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| 1 | The land use and land cover change database and its relative studies in China显示文摘In the mid-1990s, we established the national operative dynamic information serving systems on natural resources and environment. During building the land-use/land-cover change (LUCC)database for the mid-1990s, 520 scenes of remotely sensed images of Landsat Thematic Mapper (TM) were interpreted into land-use/land-cover categories at scale of 1:100,000 under overall digital software environment after being geo-referenced and ortho-rectified. The vector map of land-use/land-cover in China at the scale of 1:100,000 was recently converted into a 1-km raster database that captures all ofthe high-resolution land-use information by calculating area percentage for each kind of land use category within every cell. Being designed as an operative dynamic information serving system,monitoring the change in land-use/land-cover at national level was executed. We have completed the updating of LUCC database by comparing the TM data in the mid-1990s with new data sources received during 1999-2000 and 1989-1990. The LUCC database has supported greatly the national LUCC research program in China and some relative studies are incompletely reviewed in this paper. | LIU Jiyuan, LIU Mingliang, DENG Xiangzheng, ZhuangDafang,ZHANG Zengxiang, LUO Di(1. Inst. of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, China 2. Inst. of Remote Sensing Applications, CAS, Beijing 100101, China) | 2002 | Journal of Geographical Sciences2002，12，3： | 96 |
| 2 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 3 | An Interdisciplinary Nutrition Support Team Improves Clinical and Hospitalized Outcomes of Esophageal Cancer Patients with Concurrent Chemoradiotherapy显示文摘 | Ming-Hua Cong Shu-Luan Li Guo-Wei Cheng Jin-Ying Liu Chen-Xin Song Ying-Bing Deng Wei-Hu Shang Di Yang Xue-Hui Liu Wei-Wei Liu Shi-Yan Lu Lei Yu | 2015 | Chinese Medical Journal2015，，22： | 41 |
| 4 | Combination of small interfering RNA and lamivudine on inhibition of human B virus replication in HepG2.2.15 cells显示文摘AIM: To observe the inhibition of hepatitis B virus (HBV) replication and expression by combination of siRNA and lamivudine in HepG2.2.15 cells. METHODS: Recombinant plasmid psil-HBV was constructed and transfected into HepG2.2.15 cells. The transfected cells were cultured in lamivudine-containing medium (0.05 μmol/L) and harvested at 48, 72 and 96 h. The concentration of HBeAg and HBsAg was determined using ELISA. HBV DNA replication was examined by real- time PCR and the level of HBV mRNA was measured by RT-PCR. RESULTS: In HepG2.2.15 cells treated with combination of siRNA and lamivudine, the secretion of HBeAg and HBsAg into the supernatant was found to be inhibited by 91.80% and 82.40% (2.89 ± 0.48 vs 11.73 ± 0.38, P < 0.05; 4.59 ± 0.57 vs 16.25 ± 0.48, P < 0.05) at 96 h, respectively; the number of HBV DNA copies within culture medium was also significantly decreased at 96 h (1.04 ± 0.26 vs 8.35 ± 0.33, P < 0.05). Moreover, mRNA concentration in HepG2.2.15 cells treated with combination of siRNA and lamivudine was obviously lower compared to those treated either with siRNA or lamivudine (19.44 ± 0.17 vs 33.27 ± 0.21 or 79.9 ± 0.13, P < 0.05). CONCLUSION: Combination of siRNA and lamivudine is more effective in inhibiting HBV replication as compared to the single use of siRNA or lamivudine in HepG2.2.15 cells. | Gui-Qiu Li Wei-Zhen Xu Jing-Xia Wang Wen-Wei Deng Di Li Hong-Xi Gu | 2007 | World Journal of Gastroenterology2007，13，16： | 15 |
| 5 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 6 | Hangzhou criteria as downstaging criteria in hepatocellular ca显示文摘Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation criteria.Milan criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these patients.However,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging efficacy.Hence,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of downstaging.Methods:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of China.Results:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the HC.In group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the MC.Conclusions:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging criteria.Hangzhou downstaging criteria therefore is applicable in clinical practice. | Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan Qian-Wei Ye Sheng-Jun Xu Guang-Jiang Jiang Di Lu Xu-Yong Wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie Ji-Min Liu Jian Wu Shu-Sen Zheng Yang Yang Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 11 |
