|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 洛南盆地1995—1999年野外地点发现的石制品显示文摘本文研究了1995─1999年期间在洛南盆地南洛河及其支流两侧阶地发现的50处旷野类型旧石器地点的1751件石制品。这些野外地点分布在第2级阶地者41处,第3级阶地4处,第4级阶地3处,另外还有2处分布于较高的第5级古老的阶地上。石制品的统计分析显示洛南盆地野外地点是以大中型石片和第二次加工修理的大型石片及砾石工具为代表的、两面加工技术发达的旧石器时代早期文化。 | 王社江 沈辰 胡松梅 张小兵 王昌富 Richard Cosgrove | 2005 | 人类学学报2005，24，2： | 34 |
| 2 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 3 | 中国中部南洛河流域地貌、黄土堆积与更新世古人类生存环境显示文摘本文结合最近获得的新资料,对南洛河流域的地貌、黄土沉积和更新世环境进行综合分析。结果表明,南洛河上、中游地貌表现为河流峡谷和山间盆地相间分布的特征,盆地中河流阶地发育;下游为平缓的山前平原和低山丘陵。黄土在全流域的山顶、河流阶地和盆地等各种地貌部位均有分布。黄土沉积受地形影响较大,上游黄土堆积速率低、颗粒细;在下游有风道直通的地方,黄土堆积速率高、颗粒粗。在不同地貌部位,黄土开始堆积的年代不同,黄土底界的年代从早更新世到晚更新世均有所见。对埋藏旧石器的年代研究表明,南洛河流域的古人类活动从早更新世晚期(约800ka)开始,到晚更新世后期(约30ka)结束,期间有多期遗存。初步的孢粉和有机碳同位素分析表明,这里曾是森林草原景观,冰期时,乔木植被以松属为主,C_4类型草本减少;而间冰期时,乔木植被以松属-榆科占主导地位,C_4类植物增多。古人类在黄土堆积期和古土壤发育期都可能在这个地方活动,但这一认识需要更多的证据支持。丰富的石制品分布和较为连续的黄土沉积,使南洛河流域成为理解更新世人类行为与环境的重要区域。 | 鹿化煜 张红艳 孙雪峰 王社江 Richard Cosgrove Chen Shen 张文超 张小兵 王先彦 弋双文 马萧林 Ming Wei | 2012 | 第四纪研究2012，32，2： | 24 |
| 4 | 洛南盆地槐树坪地点2013年出土的石制品显示文摘洛南盆地槐树坪旧石器地点最初发现于1999年,该地点位于南洛河左岸(北部)支流石门河及石门河的二级支流东麻坪河(石门河一级支流为麻坪河)之间的第四级阶地上,是洛南盆地高阶地旷野旧石器地点群的代表性遗址之一。2004年4~5月和2006年6~7月,槐树坪地点曾历经两次小规模试掘。2013年4~6月,我们对该遗址进行了较大规模的系统发掘,发掘面积56 m^2,出土石锤、石料、石核、石片、工具、断块、碎屑等不同类型石制品830件。本文对2013年发掘出土的石制品进行了初步研究,统计分析结果显示,槐树坪地点加工石制品的原料来自遗址附近河流阶地砾石层中的砾石,其中以石英和石英岩为主,石英砂岩和细砂岩也有使用。剥片方式主要采用锤击法,偶见砸击法和碰砧法。石制品以中型和小型为主。工具多为石片加工而成的刮削器,偶见手斧、薄刃斧、石刀等大型工具。石器加工方向以正向居多。光释光测年数据表明,槐树坪地点埋藏石制品地层堆积物形成年代大约为距今8~9万年到1.3万年之间,其中7~8万年段的地层堆积物中包含石制品较多。槐树坪地点发现的石制品丰富了洛南盆地旧石器遗址的材料,可以使我们更深刻的了解洛南盆地高阶地旧石器遗址群的地层埋藏情况、遗址年代和石器工业内涵。 | 于青瑶 王社江 SHEN Chen 鹿化煜 COSGROVE Richard 张小兵 张红艳 张文超 WEI Ming 王晓勇 刘全玉 孙雪峰 邢路达 夏文婷 | 2017 | 人类学学报2017，36，2： | 7 |
| 5 | 共聚物在超声介导基因转染中的新功能显示文摘目的探讨超声和共聚物在促进基因转染中是否有协同作用.方法应用3种水溶性不同的共聚物F127,L61和P85.超声参数设定为1 MHz,1~3 W/cm2,脉冲作功周期为20%.选用C2C12,3T3-MDEI,和CHO 3种细胞系为研究对象.质粒DNA为可产生绿色荧光蛋白的GFP.应用荧光显微镜和流式细胞仪(FACS)评价转染率,台盼蓝染色评价细胞的成活率.每一实验结果至少重复3次以上.结果与以前的研究结果相同,超声可介导基因转染,但随着超声能量的增加,细胞的破坏也增加;单独应用3种共聚物未观察到基因转染.但当与超声同时应用,在较低浓度时共聚物可使超声介导的基因转染率提高2~4倍.结论在较低浓度时,共聚物可显著提高超声介导的基因转染作用. | 陈云超 张青萍 LIANG Hai-Dong David O. Cosgrove Martin JK Blomley Qi-Long Lu | 2005 | 中华超声影像学杂志2005，14，11： | 7 |
| 6 | 超声微泡造影影像学及治疗作用的研究进展显示文摘包裹型气体微泡已经发展为临床应用的超声造影剂.微泡造影剂不仅已广泛用于血池和组织灌注显像,其治疗作用也日渐突显,例如溶栓和作为药物或基因的载体.造影剂微泡的平均直径小于红细胞直径,因而能够自由运行于微循环.微泡能将生物活性物质(例如药物或基因)结合在其内或其外膜表面,并将此物质转运于体内特定组织,例如将抗肿瘤药物转运并结合于特定肿瘤组织.靶向性微泡能将肽段等特定性配体结合于其微泡表面,这种特定性配体可特异性地与血管壁表达的受体相结合,微泡因而在靶组织区域积聚[1]. | 梁海东 王兴华 Charles Sennoga Mike Halliwell David O Cosgrove Martin JK Blomley | 2004 | 中华医学超声杂志(电子版)2004，1，3： | 4 |
| 7 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 8 | Leitlinien für den Gebrauch von Ultraschallkontrastmitteln - Januar 2004显示文摘 | T Albrecht M Blomley L Bolondi M Claudon J.-M Correas D Cosgrove L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani L Solbiati L Thorelius F Tranquart H Weskott T Whittingham | 2004 | Ultraschall in Med2004，，04： | 3 |
