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| 1 | Endoscopic management of biliary strictures after liver transplantation显示文摘Bile duct strictures remain a major source of morbidity after orthotopic liver transplantation (OLT). Biliary strictures are classifi ed as anastomotic or non-anastomotic strictures according to location and are defi ned by distinct clinical behaviors. Anastomotic strictures are localized and short. The outcome of endoscopic treatment for anastomotic strictures is excellent. Nonanastomotic strictures often result from ischemic and immunological events, occur earlier and are usually multiple and longer. They are characterized by a far less favorable response to endoscopic management, higher recurrence rates, graft loss and need for retransplantation. Living donor OLT patients present a unique set of challenges arising from technical factors, and stricture risk for both recipients and donors. Endoscopic treatment of living donor OLT patients is less promising. Current endoscopic strategies for biliary strictures after OLT include repeated balloon dilations and placement of multiple side-by-side plastic stents. Lifelong surveillance is required in all types of strictures. Despite improvements in incidence and long term outcomes with endoscopic management, and a reduced need for surgical treatment, the impact of strictures on patients after OLT is signifi cant. Future considerations include new endoscopic technologies and improved stents, which could potentially allow for a decreased number of interventions, increased intervals before retreatment, and decreased reliance on percutaneous and surgical modalities. This review focuses on the role of endoscopy in biliary strictures, one of the most common biliary complications after OLT. | Emmanuelle D Williams Peter V Draganov | 2009 | World Journal of Gastroenterology2009，15，30： | 20 |
| 2 | Effect of percutaneous endoscopic gastrostomy on gastroesophageal reflux in mechanically-ventilated patients显示文摘瞄准:在机械地通气的病人在胃的食道的倒流(GER ) 上调查经皮的内视镜的胃造口术(木钉) 的效果。方法:在未来的、使随机化的、控制研究有周期性或坚持的联系通风机的肺病(VAP ) 和 GER >
的 36 个病人 6% 被划分成木钉组(n = 16 ) 或非木钉组(n = 20 ) 。11 通气了没有倒流的病人(GER <
3%) 用作控制组。食道的 pH-metry 被执行由在基线“渡过”方法,在木钉以后的 2 和 7 d。病人们严格地被跟随在上面为胃的滋养的残余的半侧卧的位置和控制。结果:median (范围)的重要减少倒流从 7.8 在木钉组被观察( 6.2 - 15.6 )在到 2.7 的基线( 0 - 10.4 )在 d 上 7 post-gastrostomy ( P <
0.01 ),当倒流从 9 增加了时( 6.2 - 22 )到 10.8 ( 6.3 - 36.6 )( P <
0.01 )在非木钉组。在 GER (%) 和 nasogastric 试管的停留之间的重要关联被检测(r = 0.56, P <
0.01 ) 。结论:胃造口术什么时候与滋养的胃的残余的半侧卧的位置和缺席结合了,在通气病人减少胃的食道的倒流。 | Emmanuel E Douzinas Andreas Tsapalos Antonios Dimitrakopoulos Evanthia Diamanti-Kandarakis Alexandros D Rapidis Charis Roussos | 2006 | World Journal of Gastroenterology2006，12，1： | 15 |