| 7 | Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury显示文摘High mobility group box 1(HMGB1)is a ubiquitous nuclear protein that is present in almost all cells and regulates the activity of innate immune responses in both intracellular and extracellular settings.Current evidence suggests that HMGB1 plays a pivotal role in human pathological and pathophysiological processes such as the inflammatory response,immune reactions,cell migration,aging,and cell death.Sepsis is a systemic inflammatory response syndrome(SIRS)that occurs in hosts in response to microbial infections with a proven or suspected infectious etiology and is the leading cause of death in intensive care units worldwide,particularly in the aging population.Dysregulated systemic inflammation is a classic characteristic of sepsis,and suppression of HMGB1 may ameliorate inflammation and improve patient outcomes.Here,we focus on the latest breakthroughs regarding the roles of HMGB1 in sepsis and sepsis-related organ injury,the ways by which HMGB1 are released,and the signaling pathways and therapeutics associated with HMGB1.This review highlights recent advances related to HMGB1:the regulation of HMBG1 might be helpful for both basic research and drug development for the treatment of sepsis and sepsis-related organ injury. | Chao Deng Lin Zhao Zhi Yang Jia-jia Shang Chang-yu Wang Ming-zhi Shen Shuai Jiang Tian Li Wen-cheng Di Ying Chen He Li Ye-dong Cheng Yang Yang | 2022 | Acta Pharmacologica Sinica2022，43，3： | 11 |
| 8 | Science Letters:IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1显示文摘Insulin-like growth factor binding-protein-7 (IGFBP7) was obtained from our previous colonic adenocarcinoma (CRC) and normal mucosa suppression subtraction hybridization (SSH) cDNA libraries. By RT-PCR and immunohistochemistry, we found that IGFBP7 was overexpressed in CRC tissue compared to normal tissue. However, our in vitro experiments performed in 10 CRC cell lines showed that IGFBP7 expressed only in SW480 and Caco2 cell lines, which implied an underlying reversible regulatory mechanism. Using methylation-specific PCR (MSP) and bisulfite sodium PCR (BSP), we found that its expression was associated with DNA hypomethylation of exon1. This was further supported by the in vitro study which showed restored IGFBP7 expression after demethylation agent 5-aza-2’-deoxycytidine treatment. Correlation analysis between IGFBP7 expression and prognosis indicated that overexpression of IGFBP7 in CRC tissue correlated with favourable survival. Investigation of the func-tional role of IGFBP7 through transfection studies showed that IGFBP7 protein could inhibit growth rate, decrease colony for-mation activity, and induce apoptosis in RKO and SW620 cells, suggesting it a potential tumor suppressor protein in colorectal carcinogenesis. In conclusion, our study clearly demonstrated that IGFBP7 plays a potential tumor suppressor role against colo-rectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1. | RUAN Wen-jing LIN Jie XU En-ping XU Fang-ying MA Yu DENG Hong HUANG Qiong LV Bing-jian HU Hu CUI Jing DI Mei-juan DONG Jian-kang LAI Mao-de | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，11： | 11 |
| 9 | Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity显示文摘B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated byautoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens andsignals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells.Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switchDNA recombination during B-cell activation and differentiation. Any abnormalities in these complex regulatoryprocesses may contribute to aberrant antibody production, resulting in autoimmune pathogenesis such as systemiclupus erythematosus. Newly generated knowledge from advanced modern technologies such as next-generationsequencing, single-cell sequencing and DNA methylation sequencing has enabled us to better understand B-cellbiology and its role in autoimmune development. Thus this review aims to summarize current research progress inepigenetic modifications contributing to B-cell activation and differentiation, especially under autoimmuneconditions such as lupus, rheumatoid arthritis and type 1 diabetes. | Haijing Wu Yaxiong Deng Yu Feng Di Long Kongyang Ma Xiaohui Wang Ming Zhao Liwei Lu Qianjin Lu | 2018 | Cellular & Molecular Immunology2018，15，7： | 10 |