| 9 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 10 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 11 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 12 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 13 | Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC. | Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 14 | 论医师的职业道德教育显示文摘目前,由于医疗事故的曝光及医师与药商及医疗设备制造商之间的紧密联系,医师职业道德问题已经成为医疗行业中的重要问题。针对这个问题,人们试图从医学教育中找到解决方案。本文以美国近年来所开展的医师职业道德研究成果为依据,就医师职业道德的定义,如何进行医师职业道德教育、如何评估医师职业道德进行了系统的总结,对我国医学教育工作者将来如何理解医师职业道德的本质,如何开展医学生的职业道德教育,如何评估医师职业道德研究,怎样开展医师职业道德研究,具有很高的借鉴意义。 | Ellen M. Cosgrove 耿景海(译) | 2007 | 西北医学教育2007，15，6： | 2 |
| 15 | 高强钢纤维碳纳米管混凝土双轴受压试验与破坏准则显示文摘高强钢纤维碳纳米管混凝土(HSSFCNRC)是一种新型高强复合混凝土,具有流动性好、强度高、韧性大、耐久性好等显著优点。为探讨其多轴应力状态下的强度特征和变形特性,该文利用大连理工大学的大型静、动三轴电液伺服试验机,分别对普通高强混凝土(HSPC)和HSSFCNRC进行了不同应力比条件下的二轴受压对比试验,观察其破坏形态、得到了极限应力和峰值应变等其他参数。通过对Kupfer-Gerstle破坏准则、宋玉普模型和杨健辉模型进行的比较分析发现,HSPC和HSSFCNRC都适合这几种模型,但曲线包络线要优于折线包络线,且强度高的包络线包住强度低的,HSSFCNRC包络住HSPC。通过对八面体应力空间和应变空间的破坏准则分析发现,宋玉普模型的子午线为椭圆曲线,精确度较高;而文中采用的破坏准则子午线为直线,应用简便,也可满足工程应用要求。 | 杨健辉 汪洪菊 孟海平 Tom Cosgrove | 2016 | 土木工程学报2016，49，11： | 2 |
| 16 | EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 1: Basic Principles and Technology显示文摘 | J. Bamber D. Cosgrove C. Dietrich J. Fromageau J. Bojunga F. Calliada V. Cantisani J.-M. Correas M. D’Onofrio E. Drakonaki M. Fink M. Friedrich-Rust O. Gilja R. Havre C. Jenssen A. Klauser R. Ohlinger A. Saftoiu F. Schaefer I. Sporea F. Piscaglia | 2013 | Ultraschall in Med2013，，02： | 2 |
| 17 | Visit‐to‐Visit Blood Pressure Variability and Cardiovascular Death in the Systolic Hypertension in the Elderly Program显示文摘 | John B. Kostis Jeanine E. Sedjro Javier Cabrera Nora M. Cosgrove John S. Pantazopoulos William J. Kostis Sara L. Pressel Barry R. Davis | 2014 | J Clin Hypertens2014，，1： | 2 |
| 18 | ERCP-Directed Radiofrequency Ablation and Photodynamic Therapy Are Associated with Comparable Survival in the Treatment of Unresectable Cholangiocarcinoma显示文摘 | Daniel S. Strand Natalie D. Cosgrove James T. Patrie Dawn G. Cox Todd W. Bauer Reid B. Adams James A. Mann Bryan G. Sauer Vanessa M. Shami Andrew Y. Wang | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 19 | Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting显示文摘 | Colleen Gorman Koch Liang Li Andra I. Duncan Tomislav Mihaljevic Delos M. Cosgrove Floyd D. Loop Norman J. Starr Eugene H. Blackstone | 2006 | Critical Care Medicine2006，，6： | 2 |
| 20 | Carotid Plaque Pathology: Thrombosis, Ulceration, and Stroke Pathogenesis显示文摘 | Mark Fisher Annlia Paganini-Hill Aldana Martin Michele Cosgrove James F. Toole Henry J.M. Barnett John Norris | 2005 | Stroke2005，，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员