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| 1 | Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage显示文摘Acute variceal hemorrhage,a life-threatening condition that requires a multidisciplinary approach for effective therapy,is defined as visible bleeding from an esophageal or gastric varix at the time of endoscopy,the presence of large esophageal varices with recent stigmata of bleeding,or fresh blood visible in the stomach with no other source of bleeding identified.Transfusion of blood products,pharmacological treatments and early endoscopic therapy are often effective;however,if primary hemostasis cannot be obtained or if uncontrollable early rebleeding occurs,transjugular intrahepatic portosystemic shunt(TIPS)is recommended as rescue treatment.The TIPS represents a major advance in the treatment of complications of portal hypertension.Acute variceal hemorrhage that is poorly controlled with endoscopic therapy is generally well controlled with TIPS,which has a 90%to 100%success rate.However,TIPS is associated with a mortality of 30%to 50%in such a setting.Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy failure,before the clinical condition worsens.Furthermore,admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively.This review article discusses initial management and then focuses on the specific role of TIPS as a primary therapy to control acute variceal hemorrhage,particularly as a rescue therapy following failure of endoscopic approaches. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Sylvain Favelier Pierre Pottecher Samia Hamza Anne Minello Patrick Hillon Pierre Thouant Pierre-Henri Lefevre Denis Krausé Jean-Pierre Cercueil | 2013 | World Journal of Gastroenterology2013，19，37： | 25 |
| 2 | Endovascular management of visceral artery aneurysms: When to watch, when to intervene?显示文摘Visceral artery aneurysms(VAA) include splanchnic and renal artery aneurysms. They represent a rare clinical entity, although their detection is rising due to an increased use of cross-sectional imaging. Rupture is the most devastating complication, and is associated with a high morbidity and mortality. In addition, increased percutaneous endovascular interventions have raised the incidence of iatrogenic visceral artery pseudoaneurysms(VAPAs). For this reason, elective repair is preferable in the appropriately chosen patient. Controversy still exists regarding their treatment. Over the past decade, there has been steady increase in the utilization of minimally invasive, non-operative interventions, for vascular aneurysmal disease. All VAAs and VAPAs can technically be fixed by endovascular techniques but that does not mean they should. These catheter-based techniques constitute an excellent approach in the elective setting. However, in the emergent setting it may carry a higher morbidity and mortality. The decision for intervention has to take into account the size and the natural history of the lesion, the risk of rupture, which is high during pregnancy, and the relative risk of surgical or radiological intervention. For splanchnic artery aneurysms, we should recognize that we are not, in reality, well informed about their natural history. For most asymptomatic aneurysms, expectant treatment is acceptable. For large, symptomatic or aneurysms with a high risk of rupture, endovascular treatment has become the firstline therapy. Treatment of VAPAs is always mandatory because of the high risk of rupture. We present our point of view on interventional radiology in the splanchnic arteries, focusing on what has been achieved and the remaining challenges. | Romaric Loffroy Sylvain Favelier Pierre Pottecher Pierre-Yves Genson Louis Estivalet Sophie Gehin Jean-Pierre Cercueil Denis Krausé | 2015 | World Journal of Radiology2015，7，7： | 11 |
