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| 1 | Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance显示文摘The gram-negative bacterium Helicobacter pylori(H.pylori)causes chronic gastritis,gastric and duodenal ulcers,gastric cancer and mucosa-associated lymphoid tissue lymphoma.Treatment is recommended in all symptomatic patients.The current treatment options for H.pylori infection are outlined in this review in light of the recent challenges in eradication success,largely due to the rapid emergence of antibiotic resistant strains of H.pylori.Antibiotic resistance is a constantly evolving process and numerous studies have shown that the prevalence of H.pylori antibiotic resistance varies significantly from country to country,and even between regions within the same country.In addition,recent data has shown that previous antibiotic use is associated with harbouring antibiotic resistant H.pylori.Local surveillance of antibiotic resistance is warranted to guide clinicians in their choice of therapy.Antimicrobial resistance is assessed by H.pylori culture and antimicrobial susceptibility testing.Recently developed molecular tests offer an attractive alternative to culture and allow for the rapid molecular genetic identification of H.pylori and resistance-associated mutations directly from biopsy samples or bacterial culture material.Accumulating evidence indicates that surveillance of antimicrobial resistance by susceptibility testing is feasible and necessary to inform clinicians in their choice of therapy for management of H.pylori infection. | Sinéad M Smith Colm O’Morain Deirdre McNamara | 2014 | World Journal of Gastroenterology2014，20，29： | 40 |
| 2 | Evaluating the performance of nanostructured materials as lithium-ion battery electrodes显示文摘锂离子房间的性能重重地依赖于主机电极的能力从本地结构提供并且释放 Li+ 离子。当电极材料的选择可以定义象房间潜力和能力那样的参数时,置闰的过程可以被率身体上限制固态 Li+ 散开。在锂离子电极的增加的散开率可以在散开路径通过减小被完成,由一可伸缩各自的电极尺寸完成了。另外,一些电极可以经历与收费并且排出联系的大体积变化,的紧张,可以更好通过 nanostructuring 被提供。主机的失败可以导致本地结构的 pulverisation 和能力的快速的损失提供如此的卷变化。在这篇评论文章,我们寻求在 nanostructured 锂离子电池体系结构(阳极和阴极) 的开发加亮很多重要获得,作为潜在的下一代的电气化学的精力存储设备的驱动程序。 | Mark J. Armstrong Colm O'Dwyer William J. Macklin Justin. D. Holmes | 2014 | Nano Research2014，7，1： | 23 |
| 3 | Role of Helicobacter pylori in functional dyspepsia显示文摘消化不良的原因论在病人的多数是未知的。Helicobacter pylori (H pylori ) 是在病人的一个子集的原因。估计 H pylori 的存在的非侵略的测试在不到 50 与消化不良介绍给一个家庭专业人员岁的病人的管理被推荐。脲呼吸测试或凳子抗原测试是最可靠的非侵略的测试。H pylori 的根除将与开发消化性溃疡的消化不良把风险归结为病人,如果规定,复杂并发症评估的还原剂非类固醇反煽动性的药和以后的还原剂胃的癌症的风险。推荐治疗为非与 H pylori 感染联系的溃疡消化不良应该是有 PPI 和二抗菌素的一个 10-d 疗程。治疗功效四个星期应该在与脲呼吸测试或凳子抗原测试完成治疗以后被估计。 | Colm O'Morain | 2006 | World Journal of Gastroenterology2006，12，17： | 9 |
| 4 | Colorectal cancer screening显示文摘Colorectal cancer is a major public health burden worldwide. There is clear-cut evidence that screening will reduce colorectal cancer mortality and the only contentious issue is which screening tool to use. Mos evidence points towards screening with fecal occul blood testing. The immunochemical fecal occult blood tests have a higher sensitivity than the guaiac-based tests. In addition, their automation and haemoglobin quantification allows a threshold for colonoscopy to be selected that can be accommodated within individua health care systems. | Ramona M McLoughlin Colm A O'Morain | 2006 | World Journal of Gastroenterology2006，12，42： | 8 |
