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| 1 | Epithelial-mesenchymal transition- activating transcription factors- multifunctional regulators in cancer显示文摘The process of epithelial to mesenchymal transition(EMT), first noted during embryogenesis, has also been reported in tumor formation and leads to the development of metastatic growth. It is a naturally occurring process that drives the transformation of adhesive,non-mobile epithelial like cells into mobile cells with a mesenchymal phenotype that have ability to migrate to distant anatomical sites. Activating complex network of embryonic signaling pathways, including Wnt, Notch,hedgehog and transforming growth factor-β pathways,lead to the upregulation of EMT activating transcription factors, crucial for normal tissue development and maintenance. However, deregulation of tightly regulated pathways affecting the process of EMT has been recently investigated in various human cancers. Given the critical role of EMT in metastatic tumor formation,better understanding of the mechanistic regulation provides new opportunities for the development of potential therapeutic targets of clinical importance. | Minal Garg | 2013 | World Journal of Stem Cells2013，5，4： | 26 |
| 2 | WNT/β-catenin signaling in urothelial carcinoma of bladder显示文摘Urothelial carcinoma of bladder is the second most prevalent genitourinary disease.It is a highly heterogeneous disease as it represents a spectrum of neoplasms,including non-muscle invasive bladder cancer(NMIBC),muscle invasive bladder cancer(MIBC)and metastatic lesions.Genome-wide approaches and candidate gene analysis suggest that malignant transformation of the bladder is multifactorial and a multitude of genes are involved in the development of MIBC or NMIBC phenotypes.Wnt signaling is being examined to control and maintain balance between stemness and differentiation in adult stem cell niches.Owing to its participation in urothelial development and maintenance of adult urothelial tissue homeostasis,the components of Wnt signaling are reported as an important diagnostic and prognostic markers as well as novel therapeutic targets.Mutations/epigenetic alterations in the key molecules of Wnt/β-catenin canonical pathway have been linked with tumorigenesis,development of drug resistance and enhanced survival.Present review extends our understanding on the functions of key regulatory molecules of canonical Wnt/β-catenin pathway in urothelial tumorigenesis by inducing cancer stem cell phenotype(UCSCs).UCSCs may be responsible for tumor heterogeneity,high recurrence rates and complex biological behavior of bladder cancer.Therefore,understanding the role of UCSCs and the regulatory mechanisms that are responsible for high relapse rates and metastasis could help to develop pathway inhibitors and augment current therapies.Potential implications in the treatment of urothelial carcinoma of bladder by targeting this pathway primarily in UCSCs as well as in bulk tumor population that are responsible for high relapse rates and metastasis may facilitate potential therapeutic avenues and better prognosis. | Minal Garg Niharika Maurya | 2019 | World Journal of Nephrology2019，8，5： | 11 |
| 3 | Emerging role of microRNAs in cancer stem cells:Implications in cancer therapy显示文摘A small subset of cancer cells that act as tumor initiating cells or cancer stem cells(CSCs) maintain self-renewal and growth promoting capabilities of cancer and are responsible for drug/treatment resistance,tumor recurrence and metastasis. Due to their potential clinical importance,many researchers have put their efforts over decades to unravel the molecular mechanisms that regulate CSCs functions. Micro RNAs(mi RNAs) which are 21-23 nucleotide long,endogenous noncoding RNAs,regulate gene expression through gene silencing at post-transcriptional level by binding to the 3'-untranslated regions or the open reading frames of target genes,thereby result in target mR NA degradation or its translational repression and serve important