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| 1 | 婴儿眼底出血显示文摘婴儿视网膜出血的位置和形态为眼底病的诊断提供重要线索。新生儿因产伤引起的视网膜出血常见,预后良好,为自限性。而婴儿的某些视网膜出血则可表明颅内动脉瘤、意外或非意外性损伤、和多种眼底病(如Coats病,残存性原始玻璃体增生症、早产儿视网膜病变、视网膜发育不良、高血压、近视)、或全身病(如血液病或心血管病变.感染、蛋白C缺乏)。本文根据视网膜出血的位置、形态和病因进行图解和分类。婴儿视网膜出血的及时诊断至为重要,因为通过治疗可预防早期剥夺性弱视和盲的发生。眼科体征亦为全身治疗提供有价值的评估。 | Baljit Kaur David Taylor 刘武 | 1993 | 国外医学(眼科学分册)1993，17，2： | 17 |
| 2 | 伴有脑肿胀的大脑和小脑梗死的管理推荐意见美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景和目的关于缺血性卒中后脑肿胀患者的最佳管理方案,仍有许多尚未确定的问题。需要制定相关指南来指导如何处理这种严重并发症,如何提供最佳的综合性神经科和内科治疗,以及在患者病情恶化时如何与面临外科干预复杂决策的家属进行良好的沟通。本科学声明为大脑或小脑半球缺血性卒中伴脑肿胀的患者提供了早期的管理方案。方法写作组利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有证据进行总结并指出与当前知识水平的差距。写作组通过对MEDLINE、EMBASE和Web of Science数据库进行医学文献计算机检索(最后检索时间为2013年3月,研究对象为成年人)回顾最相关的文献。在美国心脏协会(American Heart Association,ARIA)框架背景下对证据进行组织,根据AHA/美国心脏病学学会基金会以及AHA卒中委员会的证据强度分级方案进行分类。这份声明经过AHA内部的广泛同行评议。结果已有适用于由缺血性梗死引起的半球(累及整个大脑中动脉供血区或更大范围)和小脑(累及小脑后下动脉或小脑上动脉供血区)肿胀的临床标准。幕上半球缺血性卒中伴脑肿胀发生恶化的临床表现包括新发意识障碍或意识障碍加重、脑性上睑下垂以及瞳孔大小变化。在小脑梗死伴肿胀患者中,意识水平下降是脑干受压的结果,因此可能出现早期角膜反射丧失和瞳孔缩小。应制定标准化定义以促进多中心和基于人群的发病率、患病率、危险因素和转归研究。脑肿胀高危患者的识别应包括临床和神经影像学资料。如果大面积卒中患者有必要进入全面复苏状态,则需要收入具备神经监护功能的病房。这些患者最好被收入由技术熟练和经验丰富的医生(如神经重症监护医生或神经血管科医生)负责的重症监护室或卒中单元。综合性医疗管理包括气道管理和机械通气、血压控制、液体管理以及血糖和体温控制。在幕上半球缺血性卒中伴肿胀患者中,不需行常规颅内压监测或脑脊液引流,但神经功能继续恶化的患者应考虑行去骨瓣减压和硬脑膜切开术。去骨瓣减压术在≥60岁的患者中的疗效尚不确定。在神经功能恶化的小脑卒中伴肿胀患者中,应行枕骨下颅骨切除和硬脑膜切开术。当应用脑室造瘘术缓解小脑梗死后梗阻性脑积水时,应同时行枕骨下颅骨切除术以防小脑向上移位导致的病情恶化。幕上半球梗死伴肿胀患者可获得令人满意的转归,但即使行去骨瓣减压术,仍有1/3的患者会遗留严重残疾和完全生活依赖。多数小脑梗死患者在术后能获得可接受的功能转归。结论大脑和小脑梗死伴肿胀是需要立即给予专业神经重症监护、并常需要进行神经外科干预的危重情况。去骨瓣减压术是很多患者的必然治疗选择,经过选择的患者能从中受益匪浅,尽管他们可能会遗留残疾,但仍可生活自理。 | Eelco F. M. Wijdicks Kevin N. Sheth Bob S. Carter David M. Greer Scott E. Kasner W. Taylor Kimberly Stefan Schwab Eric E. Smith Rafael J. Tamargo Max Wintermark 王玉琴 牛牧 柯开富 | 2014 | 国际脑血管病杂志2014，22，4： | 11 |
| 3 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012，，2： | 7 |
| 4 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 5 | 1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience显示文摘 | Jordan M. Winter John L. Cameron Kurtis A. Campbell Meghan A. Arnold David C. Chang JoAnn Coleman Mary B. Hodgin Patricia K. Sauter Ralph H. Hruban Taylor S. Riall Richard D. Schulick Michael A. Choti Keith D. Lillemoe Charles J. Yeo | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 5 |
| 6 | The Stool DNA Test Is More Accurate Than the Plasma Septin 9 Test in Detecting Colorectal Neoplasia显示文摘 | David A. Ahlquist William R. Taylor Douglas W. Mahoney Hongzhi Zou Michael Domanico Stephen N. Thibodeau Lisa A. Boardman Barry M. Berger Graham P. Lidgard | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 4 |
| 7 | Population-Based Family History–Specific Risks for Colorectal Cancer: A Constellation Approach显示文摘 | David P. Taylor Randall W. Burt Marc S. Williams Peter J. Haug Lisa A. Cannon–Albright | 2010 | Gastroenterology2010，，3： | 3 |
