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| 1 | Laparoscopic ultrasonography as an alternative to intraoperative cholangiography during laparoscopic cholecystectomy显示文摘AIM To assess the role of laparoscopic ultrasound(LUS) as a substitute for intraoperative cholangiography(IOC) during cholecystectomy.METHODS We present a MEDLINE and Pub Med literature search, having used the key-words 'laparoscopic intraoperative ultrasound' and 'laparoscopic cholecystectomy'. All relevant English language publications from 2000 to 2016 were identified, with data extracted for the role of LUS in the anatomical delineation of the biliary tract, detection of common bile duct stones(CBDS), prevention or early detection of biliary duct injury(BDI), and incidental findings during laparoscopic cholecystectomy. Data for the role of LUS vs IOC in complex situations(i.e., inflammatory disease/fibrosis) were specifically analyzed. RESULTS We report data from eighteen reports, 13 prospective non-randomized trials, 5 retrospective trials, and two meta-analyses assessing diagnostic accuracy, with one analysis also assessing costs, duration of the examination, and anatomical mapping. Overall, LUS was shown to provide highly sensitive mapping of the extra-pancreatic biliary anatomy in 92%-100% of patients, with more difficulty encountered in delineation of the intra-pancreatic segment of the biliary tract(73.8%-98%). Identification of vascular and biliary variations has been documented in two studies. Although inflammatory disease hampered accuracy, LUS was still advantageous vs IOC in patients with obscured anatomy. LUS can be performed before any dissection and repeated at will to guide the surgeon especially when hilar mapping is difficult due to fibrosis and inflammation. In two studies LUS prevented conversion in 91% of patients with difficult scenarios. Considering CBDS detection, LUS sensitivity and specificity were 76%-100% and 96.2%-100%, respectively. LUS allowed the diagnosis/treatment of incidental findings of adjacent organs. No valuable data for BDI prevention or detection could be retrieved, even if no BDI was documented in the reports analyzed. Literature analysis proved LUS as a safe, quick, non-irradiating, costeffective technique, which is comparatively well known although largely under-utilized, probably due to the perception of a difficult learning curve. CONCLUSION We highlight the advantages and limitations of laparoscopic ultrasound during cholecystectomy, and underline its value in difficult scenarios when the anatomy is obscured. | Alexandra Dili Claude Bertrand | 2017 | World Journal of Gastroenterology2017，23，29： | 16 |
| 2 | 改良钛支架人工角膜植入术后基质金属蛋白酶及其组织抑制物在兔角膜组织的表达显示文摘目的探讨改良钛支架人工角膜植入兔眼术后,角膜组织基质金属蛋白酶(MMP-2)及其抑制物(TIMP-2)的表达与角膜溶解的关系。方法实验研究。人工角膜支架改良:钛支架表面喷砂后用羟基磷灰石涂层(HA/SB—Ti)。将20只正常新西兰白兔分3组每组6只,其中A组、B组右眼角膜板层分别植入改良支架和对照支架(SB-Ti),C组仅做角膜板层切口,余2只为D组做空白对照。同样方法分组20只兔碱烧伤角膜模型,分别为E、F、G、H组。1个月、3个月后取材行免疫组织化学检测MMP-2、TIMP-2在不同组别的表达;为去除碱烧伤因素影响,另取24只正常动物模型改良支架植入后按时间分组,分别为2周组、1月组、3月组、5月组,每组6只,2只正常动物为空白对照组,用实时定量聚合酶链反应(RT—PCR)、免疫印迹法(Western blot)检测MMP-2、TIMP-2mRNA及蛋白的表达。5月组动物及2只碱烧伤模型动物,支架植入3个月后植入镜柱。实验数据采用t检验进行统计学分析。结果F组有一例出现角膜溶解的并发症。免疫组织化学检查结果:A与B及E与F比较MMP-2表达有统计学意义(t=12.05,2.93,12.00,3.78;P〈0.05)。于2周、1个月、3个月、5个月取材后,做RT.PCR、Westernblot检测,MMP-2mRNA及MMP-2蛋白表达从支架植入开始升高,1个月达到高峰,然后下降,仅2周与3个月MMP-2蛋白表达比较无统计学意义(t=2.104,P〉0.05)。而TIMP-2mRNA及TIMP-2蛋白表达在支架植入后有波动,然后逐渐升高,TIMP-2 mRNA除1个月与正常角膜组比较无统计学意义(t=1.878,P=0.0972)。结论改良后的人工角膜由于生物活性提高抑制了MMP-2的过度表达,MMP-2、TIMP-2表达随时问的变化规律可能为临床治疗并发症提供新的方法. | 李力 Dilys Zhou 王秀梅 王小平 崔福斋 陆玉杰 黄一飞 | 2012 | 中华眼科杂志2012，48，1： | 3 |
