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| 1 | Reappraisement and refinement of zircon U-Pb isotope and trace element analyses by LA-ICP-MS显示文摘A protocol was established for simultaneous measurements of zircon U-Pb ages and trace elements by LA-ICP-MS at spot sizes of 16 32 μm.This was accomplished by introducing N 2 into ICP to increase the sensitivity.The obtained U-Pb ages for zircon standards GJ-1,TEMORA and SK10-2 are consistent with the preferred values within about 1% uncertainty (2σ) by simple external calibration against zircon standard 91500.Different data reduction softwares could yield different uncertainties for calculation of U-Pb ages.The commercially available program GLITTER4.4 could apply an improper uncertainty calculation strategy,but it may yield artificial high precisions for single analyses.Our trace element analyses indicate that Si is not an ideal internal standard for zircon when calibrated against the NIST glasses.Calibration against the NIST glasses using Si as an internal standard,a systematic deviation of 10% 30% was found for most trace elements including Zr.However,the trace element compositions of zircon can be accurately measured by calibration against multiple reference materials with natural compositions (e.g.,BCR-2G,BHVO-2G and BIR-1G),or calibration against NIST SRM 610 and using Zr as an internal standard.Analyses of two pieces of GJ-1 demonstrate that it is relatively homogenous for most trace elements (except for Ti). | LIU YongSheng HU ZhaoChu ZONG KeQing GAO ChangGui GAO Shan XU Juan CHEN HaiHong | 2010 | Chinese Science Bulletin2010，55，15： | 1011 |
| 2 | Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou, China显示文摘与在开发国家的抗菌剂代理人的滥用,增加 carbapenem 抵抗的 Enterobacteriaceae (CRE ) 的数字吸引了可观的公共担心。回顾的研究在东南中国在 Hangzhou,调查流行的中国和 CRE 的药抵抗特征从一所第三级的医院基于 242 CRE 紧张被进行。细菌的种类被识别。抗菌剂危险性被肉汤 microdilution 方法或 epsilometer 测试检验。抵抗 -lactamase 基因被聚合酶链反应识别并且定序。遗传型被种系发生的分析调查。Klebsiella pneumoniae 和 Escherichia coli 分别地是种类的最流行的类型,与在 71.9% 紧张和 21.9% 的出现。所有紧张展出了高抵抗(>70%) 对酮抗菌素, ciprofloxacin, trimethoprimsulfamethoxazole,和 nitrofurantoin 但是对 tigecycline (0.8%) 和 minocycline (8.3%) 的展出低抵抗。多于二种 -lactamase 基因怀有的 123 紧张的一个总数。 bla KPC-2 , bla SHV-11 , bla TEM-1 ,和 bla CTX-M-14 是占优势的遗传型与60.3%,61.6%,43.4%,和16.5%的察觉率,分别地,并且与在不同国家的参考序列是高度相同的,显示潜在的水平传播。IMP-4 是在这研究的最经常的班 B metallo-lactamases。在结论,连续监视和有效预防应该被强调减少 CRE 的传播。 | Yan Yang Jian Chen Di Lin Xujian Xu Jun Cheng Changgui Sun | 2018 | Frontiers of Medicine2018，12，2： | 8 |
| 3 | 牧草如何生长——植物生长与放牧管理之关联(英文)显示文摘适当管理饲料饲草资源的基本原则是理解多年生牧草如何生长。长期以来 ,对根系生长有了基本的了解 ,对去叶和环境对根系生长的影响也知之甚多。然而 ,对去叶、干旱及其他环境因素对多年生牧草的影响以及这些牧草对去叶的反应缺乏应有的理解。从牧草返青到开花 ,植物处于短枝阶段 ,适度放牧并不对多年生牧草的健康和活力造成危害 ,因为植物会弥补其失去的叶片。然而 ,当牧草从短枝向长枝阶段 (节间伸长和开花期 )转移时 ,碳水化合物主要用于节间伸长和开花过程。在开花后和休眠前期 ,碳水化合物主要向茎基和植物基部转移 ,以供来年新枝条的发育。因此 ,在花后和休眠前期 ,放牧系统必须被调节到“无放牧”状态。“无放牧”状态 ,如休息、轮牧、延迟轮牧和快速轮牧制 ,其价值在于这种定期的禁牧可提高多年生牧草的活力 ,改善草地的健康状况 ,并且在不利的环境条件下 。 | Ronald E Sosebee David B Wester J Carlos Villalobos Carlton M Britton Changgui Wan Hisham Nofal | 2005 | 草业学报2005，14，1： | 8 |
| 4 | Surface ozone observations during voyages to the Arctic and Antarctic regions显示文摘Surface ozone concentration and UV-B data between 75° N and 70° S were obtained aboard the Chinese polar scientific vessel 'Xue-long' (Snow-Dragon) during the first voyage to the Arctic and the 16th to the Antarctic in 1999-2000. Analysis of these data presents that variations of the surface ozone concentration have small amplitude during voyages except the mid-latitude in the Northern Hemisphere. As a whole, average surface ozone concentration in the Northern Hemisphere is higher than that in the Southern, and high value occurred when the ship sailed close to the continents. The average diurnal variations of the surface ozone in the Northern Hemisphere are also higher compared to the southern counterparts, and high diurnal variations were found at low latitudes, and relative low level in the polar region. | Longhua Lu Lingen Bian Yanjie Cheng Changgui Lu Jie Tang | 2001 | Chinese Science Bulletin2001，46，23： | 8 |