| 10 | Neural endoscopic assisted micro-invasive management of Chiari I malformation显示文摘背景以便为 Chiari 的管理做以后的窝解压缩我简单、不太侵略的畸形性当使用直接可视化时,一个新奇完全内视镜的过程为 Chiari 的解压缩被采用了畸形性类型我。这研究的目的是为 Chiari 类型介绍神经的内视镜的以后的窝解压缩和地图集 laminectomy 我有 Chiari 的 21 个病人打的 patients.Methods 我经历了神经的内视镜的以后的窝解压缩和地图集 laminectomy。我们为神经的内视镜的以后的窝解压缩和地图集 laminectomy 描述了过程。在这个系列的所有病人除了 syringomyelia 在孔大酒瓶下面表明了小脑的扁桃腺形成疝。在考察学习的所有病人象 3 月的手术后的 MRI 一样经历了外科手术前的 MRI。改变,但是通常是的另外的后续 MRI 在外科以后重复了 12 个月到 18 个月。手术后的 MRI 研究回顾地被考察,与外科手术前的 studies.Results 相比,所有病人显示出临床的改进,并且任何一个都没有任何复杂并发症。有 syringomyelia 的病人完全有症状消失。十一个病人(52.4%) 在后续时期期间在 syringomyelia (减少的尺寸或决定) 经历了 X 光线照相术的改进。九个病人(42.8%) 表明了减少的鸣管尺寸,(19%) 四表明了解决的鸣管。有征兆的 syringomyelia 的 15 个病人,(73.3%) 11 经历了征兆的改进。症状改进的中部的时间是在外科以后的四个月。显示的外科的 MRI 考试完成的波斯特和孔大酒瓶 region.Conclusions 内诊镜 atlanto 枕骨的解压缩外科的足够的解压缩是一个创新、安全、有效的外科的过程。它与传统的外科相比有类似的结果,然而与是最小的增加的优点侵略,有更少复杂并发症,对枕骨的多骨的结构的稳定性的减少的影响,和更快的恢复以及减少的医院停留和开销。 | DENG Kan LI Yong-ning LI Gui-lin GAO Jun YANG Zhong DI Xiao WANG Ren-zhi | 2010 | Chinese Medical Journal2010，，14： | 7 |
| 11 | Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis显示文摘 | Tao Zhu Wan-Ting Luo Gui-Hua Chen Yue-Sheng Tu Shuo Tang Huo-Jin Deng Wei Xu Wei Zhang Di Qi Dao-Xin Wang Chang-Yi Li He Li Yan-Qiao Wu Shen-Jin Li | 2018 | Chinese Medical Journal2018，，18： | 7 |
| 12 | Snaill is involved in de novo cardiac fibrosis after myocardial infarction in mice显示文摘Epithelialmesenchymal 转变(EMT ) 是在心肌的梗塞(MI ) 以后的心脏的纤维变性的重要机制。然而,它仍然保持不清楚是否 Snail1, EMT 的一个重要管理者,涉及心脏的纤维变性。在这研究,我们在老鼠探索了 Snail1 和心脏的纤维变性 markerperiostinafter MI 的表示模式然后在老鼠在 MI 以后调查了在 Snail1 和 periostin 之间的合作表示。我们的结果证明 Snail1 和 periostin 的 mRNA 和蛋白质层次显著地在梗塞区域被增加。Snail1 表示模式看起来在在 MI 以后的 14 天以内寓言。另外在 MI 以后,所有 Snail1 积极的房间能表示 periostin。这些结果显示 Snail1 主要在梗塞区域被激活并且涉及 de novo 在在老鼠的 MI 以后的心脏的纤维变性。因此,它是在为在 MI 以后的室的改变的药干预的发展的一个潜在的分子的目标。 | Yajie Liu Jianlin Du Jin Zhang Minjie Weng Xiaoqun Li Di Pu Lingzhi Gao Songbai Deng Shuang Xia Qiang She | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 7 |
| 13 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 14 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 15 | Interlayer-expanded MoS2 assemblies for enhanced electrochemical storage of potassium ions显示文摘Potassium-ion batteries are regarded as the low-cost alternative to lithium-ion batteries.However,their development is hampered by the lack of suitable electrode materials.In this work,we demonstrate that MoS2 with expanded interlayers represents a promising candidate for the electrochemical storage of potassium ions.Hierarchical interlayer-expanded MoS2 assemblies supported on carbon nanotubes are prepared via a straightforward solution method.The increased interlayer spacing not only enables the better accommodation of foreign ions,but also lowers the diffusion energy barrier and improves diffusion kinetics of ions.When investigated as the anode material of potassium ion batteries,our interlayer-expanded MoS2 assemblies exhibit an excellent electrochemical performance with large capacity(up to∼520 mAhg^−1),good rate capability(∼310 mAhg^−1 at 1,000 mAg^−1)and impressive cycling stability,superior to most competitors. | Sijia Di Pan Ding Yeyun Wang Yunling Wu Jun Deng Lin Jia Yanguang Li | 2020 | Nano Research2020，13，1： | 6 |
| 16 | The pathologic relevance of metabolic criteria in patients with biopsy-proven nonalcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease:A multicenter cross-sectional study in China显示文摘Background:This study aimed to assess the association between metabolic syndrome(Met S)and severity of nonalcoholic fatty liver disease(NAFLD),and to discuss the pathological relevance of the diagnostic criteria in metabolic(dysfunction)associated fatty liver disease(MAFLD).Methods:This was a multicenter,cross-sectional study.Patients with NAFLD confirmed by liver biopsy were enrolled between July 2016 and December 2018 from 14 centers across the mainland of China.Anthropometric and metabolic