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| 1 | Probiotic bacteria change Escherichia coli-induced gene expression in cultured colonocytes:Implications in intestinal pathophysiology显示文摘AIM: To investigate the change in eukaryotic gene expression profile in Caco-2 cells after infection with strains of Escherichia coli and commensal probiotic bacteria. METHODS: A 19 200 gene/expressed sequence tag gene chip was used to examine expression of genes after infection of Caco-2 cells with strains of normal flora E. coli,Lactobacillus plantarum,and a combination of the two. RESULTS: The cDNA microarray revealed up-regulation of 155 and down-regulation of 177 genes by E. coli . L. plantarum up-regulated 45 and down-regulated 36 genes. During mixed infection,27 genes were up-regulated and 59 were down-regulated,with nullification of stimulatory/inhibitory effects on most of the genes. Expression of several new genes was noted in this group. CONCLUSION: The commensal bacterial strains used in this study induced the expression of a large number of genes in colonocyte-like cultured cells and changed the expression of several genes involved in important cellular processes such as regulation of transcription,protein biosynthesis,metabolism,cell adhesion,ubiquitination,and apoptosis. Such changes induced by the presence of probiotic bacteria may shape the physiologic and pathologic responses they trigger in the host. | Pinaki Panigrahi Gheorghe T Braileanu Hegang Chen O Colin Stine | 2007 | World Journal of Gastroenterology2007，13，47： | 10 |
| 2 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 3 | Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease显示文摘 | Corti O Sanchez-Capelo A Colin P | 1999 | Proc Natl Acad Sci USA1999，96，12： | 2 |
| 4 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
| 5 | The 3-zones extended coherent flame model (ECFM3Z) for computing premixed/dif- fusion combustion 显示文摘 | Colin O Benkenida A | 2004 | Oil and Gas Science and Technol- ogy-Review IFP2004，59，6： | 1 |
| 6 | Proteolysis in samples of quarter milk with varying somatic cell counts显示文摘 | LE ROUX Y COLIN O LAURENT F | 1995 | Dairy Sci1995，78，： | 1 |
| 7 | The burden and costs of chronic diseases in low-income and middle-income countries显示文摘 | Dele O Abegunde Colin D Mathers Taghreed Adam | 2007 | Lancet2007，370，： | 1 |
| 8 | Treatment of severe aplastic a- nemia with a combination of horse antithymocyte globulin and eyelospo- fine, with or without sirolimus: A prospective randomized study 显示文摘 | Scheinberg P Colin OW Nunez O | 2009 | Haematologica2009，94，3： | 1 |
| 9 | Numerical methods for unsteady compressible multi-component reacting flows on fixed and moving grids 显示文摘 | MOUREAU V LARTIGUE G SOMMERER Y ANGELBERGER C COLIN O POINSOT T | 2005 | Journal of Computational Physics2005，202，2： | 1 |
| 10 | Compensatory mechanisms for chronic cerebral hypoperfusion in patients with carot idocclusion显示文摘 | Derdey n Colin Videen Tom O | 1999 | Stroke1999，30，： | 1 |
| 11 | Oomparison of efficacy of Valaciclovir and acyctovir for the treatment of herpes zoster Ophthalmicus显示文摘 | Colin J Prisant O Cochener B | 2000 | Opthalmology2000，107，8： | 1 |
| 12 | Microbes Central to Human Reproduction显示文摘 | Gregor Reid Patrizia Brigidi Jeremy P. Burton Nikhat Contractor Sylvia Duncan Emilie Fargier Colin Hill Sarah Lebeer Rocio Martín Andrew J. McBain Gil Mor Catherine O’Neill Juan Miguel Rodríguez Jonathan Swann Saskia Hemert Juliett Ansell | 2015 | Am J Reprod Immunol2015，，1： | 1 |
| 13 | Association of a promoter polymorphism of the CD14 gene and atopy显示文摘 | koppelman GH Reijmerink NE Colin Stine O | 2001 | Am J Respir Crit Care med2001，163，： | 1 |
| 14 | Selective concentration of EPA and DHA using Thermomyces lanuginosus tipase is due to fatty acid selectivity and not regioselectivity显示文摘 | Taiwo O A Jacqui L A Colin J B | 2013 | Food Chemistry2013，138，： | 1 |
| 15 | In vitro degradation of insulin-loaded poly(n-butylcyanoacrylate) nanoparticles 显示文摘 | Cariline O Sullivan Colin Birkinshaw | 2004 | Biomaterials2004，25，： | 1 |
| 16 | Regulation for conservatives : behavioral economics and the case for 'asymmetric paternalism' ( Preferences and Rational Choice : New Perspectives and Legal Implications) 显示文摘 | Colin Camerer Samuel Issacharoff George Loewenstein Ted O' Donoghue and Matthew Rabin | 2003 | University of Pennsylvania Law Review2003，，151： | 1 |
| 17 | XCMS:Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment,Matching and Identification显示文摘 | Colin A Smith Elizabeth J Want Grace O'Maille | 2006 | Analytical Chemistry2006，78，3： | 1 |
| 18 | Experience -weighted attrac- tion learning in normal - form games 显示文摘 | CAMERER COLIN F TECK H O | 1999 | Econometrica1999，67，： | 1 |
| 19 | Detection of Cloud-Base Height Using Jenoptik CHM15K and Vaisala CL31 Ceilometers显示文摘 | Martucci Giovanni Milroy Conor O’Dowd Colin D | 2010 | Journal of Atmospheric and Oceanic Technology2010，，2： | 1 |
| 20 | Recent technological advances for the determination of food authenticity显示文摘 | Linda M Reid Colin P O'Donnell Gerard Downey | 2006 | Trends in Food Science & Technology2006，17，7： | 1 |
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