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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 3 | Antioxidant activities of sicilian prickly pear(opuntia ficus indica)fruit extracts and re ducing properties of its betalains: betanin and indicaxanthin显示文摘 | Daniela B Luisa T Francesca D G | 2002 | Agricultural and Food Chemistry2002，50，23： | 1 |
| 4 | Polypropylene-polyhedral oligomeric silsesquioxanes (POSS) nanocomposites显示文摘 | Alberto F Daniela T Alberto F | 2005 | Polym2005，46，： | 1 |
| 5 | Antiangiogenic potential of the mammalian target of rapamycin inhibitor tem- sirolimus显示文摘 | Donatella DB Ludovica C Daniela T | 2006 | Cancer Res2006，66，： | 1 |
| 6 | Amyloid-β peptide inhibits activation of the nitric oxided/cGMP/cAMPresponsive element-binding protein pathway during hippocampal synaptic plasticity显示文摘 | Daniela P Ottavie V Fabrizio T | 2005 | J Neurosci2005，25，29： | 1 |
| 7 | Preparation of gelatin and enzymic hydrolysates from sheep skin scraps 显示文摘 | Peter T N Daniela K B Pentsho G D | 1995 | Bulgarian Chemical Communications1995，28，1： | 1 |
| 8 | Mineral composition and bitter pit severity in ‘Catarina' apples 显示文摘 | Cassandro V T A Daniela V C Paulo R E | 2006 | Rev Bras Frutic2006，28，1： | 1 |
| 9 | U-PA and c-met mRNA espresslion is dom-regulated in human hepatocellular carcinomas显示文摘 | Daniela T Giuseppina D Anna B | 2000 | Int J Cancer2000，87，5： | 1 |
| 10 | The response to stationary-phase stress conditions in Escherichia coli : role and regula- tion of the glutamic acid decarboxylase system 显示文摘 | DANIELA D B ANGELA T FRANCESCO B | 1999 | Mol Microbiol1999，32，6： | 1 |
| 11 | Cystatin C and Estimates of renal function:Searching for a better measure of kidney function in diabetic patients显示文摘 | Laura P Stefno T Daniela L | 2007 | Clin Chem2007，55，3： | 1 |
| 12 | Induc'don of pro- inflammatory gene expression by Escberichia coli and mycotoxin zearalenone contamination and protection by a Lactobacillus mixture in porcine IPEC-I cells 显示文摘 | Ionelia T Daniela E M Gina C P e~ al | 2015 | Toxicon2015，97，4： | 1 |
| 13 | Two acylated monoterpene glucosides from Paeonia peregina显示文摘 | Ivanka N K Mario F S Daniela I T | 1998 | Phytochemistry1998，48，3： | 1 |
| 14 | Cystatin C and estimates ofrenal function : searching for a better measure of kidney function indiabetic patient显示文摘 | Laura P Stefano T Daniela I | 2007 | Clin Chem2007，53，3： | 1 |
| 15 | Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells显示文摘 | Andre DE Daniela F Marilia T | 2008 | J Cranio Surg2008，19，1： | 1 |
| 16 | Protective efficacy against tuberculosis of ESAT-6 secreted by a live salmonella typhimurium vaccine carrier strain and expressed by naked DNA显示文摘 | Mollenkolpf H J Daniela G T Andersen P | 2001 | Vaccine2001，19，： | 1 |
| 17 | Cystatin C and Esti- mates of renal function : Searching for a better measure of kidney function in diabetic patients 显示文摘 | Laura P Stefno T Daniela L | 2007 | Clin Chem2007，55，3： | 1 |
| 18 | Catalytic combustion of hydrocarbons with Mn and Cu-doped ceria-zireonia solid solutions 显示文摘 | DANIELA T ALESSANDRO T CARLADE L | 1999 | Catal Today1999，47，： | 1 |
| 19 | Degradation of FEP thermal control materials returned from the Hubble Space Telescope显示文摘 | ZUBY T M DE GROH K K DANIELA C S | 1995 | Proceedings of the Hubble Space Telescope Solar-Array Workshop Noordwijk The Netherlands1995，1995，： | 1 |
| 20 | Enamel and dentine reminerali- zation by nano - hydroxyapatite toothpastes 显示文摘 | PETER T DANIELA L MARTUS P | 2011 | J Dent2011，39，6： | 1 |
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