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| 1 | ^(18)F-FDG PET/CT显像在鼻咽癌分期与疗效监测中的临床应用价值显示文摘背景与目的:18F-脱氧葡萄糖(fluorine-18 fluorodeoxyglucose,18F-FDG)PET/CT显像可明显提高肺癌、食管癌等多种肿瘤的诊断、分期与疗效监测的准确性,有助于更准确地制定治疗方案。本研究探讨全身18F-FDG PET/CT显像在鼻咽癌首次分期、再分期及疗效监测中的临床应用价值。方法:回顾性分析澳大利亚Peter MacCallum肿瘤中心2002年2月至2005年12月43例鼻咽癌患者的18F-FDG PET/CT全身扫描报告,根据临床资料、病理结果及临床随访结果,计算18F-FDG PET/CT与传统影像学检查CT、MRI的准确性、特异性、灵敏度、阳性预测值与阴性预测值,并对结果进行比较和分析。结果:18F-FDG PET/CT诊断鼻咽癌总的准确率、敏感性、特异性、阳性预测值与阴性预测值分别为95.3%、100.0%、85.7%、93.8%、100.0%,传统影像学检查CT、MRI分别为65.5%、79.4%、64.7%、81.8%、57.9%。18F-FDGPET/CT诊断结果使2例首次分期、7例再分期患者治疗方案得到改变,并影响1例首次分期和3例再分期患者治疗方案的制定;在疗效监测组中,指导医生修改治疗方案共11例(其中5例为原则性的修改)。18F-FDG PET/CT检测到2例第二原发肿瘤,1例是甲状腺癌,1例是低度恶性胃癌。结论:18F-FDG PET/CT全身显像对鼻咽癌N、M分期与疗效监测的临床作用可能优于CT、MR检查。 | 王国慧 Eddie W. F. Lau Ramdave Shakher David S. Binns Annette Hogg Elizabeth Drummond Rodney J. Hicks | 2007 | 癌症2007，26，6： | 19 |
| 2 | Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non–small cell carcinoma: Results of the American College of Surgery Oncology Group Z0030 Trial显示文摘 | Gail E. Darling Mark S. Allen Paul A. Decker Karla Ballman Richard A. Malthaner Richard I. Inculet David R. Jones Robert J. McKenna Rodney J. Landreneau Valerie W. Rusch Joe B. Putnam | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，，3： | 3 |
| 3 | ^(18)F-FDG PET/CT发现肿瘤患者意外病灶的临床价值显示文摘目的评价^(18)F-脱氧葡萄糖(FDG)PET/CT 全身显像探测肿瘤患者意外病灶的临床价值。方法回顾性分析澳大利亚 Peter MacCallum 肿瘤医院 PET/CT 中心2002年8月~2003年7月1727例肿瘤患者^(18)F-FDG PET/CT 全身显像报告,男980例,女747例,中位年龄63岁,随访37个月(中位时间为27.5个月)。意外病灶指新发现的与原发肿瘤无关的良性病灶或第2原发肿瘤。通过分析病历记录、病理结果、其他影像学检查结果及临床随访,确定病灶最终结果。结果 1727例患者共发现238例(13.8%)有意外病灶,其中213例220个意外病灶具有完整的随访资料。60个病灶怀疑为意外第2原发肿瘤,其中21.7%(13/60)证实为真阳性,70.0%(42/60)为假阳性,8.3%(5/60)至研究结束时未得到证实。38个甲状腺意外良性病灶,其中9个被证实为临床前恶性或恶性病灶,26个良性,3个未能证实。38个纵隔意外良性病灶,其中86.8%(33/38)证实为良性,7.9%(3/38)为原发肿瘤淋巴结侵犯,5.3%(2/38)未能证实其性质。其他部位84个意外良性病灶,94.0%(79/84)证实为真阴性,6.0%(5/84)未能证实。共22例患者被证实存在第2原发肿瘤病灶,占本研究总人群的1.3%。结论 ^(18)F-FDG PET/CT 全身显像是目前探测肿瘤患者意外病灶较好的无创方法,为制定临床治疗方案提供及时准确的依据。 | 王国慧 Eddie W.F. Lau Ramdave Shakher Robert E.Ware David S.Binns Annette Hogg Elizabeth Drummond Rodney J.Hicks | 2007 | 中华核医学杂志2007，27，1： | 3 |
| 4 | Video-assisted thoracic surgery versus open lobectomy for lung cancer: A secondary analysis of data from the American College of Surgeons Oncology Group Z0030 randomized clinical trial显示文摘 | Walter J. Scott Mark S. Allen Gail Darling Bryan Meyers Paul A. Decker Joe B. Putnam Robert W. Mckenna Rodney J. Landrenau David R. Jones Richard I. Inculet Richard A. Malthaner | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，4： | 2 |
| 5 | Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically显示文摘 | Tracy L. Putoczki Stefan Thiem Andrea Loving Rita A. Busuttil Nicholas J. Wilson Paul K. Ziegler Paul Nguyen Adele Preaudet Ryan Farid Kirsten Edwards Yeliz Boglev Rodney B. Luwor Andrew Jarnicki David Horst Alex Boussioutas Joan K. Heath Oliver M. Sieber | 2013 | Cancer Cell2013，，： | 2 |
| 6 | Tests of glycemia in diabetes显示文摘 | David E Goldstein Randie R Little Rodney A Lorenz | 2004 | Diabetes Care2004，27，7： | 1 |