| 8 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 9 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 10 | 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience显示文摘 | Jordan M. Winter M.D. John L. Cameron M.D. Kurtis A. Campbell M.D. Meghan A. Arnold M.D. David C. Chang Ph.D. M.B.A. M.P.H. JoAnn Coleman C.R.N.P. Mary B. Hodgin C.M.S.R.N. Patricia K. Sauter C.R.N.P. Ralph H. Hruban M.D. Taylor S. Riall M.D. Richard D. | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 2 |
| 11 | Omega‐3 fatty acids and/or fluvastatin in hepatitis C prior non‐responders to combination antiviral therapy – a pilot randomised clinical trial显示文摘 | David A. Sheridan Simon H. Bridge Mary M. E. Crossey Daniel J. Felmlee Fiona I. Fenwick Howard C. Thomas R. Dermot G. Neely Simon D. Taylor‐Robinson Margaret F. Bassendine | 2014 | Liver Int2014，，5： | 2 |
| 12 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 13 | Myocardial endothelin-1 release and indices of inflammation during angioplasty for acute myocardial infarction and stable coronary artery disease显示文摘 | Andrew J. Taylor Alex Bobik Mark Richards David Kaye Geoffrey Raines Paul Gould Garry Jennings | 2004 | American Heart Journal2004，，2： | 2 |
| 14 | High Detection Rates of Colorectal Neoplasia by Stool DNA Testing With a Novel Digital Melt Curve Assay显示文摘 | Hongzhi Zou William R. Taylor Jonathan J. Harrington Fareeda Taher Nazer Hussain Xiaoming Cao Charles L. Loprinzi Theodore R. Levine Douglas K. Rex Dennis Ahnen Kandice L. Knigge Peter Lance Xuan Jiang David I. Smith David A. Ahlquist | 2009 | Gastroenterology2009，，2： | 2 |
| 15 | Treatment of Travelers’ Diarrhea: Randomized Trial Comparing Rifaximin, Rifaximin Plus Loperamide, and Loperamide Alone显示文摘 | Herbert L. Dupont Zhi–Dong Jiang Jaime Belkind–Gerson Pablo C. Okhuysen Charles D. Ericsson Shi Ke David B. Huang Margaret W. Dupont Javier A. Adachi F. Javier De La Cabada David N. Taylor Sridvya Jaini Francisco Martinez Sandoval | 2007 | Clinical Gastroenterology and Hepatology2007，，4： | 2 |
| 16 | Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study显示文摘 | Daniel J Drucker John B Buse Kristin Taylor David M Kendall Michael Trautmann Dongliang Zhuang Lisa Porter | 2008 | The Lancet2008，，9645： | 2 |
| 17 | A feature extraction technique based on principal component analysis for pulsed Eddy current NDT显示文摘 | Ali Sophian Gui Yun Tian David Taylor John Rudlin | 2002 | NDT and E International2002，，1： | 2 |
| 18 | Preoperative High-resolution Magnetic Resonance Imaging Can Identify Good Prognosis Stage I, II, and III Rectal Cancer Best Managed by Surgery Alone: A Prospective, Multicenter, European Study显示文摘 | Fiona G.M Taylor Philip Quirke Richard J Heald Brendan Moran Lennart Blomqvist Ian Swift David J Sebag-Montefiore Paris Tekkis Gina Brown | 2011 | Annals of Surgery2011，，4： | 2 |
| 19 | Computer-assisted reader software versus expert reviewers for polyp detection on CT colonography显示文摘 | Suart A Taylor SH David B | 2006 | American Journal of Roentgenology2006，186，3： | 1 |
| 20 | Cranioplasty for midline metopic suture defects in adults with cleidoeranial dysplasia 显示文摘 | Taylor P Petms P David K | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，103，： | 1 |
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