| 3 | Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma显示文摘瞄准:学习的目的是与食道的癌(LASCOC ) 与权威的 chemoradiotherapy (CRT ) 对待的局部地先进的有鳞的房间在病人评估幸存的预兆的因素政体基于 5FU/CDDP 联合。方法:有用在 1994 和 2000 之间的 5FU/CDDP 联合与权威的 CRT 对待的 LASCOC 的所有病人回顾地被包括。对 CRT 的临床的完全的反应(CCR ) 被食道的内视镜检查法和 CT 扫描估计在 CRT 结束以后的 2 瞬间。幸存的预示的因素用 univariate 被估计,多,由艇长回归的变量分析当模特儿。结果:116 个病人的一个总数在学习被包括。到 CRT 的 CCR 在 86/116 (74.1%) 被观察。中部的幸存是 20 瞬间(范围 2-114 ) , 5 年的幸存是 9.4% 。到 CRT 的应答者病人的中部的幸存在非应答者病人作为与 9 瞬间(范围 2-81 ) 相比是 25 瞬间(范围 3-114 )(P <
0.001 ) 。在 univariate 分析,幸存与 CCR 被联系(P <
0.001 ) ,表演地位 <
2 (P = 0.01 ) ,瘤长度 <
6 厘米(P = 0.045 ) 并且 10% 在意义的限制的重量损失 <
(P = 0.053 ) 。在里面多变量分析,幸存对 CCR 依赖(P <
0.0001 ) ,重量损失 <
10%(P = 0.034 ) 并且表演 <
2 (P = 0.046 ) 。结论:我们的结果建议在有与权威的 CRT 对待的 LASCOC 的病人的那幸存被相关到 CCR,重量损失并且表演地位。 | Frédéric Di Fiore Stéphane Lecleire Olivier Rigal Marie-Pierre Galais Emmanuel Ben Soussan Isabelle David Bernard Paillot Jacques-Henri Jacob Pierre Michel | 2006 | World Journal of Gastroenterology2006，12，26： | 13 |
| 4 | 将卒中纳入心血管风险预测工具美国心脏协会/美国卒中协会对医疗卫生专业人员的声明显示文摘背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而,这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支持:(1)将卒中(尤其是动脉粥样硬化性卒中)患者纳入心血管病绝对风险增高的患者群体;(2)将卒中纳入血管性疾病风险预测工具的转归预测因素。方法和结果写作组成员由委员会联合主席基于先前在相关领域的研究成果来提名,并得到美国心脏协会(American Heart Association,AHA)卒中委员会科学声明监督委员会以及文稿监督委员会的批准。作者采用系统文献回顾(覆盖1980年1月至2010年3月期间的文献)并参考以往公布的指南、个人资料以及专家观点,以归纳现有证据,提出当前知识的不足,并根据AHA标准对适当的问题制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并批准了最终版本。经广泛的AHA内部同行评议以及卒中委员会领导阶层和科学声明监督委员会的审阅后,最终获得AHA科学咨询和协调委员会的批准。将卒中患者(尤其是动脉粥样硬化性卒中患者)纳入冠状动脉和心血管病绝对高危人群的原因如下。首先,有证据显示,缺血性卒中患者发生致死性和非致死性心肌梗死或猝死的绝对风险增高,10年绝对风险≥20%,这一风险阈值已被一些指南用于定义冠状动脉疾病风险等危症。其次,纳入动脉粥样硬化性卒中的原因与纳入糖尿病、周围血管病、慢性肾脏病以及其他动脉粥样硬化性疾病的原因相同,尽管尚缺乏在所有人群或患者中风险增高的统一证据。再次,缺血性卒中的大动脉粥样硬化性卒中亚型与其他这些疾病的病理生理学机制相同。将卒中纳入高危因素将导致高危人群的数量扩大约10%。然而,由于卒中的异质性,尚不确定其他卒中亚型,包括出血性卒中以及非动脉粥样硬化性卒中亚型,是否应被视为具有相同水平的风险,因此有待进一步研究。鉴于卒中对残疾和死亡的影响、卒中与其他血管性疾病预防措施的相似性以及卒中在某些人群中较冠状动脉疾病更高的重要性,将卒中、心肌梗死和猝死纳入心血管事件风险预测工具的转归预测因素是合适的。美国以外的指南常常将卒中患者纳入心血管高危人群,并将卒中作为心脏终点的一个相关转归事件。结论动脉粥样硬化性卒中患者应被纳入会进一步发生冠状动脉粥样硬化事件的高危患者(10年≥20%)。是否应纳入非动脉粥样硬化卒中亚型尚不确定。对于一级预防,缺血性卒中应被纳入绝对风险评估方案的心血管疾病转归事件。将动脉粥样硬化性卒中作为一个高危因素或者更宽泛地将缺血性卒中视作一种转归事件纳入,可能对心血管病的预防具有重要意义,因为被评定为高危风险的患者数量将大幅增加。 | Daniel T. Lackland Mitchell S.V. Elkind Ralph D'Agostino Sr Mandip S. Dhamoon David C. Goff Jr Randall T. Higashida Leslie A. McClure Pamela H. Mitchell Ralph L. Sacco Cathy A. Sila Sidney C. Smith Jr David Tanne David L. Tirschwell Emmanuel Touze Lawrence R. Wechsler 4:~ 尤寿江(译) 于海龙(译) 刘慧慧(译) 张霞(译) 刘春风(译) | 2012 | 国际脑血管病杂志2012，20，11： | 13 |
