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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients:a case series and literature update显示文摘Background:Acute respiratory distress syndrome(ARDS)has a reported incidence of 34–43%in ventilated burn patients and is associated with a mortality of 59%in the severe form.The use and experience with extracorporeal membrane oxygenation(ECMO)in burn patients developing ARDS are still limited.We present our results and discuss the significance of ECMO in treating burn patients.Methods:A retrospective analysis of burn patients treated with ECMO for ARDS between January 2017 and January 2019 was performed.Demographic,clinical,and outcome data were collected and analyzed.Results:Eight burn patients were treated at our institution with ECMO in the designated time period.Of these,all but one patient had inhalation injury,burn percentage of TBSA was 37±23%,ABSI score was 8.4±2,and R-Bauxscore was 98±21.Seven patients developed severe ARDS and one patient moderate ARDS according to the Berlin classification with a PaO_(2)/FiO_(2) ratio upon initiation of ECMO therapy of 62±22 mmHg.ECMO duration was 388±283 h.Three patients died from severe sepsis while five patients survived to hospital discharge.Conclusions:ECMO is a viable therapy option in burn patients developing severe ARDS and can contribute to survival rates similar to ECMO therapy in non-burn-associated severe ARDS.Consequently,patients with severe respiratory insufficiency with unsuccessful conventional treatment and suspected worsening should be transferred to burn units with the possibility of ECMO treatment to improve outcome. | Mehran Dadras Johannes M.Wagner Christoph Wallner Julika Huber Dirk Buchwald Justus Strauch Kamran Harati Nicolai Kapalschinski Björn Behr Marcus Lehnhardt | 2019 | Burns & Trauma2019，7，1： | 2 |
| 4 | Threshold controlling scheme for adaptive modulation and coding system显示文摘 | TAKEDA D CHOW Y C STRAUCH P | 2006 | IEICE Transactions on Communications2006，89，5： | 1 |
| 5 | Prevalence of pfima-hypera ldosteronism in moderate to severe hypertension in the Central E urope region显示文摘 | Strauch B Zelinka T Hampf M | 2003 | JHum Hypertens2003，17，5： | 1 |
| 6 | Reducing the effect of ground clutter on wind profiler velocity measurements显示文摘 | May P T R G Strauch | 1998 | J Atmos Oceanic Tech1998，15，： | 1 |
| 7 | Multilocus haplotype analyses reveal amociatlon between 5 novel IL-15 polymorphisms and asthms显示文摘 | Kurz T Strauch K Dietrich H | 2004 | J Allergy Clin Immunol2004，113，5： | 1 |
| 8 | Arterial system of the fingers显示文摘 | STRAUCH B D E BRONX N Y | 1990 | J Hand Surg(Am)1990，15，1： | 1 |
| 9 | Rapid identification and char- acterization of Vibrio species using whole - cell MALDI - TOF mass spectrometry显示文摘 | Dieckmann R Strauch E Alter T | 2010 | J App Microbiol2010，109，1： | 1 |
| 10 | Uniformly maldistributed sequences in a strict sense显示文摘 | Oto Strauch | 1995 | Monatshefte für Mathematik1995，，2： | 1 |
| 11 | Correction of lateral brow ptosis:a nonendoscopic subgaleal approach显示文摘 | STRAUCH B BAUM T | 2002 | Plast Reconstr Surg2002，109，3： | 1 |
| 12 | Ligament instability in total knee arthroplasty-causal analysis 显示文摘 | Graichen H Strauch M Katzhammer T etal | 2007 | Orthopade2007，36，65： | 1 |
| 13 | Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells显示文摘 | Griese DP Achatz S Batzlsperger CA Strauch UG Grumbeck B Weil J | 2003 | Cardiovasc Res2003，58，2： | 1 |
| 14 | 查看详情显示文摘 | Strauch F W Williams C J | | 0，，： | 1 |
| 15 | Preliminary evaluation of the first NOAA demonstration network profiler显示文摘 | WEBER B L WUERTZ D B STRAUCH R G | 1990 | J Atmos Oceanic Technol1990，7，6： | 1 |
| 16 | Axillary artery cannulation:routine use in ascending aorta and aortic arch replacement显示文摘 | Spielvogel D Lauten A | 2004 | Ann Thorac Surg2004，78，1： | 1 |
| 17 | Effects of precipitation on UHF wind profiler measurements显示文摘 | Wuertz D B B L Weber R G Strauch | 1988 | J Atmos Oceanic Tech1988，5，： | 1 |
| 18 | A dual-Doppler radar method for the determination of wind velocities within precipitating weather systems显示文摘 | Miller L J Strauch R G | 1974 | Remote Sense Environ1974，3，40： | 1 |
| 19 | Bacillus subtilis sporulation and stationary phase gene expression显示文摘 | Phillips ZE Strauch MA | 2002 | Cell Mol Life Sci2002，59，3： | 1 |
| 20 | The precision and relative accuracy of profiler wind measurements显示文摘 | STRAUCH R G WEBER B L FRISCH A S | 1987 | J Atmos Oceanic Technol1987，4，4： | 1 |
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