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| 1 | Acute interstitial edematous pancreatitis:Findings on non-enhanced MR imaging显示文摘AIM: To study the appearances of acute interstitial edematous pancreatitis (IEP) on non-enhanced MR imaging. METHODS: A total of 53 patients with IEP diagnosed by clinical features and laboratory findings were underwent MR imaging. MR imaging sequences included fast spoiled gradient echo (FSPGR) fat saturation axial T1-weighted imaging, gradient echo T1-weighted (in phase), single shot fast spin echo (SSFSE) T2-weighted, respiratory triggered (R-T) T2-weighted with fat saturation, and MR cholangiopancreatography. Using the MR severity score index, pancreatitis was graded as mild (0-2 points), moderate (3-6 points) and severe (7-10 points). RESULTS: Among the 53 patients, IEP was graded as mild in 37 patients and as moderate in 16 patients. Forty-seven of 53 (89%) patients had at least one abnormality on MR images. Pancreas was hypointense relative to liver on FSPGR T1-weighted images in 18.9% of patients, and hyperintense in 25% and 30% on SSFSE T2-weighted and R-T T2-weighted images, respectively. The prevalences of the findings of IEP on R-T T2- weighted images were, respectively, 85% for pancreatic fascial plane, 77% for left renal fascial plane, 55% for peripancreatic fat stranding, 42% for right renal fascial plane, 45% for perivascular fluid, 40% for thickened pancreatic lobular septum and 25% for peripancreatic fluid, which were markedly higher than those on in-phase or SSFSE T2-weighted images (P < 0.001).CONCLUSION: IEP primarily manifests on non-enhanced MR images as thickened pancreatic fascial plane, left renal fascial plane, peripancreatic fat stranding, and peripancreatic fluid. R-T T2-weighted imaging is more sensitive than in-phase and SSFSE T2-weighted imaging for depicting IEP. | Xiao-Ming Zhang Zhi-Song Feng Qiong-Hui Zhao Chun-Ming Xiao Donald G Mitchell Jian Shu Nan-Lin Zeng Xiao-Xue Xu Jun-Yang Lei Xiao-Bing Tian | 2006 | World Journal of Gastroenterology2006，12，36： | 9 |
| 2 | Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk显示文摘We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)hepatotoxicity.Here,we hypothesized that exogenous PA is also beneficial.To test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)posttreatment.We then collected blood and liver at 6,24,and 52 h.Post-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC alone.Interestingly,PA did not affect canonical mechanisms of APAP toxicity.Instead,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the liver.Consistent with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated mice.Furthermore,PA failed to protect against APAP in IL-6-deficient animals.Interestingly,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating IL-6.Surprisingly,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short half-life.These data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model. | Melissa M.Clemens Stefanie Kennon-McGill Joel H.Vazquez Owen W.Stephens Erich A.Peterson Donald J.Johann Felicia D.Allard Eric U.Yee Sandra SMcCullough Laura P.James Brian N.Finck Mitchell R.McGill | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 3 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 4 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 5 | The ultimate competitive advantage of continuing business model innovation显示文摘 | Donald Mitchell Carol Coles | 2003 | Journal of Business Strategy2003，，5： | 2 |
| 6 | LI‐RADS (Liver Imaging Reporting and Data System): Summary, discussion, and consensus of the LI‐RADS Management Working Group and future directions显示文摘 | Donald G. Mitchell Jordi Bruix Morris Sherman Claude B. Sirlin | 2015 | Hepatology2015，，3： | 2 |
| 7 | Community integration显示文摘 | Ross E Mitchell Donald G Reid | 2000 | Annals of Tourism Research2000，，1： | 2 |
| 8 | Prehospital thrombolysis of amassive pulmonary embolus 显示文摘 | Perkins ZB Mitchell C Donald O | 2008 | Emerg Med J2008，25，5： | 1 |
| 9 | The ultimate competitive advantage of continuing business model innovation显示文摘 | Donald Mitchell Carol Coles | 2003 | Journal of Business Strategy2003，，5： | 1 |
| 10 | Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C显示文摘 | K.Rajender Reddy Teresa L. Wright Paul J. Pockros Mitchell Shiffman Gregory Everson Robert Reindollar Michael W. Fried Preston P. Purdum Donald Jensen Coleman Smith William M. Lee Thomas D. Boyer Amy Lin Simon Pedder Jean DePamphilis | 2001 | Hepatology2001，，2： | 1 |
| 11 | Should Inernal Mammary Nodes Be Sampled in the Sentinel Lymph Node Era ?显示文摘 | Sonia L MD Donald JF Md Mitchell Cotal | 1993 | Annals of Surgical Oncology1993，128，1： | 1 |
| 12 | Community Integration: Island Tourism in Peru显示文摘 | Ross E Mitchell Donald G Reid | 2001 | Annals of Tourism Research2001，28，1： | 1 |
| 13 | A Note on Rising Food Prices 显示文摘 | DONALD MITCHELL | 2008 | The World Bank2008，，2： | 1 |
| 14 | Quantitative study of bacterial colonization of dental casts显示文摘 | Donald L. Mitchell Nadjmeh M. Hariri Manville G. Duncanson Nancy L. Jacobsen Roderick E. McCallum | 1997 | The Journal of Prosthetic Dentistry1997，，5： | 1 |
| 15 | Reld community integration Island Tourism in peru显示文摘 | ROSS E MITCHELL DONALD G | 2001 | Annals of Tourism Research2001，38，1： | 1 |
| 16 | Health-related quality of life in inflammatory bowel disease显示文摘 | Dr. Douglas A. Drossman MD Donald L. Patrick PhD C. Madeline Mitchell MURP Edwina A. Zagami BSN MEd Mark I. Appelbaum PhD | 1989 | Digestive Diseases and Sciences1989，，9： | 1 |
| 17 | Axial growth and changes in lenticular and corneal power during emmetropization in in- fants显示文摘 | Donald O Mutti G Mitchell L | 2005 | Investigative Ophthalmology and Visual Science2005，46，： | 1 |
| 18 | Patterns of recurrent and persistent intestinal metaplasia after successful radiofrequency ablation of Barrett’s esophagus显示文摘 | Robert J. Korst Sobeida Santana-Joseph John R. Rutledge Arthur Antler Vivian Bethala Anthony DeLillo Donald Kutner Benjamin E. Lee Haleh Pazwash Robert H. Pittman Michael Rahmin Mitchell Rubinoff | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，6： | 1 |
| 19 | Business Model Innovation Breakthrough Moves 显示文摘 | Donald Mitchell Carol Coles | 2004 | The Journal of Business Strategy2004，25，1： | 1 |
| 20 | An experimental investigation of the effects of preferred and relaxing music listening on pain perception显示文摘 | Mitchell LA Mac Donald RA | 2006 | J Music Ther2006，43，4： | 1 |
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