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| 1 | Gene expression in cisplatin ototoxicity and protection with p53 inhibitor显示文摘Cisplatin damages cochlear hair cells and spiral ganglion neurons through cell death signaling pathways that are not fully understood. We used focused apoptosis gene microarrays to study early changes in gene expres- sion in cochlear cultures from P3 neonatal rats treated with cisplatin (0.2 mM). After 12 hours of cisplatin treat- ment, more than 50% of the 96 genes on the array showed a significant decrease in expression, consistent with widespread cell death. However, after 3 hours of cisplatin treatment, 10 genes showed significant increase in ex- pression in total cochlear tissue. In experiments with subsets of cochlear tissues, at 3h, cisplatin induced increased expression of 12 genes in the cochlear sensory epithelium (basilar membrane) and 11 genes in the spiral ganglion (tissue of Rosenthal's canal, containing the spiral ganglion). These included pro- and anti-apoptotic genes in- volved in the p53 signaling pathway, TNF receptor family, NF-kappaB pathway, death domain family, death effec- tor domain family, Bcl-2 family, CARD family, TRAF family, and GTP signal transduction. Although the changes in gene expression showed an overlap between basilar membrane and spiral ganglion, other changes, which may reflect the unique response of each tissue, were also observed. Pifithrin-α blocked cisplatin-induced up-regulation of genes in the p53 signaling pathway when assayed by both superarray and real time PCR. The data add to our understanding of the involvement of p53 in cisplatin-induced ototoxicity and otoprotection, conferred by the p53 inhibitor Pifithrin-α. | Donald Coling Richard Salvi | 2009 | Journal of Otology2009，4，2： | 9 |
| 2 | The ultimate competitive advantage of continuing business model innovation显示文摘 | Donald Mitchell Carol Coles | 2003 | Journal of Business Strategy2003，，5： | 2 |
| 3 | Indicators of human health in ecosystems:what do we measure显示文摘 | Donald C Cole John Eyles Brian L Gibson | 1998 | The Science of the Total Environment1998，224，： | 1 |
| 4 | Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis显示文摘 | Qunfeng Cai Minal Patel Donald Coling Bo Hua Hu | 2011 | Neurobiology of Disease2011，，2： | 1 |
| 5 | The ultimate competitive advantage of continuing business model innovation显示文摘 | Donald Mitchell Carol Coles | 2003 | Journal of Business Strategy2003，，5： | 1 |
| 6 | Business Model Innovation Breakthrough Moves 显示文摘 | Donald Mitchell Carol Coles | 2004 | The Journal of Business Strategy2004，25，1： | 1 |
| 7 | Hyperglycosylated human chorionic gonadotropin and the source of pregnancy failures显示文摘 | Yasushi Sasaki Donald G. Ladner Laurence A. Cole | 2008 | Fertility and Sterility2008，，6： | 1 |
| 8 | Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults显示文摘 | David W. Denning Alex Pleuvry Donald C. Cole | 2013 | Medical Mycology2013，，4： | 1 |
| 9 | Multiple dosing strategies with acetyl L-carnitine(ALCAR)fail to alter age-relat-ed hearing loss in the Fischer 344/NHsd rat显示文摘 | Eric C Bielefeld Donald Coling Guang-Di Chen and Donald Henderson | 2008 | Journal of Negative Results in BioMedicine2008，7，： | 1 |
| 10 | An experimen- tal study of entrainment and transport in the turbulent near wake of a circular cylinder显示文摘 | BRAIN CANTWELL DONALD COLES | 1983 | Fluid Mech1983，26，136： | 1 |
| 11 | Radiation Doses in Interventional Radiology Procedures: The RAD-IR Study Part I: Overall Measures of Dose显示文摘 | Donald L. Miller Stephen Balter Patricia E. Cole Hollington T. Lu Beth A. Schueler Michael Geisinger Alejandro Berenstein Robin Albert Jeffrey D. Georgia Patrick T. Noonan John F. Cardella James St. George Eric J. Russell Tim W. Malisch Robert L. Vogelzan | 2003 | Journal of Vascular and Interventional Radiology2003，，： | 1 |
| 12 | Non-invasive assessment of endothelial function:which technique?显示文摘 | Donald AE Charakida M Cole TJ | 2006 | J Am Coll Cardiol2006，48，9： | 1 |
| 13 | The ultimate competitive advantage of continuing business model innovation显示文摘 | Mitchell Donald Carol Coles | | 0，，05： | 1 |
| 14 | Sleep disturbance in women before myocardial infarction显示文摘 | Catherine S. Cole Jean C. McSweeney Mario A. Cleves Narain Armbya Donald L. Bliwise Christina M. Pettey | 2012 | Heart & Lung - The Journal of Acute and Critical Care2012，，： | 1 |
| 15 | Indicators of human health in ecosystems:what do we measure显示文摘 | Donald C Cole John Eyles Brian L Gibson | | 0，，1： | 1 |
| 16 | Non-invasive as- sessment of endothelial function: which technique 显示文摘 | Donald AE Charakida M Cole TJ | 2006 | J Am Coil Cardiol2006，48，9： | 1 |
| 17 | Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a KATP Channel–Dependent Mechanism显示文摘 | Stavros P. Loukogeorgakis Rupert Williams Anna T. Panagiotidou Shyamsunder K. Kolvekar Ann Donald Tim J. Cole Derek M. Yellon John E. Deanfield Raymond J. MacAllister | 2007 | Circulation2007，，12： | 1 |
| 18 | Indicators of human healthe in ecosystems- what do we measure显示文摘 | Donald C Cole John Eyles Brian L Gibson | 1998 | The Science of Total Environment1998，224，： | 1 |
| 19 | Indicators of human health in ecosystem:what do we measure显示文摘 | Donald C Cole John Eyles Brain L Gibson | | 0，，1： | 1 |
| 20 | Application of the modified vaccination technique for the prevention and cure of chronic ailments显示文摘Over the years vaccination has proven to be the most successful health protection program for large populations,to prevent them from acquiring serious infectious and contagious diseases caused by exogenous antigens(ags) such as bacteria and viruses.Protection is generally achieved by an active immunization program,though passive immunization has also been employed, especially in the past,to combat diseases caused by certain bacterial infections(e.g.tetanus, diphtheria,etc.). Most recently,encouraging research data suggests that therapeutic approaches employing vaccination techniques can also be used to correct or deal with mishaps induced by or involving endogenous ags.However,most attempts at employing conventional vaccination techniques to do so have proven less than successful.In the case of cancer,one of the reasons for this is that the presentation of cancer related ags in presently available immunization frameworks is unable to evoke a powerful,specific cancer killing response.Therefore,drug treatments have been required in order to achieve additional beneficial effects. Recently,the Barabas group has developed a new vaccination technique(the third vaccination method,after active and passive immunization) called Modified Vaccination Technique(MVT). In experiments the MVT has been able to prevent-and with equal effectiveness,terminatemishaps induced by or involving endogenous ags,e.g.in an experimental autoimmune kidney disease called slowly progressive Heymann nephritis(SPHN). The MVT is safe,and is able to initiate a specific immune response in the injected host(provided the injected components are in pure form).The MVT promises to provide the next generation of vaccines for the prevention,treatment,and termination of chronic disorders in humans,such as autoimmune diseases,cancer,and chronic infections. | Arpad Z Barabas Chad D Cole Arpad D Barabas Richard M Graeff Rene Lafreniere Donald M Weir | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 0 |
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