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| 1 | Perioperative treatment options in resectable pancreatic cancer-how to improve long-term survival显示文摘Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and to determine the most effective perioperative treatment of either chemotherapy and/or radiation therapy. More extensive operations involving extended pancreatectomy, portal vein resection and pancreatic resection in resectable pancreatic cancer with limited liver metastasis, performed in specialized centers seem to be the surgical procedures with a possible impact on survival. After many years of stagnation in pharmacological clinical research on advanced pancreatic ductal adenocarcinomas(PDAC)- since the approval of gemcitabine in 1997- more effective cytotoxic substances(nab-paclitaxel) and combinations(FOLFIRINOX) are now available for perioperative treatment. Additionally, therapies with a broader mechanism of action are emerging(stroma depletion, immunotherapy, antiinflammation), raising hopes for more effective adjuvant and neoadjuvant treatment concepts, especially in the context of 'borderline resectability'. Only multidisciplinary approaches including radiology, surgery, medical and radiation oncology as the backbones of the treatment of potentially resectable PDAC may be able to further improve the rate of cure in the future. | Marianne Sinn Marcus Bahra Timm Denecke Sue Travis Uwe Pelzer Hanno Riess | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 3 |
| 2 | Oncological Superiority of Hilar En Bloc Resection for the Treatment of Hilar Cholangiocarcinoma显示文摘 | Peter Neuhaus Armin Thelen Sven Jonas Gero Puhl Timm Denecke Wilfried Veltzke-Schlieker Daniel Seehofer | 2012 | Annals of Surgical Oncology2012，，5： | 2 |
| 3 | Clinical and molecular genetic features of ARC syndrome显示文摘 | Paul Gissen Louise Tee Colin A. Johnson Emmanuelle Genin Almuth Caliebe David Chitayat Carol Clericuzio Jonas Denecke Maja Rocco Bj?rn Fischler David FitzPatrick Angeles García-Cazorla Delphine Guyot Sebastien Jacquemont Sibylle Koletzko Bruno Leheup Hann | 2006 | Human Genetics2006，，3： | 2 |
| 4 | microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans 显示文摘 | Bidzhekov K Gan L Denecke B | 2012 | Thromb Haemost2012，107，4： | 1 |
| 5 | Oncological Superiority of Hilar En Bloc Resection for the Treatment of Hilar Cholangiocarcinoma显示文摘 | Peter Neuhaus MD Armin Thelen MD Sven Jonas MD Gero Puhl MD Timm Denecke MD Wilfried Veltzke-Schlieker MD Daniel Seehofer MD | 2012 | Annals of Surgical Oncology2012，，5： | 1 |
| 6 | Multidetector computedtomography for preoperative assessment of hepatic vasculatureand prediction of splenic artery steal syndrome in patients withliver cirrhosis before transplantation显示文摘 | Grieser C Denecke T Steffen IG | 2010 | Eur Radiol2010，20，1： | 1 |
| 7 | Using ProMED-Mail and MedWorm blogs for cross-domain pattern analysis in epidemic intelligence显示文摘 | Stewart A Denecke K | 2010 | Stud Health Technol Inform2010，160，1： | 1 |
| 8 | Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction 显示文摘 | Martins P N Reutzel-Selke A Jurisch A Denecke C Attrot K Pascher A | 2006 | Transplantation2006，82，： | 1 |
| 9 | Protein secretion in plant ceils can occur via a default pathway显示文摘 | Denecke J Botterman J Deblaere R | 1990 | Plant Cell1990，2，1： | 1 |
| 10 | Appearance of hepatocellular adenomas on gadoxetic acid-enhanced MRI显示文摘 | Timm Denecke Ingo G. Steffen Sheela Agarwal Daniel Seehofer Thomas Kr?ncke Enrique Lopez H?nninen Incken-Birthe Kramme Peter Neuhaus Sanjay Saini Bernd Hamm Christian Grieser | 2012 | European Radiology2012，，8： | 1 |
| 11 | Streptozocin/5-fluorouracil chemotherapy is associated with durable response in patients with advanced pancreatic neureendocrine turnouts 显示文摘 | Dilz L M Denecke T Steffen I G | 2015 | Eur J Cancer2015，51，10： | 1 |
| 12 | The tobacco homolog of mammalian calreticulin is present in protein complexes in vivo显示文摘 | Denecke J Carlsson LE Vidal S | 1995 | Plant Cell1995，7，： | 1 |
| 13 | Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A:Formation of colloidal calciprotein particles显示文摘 | Heiss A DuChesne A Denecke B | | 0，，15： | 1 |
| 14 | Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor显示文摘 | Vercammen D Beyaert R Denecker G | 1998 | J Exp Med1998，187，9： | 1 |
| 15 | Preoperative evaluation Of living kidney donors using multirow detector computed tomography : comparison with digital subtraction angiography and intraoperative findings 显示文摘 | Hanninen EL Denecke T Steher L | 2005 | Transpo Int2005，18，10： | 1 |
| 16 | Effect of low-and high-virulence Yersinia enterocolitica strains on the inflammatory response of human umbilical vein endothelial cells显示文摘 | Denecker G | 2002 | Infect Immun2002，70，7： | 1 |
| 17 | The tobaceo homolog of mammalian calreticulin is present in protein complexes in vivo显示文摘 | Denecke J Carlsson LE Vidal S | 1995 | Plant Cell1995，7，： | 1 |
| 18 | Tissue distribution andactivity testing suggest a similar but not identical function of fetuin-B and fetuin-A显示文摘 | Denecke B Graber S Schafer C | 2003 | Biochem J2003，376，1： | 1 |
| 19 | Comparison of CT,MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy:is there a benefit in using functional imaging?显示文摘 | Denecke T Rau B Hoffmann KT | 2005 | Eur Radiol2005，15，： | 1 |
| 20 | Targeting Rael by the Yersinia effector protein YopE inhibits cuspase-l-mediated maturation and release of interleukin-lbeta显示文摘 | Schotte P Denecker G Van Den Broeke A | 2004 | J Biol Chem2004，279，25： | 1 |
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