| 5 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 6 | Metal-assisted chemical etching of silicon and the behavior of nanoscale silicon materials as Li-ion battery anodes显示文摘这评论在硅的帮助金属的化学蚀刻构画出开发和最近的进步,总结许多基本、创新的过程并且蚀刻形成大量 nanoscale 硅结构的方法。,为 Li 离子电池的阳极也是的硅的使用考察了因素象电影厚度那样,做, alloying,和他们对可逆 lithiation 进程的反应关于电池房间性能被总结并且讨论。在在 Li 离子电池改进基于硅的阳极的表演的最近的进展也被讨论。当 Li 离子电池阳极被构画出,许多 nanostructured 硅结构的使用由许多不同方法形成了,特别地集中于集体装载,核心壳结构,传导性的添加剂,和另外的参数的影响。电气化学的反应和硅阳极的房间性能上的孔,掺杂物类型,和做的水平的影响基于最近的调查结果被详细说明。硅和相关材料的未来上的观点,和他们为经由几电气化学的机制的精力存储的组合、结构的修正,也被提供。 | William McSweeney | 2015 | Nano Research2015，8，5： | 5 |
| 7 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 8 | Vitamin D deficiency in Crohn’s disease: Prevalence, risk factors and supplement use in an outpatient setting显示文摘 | Treasa Nic Suibhne Gerry Cox Martin Healy Colm O’Morain Maria O’Sullivan | 2011 | Journal of Crohn’s and Colitis2011，，2： | 3 |
| 9 | Recent technological advances for the determination of food authenticity显示文摘 | Linda M. Reid Colm P. O’Donnell Gerard Downey | 2006 | Trends in Food Science & Technology2006，，7： | 2 |
| 10 | Treatment of H elicobacter pylori Infection 2013显示文摘 | Anthony O’Connor Javier Molina‐Infante Javier P. Gisbert Colm O’Morain | 2013 | Helicobacter2013，，： | 2 |
| 11 | Confirmation of food origin claims by fourier transform infrared spectroscopy and chemometrics: extra virgin olive oil from Liguria 显示文摘 | Hennessy S Gerard D and Colm P O | 2009 | Journal of Agricultural and Food Chemistry2009，57，： | 1 |
| 12 | Investigation of coupled cobalt-silver nanoparticle system by plan view TEM | Daniel Fox Ruggero Verre Brendan J. O'Dowd Sunil K. Arora Colm C. Faulkner Igor V. Shvets | 2012 | Progress in Natural Science:Materials International2012，22，3： | 1 |
| 13 | Recent technological advances for the determination of food authentieity显示文摘 | Linda M Reid Colm P O Donnell Gerard Downey | 2006 | Trends in Food Science & Technology2006，17，7： | 1 |
| 14 | Entrywise perturbation theory and error analysis for Markov chains显示文摘 | Colm Art O’Cinneide | 1993 | Numerische Mathematik1993，，1： | 1 |
| 15 | Division of Short Gastric Vessels at Laparoscopic Nissen Fundoplication: A Prospective Double-Blind Randomized Trial With 5-Year Follow-Up显示文摘 | Colm J. O’Boyle David I. Watson Glyn G. Jamieson Jennifer C. Myers Philip A. Game Peter G. Devitt | 2002 | Annals of Surgery2002，，2： | 1 |
| 16 | Maintaining Healthy Population Diversity Using Adaptive Crossover, Mutation, and Selection 显示文摘 | BRUAN M G JOHN M COLM O | 2011 | IEEE Transactions on Evolutionary Computation2011，15，5： | 1 |
| 17 | Long-term prospective study ofHelicobacter pylori in nonulcer dyspepsia显示文摘 | Conor McCarthy MRCPI Stephen Patchett MRCPI Rose Mary Collins MB Shona Beattie SRN Conor Keane MD Professor Colm O’Morain MD | 1995 | Digestive Diseases and Sciences1995，，1： | 1 |
| 18 | Conservative management of placenta accreta and unruptured interstitial cornual pregnancy using methotrexate显示文摘 | Savita Lalchandani Michael Geary Colm O’Herlihy Orla Sheil | 2002 | European Journal of Obstetrics and Gynecology2002，，1： | 1 |
| 19 | How Scientists Commercialise New Knowledge via Entrepreneurship显示文摘 | Colm O' Gorman Orla Byrne Dipti Pandya | 2008 | Journal of Technology Transfer2008，，1： | 1 |
| 20 | Effect of eradication ofHelicobacter pylori infection on gastric epithelial cell proliferation显示文摘 | Rachel J. Cahill MD H Xia MD PhD Clive Kilgallen MB Shona Beattie SRN Hilary Hamilton SRN Prof. Colm O’morain MD MSc FRCP | 1995 | Digestive Diseases and Sciences1995，，8： | 1 |
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