| 5 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 6 | Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer显示文摘瞄准:与周期性的溃疡为十二指肠溃疡在外科以后流血在病人评估 omeprazole 维护治疗。方法:我们与周期性的溃疡为十二指肠溃疡在外科以后流血学习了 15 个连续病人。维护治疗在溃疡愈合以后被给的 Omeprazole (20 mg/d ) 。除了临床的后续,回廊 24-h 胃的 pH 试金与以前的十二指肠溃疡外科而是没有溃疡复发在那些病人和控制被执行在前并且在 omeprazole 治疗期间。结果:所有 15 溃疡在为 2 瞬间与 omeprazole (40 mg/d ) 被对待以后被愈合。有二的十一个病人(1-9 ) 周期性的溃疡流血的事件完成了后续(43, 12-72 瞬间) 。任何一个都没他们有一个流血事件当时在 omeprazole 上。一个病人中止了治疗并且有周期性的流血。在病人的胃的 pH<4 的中部的 24-h 部分时间是 80, 46-95% ,并且被归结为 32,由 omeprazole (P=0.002 ) 的 13-70% 。结论:有 omeprazole (20 mg/day ) 的长期的维护治疗在阻止周期性的溃疡流血是有效的。 | Konstantinos Demertzis Dimitrios Polymeros Theodoros Emmanuel Konstantinos Triantafyllou Pericles Tassios Spiros D Ladas | 2006 | World Journal of Gastroenterology2006，12，5： | 5 |
| 7 | Colonic gas explosion during therapeutic colonoscopy with electrocautery显示文摘有电镀物品烙术的治疗学的结肠镜检查广泛地在全世界被使用。足够的结肠的清洁为这个过程的安全被认为一个关键因素。结肠的煤气的爆炸稀罕,在有电镀物品的结肠镜检查期间是最令人恐惧的因医生之治疗而引的复杂并发症之一烙术。这复杂并发症是到爆炸集中的结肠的气体的累积的结果,但是可以被过细的肠准备阻止。这评论的目的是为治疗学的结肠镜检查讨论指示和肠准备的类型,并且与电镀物品烙术为结肠镜检查为足够的肠准备贡献建议。 | Spiros D Ladas George Karamanolis Emmanuel Ben-Soussan | 2007 | World Journal of Gastroenterology2007，13，40： | 5 |
| 8 | Improving outcomes of biliary atresia: French national series 1986–2009显示文摘 | Christophe Chardot Chantal Buet Marie-Odile Serinet Jean-Louis Golmard Alain Lachaux Bertrand Roquelaure Frédéric Gottrand Pierre Broué Alain Dabadie Frédéric Gauthier Emmanuel Jacquemin | 2013 | Journal of Hepatology2013，，6： | 4 |
| 9 | 水通道蛋白对人体皮肤重要性的研究显示文摘目的探讨水通道蛋白(AQPs)在人皮肤表皮上的功能和表达。方法免疫组化法检测30名30~40岁健康的白人女性大腿皮肤AQP3、Claudin-1和CD44表达。检测10名21~60岁亚洲健康妇女的前臂内侧AQP3表达与光暴露关系。结果在人表皮中,AQP3从基底层到粒层均有表达,但在角质层下方开始消失,AQP3和Claudin-1的表达与一种透明质酸盐受体CD44的表达呈负相关。对20~80岁之间的健康女性皮肤间接免疫荧光研究也发现,在衰老和长期慢性光暴露时皮肤AQP3表达会明显减少。结论人类皮肤供水系统缺陷可能与年龄有关,水通道蛋白在维持皮肤正常生理功能等方面具有重要意义。 | Frédéric Bonté Emmanuelle Noblesse Miléne Juan Jean Marc Verbawatz Marc Dumas | 2009 | 中华皮肤科杂志2009，42，5： | 4 |
| 10 | Renal failure and cirrhosis: A systematic review of mortality and prognosis显示文摘 | Giuseppe Fede Gennaro D’Amico Vasiliki Arvaniti Emmanuel Tsochatzis Giacomo Germani Dimosthenis Georgiadis Alberto Morabito Andrew Kenneth Burroughs | 2011 | Journal of Hepatology2011，，4： | 4 |
| 11 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 12 | Clinical profile of diabetes at diagnosis among children and adolescents at an endocrine clinic in Ghana显示文摘AIM To determine the clinical features of diabetes in children and adolescents in Ghana.METHODS Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS One hundred and six subjects presented with diabetes. Ninety(84.9%) were diagnosed by clinical features and family history as type 1, and 16(15.1%) type 2. For type 1 subjects, age range at diagnosis was 0.9-19.9 year(y), peak age of onset 12-13 year, and 3.3% were < 5 year, 21.1% 5-< 10 year, 45.6% 10-< 15 year and 30.0% 15-< 20 year. Seventy-one point one percent were female. Common clinical features were polyuria(100%), polydipsia(98.9%), and weight loss(82.2%). Mean BMI SD was -0.54, range -3.84 to 2.47. 