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| 1 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 2 | 灭活面包酵母菌对溶液中铅离子的吸附研究显示文摘为研究灭活面包酵母菌对溶液中Pb^2+的吸附效果和机理,在实验室进行批量实验,通过AAS、SEM/EDS等手段对实验结果进行分析。实验室条件下面包酵母菌吸附Pb^2+的最佳条件为:pH值4.0-5.5,菌体质量浓度4.0 g/L,初始Pb^2+浓度1.0 mmol/L,吸附温度30℃。酵母菌实验最大吸附量为45.07 mg/g,吸附效率为92.45%。不同温度下的动力学分析表明,其吸附过程是一个快速过程,且较低温度时吸附平衡过程迟滞。实验结果很好地符合Langmuir等温吸附模型,计算得面包酵母菌在10℃、20℃和30℃时的最大吸附量qmax分别为71.53 mg/g、72.10 mg/g和75.82 mg/g。SEM/EDS分析发现Pb^2+被吸附到面包酵母菌表面,与细胞壁上有机物结合后以颗粒物形式附着在细胞表面,并随着溶液中Pb^2+初始浓度的增加而增多。研究表明,灭活酵母菌是一种快速高效的Pb^2+生物吸附剂。 | 代群威 NOONAN M J 董发勤 杨丽君 王中琪 | 2008 | 安全与环境学报2008，8，4： | 7 |
| 3 | 面包酵母菌对Pb^(2+)和Cd^(2+)单双重金属离子体系的吸附效果显示文摘为了探讨灭活面包酵母菌对Pb^(2+)、Cd^(2+)的单、双重金属离子体系(以下简称双离子体系)的吸附效果及影响机制,选择灭活面包酵母菌为吸附剂,对Pb^(2+)、Cd^(2+)的单离子体系和Pb^(2+)-Cd^(2+)双离子体系吸附动力学过程和等温吸附效果进行研究。结果表明,不同离子体系中,在相同初始浓度情况下,面包酵母菌对Pb^(2+)的吸附量总是大于对Cd2+的吸附量。试验条件下,面包酵母菌对Pb^(2+)、Cd^(2+)的单离子体系和Pb^(2+)-Cd^(2+)双离子体系等温吸附符合Langmuir模型,最大吸附量q_(max)分别为0.414 9 mmol/g、0.346 8 mmol/g和0.488 5 mmol/g。SEM/EDS分析表明,Pb^(2+)、Cd^(2+)被吸附到菌体上,造成菌体变形或出现破裂,并使内部物质外泄,这可能是吸附进行一定时间后出现二次吸附过程的主要原因。灭活面包酵母对Pb^(2+)和Cd^(2+)具有良好的吸附效果,对Pb^(2+)-Cd^(2+)双离子体系的吸附,离子间的点位竞争和联合毒性作用是影响体系总体吸附效果的重要因素。 | 代群威 董发勤 NOONAN M J 杨丽君 张志贵 | 2009 | 安全与环境学报2009，9，4： | 4 |
| 4 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 5 | High-dose GM-CSF- producing vaccines impair the immune response through the recruilment of myeloid suppressor cells 显示文摘 | Serafini P Carbley R Noonan KA | 2004 | Cancer Res2004，64，17： | 1 |
| 6 | Diagnostic and therapeutic ERCP: a large single centre’s experience显示文摘 | R. J. Farrell N. Mahmud N. Noonan D. Kelleher P. W. N. Keeling | 2001 | Irish Journal of Medical Science2001，，3： | 1 |
| 7 | Nonoperative treatment of ro- tator cuff tears 显示文摘 | Mantone JK Burkhead WZ Noonan J | 2000 | Orthop Clin North Am2000，，31： | 1 |
| 8 | Rapid quantitative and qualitative confirmatory method for the determination of monofluoroacetic acid in foods by liquid chromatography mass spectrometry显示文摘 | Noonan G O Begleya T H Diachenko G W | 2007 | J Chromatogr A2007，1139，： | 1 |
| 9 | Long-term asthma control with oral montelukast and inhaled beclomethasone for adults and children 6 years and older显示文摘 | Williams B Noonan G Reiss TF | 2001 | Clin Exp Allergy2001，31，6： | 1 |
| 10 | Yield states and stress-strain relationships in a natural plastic clay 显示文摘 | GRAHAM J NOONAN M L LEW K V | 1983 | Canadian Geoteehnical Journal1983，20，3： | 1 |
| 11 | Human and rat peroxisome proliferator activated receptors (PPARs) show similar tissue distribution but different responsiveness to PPAR activators 显示文摘 | Mukherjee R Jow L Noonan D McDonnell DP | 1994 | J Steroid BiochemMol Biol1994，51，： | 1 |
| 12 | 显示文摘 | Ghezzi S Noonan DM Aluigi MG | 2000 | Biochem Biophys Res Commun2000，270，3： | 1 |
| 13 | A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma显示文摘 | Noonan K Marchionni L Anderson J | 2010 | Blood2010，116，： | 1 |
| 14 | Incidence and prevalence of spinal cord injury in Canada:a national perspective显示文摘 | Noonan VK Fingas M Farry A | | 0，，4： | 1 |
| 15 | Non-coding RNAs turn up the heat:An e- merging layer of novel regulators in the mammalian heat shock re- sponse显示文摘 | Place RF Noonan EJ | 2014 | Cell Stress Chaperones2014，19，2： | 1 |
| 16 | Treatment with a glyeosaminoglycan formulation ameliorates experimental diabetic nephropathy 显示文摘 | Gambaro G Venturini AP Noonan DM | 1994 | Kidney Int1994，46，： | 1 |
| 17 | Human resource practices as communications and the psychological contact显示文摘 | Guzzo R A Noonan K A | 1994 | Human Resource Management1994，，3： | 1 |
| 18 | Structure and Expression of the Human MDR (p-glycoprotein) Gene Family显示文摘 | Solfir R Noonan KE | 1989 | Mol Cell Biol1989，9，： | 1 |
| 19 | Recombinant infectious hematopoietic necrosis virus and viral hemorrhagic septicemia virus glycoprotein epitopes expressed in Aeromonas salmonicida induce protective immunity in rainbow trout (Oncorhynchus mykiss)显示文摘 | NOONAN B ENZMANN P J TRUST T J | 1995 | Appl Environ Microbiol1995，61，10： | 1 |
| 20 | HIV Tat, its TARgets and the control of viral gene expression显示文摘 | Brigati C Giacca M Noonan DM | 2003 | FEMS Microbiol Lett2003，220，1： | 1 |
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