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| 1 | Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression显示文摘AIM: To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in rats. METHODS: Giving a fructose-enriched diet(FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats(150-200 g) were divided into a control group and a FED group which was subdivided into 4 groups, a control FED, fenofibrate(FENO)(100 mg/kg), resveratrol(RES)(70 mg/kg) and combined treatment( FENO + RES)( half the doses). A l l treatments were given orally from the 9th week till the end of experimental period. Body weight, oral glucose tolerance test(OGTT), liver index, glucose, insulin, insulin resistance(HOMA), serum and liver triglycerides(TGs), oxidative stress(liver MDA, GSH and SOD),serum AST, ALT, AST/ALT ratio and tumor necrosis factor-α(TNF-α) were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling-3(SOCS-3), sterol regulatory element binding protein-1c(SREBP-1c), fatty acid synthase(FAS), malonyl Co A decarboxylase(MCD), transforming growth factor-β1(TGF-β1) and adipose tissue genes expression of leptin and adiponectin were investigated. Liver sections were taken for histopathological examination and steatosis area were determined.RESULTS: Rats fed FED showed damaged liver, impairment of glucose tolerance, insulin resistance, ox ida t ive s t re s s a nd dy s l ipide m ia. As fo r ge ne expression, there was a change in favor of dyslipidemia and nonalcoholic steatohepatitis(NASH) development. All treatment regimens showed some benefit in reversing the described deviations. Fructose caused deterioration in hepatic gene expression of SOCS-3, SREBP-1c, FAS, MDA and TGF-β1 and in adipose tissue gene expression of leptin and adiponectin. Fructose showed also an increase in body weight, insulin resistance(OGTT, HOMA), serum and liver TGs, hepatic MDA, serum AST, AST/ALT ratio and TNF-α compared to control. All treatments improved SOCS-3, FAS, MCD, TGF-β1 and leptin genes expression while only RES and FENO + RES groups showed an improvement in SREBP-1c expression. Adiponectin gene expression was improved only by RES. A decrease in body weight, HOMA, liver TGs, AST/ALT ratio and TNF-α were observed in all treatment groups. Liver index was increased in FENO and FENO + RES groups. Serum TGs was improved only by FENO treatment. Liver MDA was improved by RES and FENO + RES treatments. FENO + RES group showed an increase in liver GSH content.CONCLUSION: When resveratrol was given with half the dose of fenofibrate it improved NASH-related fructose-induced disturbances in gene expression similar to a full dose of fenofibrate. | Enas A Abd El-Haleim Ashraf K Bahgat Samira Saleh | 2016 | World Journal of Gastroenterology2016，22，10： | 5 |
| 2 | Changing dietary n-6:n-3 ratio using different oil sources affects performance,behavior,cytokines mRNA expression and meat fatty acid profile of broiler chickens显示文摘Typical formulated broiler diets are deficient in n-3 poly-unsaturated fatty acids(PUFA) due to widening n-6:n-3 PUFA ratio which could greatly affect performance,immune system of birds and,more importantly,meat quality.This study was conducted to evaluate the effect of modifying dietary n-6:n-3 PUFA ratio from plant and animal oil sources on performance,behavior,cytokine m RNA expression,antioxidative status and meat fatty acid profile of broiler chickens.Birds(n=420) were fed 7 diets enriched with different dietary oil sources and ratios as follows: sunflower oil in control diet(C); fish oil(FO); 1:1 ratio of sunflower oil to FO(C1 FO1); 3:1 ratio of sunflower oil to fish oil(C3 FO1); linseed oil(LO); 1:1 ratio of sunflower oil to linseed oil(C1 LO1); 3:1 ratio of sunflower oil to linseed oil(C3 LO1),resulting in dietary n-6:n-3 ratios of approximately 40:1,1.5:1,4:1,8:1,1:1,2.5:1 and 5:1,respectively.The best final body weight,feed conversion ratio as well as protein efficiency ratio of broilers were recorded in the C1 FO1 and C1 LO1 groups.Compared with the control group,the dressing percentage and breast and thigh yield were highest in the C1 FO1 and C1 LO1 groups.Narrowing the dietary n-6:n-3 ratio increased(P < 0.05) n-3 PUFA content of breast meat.Moreover,the breast meat contents of eicosapentaenoic acid and docosahexaenoic acid increased(P < 0.05) with increasing dietary FO whereas a-linolenic acid content was higher with LO supplementation.Also,enriching the diets with n-3 PUFA from FO and LO clearly decreased(P < 0.05) serum total cholesterol,triglycerides and very low-density lipoproteins and enhanced antioxidative status.The feeding frequency was decreased(P < 0.05) in the C1 FO1 and C1 LO1 groups.Likewise,n-3 PUFA-enriched diets enhanced the frequency of preening,wing flapping and flightiness.Animal oil source addition,compared to plant oil,to broiler diets enhanced the relative m RNA expression of interferon gamma,interleukin-1 beta,interleukin-2 and interleukin-6 genes,especially at low n-6:n-3 ratios.This study has clearly shown that narrowing n-6:n-3 ratio through the addition of FO or LO improved performance and immune response of broilers and resulted in healthy chicken meat,enriched with long chain n-3 PUFA. | Doaa Ibrahim Rania El-Sayed Safaa I.Khater Enas N.Said Shefaa A.M.El-Mandrawy | 2018 | Animal Nutrition2018，，1： | 5 |
