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| 1 | A CASE FOR SERVICE SYSTEMS ENGINEERING显示文摘A case is made for further developing a branch of systems engineering that focuses on problemsand issues which arise in the service sector. We promulgate this special focus not only because of thesize and importance of the service sector but also because of the unique opportunities that systemsengineering can exploit in the design and joint production and delivery of services. We begin byconsidering the economic, technological and demographic contexts within which the service sectorhas flourished; we then address both services, especially emerging services, and systems engineering,followed by a discussion of how to advance the field of service systems engineering, and concludingwith several remarks. In particular, a number of service systems engineering methods are identified toenhance the design and production/delivery of services, especially taking advantage of the uniquefeatures that characterize services - namely, services, especially emerging services, are information-driven, customer-centric, e-oriented, and productivity-focused. | James M.TIEN Daniel BERG | 2003 | Systems Science and Systems Engineering2003，12，1： | 13 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Strategies to obtain pattern fidelity in nanowire growth from large-area surfaces patterned using nanoimprint lithography显示文摘位置控制 nanowire 生长为依靠轻排放或轻吸收的基于 nanowire 的 optoelectronic 部件是重要的。为收获应用程序的太阳能, nanowires 的稠密的数组被需要;然而,到获得稠密的 nanowire 数组的一个主要障碍是种子粒子排水量并且在 nanowire 生长以前在退火的舞台期间联合。这里,我们探索三不同策略改进 nanoimprint 平版印刷术为 nanowire 生长定义的大区域的催化剂粒子数组的模式保藏。首先,我们看到在 nanoimprint 平版印刷术以前对待生长底层的热改进模式保藏。第二,我们探索由在由修改生长过程退火以前在地方修理种子粒子改进模式保藏的可能性。并且第三,我们证明一个罪恶 x 生长面具罐头充分阻止种子粒子排水量。我们显示出这些策略怎么允许我们极大地与对太阳能电池应用合适的尺寸改进成年 InP nanowire 数组的模式忠实,在取样的区域上的最终完成的 100% 模式保藏。这些策略的通用性质通过 GaAs 和差距 nanowires 的合成被支持。 | Gaute Otnes Magnus Heurlin Mariusz Graczyk Jesper Wallentin Daniel Jacobsson Alexander Berg Ivan Maximov Magnus T. Borgstrom | 2016 | Nano Research2016，9，10： | 6 |
| 4 | ON SERVICES RESEARCH AND EDUCATION显示文摘The importance of the services sector can not be overstated; it employs 82.1 percent of the U. S. workforce and 69 percent of graduates from an example technological university. Yet, university research and education have not followed suit. Clearly, services research and education deserve our critical attention and support since services – and services innovation – serve as an indispensable engine for global economic growth. The theme of this paper is that we can and should build services research and education on what has occurred in manufacturing research (especially in regard to customization and intellectual property) and education; indeed, services and manufactured goods become indistinguishable as they are jointly co-produced in real-time. Fortunately, inasmuch as manufacturing concepts, methodologies and technologies have been developed and refined over a long period of time (i.e., since the 1800s), the complementary set of concepts, methodologies and technologies for services are more obvious. However, while new technologies (e.g., the Internet) and globalization trends have served to enable, if not facilitate, services innovation, the same technologies (e.g., the Internet) and 21st Century realities (e.g., terrorism) are making services innovation a far more complex problem and, in fact, may be undermining previous innovations in both services and manufacturing. Finally, there is a need to define a “knowledge-adjusted” GDP metric that can more adequately measure the growing knowledge economy, one driven by intangible ideas and services innovation. | James M.TIEN Daniel BERG | 2006 | Journal of Systems Science and Systems Engineering2006，15，3： | 5 |