role in several cellular,physiological and developmental processes. Aberrant mi RNAs expression and their implication in CSCs regulation by controlling asymmetric cell division,drug/treatment resistance and metastasis make mi RNAs a tool of great therapeutic potential against cancer. Recent advancements on the biological complexities of CSCs,modulation in CSCs properties by mi RNA network and development of mi RNA based treatment strategies specifically targeting the CSCs as an attractive therapeutic targets for clinical application are being critically analysed. | Minal Garg | 2015 | World Journal of Stem Cells2015，7，8： | 4 |
| 4 | MicroRNAs,stem cells and cancer stem cells显示文摘This review discusses the various regulatory charac-teristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells. It controls the stem cell functions by controlling a wide range of pathological and physiological processes, including development, differentiation, cellular proliferation, programmed cell death, oncogenesis and metastasis. Through either mRNA cleavage or translational repression, miRNAs alter the expression of their cognate target genes; thereby modulating cellular pathways that affect the normal functions of stem cells, turning them into cancer stem cells, a likely cause of relapse in cancer patients. This present review further emphasizes the recent discoveries on the functional analysis of miRNAs in cancer metastasis and implications on miRNA based therapy using miRNA replacement or anti-miRNA technologies in specific cancer stem cells that are required to establish their efficacy in controlling tumorigenic potential and safe therapeutics. | Minal Garg | 2012 | World Journal of Stem Cells2012，4，7： | 4 |
| 5 | Soil loss estimation using GIS and Remote sensing techniques:A case of Koga watershed,Northwestern Ethiopia显示文摘Soil loss by runoff is a severe and continuous ecological problem in Koga watershed.Deforestation,improper cultivation and uncontrolled grazing have resulted in accelerated soil erosion.Information on soil loss is essential to support agricultural productivity and natural resource management.Thus,this study was aimed to estimate and map the mean annual soil loss by using GIS and Remote sensing techniques.The soil loss was estimated by using Revised Universal Soil Equation(RUSLE)model.Topographic map of 1:50,000 scale,Aster Digital Elevation Model(DEM)of 20 m spatial resolution,digital soil map of 1:250,000 scale,thirteen years rainfall records of four stations,and land sat imagery(TM)with spatial resolution of 30 m was used to derive RUSLE's soil loss variables.The RUSLE parameters were analyzed and integrated using raster calculator in the geo-processing tools in ArcGIS 10.1 environment to estimate and map the annual soil loss of the study area.The result revealed that the annual soil loss of the watershed extends from none in the lower and middle part of the watershed to 265 t ha^(-1) year^(-1) in the steeper slope part of the watershed with a mean annual soil loss of 47 t ha^(-1) year^(-1).The total annual soil loss in the watershed was 255283 t,of these,181801(71%)tones cover about 6691(24%)hectare of land.Most of these soil erosion affected areas are spatially situated in the upper steepest slope part(inlet)of the watershed.These are areas where Nitosols and Alisols with higher soil erodibility character(0.25)values are dominant.Hence,Slope gradient and length followed by soil erodibility factors were found to be the main factors of soil erosion.Thus,sustainable soil and water conservation practices should be adopted in steepest upper part of the study area by respecting and recognizing watershed logic,people and watershed potentials. | Habtamu Sewnet Gelagay Amare Sewnet Minale | 2016 | International Soil and Water Conservation Research2016，4，2： | 3 |
