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| 1 | 可疑痴呆人群中阿尔茨海默氏病临床前的认识损害特征及其与中医证候的关系显示文摘To look for predictive markers preceding Alzheimer’s dementia. Methods: This study involved multitudinal assessment of individuals in whom there was cognitive impairment that was insufficient to warrant a diagnosis of dementia, which were followed up for mean 11 months. Results: A diagnosis of probable AD was made in 58% of cases, VD in 21 %, FLD in 5% and dementia of uncertain aetiology in the remainder. 42% subjects with memory loss are as result of ageassociated cognitive decline, 25% subjects are due to cerebralvascular accident, 1 .8% subjects due to menopausal symptoms. 30.4% are of memry loss of unknown aetiology. Cognitive markers preceding dementia found within this stUdy actually have discriminant function of the earliest changes of AD from age-associated cognitive decline. The group that developed dementia on follow-up does not differ significanily from the memory loss group on the WAIS-R total scores or on the digit forward , digit backward and picture completion. However, the subtest score for similarities on the WAIS-R is sighficanly lower in patients who became demented comparing with the rest of sample. Verbal memory such as story recall immediate and story recall delayed, verbal learning discriminant index, verbal fluency raw score showed significant lower in patients who became dementia . Moreover digit copy transformed score on the SSRS also is very significanily lower in patients who became demented than those who were stable memory loss. The kidney deficiency syndrom of Chinese medicine was most common in QD, and the phlegm syndrome and the blood stasis syndrome were more common. The scores of the picture completion subtest and the story recall immdiate subtest were significanily correlated to the score of the phlegm syndrome respectively. The scores of the picture completion subtest and the similarities subtest were significanily correlated with the score of the kidney deficiency syndrome respectively .Suggestion: Often a significandy long interval, well in excess of the mean follow up of 11 months in our study, is required before one can he certain that a person with no dementia but with significant memory impairment, is or is not going on to develop a dementia. Folstein MMSE scores are significanily predictive for the outcome of cognitive impairment. The digit copy transformed score and the similarities were more significantly predictive for the outcome than the above four measures of verbal memory. The scores of neuropsychological test were correlated to the scores of syndrome of Chinese medicine. | 田金洲 杨承芝 盛彤 刘桓 JudyHaworth RomolaBucks GordonWilcockDM FRCP | 1999 | 湖北中医学院学报1999，1，4： | 46 |
| 2 | Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia显示文摘 | A. M. Scott FRACP Dr. J. E. Kellow MD FRACP B. Shuter MSc H. Cowan RN A.-M. Corbett NMT J. W. Riley MD FRACP M. R. Lunzer FRCP FRACP R. P. Eckstein FRCPA R. H?schl MD S.-K. Lam MD FRCP FRACP M. P. Jones PhD | 1993 | Digestive Diseases and Sciences1993，，12： | 2 |
| 3 | Animal models of fulminant hepatic failure显示文摘 | John Terblanche ChM FCS(SA) FRCS(Eng) FRCPS(Glasg) FACS(Hon) Rosemary Hickman ChM MD | 1991 | Digestive Diseases and Sciences1991，，6： | 2 |
| 4 | Endoscopic management of biliary complications after orthotopic liver transplantation显示文摘 | Deepak V. Gopal MD FRCP(C) Patrick R. Pfau MD Michael R. Lucey MD FRCP(I) | 2003 | Current Treatment Options in Gastroenterology2003，，6： | 2 |
| 5 | Delirium in elderly patients显示文摘 | Martin G Cole MD FRCP(C) | 2004 | Am J Geriatr Psychiatry2004，12，： | 1 |
| 6 | Capsule endoscopy in the pediatric patient显示文摘 | Ernest G. Seidman MD FRCP(C) FACG Martha H. Dirks MD FRCP(C) | 2006 | Current Treatment Options in Gastroenterology2006，，5： | 1 |
| 7 | Chronic fatigue: Symptom and syndrome 显示文摘 | Simon Wessely FRCP | 2001 | Ann Intern Med2001，134，： | 1 |
| 8 | Management of acne: A report from a global alliance to improve outcome of ane显示文摘 | Harold Gollnick MD William Cunliffe MD FRCP | 2003 | J Am Acad Dermatol2003，49，： | 1 |
| 9 | Physical growth and current health status of infants who were of extremely low birth weight and controls at adolescence显示文摘 | Saroj Saigal MD FRCP(C) Barbara L | 2001 | Pediatrics2001，108，： | 1 |
| 10 | Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability显示文摘 | Dr. Gareth R. Davies MRCP Martin E. Wilkie MRCP David S. Rampton FRCP | 1993 | Digestive Diseases and Sciences1993，，3： | 1 |
| 11 | Effect of buprenorphine on pancreatic enzyme synthesis and secretion in normal rats and rats with acute edematous pancreatitis显示文摘 | Dr. J. M. Ogden PhD I. M. Modlin MD PhD F. S. Gorelick MD I. N. Marks BSc MB FRCP FACG | 1994 | Digestive Diseases and Sciences1994，，11： | 1 |
| 12 | Misoprostol reduces indomethacin-induced changes in human small intestinal permeability显示文摘 | Ingvar Bjarnason MD Paul Smethurst MBiol Christopher G. Fenn PhD Carole E. Lee BSc Ian S. Menzies FRCPath A. Jonathan Levi FRCP | 1989 | Digestive Diseases and Sciences1989，，3： | 1 |
| 13 | Gastric mucosal toxicity of duodenal juice constituents in the rat显示文摘 | David Armstrong MA MRCP (UK) Edward R. C. Rytina MD Gerard M. Murphy PhD Professor R. Hermon Dowling MD FRCP | 1994 | Digestive Diseases and Sciences1994，，2： | 1 |
| 14 | Dyslipidemia in type 2 diabetes and the effects of thiazolidinediones显示文摘 | David S. H.Bell MB FRCP FACE FRCPS | | 0，，： | 1 |
| 15 | Virology, epidemiology,pathogenesis,and control of enterovirus 71 显示文摘 | Prof Tom Solomon FRCP Penny Lewthwaite David Perera | 2010 | Lancet Infect Dis2010，10，： | 1 |
| 16 | Olsalazine in maintenance of clinical remission in patients with ulcerative colitis显示文摘 | Prof. J. P. Wright MB CHB FRCP PhD E. A. O’Keefe BM BCH MRCP L. Cuming BA K. Jaskiewicz MD MRCPath(Lon) PhD | 1993 | Digestive Diseases and Sciences1993，，10： | 1 |
| 17 | The first 500 patients with sacral anteior root stimulator inplants: general description 显示文摘 | GS Brindley MD FRCP FRS | 1994 | Paraplegia1994，32，12： | 1 |
| 18 | Eikelboom, MBBS, MSc, FRACP, FRCPA Folic Acid- Based Multivitamin Therapy to Prevent Stroke显示文摘 | GRAEME J HANKEY M D FRCP FRACP John W | 2004 | Stroke2004，35，5： | 1 |
| 19 | Measurement of absolute bone blood flow by positron emission tomography显示文摘 | Claude Nahmias Ph.D. W. Peter Cockshott M.D. FRCP FRCR L. W. Belbeck D.V.M. E. S. Garnett M.D. FRCP | 1986 | Skeletal Radiology1986，，3： | 1 |
| 20 | The ramifications of HLA-B27显示文摘 | Nicholas J Sheehan MD FRCP | 2004 | J R Soc Med2004，97，： | 1 |
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