| 7 | Guidelines for the Evaluation and Management of Status Epilepticus显示文摘 | Gretchen Brophy Rodney Bell Jan Claassen Brian Alldredge Thomas Bleck Tracy Glauser Suzette LaRoche James Riviello Lori Shutter Michael Sperling David Treiman Paul Vespa | 2012 | Neurocritical Care2012，，1： | 1 |
| 8 | Cerebrospinal fluid pressure monitoring after repair of cerebrospinal fluid leaks显示文摘 | Rodney J Schlosser Eileen Maloney Wilensky M.Sean Grady James N Palmer David W Kennedy William E Bolger | 2004 | Otolaryngology - Head and Neck Surgery2004，，4： | 1 |
| 9 | The castability of Ti-5553 alloy:Its microstructure and properties显示文摘 | Veeck Stewart Lee David Boyer Rodney etc | 2005 | Journal of Advanced Materials2005，37，4： | 1 |
| 10 | Assembling a Gene Regulatory Network for Specification of the B Cell Fate显示文摘 | Kay L. Medina Jagan M.R. Pongubala Karen L. Reddy David W. Lancki Rodney DeKoter Matthias Kieslinger Rudolf Grosschedl Harinder Singh | 2004 | Developmental Cell2004，，4： | 1 |
| 11 | Sexual Dysfunction in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Improvement After Trigger Point Release and Paradoxical Relaxation Training显示文摘 | Rodney U. Anderson David Wise Timothy Sawyer Christine A. Chan | 2006 | The Journal of Urology2006，，4： | 1 |
| 12 | Stages of collaboration and the realities of professional learning communities显示文摘 | Anne-Marie Dooner David Mandzuk Rodney A. Clifton | 2007 | Teaching and Teacher Education2007，，3： | 1 |
| 13 | Assessment of the Quality of Medical Care Among Patients with Early Stage Prostate Cancer Undergoing Expectant Management in the United States显示文摘 | Jamie Ritchey E. Greer Gay Benjamin A. Spencer David C. Miller Lauren P. Wallner Andrew K. Stewart Rodney L. Dunn Mark S. Litwin John T. Wei | 2012 | The Journal of Urology2012，，3： | 1 |
| 14 | Society of Automotive Engineer显示文摘 | DAVID LAZAROVICH RODNEY MICHALKO and EDWIN YUE Design and Integration of the Power Management and Generation System for the Dash/400 airplane (Allied signal Inc) | 1998 | SAE Transactions Journal of Aerospace Section1998，，： | 1 |
| 15 | Non-glide effects and dislocation core fields in BCC metals显示文摘A hallmark of low-temperature plasticity in body-centered cubic(BCC)metals is its departure from Schmid’s law.One aspect is that non-glide stresses,which do not produce any driving force on the dislocations,may affect the yield stress.We show here that this effect is due to a variation of the relaxation volume of the 1/2<111>screw dislocations during glide.We predict quantitatively nonglide effects by modeling the dislocation core as an Eshelby inclusion,which couples elastically to the applied stress.This model explains the physical origin of the generalized yield criterion classically used to include non-Schmid effects in constitutive models of BCC plasticity.We use first-principles calculations to properly account for dislocation cores and use tungsten as a reference BCC metal.However,the methodology developed here applies to other BCC metals,other energy models and other solids showing nonglide effects. | Antoine Kraych Emmanuel Clouet Lucile Dezerald Lisa Ventelon François Willaime David Rodney | 2019 | npj Computational Materials2019，，1： | 1 |