| 6 | 初级保健中的过度诊断:分析问题,寻找答案显示文摘如果某种病症即使未被诊断出来也不会在患者的有生之年引起症状或伤害,而恰恰它却被诊断出来了,那么这就算是过度诊断。人们越来越认识到,过度诊断是癌症筛查和其他疾病筛查的负面产物。预防是初级保健的重要组成部分,这种保健服务面向广大人群,因此,从公共卫生的角度来看,初级保健中的过度诊断是一个重要的问题,具有深远的影响。在初级保健服务过程中产生的过度治疗,其范围大小尚不清楚,尽管无症状的乳腺癌、前列腺癌、甲状腺癌和肺癌常常有文献描述,但关于慢性肾脏疾病、抑郁症和注意力缺陷/多动障碍的过度诊断也有报道。然而,过度诊断在任何筛查项目中都难以避免,并且可能在很多临床场景下发生。过度诊断可以通过其导致的过度治疗(伴有相关的潜在毒性)、诊断相关的焦虑或抑郁、标签化或通过过度诊断带来的经济负担,对患者造成伤害。许多根深蒂固的因素促进过度诊断,包括越来越多地使用先进的诊断技术、经济激励措施、鼓励更多使用测试和治疗的医学文化、证据中的局限性所导致的诊断效用的模糊、使用无益的筛查、扩大疾病定义等。由于医生和患者之间缺乏对问题的认识以及术语混淆(过度诊断常常与相关概念相混淆),减少过度诊断的努力由此受到阻碍。理清术语概念将有助于医生对过度诊断问题的理解,有助于为描述其在初级保健中的流行情况及其带来的后果进一步积累证据。希望国际上在疾病定义和诊断标准上能够统一,这也将有助于减少未来的过度诊断。 | Minal S Kale Deborah Korenstein 李俊(译) | 2018 | 英国医学杂志中文版2018，21，12： | 3 |
| 7 | The development of laminin-alginate microspheres encapsulated with Ginsenoside Rg1 and ADSCs for breast reconstruction after lumpectomy显示文摘Many technologies have been developed for breast reconstruction after lumpectomy.Although the technologies achieved promising success in clinical,there are still many shortages hanging over and trouble the researchers.Tissue engineering technology was introduced to plastic surgery that gave a light to lumpectomy patients in breast reconstruction.The unexpected absorption rate,resulting from limited vascularization and low cell survival rate,is a major factor that leads to unsatisfactory results for the previous studies in our lab.In the study,the laminin-modified alginate synthesized by a new method of low concertation of sodium periodate would be mixed with ADSCs and Rg1 in the medium;and then sprayed into a calcium chloride(CaCl2)solution to prepare into microsphere(abbreviated as ADSC-G-LAMS)by bio-electrospray with a power syringe for the mass production and smaller bead size.The developed ADSC-G-LAMS microspheres had the diameter of 232±42μm.Sustained-release of the Rg1 retained its biological activity.WST-1,live/dead staining,and chromosome aberration assay were evaluated to confirm the safety of the microspheres.In in vivo study,ADSC-G-LAMS microspheres combined with autologous adipocytes were transplanted into the dorsum of rats by subcutaneous injection.The efficacy was investigated by H&E and immunofluorescence staining.The results showed that the bioactive ADSC-G-LAMS microspheres could integrate well into the host adipose tissue with an adequate rate of angiogenesis by constantly releasing Rg1 to enhance the ADSC or adipocyte survival rate to join tissue growth and repair with adipogenesis for breast reconstruction after lumpectomy. | I-Hsuan Yang Yo-Shen Chen Jia-Jing Li Ya-Jyun Liang Tzu-Chieh Lin Subhaini Jakfar Minal Thacker Shinn-Chih Wu Feng-Huei Lin | 2021 | Bioactive Materials2021，6，6： | 3 |
| 8 | Epithelial plasticity and cancer stem cells:Major mechanisms of cancer pathogenesis and therapy resistance显示文摘Epithelial-mesenchymal transition(EMT) has been linked with aggressive tumor biology and therapy resistance. It plays central role not only in the generation of cancer stem cells(CSCs) but also direct them across the multiple organ systems to promote tumor recurrence and metastasis. CSCs are reported to express stem cell genes as well as specific cell surfacemarkers and allow aberrant differentiation of progenies.It facilitates cancer cells to leave primary tumor, acquire migratory characteristics, grow into new environment and develop radio-chemo-resistance. Based on the current information, present review discusses and summarizes the recent advancements on the molecular mechanisms that derive epithelial plasticity and its major role in generating a subset of tumor cells with stemness properties and pathophysiological spread of tumor. This paper further highlights the critical need to examine the regulation of EMT and CSC pathways in identifying the novel probable therapeutic targets.These improved therapeutic strategies based on the co-administration of inhibitors of EMT, CSCs as well as differentiated tumor cells may provide improved antineoplastic response with no tumor relapse. | Minal Garg | 2017 | World Journal of Stem Cells2017，9，8： | 2 |
| 9 | Control of temporal lobe epilepsy following en bloc resection of low-grade tumors显示文摘 | Peter JK Minal H Ivan J | 1993 | J Neurosurg1993，78，： | 2 |
