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| 1 | Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis显示文摘AIM: To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.METHODS: A cohort of 154 patients with confirmed liver cirrhosis(112 ethylic, 108 men, age 34-72 years)were enrolled in the study. Hepatic venous pressure gradient(HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay(ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.RESULTS: The mean value of HVPG was 16.18 ± 5.6 mm Hg. Compared to controls, the plasma levels of osteopontin in cirrhotic patients were significantly higher(P < 0.001). The plasma levels of osteopontin were positively related to HVPG(P = 0.0022, r = 0.25) and differed among the individual Child-Pugh groups of patients. The cut-off value of 80 ng/m L osteopontin distinguished patients with significant portal hypertension(HVPG above 10 mm Hg) at 75% sensitivity and 63% specificity. The mean follow-up of patients was 3.7 ± 2.6 years. The probability of cumulative survival was 39% for patients with HVPG > 10 mm Hg and 65% for those with HVPG ≤ 10 mm Hg(P = 0.0086, odds ratio(OR), 2.92, 95% confidence interval(CI): 1.09-7.76). Osteopontin showed a similar prognostic value to HVPG. Patients with osteopontin values above 80 ng/m L had significantly lower cumulative survival compared to those with osteopontin ≤ 80 ng/m L(37% vs 56%, P = 0.00035; OR = 2.23, 95%CI: 1.06-4.68).CONCLUSION: Osteopontin is a non-invasive parameter of portal hypertension that distinguishes patients with clinically significant portal hypertension. It is a strong prognostic factor for survival. | Radan Bruha Marie Jachymova Jaromir Petrtyl Karel Dvorak Martin Lenicek Petr Urbanek Tomislav Svestka Libor Vitek | 2016 | World Journal of Gastroenterology2016，22，12： | 20 |
| 2 | Metabolic aspects of adult patients with nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is a major cause of chronic liver disease and it encompasses a spectrum from simple steatosis to steatohepatitis, fibrosis, or cirrhosis. The mechanisms involved in the occurrence of NAFLD and its progression are probably due to a metabolic profile expressed within the context of a genetic predisposition and is associated with a higher energy intake. The metabolic syndrome(MS) is a cluster of metabolic alterations associated with an increased risk for the development of cardiovascular diseases and diabetes. NAFLD patients have more than one feature of the MS, and now they are considered the hepatic components of the MS. Several scientific advances in understanding the association between NAFLD and MS have identified insulin resistance(IR) as the key aspect in the pathophysiology of both diseases. In the multi parallel hits theory of NAFLD pathogenesis, IR was described to be central in the predisposition of hepatocytes to be susceptible to other multiple pathogenetic factors. The recent knowledge gained from these advances can be applied clinically in the prevention and management of NAFLD and its associated metabolic changes. The present review analyses the current literature and highlights the new evidence on the metabolic aspects in the adult patients with NAFLD. | Ludovico Abenavoli Natasa Milic Laura Di Renzo Tomislav Preveden Milica Medi?-Stojanoska Antonino De Lorenzo | 2016 | World Journal of Gastroenterology2016，22，31： | 17 |
| 3 | Depression and anxiety levels in therapy-nave patients with inflammatory bowel disease and cancer of the colon显示文摘AIM: To assess whether depression and anxiety are more expressed in patients with the first episode of inflammatory bowel disease (IBD) than in individuals with newly discovered cancer of the colon (CCa). METHODS: A total of 32 patients with IBD including 13 males and 19 females, aged 27 to 74, and 30 patients with CCa including 20 males and 10 females, aged 39-78, underwent a structured interview, which comprised Hamilton’s Depression Rating Inventory, Hamilton’s Anxiety Rating Inventory and Paykel’s Stressful Events Rating Scale. RESULTS: Patients of the IBD group expressed both depression and anxiety. Depressive mood, sense of guilt, psychomotor retardation and somatic anxiety were also more pronounced in IBD patients. The discriminant function analysis revealed the total depressive score was of high importance for the classification of a newly diagnosed patient into one of the groups. CONCLUSION: Newly diagnosed patients with IBD have higher levels of depression and anxiety. Moreover, a psychiatrist in the treatment team is advisable from the beginning. | Branislav R Filipovi Branka F Filipovi Mirko Kerkez Nikola Milini Tomislav Ran■elovi | 2007 | World Journal of Gastroenterology2007，13，3： | 10 |
