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| 1 | CRP与斑块破裂有关显示文摘目的 探讨多个斑块破裂、C反应蛋白(CRP)与急性心梗(AMI)预后的关系。背景多项研究表明破裂或不稳定斑块不仅存在于罪犯病变部位,而且还包括急性冠脉综合症(ACS)患者的整个冠脉系统。方法 用血管内超声观察斑块破裂和CRP浓度之间的关系。共检查45例首次AMI病人的45条梗死-相关动脉和84条其他的大冠脉。结果 21例病人(47%)在罪犯部位斑块破裂,11例病人(24%)在远离部位有17个斑块破裂。与一个斑块破裂或无破裂病人比较。多斑块破裂病例有多种危险因子者多2倍以上(分别为82%及40%、29%,P=0.01)。罪犯处斑块破裂的病人血浆CRP水平高于无斑块破裂者(分别为3.1及1.9mg/l,P=0.04),CRP水平与斑块数正相关(P〈0.01),虽然所有罪犯斑块均经PCI处理。多处斑块破裂者预后较差。结论 CRP水平与病人多个斑块破裂有直接关系,临床预后不佳。因此,斑块不稳定不只是血管的一个局部事件,而是反映了整个冠脉树的一个更普遍的炎症反应。 | J Am Coll Cardiol 张伟丽 | 2005 | 中国分子心脏病学杂志2005，5，3： | 78 |
| 2 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 3 | 植物中鱼藤酮类化合物检测方法的改进显示文摘现有分析鱼藤酮的高效液相色谱方法是针对鱼藤酮的检测而建立的 ,因此它不适合于鱼藤酮类化合物的分析检测。比较鱼藤酮类化合物的UV吸收光谱发现 ,原方法中的检测波长 (2 80nm~ 30 0nm)不适于鱼藤素、毛鱼藤酮及其类似物的检测。通过试验确定适合鱼藤酮类化合物的检测波长为 2 40nm。用CHCl3 MeOH(体积比 9∶1)溶剂提取出的植物中的鱼藤酮类化合物 ,经C18柱进行色谱分离后 ,以MeOH H2 O(体积比 6 6∶34 )为洗脱剂对鱼藤酮类化合物进行等度洗脱。实验结果表明 ,改进的方法可一次性分离检测出鱼藤酮、鱼藤素、毛鱼藤酮及其 12a 羟基 和 6a ,12a 脱氢 类似物 ,各峰分离良好。 | 曾鑫年 COLL Josep 张善学 刘新清 CAMPS Francisco | 2002 | 色谱2002，20，2： | 22 |
| 4 | Physiopathology of splanchnic vasodilation in portal hypertension显示文摘In liver cirrhosis, the circulatory hemodynamic alterations of portal hypertension signifi cantly contribute to many of the clinical manifestations of the disease. In the physiopathology of this vascular alteration, mesen- teric splanchnic vasodilation plays an essential role by initiating the hemodynamic process. Numerous studies performed in cirrhotic patients and animal models have shown that this splanchnic vasodilation is the result of an important increase in local and systemic vasodilators and the presence of a splanchnic vascular hyporesponsiveness to vasoconstrictors. Among the molecules and factors known to be potentially involved in this arterial vasodilation, nitric oxide seems to have a crucial role in the physiopathology of this vascular alteration. However, none of the wide variety of mediators can be described as solely responsible, since this phenomenon is multifactorial in origin. Moreover, angiogenesis and vascular remodeling processes alsoseem to play a role. Finally, the sympathetic nervous system is thought to be involved in the pathogenesis of the hyperdynamic circulation associated with portal hypertension, although the nature and extent of its role is not completely understood. In this review, we discuss the different mechanisms known to contribute to this complex phenomenon. | María Martell Mar Coll Nahia Ezkurdia Imma Raurell Joan Genescà | 2010 | World Journal of Hepatology2010，2，6： | 13 |
| 5 | MicroRNAs in cancer biology and therapy:Current status and perspectives显示文摘The study of a class of small non-coding RNA molecules,named microRNAs(miRNAs),has advanced our understanding of many of the fundamental processes of cancer biology and the molecular mechanisms underlying tumor initiation and progression.MiRNA research has become more and more attractive as evidence is emerging that miRNAs likely play important regulatory roles virtually in all essential bioprocesses.Looking at this field over the past decade it becomes evident that our understanding of miRNAs remains rather incomplete.As research continues to reveal the mechanisms underlying cancer therapy efficacy,it is clear that miRNAs contribute to responses to drug therapy and are themselves modified by drug therapy.One important area for miRNA research is to understand the functions of miRNAs and the relevant signaling pathways in the initiation,progression and drug-resistance of tumors to be able to design novel,effective targeted therapeutics that directly target pathologically essential miRNAs and/or their target genes.Another area of increasing importance is the use of miRNA signatures in the diagnosis and prognosis of various types of cancers.As the study of noncoding RNAs is increasingly more popular and important,it is without doubt that the next several years of miRNA research will provide more fascinating results. | Colles Price Jianjun Chen | 2014 | Genes & Diseases2014，1，1： | 11 |
