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| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Yongsheng Liu Zhaochu Hu Shan Gao Detlef Günther Juan Xu Changgui Gao Haihong Chen | 2008 | Chemical Geology2008，，1： | 3 |
| 3 | Sample analysis using laser ablation inductively coupled plasma mass spectrometry显示文摘 | Detlef G Bodo H | 2005 | TrAC Trends in Analytical Chemistry2005，24，3： | 1 |
| 4 | Climate policy through changing consumption choices:Options and obstacles for reducing greenhouse gas emissions显示文摘 | Girod B Detlef P V Edgar G H | 2014 | Global Environmental Change2014，25，4： | 1 |
| 5 | Effect of cell recycle on continuous butanol-acetone fermentation with Clostridium acetobutylicum under phosphate limitation显示文摘 | Detlef S Gerhard G | | 0，，01： | 1 |
| 6 | A “wire” signal smoothing device for laser ablation inductively coupled plasma mass spectrometry analysis显示文摘 | Zhaochu Hu Yongsheng Liu Shan Gao Shaoquan Xiao Laishi Zhao Detlef Günther Ming Li Wen Zhang Keqing Zong | 2012 | Spectrochimica Acta Part B: Atomic Spectroscopy2012，，： | 1 |
| 7 | Quantitative analysis of major, minor and trace elements in fluid inclusions using laser ablation-inductively coupled plasma mass spectrometry显示文摘 | Detlef G Andreas A Rolf F | 1998 | Journal of Analytical Atomic Spectrometry1998，13，： | 1 |
| 8 | Dual-stimuli responsive PNIPAM microgel achieved via layer-by-layer assembly:Magnetic and thermo-responsive显示文摘 | John E W Akhilesh K G Detlef M | 2008 | J Colloid Interf Sci2008，324，： | 1 |
| 9 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms of the Digestive System: Well-Differentiated Pancreatic Non-Functioning Tumors显示文摘 | Falconi Massimo Bartsch Detlef Klaus Eriksson Barbro Kl?ppel Günter Lopes José M O’connor Juan M Salazar Ramón Taal Babs G Vullierme Marie Pierre O’toole Dermot | 2012 | Neuroendocrinology2012，，： | 1 |
| 10 | MicroRNA-196a and -196b as Potential Biomarkers for the Early Detection of Familial Pancreatic Cancer显示文摘 | Emily P. Slater Konstantin Strauch Susanne Rospleszcz Annette Ramaswamy Irene Esposito Günter Kl?ppel Elvira Matth?i Kristin Heeger Volker Fendrich Peter Langer Detlef K. Bartsch | 2014 | Translational Oncology2014，，： | 1 |
| 11 | Mobility and H2O loss from fluid inclusions in natural quartz crystals显示文摘 | Andreas Audétat Detlef Günther | 1999 | Contributions to Mineralogy and Petrology (-)1999，，1： | 1 |
| 12 | Automated gene ontology annotation for anonymous sequence data显示文摘 | Steffen H Detlef G Hans L | 2003 | Nucleic Acids Research2003，31，13： | 1 |
| 13 | Automated gene ontology annotation for anonymous sequence data显示文摘 | STEFFEN H DETLEF G HANS L | 2003 | Nucleic Acids Research2003，31，13： | 1 |
| 14 | Heat transfer and large scale dynamics in turbulent Rayleigh-B4nard conveetion显示文摘 | Guenter A Siegfried G Detlef L | 2009 | Rev Mod Phys2009，81，： | 1 |
| 15 | Capabilities of femtosecond laser ablation ICP-MS for the major,minor,and trace element analysis of high alloyed steels and super alloys显示文摘 | Helmar Wiltsche Detlef Günther | | 0，，： | 1 |
| 16 | Effect of ignition position on the run-up distance to DDT for hydrogen-air explosions显示文摘 | Robert B Detlef A Rainer G | 2011 | Journal of Loss Prevention in the Process Industries2011，24，2： | 1 |
| 17 | Analysing the costs and benefits of climate policy: Value judgements and scientific uncertainties 显示文摘 | Andries F Hof Michel G J den Elzen Detlef P van Vuuren | 2008 | Global Environmental Change2008，18，3： | 1 |
| 18 | The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells显示文摘 | Christoph Herold Marion Ganslmayer Matthias Ocker Martin Hermann Albert Geerts Eckhart G Hahn Detlef Schuppan | 2002 | Journal of Hepatology2002，，2： | 1 |
| 19 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Yongsheng Liu Zhaochu Hu Shan Gao Detlef Günther Juan Xu Changgui Gao Haihong Chen | 2008 | Chemical Geology2008，，1： | 1 |
| 20 | New Functional Safety Standard WD ISO 26262 and the Potential Impact on the ECU Development for the Indian Market 显示文摘 | Lakshmi G Meti Detlef Zerfowski | 2009 | SAE 2009-28-00212009，，： | 1 |
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