Presence of thyroid-associated ophthalmopathy in Hashimoto's thyroiditis显示文摘·AIM: To determine the prevalence of ophthalmopathy in Hashimoto's patients and to make a comparison in subgroups of patients·METHODS: The study involved 110 Hashimoto's thyroiditis patients and 50 control subjects attending to the endocrinology department of the hospital. Subgroup classification of patients was made as euthyroid,subclinic and clinic in Hashimato's thyroiditis. All patients were evaluated by a single experienced ophthalmologist for the prevalence and characteristics of eye signs.·RESULTS:Theoverallprevalencesofeyechanges were22.7%(25 patients) in patients and 4%(2 persons) in control subjects respectively(P =0.002). In patients the most common symptom was retrobulbar eye pain with or without any eye movement. Thirteen patients had significant upper eyelid retraction(11.8%). Six patients had eye muscle dysfunction as reduced eye movements in up gaze. In control patients one person had proptosis and another had lid retraction. The clinical activity score and classification of the ophthalmopathy did not show any significant differences among subgroups.·CONCLUSION:Theeyesignsweremostlymild(22.7%)and the most common eye sign was the presence of upper eyelid retraction(11.8%). Additionally six patients had eye muscle dysfunction as reduced eye movements in up gaze. Therefore we recommend to make a routine ophthalmic examination in Hashimoto's thyroiditis patients in order not to omit the associated ophthalmopathy. | Emrah Kan Elif Kilic Kan Gülcin Ecemis Ramis Colak | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 2 |
| 12 | Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats显示文摘 | Gokhan Bayramoglu Hakan Senturk Aysegul Bayramoglu Mustafa Uyanoglu Suat Colak Ayse Ozmen Durdane Kolankaya | 2014 | Cytotechnology2014，，2： | 2 |
| 13 | Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study显示文摘AIM To evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery. METHODS We retrospectively analyzed parameters, including age, sex, complete blood cell count parameters, nodule diameter, nodule localization, thyroid function testing, and pathology reports, in patients who underwent thyroid surgery. The patients were divided into malignant (n = 92) and benign (n = 413) groups depending on the final pathological results. Both groups were compared for demographic and clinicalparameters. The Kolmogorov-Smirnov normality test was used to determine if the quantitative variables had a normal distribution. The nonparametric MannWhitney U test was used to compare quantitative data that were not normally distributed, and Pearson's chisquared test was used to compare the qualitative data. The correlation between the final pathological results and fine-needle aspiration biopsy findings was calculated using the cross-tabulation method.RESULTS This study included 406 women and 99 men aged between 15 and 85 years. No significant differences were found between the groups with respect to age, sex, white blood cell count, neutrophil count, lymphocyte count, thrombocyte count, red cell distribution width, platelet distribution width, mean platelet volume, platecrit, nodule localization, and thyroid function testing. On the other hand, there were significant differences between the groups with respect to nodule size (P = 0.001), cervical lymphadenopathy(P = 0.0001) and nodular calcification (P = 0.0001). Compared with the malignant group, the benign group had a significantly greater nodule size (35.4 mm vs 27.6 mm). The best cut-off point (≤ 28 mm) for nodule size, as determined by the receiver operating characteristic curve, had a sensitivity and specificity of 67.7% and 64.4%, respectively. The correlation between fine-needle aspiration biopsy and the final pathological results was assessed using the cross-table method. The sensitivity and specificity of fine-needle aspiration biopsy were 60% and 98%, respectively.CONCLUSION This study showed that significant differences existed between the malignant and benign groups with regard to nodule size, cervical lymphadenopathy, and nodular calcification. | Arif Emre Sami Akbulut Mehmet Sertkaya Muharrem Bitiren Ilhami Taner Kale Ertan Bulbuloglu Cemil Colak | 2018 | World Journal of Clinical Cases2018，6，3： | 2 |
| 14 | Comparison of lamivudine and alpha-interferon combination with alpha-interferon alone in the treatment of HBeAg-positive chronic hepatitis B显示文摘 | Ayaz C Celen MK Colak H | 2006 | Indian J Gastroenterol2006，25，： | 1 |
| 15 | The influence of tubular phenotypic changes on the development of diffuse interstitial fibrosis in renal allografts显示文摘 | Ozdemir BH Ozdemir AA Colak T | 2011 | Transplant Proc2011，43，2： | 1 |
| 16 | Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity显示文摘 | Erken HA Erken G Colak R | 2013 | High Alt Med Biol2013，14，4： | 1 |
| 17 | Correlation of Volume Control Parameters With Health-Related Quality of Life in Renal Transplant Patients显示文摘 | Colak H Sert I Ekmekci C | 2015 | Transplant Proc2015，，01： | 1 |
| 18 | Effects of moisture content on formaldehyde emission and mechanical properties of plywood显示文摘 | AYDIN I COLAKOGLU G COLAK S | 2006 | Building and Environment2006，41，10： | 1 |
| 19 | Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis 显示文摘 | Zhu Y Colak T Shenoy M | 2011 | Gastroenterology2011，141，1： | 1 |
| 20 | A Randomized Clinical Study Evaluating the Need for Drainage After Limberg Flap for Pilonidal Sinus显示文摘 | Tahsin Colak Ozgur Turkmenoglu Ahmet Dag Tamer Akca Suha Aydin | 2010 | Journal of Surgical Research2010，，1： | 1 |
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