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| 1 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 2 | Method of delivery and pregnancy outcomes in Asia: the WHO global survey on maternal and perinatal health 2007–08显示文摘 | Pisake Lumbiganon Malinee Laopaiboon A Metin Gülmezoglu Jo?o Paulo Souza Surasak Taneepanichskul Pang Ruyan Deepika Eranjanie Attygalle Naveen Shrestha Rintaro Mori Nguyen Duc Hinh Hoang Thi Bang Tung Rathavy Kang Chuyun Kannitha Cheang Mario Festin Venus | 2010 | The Lancet2010，，9713： | 2 |
| 3 | Paclitaxel and its formulations显示文摘 | Anil KS Alka G Deepika A | 2002 | Inter J Pharmac2002，235，1： | 1 |
| 4 | Effect of culture medium and cryoprotectants on the growth and survival of probiotic lactobacilli during freeze drying 显示文摘 | Siaterlis A Deepika G Charalampopoulos D | 2009 | Letters in Applied Microbiology2009，48，： | 1 |
| 5 | Air pollutants : the key stages in the pathway towards the development of cardio- vascular disorders 显示文摘 | SHREY K SUCHIT A DEEPIKA D | 2011 | Environ Toxicol Pharmacol2011，31，： | 1 |
| 6 | Air pollutants: the key stages in the pathway towards the development of cardiovascular disorders 显示文摘 | Shrey K Suchit A Deepika D | 2011 | Environ Toxicol Pharmacol2011，31，： | 1 |
| 7 | Effect of culturemedium and cryoprotectants on the growth and survival of probioticlactobacilli during freeze drying显示文摘 | Siaterlis A Deepika G Charalampopoulos D | 2009 | Lett Appl Microbiol2009，48，3： | 1 |
| 8 | Air pollutants:the key stages in the pathway towards the development of cardiovascular disorders显示文摘 | Shrey K Suchit A Deepika D | 2011 | Environ Toxicol Pharmacol2011，31，1： | 1 |
| 9 | High - efficient pro- duction of boron nitride nanosheets via an optimized ball milling process for lubrication in oil显示文摘 | DEEPIKA LI L H GLUSHENKOV A M | 2014 | Sci Rep2014，4，07： | 1 |
| 10 | Annual report surveillance of adverse events following immunisation in Australia,2010 显示文摘 | Deepika M Jane C Peter B et a/ | 2011 | Communicable Diseases Intelligence Quarterly Report2011，35，4： | 1 |
| 11 | TNF-αhaplotype association with polycystic ovary syndrome--a South Indian study显示文摘 | Deepika ML Reddy KR Yashwanth A | 2013 | Assist Reprod Genet2013，30，11： | 1 |
| 12 | HIV knowledge improvement a-mong nurses in india: Using a train-the-trainer program显示文摘 | NYAMATHI A VATSA M DEEPIKA C | 2008 | J Assoc Nurses AIDS Care2008，19，6： | 1 |
| 13 | Paelitaxel and its formulations显示文摘 | Anil K S Alka G Deepika A | 2002 | Int J Pharm2002，235，122： | 1 |
| 14 | Paclitaxel and its formulations 显示文摘 | Anil KS Alka G Deepika A | 2002 | Int J Pharm2002，235，122： | 1 |
| 15 | TNF-αhaplotype association with polycystic ovary syndrome-a South Indian study显示文摘 | Deepika ML Reddy KR Yashwanth A | 2013 | J Assist Reprod Genet2013，30，11： | 1 |
| 16 | Paroxysmal sympathetichyperactivity in a child with moyamoya disease 显示文摘 | Deepika A Reddy M Shukla D | 2014 | JNeurosurg Anesthesiol2014，26，1： | 1 |
| 17 | Efficient regeneration of pla- ntlets from callus and mesophyll derived protoplasts of Robinia pseudoacacia L显示文摘 | Kanwar K Bhardwaj A Deepika R | 2009 | Plant Cell Tissue and Organ Culture2009，96，1： | 1 |
| 18 | Efficient regeneration of plantlets from callus and mesophyll derived protoplasts of Robinia pseudoacacia L显示文摘 | Kanwar K Bhardwaj A Deepika R | 2009 | Plant Cell Tiss Organ Cult2009，96，： | 1 |
| 19 | Correlation of subendometrial- endometrial blood flow assessment by two - dimensional power Doppler with pregnancy outcome in frozen - thawed embryo transfer cyeles 显示文摘 | Sardana D Upadhyay A J Deepika K | 2014 | Journal of Human Reproductive Sciences2014，7，2： | 1 |
| 20 | Effect of culture medium and cryoprotectants on the growth and survival of probiotic lactob acilli during freeze drying显示文摘 | Siaterlis A Deepika G Charalampopoulos D | | 0，，03： | 1 |
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