| 6 | A novel ubiquitin carboxyl terminal hydroase is involved in toad oocyte maturation显示文摘p28, a 28kD protein from toad (Bufo bufo gargarizans) oocytes, was identified by using p13suc1-agaroseaffinity chromatography. Sequence homology analysis of the full-length cDNA of p28 (Gene Bank accessionnumber: AF 314091) indicated that it encodes a protein containing 224 amino-acids with about 55% iden-tities and more than 70% positives to human, rat or mouse UCH-L1, and contains homological functionaldomains of UCH family. Anti-p28 monoclonal antibody, on injecting into the oocytes, could inhibit theprogesterone-induced resumption of meiotic division in a dose-dependent manner. The recombinant proteinp28 showed similar SDS/PAGE behaviors to the native one, and promoted ubiquitin ethyl ester hydrolysis,a classical catalytic reaction for ubiquitin carboxyl terminai hydrolases (UCHs). The results in this paperreveal that a novel protein, p28, exists in the toad oocytes, is a UCH L1 homolog, was engaged in theprocess of progesterone-induced oocyte maturation possibly through an involvement in protein turnover anddegradation. | ZHAO GUI SUN1,2,3,*, WEI HUA KONG2,*, YAN JUN ZHANG2, SHAN YAN1, JI NING LU1, ZHENG GU1, FENG LIN1, JIA KE TSO1,**1 National Laboratory of Contraceptives and Devices Research, Shanghai Institute of Planned ParenthoodResearch, Shanghai 200032, China2 Colle | 2002 | Cell Research2002，12，4： | 8 |
| 7 | Influence of different inoculation methods on the evaluation of the resistance to rice sheath blight(Rhizoctonia solani Kuhn)显示文摘To establish a standard system for genetic studies on sheath blight resistance. a field test was conducted at the experimental farm of Yangzhou University to compare several procedures for inoculating rice plants with R. | PAN Xuebiao CHEN Zongxiang XU Jingyou TONG Yunhui WANG Zibin PAN Xingyuan Dept of Agro of Agri Coll,Yangzhou Univ,Yangzhou 225009,China | 1998 | Chinese Rice Research Newsletter1998，6，2： | 6 |
| 8 | Single-lung transplantation in emphysema:Retrospective study analyzing survival and waiting list mortality显示文摘AIM: To performed remains a subject of debate and is the principal aim of the study. METHODS: This retrospective analysis included 73 patients with emphysema(2000-2012). The outcomes of patients undergoing single-lung transplantation(SL)(n = 40) or double-lung transplant(DL)(n = 33) were compared in a Cox multivariate analysis to study the impact of the technique, postoperative complications and acute and chronic rejection on survival rates. Patients were selected for inclusion in the waiting list according to the International Society of Heart Lung Transplantation criteria. Pre and postoperative rehabilitation and prophylaxis, surgical technique and immunosuppressive treatment were similar in every patients. Lung transplantation waiting list information on a national level and retrospective data on emphysema patient survival transplanted in Spain during the study period, was obtained from the lung transplantation registry managed by the National Transplant Organization(ONT). RESULTS: Both groups were comparable in terms of gender and clinical characteristics. We found significant differences in the mean age between the groups, the DL patients being younger as expected from the inclusion criteria. Perioperative complications occurred in 27.6% SL vs 54% DL(P = 0.032). Excluding perioperative mortality, median survival was 65.3 mo for SL and 59.4 mo for DL(P = 0.96). Bronchiolitis obliterans and overall 5-year survival were similar in both groups. Bacterialrespiratory infection, cytomegalovirus and fungal infection rates were higher but not significant in SL. No differences were found between type of transplant and survival(P = 0.48). To support our results, national data on all patients with emphysema in waiting list were obtained(n = 1001). Mortality on the waiting list was 2.4% for SL vs 6.2% for DL. There was no difference in 5 year survival between 235 SL and 430 DL patients transplanted(P = 0.875).CONCLUSION: Our results suggest that SL transplantation in emphysema produce similar survival than DL with less postoperative complication and significant lower mortality in waiting list. | José M Borro María Delgado Elisabeth Coll Salvador Pita | 2016 | World Journal of Transplantation2016，6，2： | 6 |