| 5 | Evaluation of asthma control: a questionnaire-based survey in China显示文摘 | Su Nan Lin Jiangtao Chen Ping Li Jing Wu Changgui Yin Kaisheng Liu Chuntao Chen Yiqiang Zhou Xin Yuan Yadong Huang Xingang | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 6 | Development characteristics of the fault system and its control on basin structure, Bodong Sag, East China显示文摘The Bodong Sag,located in the Bohai Sea,offshore China,is one of the most petroliferous basins in China.Based on three dimensional seismic reflection data and time slice data,we analyze the fault system of the Bodong area in detail,establish the fault structure pattern of different types and summarize the distribution of the fault system.It is concluded that the development characteristics of the Cenozoic fault system are in accordance with the dextral stress field of the Tanlu Fault,which displayed a brush structure with NNE strike-slip faults as its principal faults,NE-trending extensional faults as secondary faults and EW-trending faults as minor faults.Faults can be divided into (1) strike-slip type,(2) extensional type,(3) strike-slip extensional type and (4) extensional strike-slip type.The spatial structures of different faults have obvious differences because of the fault properties and activity intensity.The fault system at different stages shows tremendous differences because of the transition of the Tanlu Fault from sinistral strike-slip to dextral strike-slip,the transition between extension and strike-slip,and the transition from mantle upwelling to thermal subsidence.According to the controlling effect of faults on basin structure,the Cenozoic basin experienced four evolutionary stages,(a) transition stage from sinistral strike-slip to dextral strike-slip,(b) strike-slip extensional faulted stage,(c) extensional strike-slip faulted stage and (d) strike-slip depression stage.The identification of temporal and spatial differences of faults could be used as a significant guideline for oil and gas exploration in the Bodong area. | Wu Zhiping Cheng Yanjun Yan Shiyong Su Wen Wang Xin Xu Changgui Zhou Xinhuai | 2013 | Petroleum Science2013，10，4： | 4 |
| 7 | Technique for Advanced Electrochemical Oxidation Treatment of Nanofiltration Concentrate of Landfill Leachate显示文摘Landfill leachate treated with combined process of 'pretreatment +biological treatment +advanced treatment(NF)' to produce nanofiltration concentrate, which bio-chemical ratio(B/C) is less than 0.1 and CODcr concentration is 2 000-2 500 mg/L, high salt content. Which cannot be discharged under existing environmental standards. According to analysis based on electrochemical advanced oxidation mechanism, a two-step electrochemical technique was recommended. In the first step, a pulse electrochemical technique was adopted. With Fe as consumption electrode and current density of 10 mA/cm2, the pollutants were removed by means of Fenton reaction, electroflotation and electrocoagulation. In the second step, a double function electrode was used to perform electrocatalytic oxidation by means of titanium metallic oxidates. In the condition that current density being 12.5 mA/cm2, the pollutants were further removed by oxidation and electrolytic deposition. Result shows that the removing rate of CODcr, NH3-N and Cl- were 70%-85%, 90% and 25%, respectively; average value of B/C ratio increased from 0.09 to 0.38 and conductivity reduced by 10%. | XIONG Changgui LI Guang ZHANG Zhiliang XIA Zhengwu LI Jian YE Hongji | 2014 | Wuhan University Journal of Natural Sciences2014，19，4： | 4 |