| 4 | Incretin based therapies:A novel treatment approach for non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease is considered a hepatic manifestation of metabolic syndrome(MS).The current treatment of non-alcoholic fatty liver disease(NAFLD)principally includes amelioration of MS components by lifestyle modifications but the lack of success in their implementation and sustainment arises the need for effective pharmacological agent in fatty liver treatment.Incretins are gut derived hormones secreted into the circulation in response to nutrient ingestion that enhances glucose-stimulated insulin secretion.Glucagon-like peptide-1(GLP-1)is the most important incretin.Its receptor agonist and inhibitors of dipeptidyl peptidase-4(DPP-4)are used in treatment of type2 diabetes mellitus.DPP-4 serum activity and hepatic expression are shown to be elevated in several hepatic diseases.There are several experimental and clinical trials exploring the efficacy of incretin based therapies in NAFLD treatment.They suggest that GLP-1 analogues might have beneficial effect on hepatic steatosis acting as insulin sensitizers and directly by stimulating GLP-1 receptors expressed on hepatocytes.The use of DPP-4 inhibitors also results in hepatic fat reduction but the mechanism of action remains unclear.There is growing evidence that incretin based therapies have beneficial effects on hepatocytes,however further study analysis are needed to assess the long term effect of incretin based therapies on NAFLD. | Kristina Blaslov Tomislav Bulum Karin Zibar Lea Duvnjak | 2014 | World Journal of Gastroenterology2014，20，23： | 10 |
| 5 | Electromagnetic Fields and Induced Voltages on Underground Pipeline in the Vicinity of AC Traction System显示文摘 | Bosko Milesevic Bozidar Filipovic-Grcic Tomislav Radosevic | 2014 | Journal of Energy and Power Engineering2014，8，7： | 8 |
| 6 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 7 | Rectal cancer and Fournier's gangrene- current knowledge and therapeutic options显示文摘Fournier's gangrene(FG) is a rapid progressive bacterial infection that involves the subcutaneous fascia and part of the deep fascia but spares the muscle in the scrotal,perianal and perineal region. The incidence has increased dramatically,while the reported incidence of rectal cancer-induced FG is unknown but is extremely low. Pathophysiology and clinical presentation of rectal cancer-induced FG per se does not differ from the other causes. Only rectal cancer-specific symptoms before presentation can lead to the diagnosis. The diagnosis of rectal cancer-induced FG should be excluded in every patient with blood on digital rectal examination,when urogenital and dermatological causes are excluded and when fever or sepsis of unknown origin is present with perianal symptomatology. Therapeutic options are more complex than for other forms of FG. First,the causative rectal tumor should be removed. The survival of patients with rectal cancer resection is reported as 100%,while with colostomy it is 80%. The preferred method of rectal resection has not been defined. Second,oncological treatment should be administered but the timing should be adjusted to the resolution of the FG and sometimes for the healing of plastic reconstructive procedures that are commonly needed for the reconstruction of large perineal,scrotal and lower abdominal wall defects. | Tomislav Bruketa Matea Majerovic Goran Augustin | 2015 | World Journal of Gastroenterology2015，21，30： | 5 |
| 8 | Pre-and intraoperative predictors of acute kidney injury after liver transplantation显示文摘BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To identify the predictors of acute kidney injury after liver transplantation.METHODS The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia.AKI was defined according to the Kidney Disease:Improving Global Outcomes criteria.RESULTS Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage 1.Only 5.38%of patients required renal replacement therapy after LT.The majority of patients(82.8%)developed AKI within the first two days after the procedure.Multivariate logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term survival.The pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors. | Anna Mrzljak Lucija Franusic Jadranka Pavicic-Saric Tomislav Kelava Zeljka Jurekovic Branislav Kocman Danko Mikulic Ivan Budimir-Bekan Mladen Knotek | 2020 | World Journal of Clinical Cases2020，8，18： | 4 |
| 9 | Carcinosarcoma of the stomach:A case report and review of the literature显示文摘Carcinosarcomas are rare,malignant,biphasic tumors. We report the case of a 62-year-old man with gastric carcinosarcoma,along with its clinical,macroscopic and histopathological features. Macroscopically,a specimen of deformed stomach was obtained that measured 200 mm×150 mm×100 mm. A 150 mm×100 mm× 50 mm exophytic tumoral mass (Borrmann typeⅠ) was found,which involved the posterior wall from the cardia to the antrum. Histopathologically,a mixed type of malignancy was revealed: an adenocarcinoma with intestinal metaplasia,with interposed fascicles of fusiform atypical cells and numerous large,rounded and oval cells. The tumor showed positive histochemistry for cytokeratin 18,epithelial membrane antigen,carcinoembryonic antigen,chromogranin A and vimentin. Liver metastases were diagnosed 8 mo postoperatively,and the patient died 4 mo later. A review of the available literature is also presented. | Tomislav Randjelovic Branka Filipovic Darko Babic Vesna Cemerikic Branislav Filipovic | 2007 | World Journal of Gastroenterology2007，13，41： | 3 |