parameters were collected to assess the pathological relevance.Results:Of 246 enrolled patients with NAFLD,150(61.0%)had the comorbidity of Met S.With the increase of metabolic components,the proportions of nonalcoholic steatohepatitis(NASH)and significant fibrosis were notably increased.The comorbid three metabolic components significantly increased the proportion of NASH,and further increase of metabolic components did not increase the proportion of NASH.However,the increase of metabolic components was parallel to the increase of the proportion of liver fibrosis.Among the 246 patients,239(97.2%)met the diagnostic criteria of MAFLD.Although non-MAFLD patients had less NASH,they present with similar proportion of significant fibrosis and cirrhosis.In the diagnostic criteria of MAFLD,BMI≥23 kg/m2 was related to NASH(Mantel-Haenszel Common Estimate OR:2.975;95%CI:1.037–8.538;P=0.043),and T2 DM was related to significant fibrosis(Mantel-Haenszel Common Estimate OR:2.531;95%CI:1.388–4.613;P=0.002).The homeostasis model assessment of insulin resistance(HOMA-IR)≥2.5 was the most significant factor for NASH(OR:4.100;95%CI:1.772–9.487;P=0.001)and significant factor for liver fibrosis(OR:2.947;95%CI:1.398–6.210;P=0.004)after the adjustments of the BMI and diabetes.Conclusions:Metabolic dysregulations are important risk factors in NAFLD progression.The insulin resistance status may play a predominant role in the progression in MAFLD patients. | Rui-Xu Yang Zheng-Sheng Zou Bi-Hui Zhong Hong Deng Fang-Ping He Jun-Ping Shi Cai-Yan Zhao Yu-Qiang Mi Yong-Jian Zhou Fu-Sheng Di Rui-Dan Zheng Qin Du Jia Shang Branko Popovic Jin Jun Chen Jian-Gao Fan | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 5 |
| 17 | Study of probability integration method parameter inversion by the genetic algorithm显示文摘In order to obtain accurate probability integration method(PIM) parameters for surface movement of multi-panel mining, a genetic algorithm(GA) was used to optimize the parameters. As the measured surface movement is affected by more than one mining panel, traditional PIM parameter inversion model is difficult to ensure the reliability of the results due to the complexity of rock movement. With crossover,mutation and selection operators, GA can perform a global optimization search and has high computation efficiency. Compared with the pattern search algorithm, the fitness function can avoid falling into local minima traps. GA reduces the risk of local minima traps which improves the accuracy and reliability with the mutation mechanism. Application at Xuehu colliery shows that GA can be used to inverse the PIM parameters for multi-panel surface movement observation, and reliable results can be obtained. The research provides a new way for back-analysis of PIM parameters for mining subsidence under complex conditions. | Li Peixian Peng Di Tan Zhixiang Deng Kazhong | 2017 | International Journal of Mining Science and Technology2017，27，6： | 5 |
| 18 | Photodeposition of CoOx and MoS2 on CdS as dual cocatalysts for photocatalytic H2 production显示文摘Photocatalytic Hproduction from water splitting has a promising prospect for alleviating energy and environmental issues.However,the fast recombination of photogenerated charge carriers limits the photocatalytic efficiency and its practical application.Cocatalyst engineering is an effective strategy to spatially separate photogenerated charge carriers.In this work,noble-metal-free MoSand CoOcocatalysts are loaded on CdS nanorods by a two-step photodeposition method.The MoSfunctions as the reduction cocatalyst to trap electrons and Co Oas the oxidation cocatalyst to trap holes.Transmission electron microscopy(TEM),inductively coupled plasma(ICP),X-ray photoelectron spectroscopy(XPS)and MottSchottky results demonstrate the effectiveness of photodeposition for loading MoSand CoOdual cocatalysts on CdS and their impact on the photochemical properties.The optimized CdS-MoS-CoOcomposite exhibits a high photocatalytic H-production rate of 7.4 mmol g^(-1)h^(-1)and an apparent quantum efficiency(QE)of 7.6%at 420 nm.Further analysis on time-resolved photoluminescence(TRPL)indicates that the introduction of dual cocatalysts greatly prolongs the lifetime of photogenerated charge carriers and deceases the charge recombination rates,consequently leading to superior photocatalytic H-production performance.This work provides a facile and effective strategy for the construction of highly efficient dual-cocatalyst-modified CdS photocatalyst for high-performance photocatalytic Hproduction. | Tingmin Di Quanrong Deng Geming Wang Shenggao Wang Linxi Wang Yuhua Ma | 2022 | Journal of Materials Science & Technology2022，，29： | 5 |