| 3 | Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C显示文摘AIM:To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus(HCV)infection.METHODS:The study included 30 children with chronic HCV infection before receiving antiviral therapy.Chronic HCV infection was defined by positive anti-HCV,a positive polymerase chain reaction for HCV-RNA for more than 6 mo with absence of any associated liver disease.A second group of 30 age-and sex-matched healthy children served as controls.Serum C4a levels were measured by enzyme-linked immunosorbent assay.Liver fibrosis stage and inflammatory grade were assessed using Ishak scoring system.Serum C4a levels were compared according to different clinical,laboratory and histopathological parameters.Statistical significance for quantitative data was tested by MannWhitney U non-parametric tests.For qualitative data,significance between groups was tested by 2test.Correlation was tested by Spearman’s test.Results were considered significant if P value≤0.05.RESULTS:The age of the patients ranged from 3.5to 18 years and that of controls ranged from 4 to 17years.C4a mean levels were merely lower in patients(153.67±18.69 mg/L)than that in the controls(157.25±11.40 mg/L)with no statistical significance(P=0.378).It did not differ significantly in patients with elevated vs those with normal transaminases(152.25±16.62 vs 155.36±21.33;P=0.868)or with different HCV viremia(P=0.561).Furthermore,there was no statistical significant difference in serum levels between those with no/mild fibrosis and those with moderate fibrosis(154.65±20.59 vs 152.97±17.72;P=0.786)or minimal and mild activity(155.1±21.93 vs 152.99±17.43;P=0.809).Though statistically not significant,C4a was highest in fibrosis score 0(F0),decreasing in F1 and F2 to be the lowest in F3.When comparing significant fibrosis(Ishak score≥3)vs other stages,C4a was significantly lower in F3 compared to other fibrosis scores(143.55±2.33 mg/L vs 155.26±19.64 mg/L;P=0.047)and at a cutoff value of less than 144.01 mg/L,C4a could discriminate F3 with 76.9%sensitivity and75%specificity from other stages of fibrosis.CONCLUSION:Serum complement C4a did not correlate with any of transaminases,HCV viremia or with the histopathological scores.Although C4a decreased with higher stages of fibrosis,this change was not significant enough to predict individual stages of fibrosis.Yet,it could predict significant fibrosis with acceptable clinical performance. | Behairy E Behairy Ghada M El-Mashad Ragab S Abd-Elghany Enas M Ghoneim Mostafa M Sira | 2013 | World Journal of Hepatology2013，5，8： | 4 |
| 4 | Germination of Chenopodium Album in Response to Microwave Plasma Treatment显示文摘The seeds of Lamb's Quarters(Chenopodium album agg.)were stimulated by low-pressure discharge.The tested seeds were exposed to plasma discharge for different time durations(from 6 minutes to 48 minutes).Germination tests were performed under specified laboratoryconditions during seven days in five identical and completely independent experiments.Significantdifferences between the control and plasma-treated seeds were observed.The treated seeds showedstructural changes on the surface of the seat coat.They germinated faster and their sproutaccretion on the first day of seed germination was longer.Germination rate for the untreatedseeds was 15% while it increased approximately three times(max 55%)for seeds treated byplasma from 12 minutes to 48 minutes. | Bo■ena ER Vitězslav STRA■K Michal ER■ Milan TICH■ Petr PATENKA | 2008 | Plasma Science and Technology2008，10，4： | 4 |
| 5 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 6 | A review on zero energy buildings-Pros and cons显示文摘Enhancing the energy efficiency of structures has been a staple of energy policies.The key goal is to slash elec-tricity usage in order to minimize the footprint of houses.This goal is sought by putting restrictions on the design specifications with respect to the properties of the raw materials and components as well as the exploitation of sustainable sources of energy.These facts for the basis for zero-energy building(ZEB)being established.This novel technology has faced several obstacles impeding its commercialization and future advancement.This inves-tigation therefore holistically explored and evaluated the state of zero energy building and factors impeding their commercialization.The review further proposed some suggestion in terms of technology that can be considered by the sector to augment existing technologies.Similarly,the investigation touched on the effect of occupant’s character in zero energy structures.Policies in terms of government subsidies and tax rebates were recommended to encourage more investors into the sector.Finally,the perception of zero energy building being more expensive compared to the traditional structures can equally be curbed via efficient and effective public sensitization. | Tabbi Wilberforce A.G.Olabi Enas Taha Sayed Khaled Elsaid Hussein M.Maghrabie Mohammad Ali Abdelkareem | 2023 | Energy and Built Environment2023，4，1： | 3 |