| 10 | Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/β-catenin in urinary bladder cancer patients显示文摘BACKGROUND Aberrant activation of phosphorylated form of glycogen synthase kinase-3β[pS9 GSK-3β(Serine 9 phosphorylation)] is known to trigger Wnt/β-catenin signal cascade but its clinicohistopathological implications in bladder carcinogenesis remain unknown.AIM To investigate the diagnostic and prognostic relevance of expressions of pS9 GSK-3β, β-catenin and its target genes in the pathobiology of bladder cancer.METHODS Bladder tumor tissues from ninety patients were analyzed for quantitative expression and cellular localization of pS9 GSK-3β by immunohistochemical(IHC) staining. Real time-quantitative polymerase chain reaction and IHC were done to check the expression of β-catenin, Cyclin D1, Snail and Slug at transcriptome and protein level respectively. Clinicohistopathological variables were obtained from histology reports, follow up and OPD visits of patients.Expressions of the markers were statistically correlated with these variables to determine their significance in clinical setting. Results were analysed using SPSS20.0 software.RESULTS Aberrant(low or no membranous/high nuclear/high cytoplasmic) expression of pS9 GSK-3β was noted in 51% patients and found to be significantly associated with tumor stage and tumor grade(P = 0.01 and 0.04; Mann Whitney U test).Thirty one percent tumors exhibited aberrant co-expression of pS9 GSK-3β andβ–catenin proteins and showed strong statistical association with tumor stage,tumor type, smoking/tobacco chewing status(P = 0.01, 0.02 and 0.04, MannWhitney U test) and shorter overall survival probabilities of patients(P = 0.02;Kaplan Meier test). Nuclear immunostaining of Cyclin D1 in tumors with altered pS9 GSK-3β/β–catenin showed relevance with tumor stage, grade and type.CONCLUSIONβ–catenin and pS9 GSK-3β proteins are identified as markers of diagnostic/prognostic significance in disease pathogenesis. Observed histopathological association of Cyclin D1 identifies it as marker of potential relevance in tumors with altered pS9 GSK-3β/β-catenin. | Niharika Maurya Rinni Singh Apul Goel Atin Singhai Uday Pratap Singh Vinita Agrawal Minal Garg | 2019 | World Journal of Clinical Oncology2019，10，4： | 2 |
| 11 | Vascular endothelial growth factor gene polymorphisms in North Indian patients with recurrent miscarriages显示文摘 | Shagun Aggarwal Farah Parveen Rehan Mujeeb Faridi Shubha Phadke Minal Borkar Suraksha Agrawal | 2010 | Reproductive BioMedicine Online2010，，： | 2 |
| 12 | Targeting microRNAs in epithelial-to-mesenchymal transition-induced cancer stem cells: therapeutic approaches in cancer显示文摘 | Minal Garg | 2015 | Expert Opinion on Therapeutic Targets2015，，2： | 2 |
| 13 | Polyoxygenated steroids of marine origin显示文摘 | Minale L Riccio R | 1993 | Chem Rev1993，93，： | 1 |
| 14 | Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States显示文摘 | Minal K Kimberly P Alan K | 2014 | Clin Infect Dis2014，，59： | 1 |
| 15 | Effcient associative memory using small-world architecture显示文摘 | Bohland J W Minal A A | 2001 | Neurocomputing2001，38，： | 1 |
| 16 | Safety profile of fast-track extubation in pediatric congenital heart disease surgery patients in a tertiary care hospital of a developing country: An observational prospective study 显示文摘 | Akhtar MI Hamid M Minal F | 2014 | J Anaesthesiol Clin Pharmaeol2014，30，3： | 1 |
| 17 | One-stage intrathoracic repair of extended aortic aneurysms显示文摘 | Minale C Splittgerber FH Wendt G | 1994 | J Card Surg1994，9，5： | 1 |
| 18 | Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis显示文摘 | Qunfeng Cai Minal Patel Donald Coling Bo Hua Hu | 2011 | Neurobiology of Disease2011，，2： | 1 |
| 19 | Study of the Morphological Hysteresis in Immiscible Polymer Blends显示文摘 | Minale M Mewis J Moldenaers P | 1998 | AIChE Journal1998，44，4： | 1 |
| 20 | Micropropagation of Vitis vinifera L : towards an improved protocol 显示文摘 | Minal Mhatre C K Salunkhe P S Rao | 2000 | Scientia Horticuhurae2000，84，3： | 1 |
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