| 3 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 4 | Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer显示文摘Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease,resulting in increased local drug concentrations.Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy.The patient was treated with a combination of gemcitabine and oxaliplatin using HAI.The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI.The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper.HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials. | Boris Guiu Julie Vincent Séverine Guiu Sylvain Ladoire Pablo Ortega-Deballon Jean-Pierre Cercueil Bruno Chauffert Franois Ghiringhelli | 2010 | World Journal of Gastroenterology2010，16，9： | 4 |
| 5 | 一种诊断肝纤维化的有效方法——评Wáng等IVIM诊断肝纤维化的论文显示文摘自从Le Bihan等作者于1986年描述体素内不相干运动(intravoxel incoherent motion,IVIM)磁共振弥散成像以来,这项技术取得了很大进展[1-4]。特别是在肝硬化和纤维化的情况下,许多研究显示了各种病理对弥散参数的影响。然而由于IVIM弥散参数值扫描的不稳定性,这些参数在个体患者诊断方面临床意义不大[5]。精确测量PF(f)和Dfast(D*)非常困难[6,7]。许多研究者试图提高测量精度、更好地理解扩弥散模式、改进图像采集序列或图像后处理。但是直到今天,肝脏IVIM参数测量的稳定性仍然不足,并难以满足日常的临床应用[5]。 | Jean-Pierre Cercueil | 2017 | 新发传染病电子杂志2017，2，4： | 3 |
| 6 | Transcatheter Arterial Embolization of Splenic Artery Aneurysms and Pseudoaneurysms: Short- and Long-Term Results显示文摘 | Romaric Loffroy Boris Guiu Jean-Pierre Cercueil C?me Lepage Nicolas Cheynel Eric Steinmetz Frédéric Ricolfi Denis Krausé | 2008 | Annals of Vascular Surgery2008，，5： | 2 |
| 7 | Outcome of transcatheter arterial embolization for bladder and prostate hemorrhage显示文摘 | Delgal A Cercueil JP Koutlidis N | 2010 | J Urol2010，183，： | 1 |
| 8 | Retinol-binding protein 4 is an independent factor associated with triglycerides and a determinant of very low-density lipoprotein-apolipoprotein B100 catabolism in type 2 diabetes mellitus显示文摘 | Verges B Guiu B Cercueil JP | | 0，，： | 1 |
| 9 | Raltitrexed and oxaliplatin he- patic arterial infusion for advanced colorectal cancer:a retrospective study显示文摘 | Khouri C Guiu B Cercueil JP | 2010 | Anticancer Drugs2010，21，6： | 1 |
| 10 | Arterial embolization for massive hematuria following transurethral prostatectomy显示文摘 | Michel F Dubruille T Cercueil JP | 2002 | J Urol2002，168，2： | 1 |
| 11 | Rahitrexed and oxali- platin hepatic arterial infusion for advanced coIorectaI canc- er: a retrospective study 显示文摘 | Khouri C Guiu B Cercueil JP | 2010 | Anticancer Drugs2010，21，6： | 1 |
| 12 | Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer显示文摘 | KHOURI C GUIU B CERCUEIL J P | 2010 | Anticancer Drugs2010，21，6： | 1 |
| 13 | Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer:a retrospective study显示文摘 | Khouri C Guiu B Cercueil JP | | 0，，06： | 1 |
| 14 | Retinol-binding protein 4 is an independent factor associated with triglycerides and a determi- nant of very low-density lipopmtein-apolipopmtein BIO0 catabolism in type 2 diabetes mellitus 显示文摘 | Verges B Guiu B Cercueil ]P | 2012 | Artedoscler Thromb Vasc Biol2012，32，12： | 1 |
| 15 | Liver segmentation: practical tips显示文摘 | Germain T Favelier S Cercueil JP | 2014 | Diagn Interv Imaging2014，95，11： | 1 |
| 16 | Raltitrexed and oxaliplatin hepatic arterial inFusion for advanced colorectal cancer:a retrospective study显示文摘 | Khouri C Guiu B Cercueil JP | | 0，，： | 1 |
| 17 | Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study显示文摘 | Cedric Khouri Boris Guiu Jean Pierre Cercueil Bruno Chauffert Sylvain Ladoire Francois Ghiringhelli | 2010 | Anti-Cancer Drugs2010，，6： | 1 |
| 18 | Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer:a retrospective study显示文摘 | Khouri C Guiu B Cercueil JP | | 0，，： | 1 |
| 19 | Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer:, a retrospective study显示文摘 | Khouri C Guiu B Cercueil JP | 2010 | Anticancer Drugs2010，21，6： | 1 |
| 20 | Endovascular therapeutic embolisation: an overview of occluding agents and their effects on embolised tissues 显示文摘 | LOFFROY R GUIU B CERCUEIL JP | 2009 | Curr Vasc Pharmacol2009，7，2： | 1 |
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