| 10 | Current practice variations in the management of anterior cruciate ligament injuries in Croatia显示文摘AIM: To investigate current preferences and opinions on the diagnosis, treatment and rehabilitation of patients with anterior cruciate ligament(ACL) injury in Croatia. METHODS: The survey was conducted using a questionnaire which was sent by e-mail to all 189 members of the Croatian Orthopaedic and Traumatology Association. Only respondents who had performed at least one ACL reconstruction during 2011 were asked to fill out the questionnaire. RESULTS: Thirty nine surgeons responded to the survey. Nearly all participants(95%) used semitendinosus/gracilis tendon autograft for reconstruction and only 5% used bone-patellar tendon-bone autograft. No other graft type had been used. The accessory anteromedial portal was preferred over the transtibial approach(67% vs 33%). Suspensory fixation was the most common graft fixation method(62%) for the femoral side, followed by the cross-pin(33%) and bioabsorbable interference screw(5%). Almost all respondents(97%) used a bioabsorbable interference screw for tibial side graft fixation. CONCLUSION: The results show that ACL reconstruction surgery in Croatia is in step with the recommendations from latest world literature. | Alan Mahnik Silvija Mahnik Damjan Dimnjakovic Stjepan Curic Tomislav Smoljanovic Ivan Bojanic | 2013 | World Journal of Orthopedics2013，4，4： | 3 |
| 11 | Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME显示文摘AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addition of BPC 157(L-NAME + L-arginine + BPC 157), there was a marked beneficial effect. BPC 157 treatment for esophagogastric anastomosis, along with NOS-blocker L-NAME and/or NOS substrate L-arginine, demonstrated an innate NO-system disability(as observed with L-arginine effectiveness). BPC 157 distinctively affected corresponding events: worsening(obtained with L-NAME administration that was counteracted); or amelioration(L-arginine + BPC 157-rats correspond to BPC 157-rats).CONCLUSION Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. | Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov Sven Seiwerth Predrag Sikiric | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 12 | Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes显示文摘Diabetes mellitus,a chronic disease of metabolism,is characterized by a disordered production or cellular utilization of insulin.Diabetic foot disease,which comprises the spectrum of infection,ulceration,and gangrene,is one of the most severe complications of diabetes and is the most common cause of hospitalization in diabetic patients.The aim of this study is to provide an evidence-based overview of diabetic foot complications.Due to neuropathy,diabetic foot infections can occur in the form of ulcers and minor skin lesions.In patients with diabetic foot ulcers,ischemia and infection are the main causes of non-healing ulcers and amputations.Hyperglycemia compromises the immune system of individuals with diabetes,leading to persistent inflammation and delayed wound healing.In addition,the treatment of diabetic foot infections is challenging due to difficulty in accurate identification of pathogenic microorganisms and the widespread issue of antimicrobial resistance.As a further complicating factor,the warning signs and symptoms of diabetic foot problems can easily be overlooked.Issues associated with diabetic foot complications include peripheral arterial disease and osteomyelitis;accordingly,the risk of these complications in people with diabetes should be assessed annually.Although antimicrobial agents represent the mainstay of treatment for diabetic foot infections,if peripheral arterial disease is present,revascularization should be considered to prevent limb amputation.A multidisciplinary approach to the prevention,diagnosis,and treatment of diabetic patients,including those with foot ulcers,is of the utmost importance to reduce the cost of treatment and avoid major adverse consequences such as amputation. | Tatjana Matijević Jasminka Talapko Tomislav Meštrović Marijan Matijević Suzana Erić Ivan Erić IvanaŠkrlec | 2023 | World Journal of Clinical Cases2023，11，8： | 2 |