60.0% presented in diabetic ketoacidosis(DKA). Nine had infections at onset(skin, abscess, leg ulcer). Mean± SD HbA 1c at diagnosis was 12.7% ± 1.9%(115±21 mmol/mol). Four have since died: Hypoglycaemia(2), recurrent DKA(1), osteosarcoma(1). Two other type 1 cases died of DKA at presentation in emergency before being seen by the paediatric endocrinologist. Crude mortality rate including these 2 cases was 32.2/1000 patient years. Type 2 cases were 81% female, age of onset 9-19 year. Mean BMI SD was 1.49, range -0.87 to 2.61. Forty-three point eight percent presented in DKA. All type 2 cases had acanthosis nigricans. Overall, 9.8% did not have home refrigeration, most using clay pot evaporative cooling for insulin storage. CONCLUSION Type 1 occurs with a female preponderance and high DKA rates. Type 2 also occurs. Typology based on clinical features is difficult. Community and professional awareness is warranted. | Emmanuel Ameyaw Serwah B Asafo-Agyei Sumithira Thavapalan Angela C Middlehurst Graham D Ogle | 2017 | World Journal of Diabetes2017，8，9： | 2 |
| 13 | Ropivacaine 0.15% Plus Sufentanil 0.5 μg/mL and Ropivacaine 0.10% Plus Sufentanil 0.5 μg/mL Are Equivalent for Patient-Controlled Epidural Analgesia During Labor显示文摘 | Emmanuel Boselli Richard Debon Frédéric Duflo Boris Bryssine Bernard Allaouchiche Dominique Chassard | 2003 | Anesthesia & Analgesia2003，，4： | 2 |
| 14 | Adipokines in Nonalcoholic Steatohepatitis: From Pathogenesis to Implications in Diagnosis and Therapy显示文摘 | Emmanuel A. Tsochatzis George V. Papatheodoridis Athanasios J. Archimandritis Fulvio D’Acquisto | 2009 | Mediators of Inflammation2009，，： | 2 |
| 15 | Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids显示文摘 | Alexandre Louvet Emmanuel Diaz Sébastien Dharancy Hugues Coevoet Frédéric Texier Thierry Thévenot Pierre Deltenre Valérie Canva Christophe Plane Philippe Mathurin | 2007 | Journal of Hepatology2007，，3： | 2 |
| 16 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 17 | A novel ligin on poplar trees with a reduced caffeicacid/5-hydroxyferulic acid O-methyl-transferase activity显示文摘 | Janvan D Marie B Emmanuelle C | 1995 | Plant Journal1995，8，6： | 1 |
| 18 | Amiodarone reduces transmural heterogeneity of repolarization in the human heart显示文摘 | Emmanuel D Gilles L Flavien C | 1998 | JACC1998，32，： | 1 |
| 19 | Analyzing water use patterns for demand management:the case of the city of Masvingo,Zimbabwe显示文摘 | EMMANUEL D PIETER V Z | 2003 | Physics and Chemistry of the Earth Parts A/B/C2003，28，2027： | 1 |
| 20 | Finite element modelling of exural behaviour of externally bonded CFRP reinforced concrete structures显示文摘 | EMMANUELLE D ERIC R | 2002 | Engineering Structures2002，，24： | 1 |
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