| 19 | A comparative study of hydrothermal aging effect on cerium and lanthanum doped Cu/SSZ-13 catalysts for NH_(3)-SCR显示文摘Ce-or La-doped Cu/SSZ-13 catalysts were prepared by a hydrothermal method and Cu,Ce or La ions were incorporated through stepwise ion exchange,The catalyst activity was measured for the ammonia selective catalytic reduction reaction.The structure and composition of catalyst were characterized by using X-ray diffraction,scanning electron microscopy,inductively coupled plasma mass spectrometry solid-state NMR,NH_(3)-TPD techniques,and the active components were examined by XPS and XANES.The results indicate that the Ce and La doping can both completely preserve the SCR activity of Cu/SSZ-13 above 300℃,but there is also a decrease of activity below 200℃.On the other hand,Ce doping is beneficial to the formation of framework aluminum,stabilizes molecular sieve framework and Cu active sites of Cu/SSZ-13,thereby improves the catalyst hydrothermal stability.But La doping will decrease the amount of framework aluminum and Cu active sites of Cu/SSZ-13 after hydrothermally aging,even destroy zeolite CHA structure.This is quite harmful to the catalyst hydrothermal stability. | Di Deng Shujun Deng Dandan He Zhiheng Wang Zhipeng Chen Yi Ji Guoping Yan Guangjin Hou Licheng Liu Hong He | 2021 | Journal of Rare Earths2021，39，8： | 5 |
| 20 | Influence of nanoparticle concentrations on flow boiling heat transfer coefficients of Al_2O_3/R141b in micro heat exchanger by direct metal laser sintering显示文摘Al_2O_3/R141 b + Span-80 nanorefrigerant for 0.05 wt.% to 0.4 wt.% is prepared by ultrasonic vibration to investigate the influence of nanoparticle concentrations on flow boiling heat transfer of Al_2O_3/R141 b + Span-80 in micro heat exchanger by direct metal laser sintering. Experimental results show that nanoparticle concentrations have significantly impact on heat transfer coefficients by homogeneity test of variances according to mathematical statistics. The heat transfer performance of Al_2O_3/R141 b+ Span-80 nanorefrigerant is enhanced after adding nanoparticles in the pure refrigerant R141 b. The heat transfer coefficients of 0.05 wt.%, 0.1 wt.%, 0.2 wt.%, 0.3 wt.%and 0.4 wt.% Al_2O_3/R141 b + Span-80 nanorefrigerant respectively increase by 55.0%, 72.0%, 53.0%, 42.3% and 39.9% compared with the pure refrigerant R141 b. The particle fluxes from viscosity gradient, non-uniform shear rate and Brownian motion cause particles to migrate in fluid especially in the process of flow boiling. This migration motion enhances heat transfer between nanoparticles and fluid. Therefore, the heat transfer performance of nanofluid is enhanced. It is important to note that the heat transfer coefficients nonlinearly increase with nanoparticle concentrations increasing. The heat transfer coefficients reach its maximum value at the mass concentration of 0.1% and then it decreases slightly. There exists an optimal mass concentration corresponding to the best heat transfer enhancement. The reason for the above phenomenon is attributed to nanoparticles deposition on the minichannel wall by Scanning Electron Microscopy observation. The channel surface wettability increases during the flow boiling experiment in the mass concentration range from 0.2 wt.% to 0.4 wt.%. The channel surface with wettability increasing needs more energy to produce a bubble. Therefore, the heat transfer coefficients decrease with nanoparticle concentrations in the range from 0.2 wt.% to 0.4 wt.%. In addition, a new correlation has been proposed by fitting the experimental data considering the influence of mass concentrations on the heat transfer performance. The new correlation can effectively predict the heat transfer coefficient. | Jianyang Zhou Xiaoping Luo Cong Deng Mingyu Xie Lin Zhang Di Wu Feng Guo | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 4 |
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