| 13 | Importance of genetic polymorphisms in liver transplantation outcomes显示文摘Although,liver transplantation serves as the only curative treatment for patients with end-stage liver diseases,it is burdened with complications,which affect survival rates.In addition to clinical risk factors,contribution of recipient and donor genetic prognostic markers has been extensively studied in order to reduce the burden and improve the outcomes.Determination of single nucleotide polymorphisms(SNPs)is one of the most important tools in development of personalized transplant approach.To provide a better insight in recent developments,we review the studies published in the last three years that investigated an association of recipient or donor SNPs with most common issues in liver transplantation:Acute cellular rejection,development of new-onset diabetes mellitus and non-alcoholic fatty liver disease,hepatocellular carcinoma recurrence,and tacrolimus concentration variability.Reviewed studies confirmed previously established SNP prognostic factors,such as PNPLA3 rs738409 for nonalcoholic fatty liver disease development,or the role of CYP3A5 rs776746 in tacrolimus concentration variability.They also identified several novel SNPs,with a reasonably strong association,which have the potential to become useful predictors of post-transplant complications.However,as the studies were typically conducted in one center on relatively low-to-moderate number of patients,verification of the results in other centers is warranted to resolve these limitations.Furthermore,of 29 reviewed studies,28 used gene candidate approach and only one implemented a genome wide association approach.Genome wide association multicentric studies are needed to facilitate the development of personalized transplant medicine. | Tomislav Kelava Petra Turcic Antonio Markotic Ana Ostojic Dino Sisl Anna Mrzljak | 2020 | World Journal of Gastroenterology2020，26，12： | 2 |
| 14 | Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice显示文摘Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host's defense mechanisms.Pathogens employing this strategy are currently threatening global rice production.In the present study,variations in the virulence of the highly destructive Barkholderiaplantarii were observed in different rice-producing regions.The environment-linked variation was not attributable to any known host-related or external factors.Co-occurrence analyses indicated a connection between reduced virulence and 5-Amino-l,3,4-thiadiazole-2-thiol(ATT),a non-bactericidal organic compound.ATT,which accumulates in rice plants during metabolization of specific agrochemicals,was found to reduce virulence factor secretion by B.plantarii up to 88.8%and inhibit pathogen virulence by hijacking an upstream signaling cascade.Detailed assessment of the newly discovered virulence inhibitor resulted in mechanistic insights into positive effects of ATT accumulation in plant tissues.Mechanisms of virulence alleviation were deciphered by integrating high-throughput data,gene knockout mutants,and molecular interaction assays.TroK,a histidine protein kinase in a two-component system that regulates virulence factor secretion,is likely the molecular target antagonized by ATT.Our findings provide novel insights into virulence modulation in an important plant-pathogen system that relies on the host's metabolic activity and subsequent signaling interference. | Haruna Matsumoto Yuan Qian Xiaoyan Fan Sunlu Chen Yanxia Nie Kun Qiao Dandan Xiang Xinzhong Zhang Meng Li Bo Guo Peilin Shen Qiangwei Wang Yunlong Yu Tomislav Cemava Mengcen Wang | 2022 | Fundamental Research2022，2，2： | 2 |
| 15 | Torrential flood prevention in the Kolubara river basin显示文摘One of the most vulnerable parts to natural hazards in Serbia is Kolubara river basin. In the past, during the period from 1929 to 2013, 121 torrential flood events in the Kolubara river basin were recorded which show that this territory is extremely vulnerable to the torrential floods. The extreme event which occurred in May 2014 causing the catastrophic material damages and casualties was the latest and historical flood. The analysis of natural conditions in the Kolubara basin uniformly showed that this area is predisposed to a greater number of torrential floods due to its geomorphological, hydrological and land use properties. Torrential floods are closely related to the intensity and spatial distribution of erosive processes in the upper part of the Kolubara basin. The estimation of soil erosion potential is generally achieved by Erosion Potential Model(EPM). For the purposes of determining the degree of torrential properties in various water streams in the Kolubara basin, the calculation ofsusceptibility to torrential floods was assessed by Flash Flood Potential Index(FFPI). More than half of the basin area(57.2%) is located within the category of very weak and weak erosion(Z_(sr) = 0.35), but the category of medium erosion is geospatially very common. Such a distribution of medium erosion category provides conditions for generating, i.e. production of sediment which would boost torrential properties of water streams. After the classification of the obtained FFPI values it was determined that 25% of the Kolubara basin is very susceptible to torrents and this data should be seriously taken into consideration. Based on the analyses, the best and most successful manner of defence is prevention which consists of the integrated river basin management system(integrated torrent control system) so that technical works in hydrographic networks of torrents and biological and biotechnical works on the slope of the basin would be the best solution. Permanent control of erosive and torrential processes in the river basin will be not only important for flood control but it can also protect the existing and future water reservoirs and retentions fromsiltation with erosion sediment which is of great significance to the water management, agriculture, energy sector, and the entire society. | KOSTADINOV Stanimir DRAGI?EVI? Slavoljub STEFANOVI? Tomislav NOVKOVI? Ivan PETROVI? M.Ana | 2017 | Journal of Mountain Science2017，14，11： | 2 |