| 5 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 6 | A CALCULUS FOR SERVICES INNOVATION显示文摘在服务区的革新 - 特别在电子服务(电子服务) 领域 - 能被首先认为战略司机是 andfoci 系统地开发,然后战术的原则和 enablers,并且最后,运作的决定归因,所有哪个组成服务革新的一个过程或演算。更明确地,有四位顾客司机(即,合作,定制,集成和改编),三企业 foci (即,集中创造、集中答案、集中比赛),六个企业原则(即,重建市场边界,大图画的焦点不数,在存在需求以外的活动范围,得到战略顺序权利,克服组织上的障碍并且造进策略的执行),八技术 enablers (即,软件算法,自动化,电信,合作,标准化,定制,组织,和全球化),并且决定信息科学的六个属性(即,决定驱动,基于信息,即时,连续地适应、顾客中央、computationally集中)。四个顾客驱动程序都针对授权个人,这应该被注意 - 分别地,也就是说处于一种合作状况在认识到个人装作出贡献,收到设定或个性化的注意,存取一个综合系统或进程,并且获得适应即时或即时的输入。Thedeveloped 过程或演算服务为革新识别潜在的空白或蓝海洋。除了在服务和相关经验阐述当前的革新,白空格为可能的未来革新被识别;他们包括能减轻更早的革新的未预见到的后果或弊病的那些,保卫我们的权利到隐私,保护我们免受在总是上的伤害,互连的世界,向我们提供一个权威的搜索引擎,并且产生能足够地测量成长知识经济的一个 GDP 度量标准,无形的想法和服务革新驾驶的。 | James M. TIEN Daniel BERG | 2007 | Journal of Systems Science and Systems Engineering2007，16，2： | 4 |
| 7 | Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis显示文摘BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat, as well as decrease in markers of hepatic inflammation among NASH patients. | Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 8 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 9 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 10 | Completely transvaginal NOTES cholecystectomy using magnetically anchored instruments显示文摘 | Daniel J. Scott Shou-jiang Tang Raul Fernandez Richard Bergs Mouza T. Goova Ilia Zeltser Farid J. Kehdy Jeffrey A. Cadeddu | 2007 | Surgical Endoscopy2007，，12： | 2 |
| 11 | Incidence and clinical course of Crohn’s disease during the first year — Results from the IBD Cohort of the Uppsala Region (ICURE) of Sweden 2005–2009显示文摘 | Daniel Sj?berg Tommy Holmstr?m M?rit Larsson Anne-Lie Nielsen Lars Holmquist Anders Ekbom Anders R?nnblom | 2014 | Journal of Crohn’s and Colitis2014，，3： | 2 |
| 12 | Tbr2-expressing intermediate progenitor cells in the adult mouse hippocampus are unipotent neuronal precursors with limited amplification capacity under homeostasis显示文摘神经发生在马头鱼尾的怪兽在二坚持成年哺乳动物的大脑,侧面的室的 subventricular 地区和有牙齿的回转的 subgranular 地区的地点。在成年 subgranular 地区,光线的 gliallike 房间(RGL ) 是能产生星形细胞和神经原的 multipotent 干细胞。在产生神经原的过程, RGL 不均匀地划分产生一 RGL 和一个中间的祖先房间(欧洲电脑生产厂商) 。欧洲电脑生产厂商被认为是放大增殖并且最后产生成熟小粒神经原的房间的运输的一张人口。在同种细胞的水平的单个欧洲电脑生产厂商的性质很好没被理解。而且,欧洲电脑生产厂商是否能产生星形细胞或回复回到 RGL,不是清楚的,除产生神经原以外。这里,我们为同种细胞的分析开发了基因标记策略并且在在用 Tbr2 克里族 T2 老鼠。用这种技术,我们识别了 Tbr2 克里族 T2 作为不在动态平衡下面产生星形细胞或 RGL 的 unipotent neuronal 先锋把欧洲电脑生产厂商标记。另外,我们证明这些标记的欧洲电脑生产厂商很快以一种同步方式产生不成熟的神经原并且不在动态平衡下面经历扩大的重要数量,在受到充实的环境 / 跑的动物,或在有不同年龄的动物。在摘要,我们的学习建议在成年老鼠马头鱼尾的怪兽的表示 Tbr2 欧洲电脑生产厂商是 unipotent 先锋并且没有主要扩大,很快产生不成熟的神经原。 | Daniel A. Berg , Ki-Jun Yoon Brett Will Alex Y. Xiao Nam-Shik Kim Kimberly M. Christian Hongjun Song Guo-li Ming | 2015 | Frontiers in Biology2015，10，3： | 2 |
| 13 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 14 | Current knowledge on diagnosis and stagingof neuroendocrine tumors显示文摘 | Kjell berg Daniel Castellano | | 0，，1： | 1 |
| 15 | Copula Goodness--of--fit Testing: Overview and Power Comparison显示文摘 | Daniel Berg | 2009 | Taylor and Francis Journals2009，15，78： | 1 |
| 16 | Effect of comprehensive cardiac rehabilitation after heart valve surgery (CopenHeartVR): study protocol for a randomised clinical tria显示文摘 | Kirstine Laerum Sibilitz Selina Kikkenborg Berg Tina Birgitte Hansen Signe Stelling Risom Trine Bernholdt Rasmussen Christian Hassager Lars K?ber Daniel Steinbrfichel Christian Gluud Per Winkel Lau Caspar Thygesen Jane Lindschou Hansen Jean Paul Schmid Viviane Conraads Barbara Christina Brocki Ann-Dorthe Zwisler | 2013 | Trials2013，14，： | 1 |
| 17 | The rat macrophage scavenger receptor CD163:expression,regulation and role in inflammatory mediator production显示文摘 | Polfliet MM Fabriek BO Daniels WP Dijkstra CD van den Berg TK | 2006 | Im m unobiology2006，211，68： | 1 |
| 18 | Flapping and flexible wings for biological and micro air vehicles显示文摘 | Wei Shyy Mats Berg Daniel Ljungqvist | 1999 | Progress in Aerospace Sciences1999，35，： | 1 |
| 19 | Blurring the Boundary:Convergence of Factory and Service Processes 显示文摘 | Joel Goldhar Daniel Berg | 2010 | Journal ofManufacturing Technology Management2010，，23： | 1 |
| 20 | Creating innovative opportunities through research collabora- tion: an evolutionary framework and empirical illustration in engi- neering 显示文摘 | MAUREEN MCKELVEY N OLOFZARING DANIEL LJUNG- BERG | 2014 | Technovation2014，，18： | 1 |
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