| 3 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 4 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 5 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 6 | A case of intraepidermal merkel cell carcinoma within squmous cell carcinoma in - situ : Merkel cell carcinoma in - situ? 显示文摘 | Hikmat A Dily F George K | 2004 | Am J Dermatopathol2004，26，3： | 1 |
| 7 | Delayed contrast-enhanced magnetic reso- nance imaging for the detection of autoimmune myocarditis and long-term follow- up显示文摘 | Dili T Ekinci O Hansel J | 2005 | J Cardiovasc Magn Reson2005，7，2： | 1 |
| 8 | Cantonese tone perception ability of cochlear implant children in comparison with normal-hearing children显示文摘 | Kathy Y.S Lee C.A van Hasselt S.N Chiu Dilys M.C Cheung | 2002 | International Journal of Pediatric Otorhinolaryngology2002，，2： | 1 |
| 9 | Acute severe asthma: Triage, treatment and thereafter显示文摘 | Felix Chua Dilys Lai | 2007 | Current Anaesthesia & Critical Care2007，18，2： | 1 |
| 10 | Environment ms an influence on managerial autonomy 显示文摘 | DilI W | 1958 | Administration Science Quarterly1958，2，： | 1 |
| 11 | Transanal endoscopic microsurgery for rectal tumours using a Single Incision Laparoscopic Port 显示文摘 | Mansvelt B I Dili A Molle G | 2013 | Acta Chir Belg2013，113，： | 1 |
| 12 | Lipoprotein metabolism and vascular complications in pregnancy 显示文摘 | Shahzya S Huda Naveed Sattar Dilys J Freeman | 2009 | Clin Lipidot2009，4，1： | 1 |
| 13 | The origins and evolution of the conservation-poverty debate : A review of key Literature, events and policy processes显示文摘 | Dilys Roe | 2008 | Oryx2008，42，4： | 1 |
| 14 | Biphasic and monophasic pattern of brain natriuretic peptide release in acute myocardial infarction显示文摘 | Dili(c)M Nalbanti(c) AD Arslanagi(c) A | | 0，，1： | 1 |
| 15 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | 2010 (9716)2010，，9716： | 1 |
| 16 | Bipha- sic and monophasic pattern of brain natriuretie pep- tide release in acute myocardial infarction 显示文摘 | Dili M Nalbanti AD Arslanagi A | 2011 | Coll Antropol2011，35，1： | 1 |
| 17 | Cerebrovascular events : correlationwith plaque type,velocity parameters and multiple risk factors显示文摘 | Dilie M Kulic M P alic S etal | 2010 | Med Arh2010，64，： | 1 |
| 18 | Endoscopic exploration and lymph node sampling of the axilla: Preliminary findings of a randomized pilot study comparing clinical and anatomo-pathologic results of endoscopic axillary lymph node sampling with traditional surgical treatment显示文摘 | Jaques Salvat Jean-Francois Knopf Jean-Marc Ayoubi Liamine Slamani Alain Vincent-Genod Muguette Guilbert Dilys Walker | 1996 | European Journal of Obstetrics and Gynecology1996，，2： | 1 |
| 19 | A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis显示文摘 | ShijiangHe BoSong DiLi ChangfengZhu WenpengQi YanqinWen LihuaWang ShipingSong HaipingFang ChunhaiFan | 2010 | Adv Funct Mater2010，，3： | 1 |
| 20 | Thermal comfort study of Kerala traditional residential buildings based on questionnaire survey among occupants of traditional and modern buildings显示文摘 | DILI A S NASEER M A VARGHESE T Z | 2010 | Energy and Buildings2010，42，11： | 1 |
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