| 8 | Structure of summer atmospheric boundary layer in the center of Arctic Ocean and its relation with sea ice extent change显示文摘The atmospheric vertical structure and changed characteristics of boundary layer parameters, as well as their relations with sea ice and temperature changes in the center of Arctic Ocean(80°–88°N) are presented by adopting GPS sounding data obtained by the 4th–6th Arctic expeditions of China and NCEP(National Centre for Environmental Prediction) reanalysis data. Obvious differences are observed regarding the tropopause, boundary layer height, temperature inversion, and vertical structure of wind speed and direction in the center Arctic Ocean in the summer of 2012, 2010, and 2014. These differences can be explained by the relations between temperature and changes in sea ice extent in September from 1979 to 2014. In September 2012, the Arctic sea ice extent decreased by 44% an with obvious warming process. In September 2010 and 2014, it decreased by 22.6% and 17% with an obvious cooling process, respectively. A comparison of the two processes shows that sea ice change has a significant influence on the structure of the atmospheric boundary layer. In the recent 30 years, the temperature changes of 1000 and 850 h Pa in the center of the Arctic Ocean have displayed an obvious warming trend and negative correlation with sea ice extent. These changes indicate that the continuous reduction of Arctic sea ice will continue the warming of the troposphere middle layer. | BIAN LinGen DING MingHu LIN Xiang LU ChangGui GAO ZhiQiu | 2016 | Science China Earth Sciences2016，59，5： | 4 |
| 9 | The vertical structure of the atmospheric boundary layer over the central Arctic Ocean显示文摘The tropopause height and the atmospheric boundary layer(PBL)height as well as the variation of inversion layer above the floating ice surface are presented using GPS(global position system)radiosonde sounding data and relevant data obtained by China’s fourth arctic scientific expedition team over the central Arctic Ocean(86–88 N,144–170 W)during the summer of 2010.The tropopause height is from 9.8 to 10.5 km,with a temperature range between–52.2 and–54.1 C in the central Arctic Ocean.Two zones of maximum wind(over 12 m/s)are found in the wind profile,namely,low-and upper-level jets,located in the middle troposphere and the tropopause,respectively.The wind direction has a marked variation point in the two jets from the southeast to the southwest.The average PBL height determined by two methods is 341 and 453m respectively.These two methods can both be used when the inversion layer is very low,but the results vary significantly when the inversion layer is very high.A significant logarithmic relationship exists between the PBL height and the inversion intensity,with a correlation coefficient of 0.66,indicating that the more intense the temperature inversion is,the lower the boundary layer will be.The observation results obviously differ from those of the third arctic expedition zone(80–85 N).The PBL height and the inversion layer thickness are much lower than those at 87–88 N,but the inversion temperature is more intense,meaning a strong iceatmosphere interaction in the sea near the North Pole.The PBL structure is related to the weather system and the sea ice concentration,which affects the observation station. | BIAN Lingen MA Yongfeng LU Changgui LIN Xiang | 2013 | Acta Oceanologica Sinica2013，32，10： | 3 |
| 10 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Yongsheng Liu Zhaochu Hu Shan Gao Detlef Günther Juan Xu Changgui Gao Haihong Chen | 2008 | Chemical Geology2008，，1： | 3 |
| 11 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 12 | The characteristics of Na + , K + and free proline distribution in several drought-resistant plants of the Alxa Desert, China显示文摘 | Suomin Wang Changgui Wan Yanrong Wang Hua Chen Zhiyu Zhou Hua Fu Ronald E Sosebee | 2003 | Journal of Arid Environments2003，，3： | 2 |
| 13 | Metabolic syndrome, diabetes, and hyperuricemia显示文摘 | Changgui Li Ming-Chia Hsieh Shun-Jen Chang | 2013 | Current Opinion in Rheumatology2013，，2： | 2 |