| 16 | Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting显示文摘 | Colleen Gorman Koch Liang Li Andra I. Duncan Tomislav Mihaljevic Delos M. Cosgrove Floyd D. Loop Norman J. Starr Eugene H. Blackstone | 2006 | Critical Care Medicine2006，，6： | 2 |
| 17 | Time for the new approach in management of early phase of severe acute pancreatitis?显示文摘 | Darko Zdravkovic Dragoljub Bilanovic Tomislav Randjelovic Borislav Toskovic | 2010 | Chinese Medical Journal2010，，2： | 2 |
| 18 | Overhauling the assessment of agrochemical-driven interferences with microbial communities for improved global ecosystem integrity显示文摘Recent studies have shown that various agrochemicals can substantially affect microbial communities;especially those that are associated with cultivated plants.Under certain circumstances,up to 50% of the naturally occurring microorganisms can be negatively affected by common agricultural practices such as seed coating with fungicide-based matrices.Nevertheless,the off-target effects of commonly applied agrochemicals are still understudied in terms of their interferences with microbial communities.At the same time,agrochemical inputs are steadily increasing due to the intensification of agriculture and the increasing pathogen pressure that is currently observed worldwide.In this article,we briefly reflect on the current knowledge related to pesticide interference with microbial communities and discuss negative implications for the plant holobiont as well as such that are spanning beyond local system borders.Cumulative effects of pesticide inputs that cause alterations in microbial functioning likely have unforeseen implications on geochemical cycles that should be addressed with a high priority in ongoing research.A holistic assessment of such implications will allow us to objectively select the most suitable means for food production under the scenario of a growing global population and aggravating climatic conditions.We present three hypothetical solutions that might facilitate a more sustainable and less damaging application of pesticides in the future. | Mengcen Wang Tomislav Cernava | 2020 | Environmental Science and Ecotechnology2020，，4： | 2 |
| 19 | Cardiovascular risk and aging:the need for a more comprehensive understanding显示文摘The first half of the 20th century was marked by a shift in morbidity and mortality pat-terns in industrialized countries all over the world,moving from the leading role of infec-tious diseases to the increasing role of chronic,non-communicable diseases.In particular,cardiovascular disease(CVD)has been an important cause of mor-bidity and mortality,with coronary heart disease(CHD)being the leading cause of death.The primary reason for this transition was the discovery of anti-biotics and vaccines,the widespread use of which has led to a decline in infectious diseases and increase in life expectancy and population aging.[1] | Ljiljana Trtica Majnarić Zvonimir Bosnić Tomislav Kurevija Thomas Wittlinger | 2021 | Journal of Geriatric Cardiology2021，18，6： | 2 |
| 20 | Electric Vehicle Charging Management Based on Deep Reinforcement Learning显示文摘A time-variable time-of-use electricity price can be used to reduce the charging costs for electric vehicle(EV)owners.Considering the uncertainty of price fluctuation and the randomness of EV owner’s commuting behavior,we propose a deep reinforcement learning based method for the minimization of individual EV charging cost.The charging problem is first formulated as a Markov decision process(MDP),which has unknown transition probability.A modified long short-term memory(LSTM)neural network is used as the representation layer to extract temporal features from the electricity price signal.The deep deterministic policy gradient(DDPG)algorithm,which has continuous action spaces,is used to solve the MDP.The proposed method can automatically adjust the charging strategy according to electricity price to reduce the charging cost of the EV owner.Several other methods to solve the charging problem are also implemented and quantitatively compared with the proposed method which can reduce the charging cost up to 70.2%compared with other benchmark methods. | Sichen Li Weihao Hu Di Cao Tomislav Dragicevic Qi Huang Zhe Chen Frede Blaabjerg | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，3： | 2 |
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