| 9 | New tools for optimizing fluid resuscitation in acute pancreatitis显示文摘Acute pancreatitis(AP)is a frequent disease with degrees of increasing severity responsible for high morbidity.Despite continuous improvement in care,mortality remains significant.Because hypovolemia,together with microcirculatory dysfunction lead to poor outcome,fluid therapy remains a cornerstone of the supportive treatment.However,poor clinical evidence actually support the aggressive fluid therapy recommended in recent guidelines since available data are controversial.Fluid management remains unclear and leads to current heterogeneous practice.Different strategies may help to improve fluid resuscitation in AP.On one hand,integration of fluid therapy in a global hemodynamic resuscitation has been demonstrated to improve outcomein surgical or septic patients.Tailored fluid administration after early identification of patients with high-risk of poor outcome presenting inadequate tissue oxygenation is a major part of this strategy.On the other hand,new decision parameters have been developed recently to improve safety and efficiency of fluid therapy in critically ill patients.In this review,we propose a personalized strategy integrating these new concepts in the early fluid management of AP.This new approach paves the way to a wide range of clinical studies in the field of AP. | Perrine Bortolotti Fabienne Saulnier Delphine Colling Alban Redheuil Sebastien Preau | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 10 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 11 | Transcriptomic and metabolomic analyses of cucumber fruit peels reveal a developmental increase in terpenoid glycosides associated with age-related resistance to Phytophthora capsici显示文摘The oomycete,Phytophthora capsici,infects cucumber(Cucumis sativus L.)fruit.An age-related resistance(ARR)to this pathogen was previously observed in fruit of cultivar‘Vlaspik’and shown to be associated with the peel.Young fruits are highly susceptible,but develop resistance at~10–12 days post pollination(dpp).Peels from resistant(16 dpp)versus susceptible(8 dpp)age fruit are enriched with genes associated with defense,and methanolic extracts from resistant age peels inhibit pathogen growth.Here we compared developing fruits from‘Vlaspik’with those of‘Gy14’,a line that does not exhibit ARR.Transcriptomic analysis of peels of the two lines at 8 and 16 dpp identified 80 genes that were developmentally upregulated in resistant‘Vlaspik’16 dpp versus 8 dpp,but not in susceptible‘Gy14’at 16 dpp.A large number of these genes are annotated to be associated with defense and/or specialized metabolism,including four putative resistance(R)genes,and numerous genes involved in flavonoid and terpenoid synthesis and decoration.Untargeted metabolomic analysis was performed on extracts from 8 and 16 dpp‘Vlaspik’and‘Gy14’fruit peels using Ultra-Performance Liquid Chromatography and Quadrupole Time-of-Flight Mass Spectrometry.Multivariate analysis of the metabolomes identified 113 ions uniquely abundant in resistant‘Vlaspik’16 dpp peel extracts.The most abundant compounds in this group had relative mass defects consistent with terpenoid glycosides.Two of the three most abundant ions were annotated as glycosylated nor-terpenoid esters.Together,these analyses reveal potential mechanisms by which ARR to P.capsici may be conferred. | Ben N Mansfeld Marivi Colle Yunyan Kang A Daniel Jones Rebecca Grumet | 2017 | Horticulture Research2017，4，1： | 3 |