| 14 | Clinical and functional comparison of dynamic hip screws and intramedullary nails for treating proximal femur metastases in older individuals显示文摘Objective:To compare the outcomes of dynamic hip screws(DHS)and intramedullary nailing(IMN)in the treatment of extra-capsular metastatic carcinoma of the proximal femur.Methods:A retrospective case analysis method was used to examine data of patients with proximal metastatic cancer of the femur who were treated with internal fixation in Department of Orthopaedics,Beijing Friendship Hospital,from January 2007 to December 2018.Blood loss,postoperative pain,functional score,length of stay,and survival rates were compared,and postoperative complications were assessed.Results:Complete follow-up data were available for 33 patients.The mean follow-up period was 12.2±3.6(range:9-32)months and the average age was 72.3±4.7(range:59-83)years old.There were 20 females and 13 males.Twenty-three patients had undergone IMN and 10 DHS,according to bone defects and the patient’s overall condition.The median survival time was 10 months in the IMN group and 11 months in the DHS group.Duration of surgery(t=-7.366,P<0.001)and length of hospital stay(t=-3.509,P<0.001)differed significantly between the two groups.There was one case of breakage of internal fixation in the IMN group.Conclusions:There was no significant difference between DHS and IMN in terms of surgical efficacy.IMN and DHS were different in terms of surgical time and hospital stay.However,due to the limited number of cases in this study,multi-factor analysis has not been performed and needs to be further verified in future analysis.When developing a surgical plan,it is recommended to consider the patient’s condition and the surgeon’s experience. | Hua Gao Xiaodong Bai Wentao Chen Yadong Li Liang Zhao Changgui Liu Zhenyu Liu Baojun Wang | 2020 | Chinese Journal of Cancer Research2020，32，3： | 2 |
| 15 | Pathophysiology of obesity and its associated diseases显示文摘The occurrence of obesity has increased across the whole world. Many epidemiological studies have indicated that obesity strongly contributes to the development of cancer, cardiovascular diseases, type 2 diabetes, liver diseases and other disorders, accounting for a heavy burden on the public and on health-care systems every year. Excess energy uptake induces adipocyte hypertrophy, hyperplasia and formation of visceral fat in other non-adipose tissues to evoke cardiovascular disease, liver diseases. Adipose tissue can also secrete adipokines and inflammatory cytokines to affect the local microenvironment,induce insulin resistance, hyperglycemia, and activate associated inflammatory signaling pathways. This further exacerbates the development and progression of obesity-associated diseases. Although some progress in the treatment of obesity has been achieved in preclinical and clinical studies, the progression and pathogenesis of obesity-induced diseases are complex and unclear. We still need to understand their links to better guide the treatment of obesity and associated diseases. In this review, we review the links between obesity and other diseases, with a view to improve the future management and treatment of obesity and its co-morbidities. | Xin Jin Tingting Qiu Li Li Rilei Yu Xiguang Chen Changgui Li Christopher G.Proud Tao Jiang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 2 |
| 16 | Rapid and accurate determination of the potency of varicella vaccine by quantitive polymerase chain reaction 显示文摘 | Marsha S Russell Changgui Li Louise Larocque | 2011 | Vaccine2011，29，： | 1 |
| 17 | Changes in soil properties and vegetation following exclosure and grazing in degraded Alxa desert steppe of Inner Mongolia, China显示文摘 | Shifang Pei Hua Fu Changgui Wan | 2007 | Agriculture Ecosystems and Environment2007，，1： | 1 |
| 18 | In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard显示文摘 | Liu Yongsheng Hu Zhaochu Gao Shan Ganther D Xu Juan Gao Changgui Chen Haibong | | 0，，： | 1 |
| 19 | In situ U -Pb dating and trace element analysis of zircons in thin sections of eclo- gite:refining constraints on the ultra high-pressure metamorphism of the Sulu terrane, China 显示文摘 | Zong Keqing Liu Yongsheng Gao Changgui | 2010 | Chemical Geology2010，269，34： | 1 |
| 20 | Hydraulic lift in drought-tolerant and-susceptible maize hybrids显示文摘 | WAN Changgui XU Wenwei SOSEBEE R E | 2000 | Plant and soil2000，219，12： | 1 |
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