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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Phoenixin: uncovering its receptor, signaling and functions显示文摘Phoenixin (PNX ) 是被连接了到繁殖功能的最新发现的肽,两个在视下丘和垂体。这评论将集中于与这新奇 neuropeptide 有关的最近的发现。开始, PNX 增加了释放刺激的荷尔蒙(GnRH ) 的 gonadotropin,这被发现从垂体房间的 luteinizing 荷尔蒙(LH ) 版本。重要地,在扩大的雌老鼠的 PNX 击倒到 2.3 天的动情期的周期。用新奇 hypothalamic 房间线,我们发现 PNX 在 kisspeptin (吻) 和 GnRH 基因表示和分泌物上有一个 stimulatory 角色。PNX 受体用 GPR173 击倒的 siRNA 被揭开,孤儿受体要求了绑 PNX。我们发现了在 hypothalamic 神经原通过蛋白质 kinase A (PKA ) 发信号的 PNX-R。很多研究表明的 Althuogh 那 PNX 在繁殖功能起一个重要作用,也有证据,它可以有另外的功能,调整心,喂,记忆,和焦虑,两个在大脑和圆周。 | Emma K MCILWRAITH Denise D BELSHAM | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 3 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 4 | Transcatheter Arterial Embolization of Splenic Artery Aneurysms and Pseudoaneurysms: Short- and Long-Term Results显示文摘 | Romaric Loffroy Boris Guiu Jean-Pierre Cercueil C?me Lepage Nicolas Cheynel Eric Steinmetz Frédéric Ricolfi Denis Krausé | 2008 | Annals of Vascular Surgery2008，，5： | 2 |
| 5 | Review in depth and meta-analysis of controlled trials on colorectal cancer screening by faecal occult blood test显示文摘 | Denis Heresbach Sylvain Manfredi Pierre N. D?Halluin Jean-Fran?ois Bretagne Bernard Branger | 2006 | European Journal of Gastroenterology & Hepatology2006，，4： | 2 |
| 6 | Toward a the of organization culture and effectiveness显示文摘 | Denision D R Mishra A K | | 0，，： | 1 |
| 7 | Developmental validation of short tandem repeat reagent kit for forensic DNA profiling of canine biological material 显示文摘 | Dayton M Koskinen MT Tom BK Mattila A-M Johnston E Halverson J Fantin D Denise S Budowle B Smith DG Kan- thaswamy S | 2009 | Croatian Medical Journal2009，50，： | 1 |
| 8 | Measuring Or- ganizational Cultures:A Qualitative and Quantitative Study across Twenty Cases 显示文摘 | Geert Hofstede Bram Neuijen Denise D etal | 1990 | Administrative Science Quarterly1990，，2： | 1 |
| 9 | Canine Population Data Generated fi:om a Multiplex STR Kit for Use in Forensic Casework 显示文摘 | Kanthaswamy S Ttom BK Mattila A-M Johnston E Dayton M Kinaga J Erickson B J-A Halverson J Fantin D Denise S Kou A Malladi V Satkoski J Budowle B Smith DG Koskinen MT | 2009 | Journal of Forensic Sciences2009，54，4： | 1 |
| 10 | Comparative bioleaching and mineralogy of eomposited sulfide ores contai- ning enargite, covellite and ehaleoeite by mesophilic and thermophilic microorganisms 显示文摘 | JAEHEON L SEVKET A DENISE L D | 2011 | Hydrometallurgy2011，105，34： | 1 |
| 11 | Housing problem and housing policy显示文摘 | C William D Denise | | 0，，07： | 1 |
| 12 | Serum vitamin D,parathyroid hormone levels,and carotid atherosclerosis显示文摘 | Jared P Reis Denise von Muhlen Erin D Michos | | 0，，207： | 1 |
| 13 | Serum vi- tamin D parathyroid hormone levels and carotid atherosclerosis 显示文摘 | Jared P Reis Denise Von Mtlhlen Erin D Michos | 2009 | Atheroselerosis2009，20，7： | 1 |
| 14 | Leverage and investment in diversified firms显示文摘 | Seoungpil A Denis D J Diane K D | | 0，，： | 1 |
| 15 | Saturated faTTy acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus:implications for the pathogenesis of obesity显示文摘 | Milanski M Degasperi G Coope A Morari J Denis R Cintra D E Tsukumo D M Anhe G | | 0，，02： | 1 |
| 16 | Degenerative lumbar scoliosis associated with spinal stenosis显示文摘 | Ploumis A Transfledt D Denis F | | 0，，： | 1 |
| 17 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 18 | NOD2/CARD15 gene polymorphisms in Crohn’s disease: a genotype–phenotype analysis显示文摘 | Denis Heresbach Véronique Gicquel-Douabin Brigitte Birebent Pierre-Nicolas D’halluin Nathalie Heresbach-Le Berre Stéphane Dreano Laurent Siproudhis Alain Dabadie Michel Gosselin Jean Mosser Gilbert Semana Jean-Fran?ois Bretagne Jacqueline Yaouanq | 2004 | European Journal of Gastroenterology & Hepatology2004，，1： | 1 |
| 19 | Letter by Monneret et al Regarding Article, “Cardiac Structure and Function Across the Glycemic Spectrum in Elderly Men and Women Free of Prevalent Heart Disease: The Atherosclerosis Risk In the Community Study”显示文摘 | Denis Monneret Dominique Bonnefont-Rousselot Frédéric Roche | 2015 | Circulation: Heart Failure2015，，： | 1 |
| 20 | Toward a theory of organizational culture and effectiveness 显示文摘 | DENISION D R MISHRA A K | 1995 | Organization Science1995，6，2： | 1 |
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