| 12 | Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals显示文摘发炎是对试图消除侮辱的微生物引起的感染或无菌的损害的主人反应,修理织物并且恢复动态平衡。巨噬细胞和 NLRP3 inflammasome 是为侮辱的两种类型的关键哨兵。尽管 NLRP3 inflammasome 被在无菌的损害期间释放的微生物引起的产品和分子激活,这很好被建立,信号的这些不同类型得到的回答是否是不同的,是不清楚的。在这研究,我们把 lipopolysaccharide 和肿瘤坏死因素用作原型的微生物引起、无菌的信号 1 刺激,分别地告知 NLRP3 inflammasome。我们然后使用了细菌的毒素 nigericin 和免除坏死的房间的一个普通产品, ATP 原型的微生物引起、无菌的信号 2 刺激,分别地在鼠标和人的巨噬细胞触发 NLRP3 inflammasome 建筑群的汇编。当信号 1 和信号 2 是无菌的时,我们发现 NLRP3 inflammasome 回答最弱,但是当二个信号中的至少一个是微生物引起的时,回答更快、更强壮。最终,最快速并且当两个信号是微生物引起的时,有势力回答被得到。一起,这些数据建议微生物引起对无菌的信号是不同的,运动地并且在大小,处于他们产生 inflammasome 依赖的回答的能力。对无菌对微生物引起的刺激的 NLRP3 回答的这个层次多半反映迫切需要让免疫系统对感染的存在很快作出回应停止病原体传播。 | Jelena S Bezbradica Rebecca C Coll Kate Schroder | 2017 | Cellular & Molecular Immunology2017，14，1： | 3 |
| 13 | Mitochondrial DNA synthesis fuels NLRP3 inflammasome显示文摘 | Rebecca C. Coll Caroline L. Holley Kate Schroder | 2018 | Cell Research2018，28，11： | 3 |
| 14 | Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients显示文摘BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)loss.AIM To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs therapy.METHODS Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in monotherapy.Hepatitis B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were eligible.Patients with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were excluded.HBsAg and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six weeks.HBsAg loss rate was evaluated in both groups.Adverse events were recorded in both groups.The kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression model.RESULTS Sixty-five patients were enrolled,61%receiving tenofovir and 33%entecavir.Thirty-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA group.After matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(P<0.05).The slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not change.Eight(22%)patients discontinued Peg-IFN due to adverse events.The HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA group.CONCLUSION The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to NA therapy.Side effects of Peg-IFN can limit its use in clinical practice. | Teresa Broquetas Montserrat Garcia-Retortillo Miquel Mico Lidia Canillas Marc Puigvehi Nuria Canete Susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA Carrion | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 15 | Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment显示文摘 | Sarah Raevens Anja Geerts Christophe Van Steenkiste Xavier Verhelst Hans Van Vlierberghe Isabelle Colle | 2015 | Liver Int2015，，6： | 2 |
| 16 | Modulation of Portal Graft Inflow: A Necessity in Adult Living-Donor Liver Transplantation?显示文摘 | Roberto Troisi Guy Cammu Giuseppe Militerno Luc De Baerdemaeker Johan Decruyenaere Eric Hoste Peter Smeets Isabelle Colle Hans Van Vlierberghe Mirko Petrovic Dirk Voet Eric Mortier Uwe J. Hesse Bernard de Hemptinne | 2003 | Annals of Surgery2003，，3： | 2 |
| 17 | 科研支撑服务研究:科研环境、管理机构与图书馆显示文摘2010年,OCLC研究中心和英国研究信息网(Research Information Network,RIN),分别委托美国的图书馆与学术信息咨询公司Kroll Research Associates和英国伦敦大学的信息行为与评估研究中心(Centrefor Information Behaviourandthe Evaluation of Research,CIBER),对高校中的科研支撑条件与服务状况同时展开研究。这两个机构相互协作,分别选择4个研究型大学作为样本,通过采访和焦点访谈的方法,从研究者、科研管理人员和图书馆员中搜集有关科研服务的数据。下表列出8个学校的相关数据: | John Mac Coll Michael Jubb 宋丹辉(编译) | 2011 | 图书情报工作动态2011，，7： | 2 |
| 18 | Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment显示文摘 | Coll E Botey A Alvarezl | 2000 | Am J Kidney Dis2000，36，1： | 2 |
| 19 | Angiogenesis in liver disease显示文摘 | Mercedes Fernández David Semela Jordi Bruix Isabelle Colle Massimo Pinzani Jaume Bosch | 2009 | Journal of Hepatology2009，，3： | 2 |
| 20 | What Strategies Can Support the Evolutionary Emergence of Cooperation显示文摘 | Hirshleifer Coll | 1998 | Journal of Conflict Resolution1998，，32： | 1 |
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