| 7 | A signature of immune function genes associated with recurrence-free survival in breast cancer patients显示文摘 | Maria Libera Ascierto Maciej Kmieciak Michael O. Idowu Rose Manjili Yingdong Zhao Margaret Grimes Catherine Dumur Ena Wang Viswanathan Ramakrishnan Xiang-Yang Wang Harry D. Bear Francesco M. Marincola Masoud H. Manjili | 2012 | Breast Cancer Research and Treatment2012，，3： | 2 |
| 8 | Lineage relationship of CD8^+ T cell subsets is revealed by progressive changes in the epigenetic landscape显示文摘 | Joseph G. Crompton Manikandan Narayanan Suresh Cuddapah Rahul Roychoudhuri Yun Ji Wenjing Yang Shashank J. Patel Madhusudhanan Sukumar Douglas C. Palmer Weiqun Peng Ena Wang Francesco M. Marincola Christopher A. Klebanoff Keji Zhao John S. Tsang Luca Gatt-inoni Nicholas P. Restifo | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 9 | CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair显示文摘 | Enas R. Abu-Zhayia Samah W. Awwad Bella M. Ben-Oz Hanan Khoury-Haddad Nabieh Ayoub | 2018 | Journal of Molecular Cell Biology2018，10，4： | 2 |
| 10 | Randomization by minimization for unbalanced treatment allocation显示文摘 | Han B Enas NH McEntegart D | | 0，，27： | 1 |
| 11 | On the existence of extremal positive definite solutions of the nonlinear matrix equationX' + Σmi=1Ai*XδiAi =I显示文摘 | AM.Sarhan Naglaa M.El-Shazly Enas M.Shehata | | 0，，： | 1 |
| 12 | Seizure classification in EEG signals utilizing Hilbert-Huang transform显示文摘 | Rami J O Enas W A | 2011 | Biomedical Engineering Online2011，10，1： | 1 |
| 13 | Optimization of polysac- charides extraction from Gynostemma pentaphyllum Makino using Uni form Design 显示文摘 | Wang Zhaojing Luo Dianhui Cai Ena | 2007 | Carbohydr Polym2007，69，： | 1 |
| 14 | Spiral CT virtual bronchoscopy with multiplanar reformatting in the evaluation of post-intubation tracheal stenosis: comparison between endoscopic, radiological and surgical findings显示文摘 | Mohamed Shehata Taha Badr Eldin Mostafa Marwa Fahmy Maha Khaled A. Ghaffar Enas Abdel Ghany | 2009 | European Archives of Oto-Rhino-Laryngology2009，，： | 1 |
| 15 | Human Metapneumovirus (hMPV) in Acute Respiratory Infection: A Clinic-Based Study in Egypt显示文摘 | Sohier Yahia Amina Y. Kandeel Enas Hammad Abdel-Hady El-Gilany | 2012 | The Indian Journal of Pediatrics2012，，： | 1 |
| 16 | Amblyopia screening for first and second-grade children in Jordan显示文摘AIM:To share the results of a national screening program for amblyopia in school children in the north of Jordan.METHODS:This is a prospective national screening study for amblyopia.The program rolls first and second-grade children(6 to 7 years old) in the north of Jordan.The eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic retinoscopy.Monocular visual acuity was tested using an ETDRS visual acuity chart without correction.Moreover,children were tested with full cycloplegic refraction when the test criteria were met.Unilateral amblyopia was defined as a best-corrected visual acuity difference of 2 or more lines.In comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best eye.RESULTS:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with amblyopia.In their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population. | Khalil M.Al-Salem Mohammad S.Saleem Ismat Ereifej Hamzeh M.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-Momani Layal Mohammed Hammad Omar Ahmad al-Habahbeh Yaqeen M.Assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al Maaitah Deya'-Aldin Muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah Mahmoud Mohammad Murad Amany Jehad Faleh AL-Zurqan Enas Jamal Mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a Majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.Matar | 2022 | International Journal of Ophthalmology(English edition)2022，15，2： | 1 |
| 17 | Optimization of polysaccharides extraction from gynostemma pentaphyllum makino using uniformdesign显示文摘 | Wang Z Luo D Ena C | 2007 | Carbohydrate Polymers2007，69，2： | 1 |
| 18 | Application of an innovative methodology to improve the starting-up of UASB reactors treating domestic sewage显示文摘 | Rodriguez J A P ena M R Manzi V | 2001 | Water Science and Technology2001，44，4： | 1 |
| 19 | Adenosine deami- nase activity in cerebrospinal fluid:a useful test for me- ningeal tuberculosis, even in patiens with AIDS显示文摘 | Ena J Crespo M J Vallis V | 1988 | J In- fect Dis1988，158，4： | 1 |
| 20 | The OSCE Ap- proach in nursing education:objective structured clinical ex- aminations can be effective vehicles for nursing education and practice by promoting the mastery of clinical skills and decision-making in controlled and safe learning environ- ments显示文摘 | Bartfay WJ Rombough Rosemarie Howse Ena | 2004 | The Canada Nurse2004，35，3： | 1 |
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