| 16 | Effects of β-carotene and α-tocopherol on the levels of tissue cholesterol and triglyceride in hypercholesterolemic rabbits显示文摘 | Kamalakshi C. Sulli Jidong Sun David W. Giraud Rodney A. Moxley Judy A. Driskell | 1998 | The Journal of Nutritional Biochemistry1998，，6： | 1 |
| 17 | Estimation of masstransport overpotentials during long-term PEMFC operation显示文摘 | David L Wood Ⅲ Rodney L | | 0，，08： | 1 |
| 18 | Ribosomal RNA in vertebrates:Evoltion and phylogentie applications显示文摘 | David P M Rodney L H | 1990 | Armu Rev Eeol Syst1990，21，1： | 1 |
| 19 | Rigorous Surveillance Protocol Increases Detection of Curable Cancers Associated with Barrett’s Esophagus显示文摘 | Rebecca C. Fitzgerald Ibtisan T. Saeed David Khoo Michael J.G. Farthing W. Rodney Burnham | 2001 | Digestive Diseases and Sciences2001，，9： | 1 |
| 20 | Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity显示文摘AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV.METHODS:Nucleotides 3519-3935 of the non-structural 3(NS3) region were amplified by using reverse transcription polymerase chain reaction(PCR).PCR products of the HCV NS3 regions were integrated into a PCR T7TOPO TA vector and then sequenced in both directions using an automated DNA sequencer.Relative major histocompatibility complex binding levels of wild-type and variant peptides were performed by fluorescence polarization-based peptide competition assays.Peptides with wild type and variant sequences of NS3 were synthesized locally using F-moc chemistry and purified by high-performance liquid chromatography.Specific cytotoxic T lymphocytes(CTLs) clones toward HCV NS3 wild-type peptides were generated through limiting dilution cloning.The CTL clones specifically recognizing HCV NS3 wild-type peptides were tested by tetramer staining and flow cytometry.Cytolytic activity of CTL clones was measured using target cells labeled with the fluorescence enhancing ligand,DELFIA EuTDA.RESULTS:The pattern of natural variants within three human leukocyte antigen(HLA)-A2-restricted NS3 epitopes has been examined in one patient with chronic HCV infection at 12,28 and 63 mo post-infection.Results obtained may provide convincing evidence of immune selection pressure for all epitopes investigated.Statistical analysis of the extensive sequence variation found within these NS3 epitopes favors a Darwinian selection model of variant viruses.Mutations within the epitopes coincided with the decline of CTL responses,and peptide-binding studies suggested a signif icant impact of the mutation on T cell recognition rather than peptide presentation by HLA molecules.While most variants were either not recognized or elicited low responses,such could antagonize CTL responses to target cells pulsed with wild-type peptides.CONCLUSION:Cross-recognition of CTL epitopes from wild-type and naturally-occurring HCV variants may lead to impaired immune responses and ultimately contribute to viral persistence. | Shuping Wang Rico Buchli Jennifer Schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
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