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| 1 | The use of a standardized Chinese herbal formula in patients with advanced lung cancer:a feasibility study显示文摘Objective: Increasing numbers of cancer patients are using Chinese herbs(CHs). However, differences among prior studies make it difficult to draw firm conclusions about the clinical usefulness of any specific CH formula. The primary objective of this study was to establish the acceptability of taking a standardized CH formula for patients with advanced lung cancer. The secondary objective was to identify any toxicities attributable to this CH formula and to measure changes in quality of life.Methods: A single-arm, prospective study of a 6-week intervention with a selected CH formula in15 patients with stage 4 nonsmall-cell lung cancer(NSCLC, Seventh American Joint Committee on Cancer TNM staging system).Results: Patients with advanced lung cancer were interested in using the CH formula. Completion(93%)and adherence(98%) levels were very high and most patients perceived the CH treatment as easy to take and were willing to take the CHs used in the study again if it was available. About half of the patients reported adverse events, all of which were mild(Grade 1 or 2) and only a small minority(8%) were potentially related to CHs. No biochemical or hematological evidence of toxicity was observed. Overall, there were improvement in quality of life, and reduced feelings of tiredness and sleepiness.Conclusion: This study provides preliminary evidence that short-term use of a carefully selected and prepared CH formula in patients with stage 4 NSCLC is acceptable and safe. | Goulnar Kasymjanova Anh-Thi Tran Victor Cohen Carmela Pepe Lama Sakr David Small Jason Scott Agulnik Robert Thomas Jagoe | 2018 | Journal of Integrative Medicine2018，16，6： | 2 |
| 2 | Spatial patterns of ecohydrologic properties on a hillslope-alluvial fan transect, central New Mexico显示文摘 | David R. Bedford Eric E. Small | 2007 | Catena2007，，1： | 1 |
| 3 | Consumption processes and food web structure in the Columbia River Estuary显示文摘 | Simenstad C A Small L F David M C | 1990 | Progress In Oceanography1990，25，14： | 1 |
| 4 | Anechocardiographic study显示文摘 | Small Ridge RC Railer S David J | 1979 | Am J Med1979，66，： | 1 |
| 5 | Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer Patients显示文摘 | Serena S. Kwek Vinh Dao Ritu Roy Yafei Hou David Alajajian Jeffrey P. Simko Eric J. Small Lawrence Fong | 2012 | The Journal of Immunology2012，，7： | 1 |
| 6 | Extended-Field Irradiation and Intracavitary Brachytherapy Combined With Cisplatin and Amifostine for Cervical Cancer With Positive Para-Aortic or High Common Iliac Lymph Nodes: Results of Arm II of Radiation Therapy Oncology Group (RTOG) 0116显示文摘 | William Small Kathryn Winter Charles Levenback Revathy Iyer Sharon R. Hymes Anuja Jhingran David Gaffney Beth Erickson Kathy Greven | 2011 | International Journal of Gynecological Cancer2011，，： | 1 |
| 7 | The War-Proneness of Democratic Regime显示文摘 | Melvin Small David Singer | 1976 | The Jerusalem Journal of In- ternational Relations1976，，1： | 1 |
| 8 | ACR Appropriateness Criteria? on Advanced Cervical Cancer Expert Panel on Radiation Oncology—Gynecology显示文摘 | David K. Gaffney Beth A. Erickson-Wittmann Anuja Jhingran Nina A. Mayr Ajmel A. Puthawala David Moore Gautam G. Rao William Small Mahesh A. Varia Aaron H. Wolfson Catheryn M. Yashar William Yuh Higinia Rosa Cardenes | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，： | 1 |
| 9 | Epidemic dynamics on scale-free networks with piecewise linear infectivity and immunization显示文摘 | Fu X C Small M David M | 2008 | Phys Rev E2008，77，03： | 1 |
| 10 | Resort to Arms: International and Civil Wars, 1816-1980显示文摘 | Small Melvin and Singer David J | 1982 | Sage Publications1982，，： | 1 |
| 11 | Valuing time and reliability: assessing the evidence from road pricing demonstrations显示文摘 | Brownstone David Small Kenneth A | 2005 | Transportation Research Part A2005，39，： | 1 |
| 12 | Multiple Auditory Steady-state Responses to Bone-Conduction stimuli in Adults with Normao Heraing显示文摘 | Susan A Small David R Stapells | 2004 | Journal of the American Academy of Audiology2004，3，： | 1 |
| 13 | Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration显示文摘 | Hamdi K Hamdi Jacob Reznik Raquel Castellon Shari R Atilano John M Ong Nitin Udar Jeffrey H Tavis Annette M Aoki Anthony B Nesburn David S Boyer Kent W Small Donald J Brown M Cristina Kenney | 2002 | Biochemical and Biophysical Research Communications2002，，3： | 1 |
| 14 | Network science meets algebraic topology显示文摘Network science is largely consumed with the study of graphs with heterogeneous degree:typically large graphs with no strong topological symmetry.Network science borrows approaches from statistical physics to understand this heterogeneous structure,in a manner quite distinct from the rich symmetry of the graphs that are studied by algebraic graph theorists.Shi et al.[1]move toward bridging this divide by switching the focus from the analysis of node degree sequence to cycles.Rather than focusing on a statistical description of degrees and the connective paths between nodes,they instead study cycles of specific order within networks. | Lingqing Shen David MWalker Michael Small | 2019 | National Science Review2019，6，6： | 0 |
| 15 | 扎里亚季耶公园 俄罗斯莫斯科市显示文摘距圣巴西勒教堂、红场与克里姆林宫仅几步之遥,扎里亚季耶公园所处位置历史悠久,在这里可以饱览俄罗斯的所有历史和其不断发展的愿景。此处占地35英亩,无数次见证着历史的沧桑变迁。19世纪,这里曾是犹太人飞地。后来,一座斯大林主义摩天大楼在此处破土动工,尽管最终未曾建成。欧洲最大的酒店——罗西娅酒店——也一直屹立于此,直到2007年才被拆除。之后五年里,由于设计师诺曼·福斯特一直在负责筹划将其扩建为商业中心,这片占据莫斯科市中心四分之一面积的核心地段一直被围墙环绕。2012年,莫斯科市政府与莫斯科首席建筑师谢尔盖·库兹涅佐夫组织了一场设计竞赛,旨在将这片曾经私有化的商业区域改造成一处绿地公园。由DS+R建筑事务所牵头、与Hargreaves设计事务所、Citymakers公司联合组成的国际竞标团队最终从来自27个国家的90份设计方案中脱颖而出。 | Charles Renfro David Chacon Brian Tabolt Ayat Fadaifard Seongbeom Mo Dino Kiratzidis Gabriel Bollag James Murray Zoe Small Trevor Lamphier Mike Robitz Lindsay Harkema Jose Tijerina Kelsey Olafson 无 | 2021 | 世界建筑导报2021，36，6： | 0 |
| 16 | RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression显示文摘As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including tumorigenesis.It was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to tumorigenesis.Here,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in AML.Moreover,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature miR-126.Mechanistically,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of pre-miR-126.YTHDF2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in AML.Overall,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis. | Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su Brandon Tan Chao Shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin Chun-Wei Chen David Ann Zhijian Qian Xiaolan Deng Jianjun Chen Zhenhua Chen | 2024 | Genes & Diseases2024，11，1： | 0 |
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