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| 1 | 'Micro-deletions' of the human Y chromosome and their relationship with male infertility显示文摘The Y chromosome evolves from an autochromosome and accumulates male-related genes including sex-determining region of Y-chromosome (SRY) and several spermatogenesis-related genes. The human Y chromosome (60 Mb long) is largely composed of repeti-tive sequences that give it a heterochromatic appearance, and it consists of pseudoautosomal, euchromatic, and heterochromatic regions. Located on the two extremities of the Y chromosome, pseudoautosomal regions 1 and 2 (PAR1 and PAR2, 2.6 Mb and 320 bp long, re-spectively) are homologs with the termini of the X chromosome. The euchromatic region and some of the repeat-rich heterochromatic parts of the Y chromosome are called 'male-specific Y' (MSY), which occupy more than 95% of the whole Y chromosome. After evolu-tion, the Y chromosome becomes the smallest in size with the least number of genes but with the most number of copies of genes that are mostly spermatogenesis-related. The Y chromosome is characterized by highly repetitive sequences (including direct repeats, inverted repeats, and palindromes) and high polymorphism. Several gene rearrangements on the Y chromosome occur during evolution owing to its specific gene structure. The consequences of such rearrangements are not only loss but also gain of specific genes. One hundred and fifty three haplotypes have been discovered in the human Y chromosome. The structure of the Y chromosome in the GenBank belongs to haplotype R1. There are 220 genes (104 coding genes, 111 pseudogenes, and 5 other uncategorized genes) according to the most recent count. The 104 coding genes encode a total of about 48 proteins/protein families (including putative proteins/protein families). Among them, 16 gene products have been discovered in the azoospermia factor region (AZF) and are related to spermatogenesis. It has been dis-covered that one subset of gene rearrangements on the Y chromosome, 'micro-deletions', is a major cause of male infertility in some populations. However, controversies exist about different Y chromosome haplotypes. Six AZFs of the Y chromosome have been discov-ered including AZFa, AZFb, AZFc, and their combinations AZFbc, AZFabc, and partial AZFc called AZFc/gr/gr. Different deletions in AZF lead to different content spermatogenesis loss from teratozoospermia to infertility in different populations depending on their Y hap-lotypes. This article describes the structure of the human Y chromosome and investigates the causes of micro-deletions and their relation-ship with male infertility from the view of chromosome evolution. After analysis of the relationship between AZFc and male infertility, we concluded that spermatogenesis is controlled by a network of genes, which may locate on the Y chromosome, the autochromosomes, or even on the X chromosome. Further investigation of the molecular mechanisms underlying male fertility/infertility will facilitate our knowledge of functional genomics. | Zheng Li Christopher J Haines Yibing Han | 2008 | Journal of Genetics and Genomics2008，35，4： | 25 |
| 2 | 地表蒸散的遥感估算模型及其在农业干旱监测中的应用显示文摘蒸散是地表水热交换的主要过程,其空间特征差异明显,而遥感技术的发展与应用使得区域蒸散估算成为现实。本文介绍了基于能量平衡法的单层与双层遥感蒸散模型,并对这2类遥感模型的优缺点分别进行了评述和比较。重点综述了近年来得到发展和应用的大气-陆地交换反演模型(ALEXI),阐述其主要结构、特色和过程。该模型通过耦合双层能量平衡模型(TSEB)和简化边界层模型,减少以往模型对台站气象数据的依赖,明显提高区域蒸散估算精度。研究表明,基于该模型的蒸散胁迫指数(ESI)具有很强的区域干旱监测能力。在今后研究中,多元遥感数据融合技术、陆面数据同化系统与遥感蒸散模型的结合将成为该领域的研究热点。 | 郑有飞 陈鹏 吴荣军 Xiwu Zhan Christopher Hain Jicheng Liu | 2011 | 生态学杂志2011，30，4： | 13 |
| 3 | Comprehensive assessment of serum estradiol impact on selected physiologic markers observed during in-vitro fertilization and embryo transfer cycles显示文摘 | KONG Wing Shan CHEUNG Lai Ping HAINES Christopher John | 2009 | J of Exp Clin Assist Reprod2009，6，5： | 1 |
| 4 | Increased messenger RNA expression of vascular endothelial growth factor and its receptors in the implantation site of the human oviduct with ectopic gestation显示文摘 | Po Mui Lam Christine Briton-Jones Che Kwok Cheung See Wai Leung Lai Ping Cheung Christopher Haines | 2004 | Fertility and Sterility2004，，3： | 1 |
| 5 | Ultrastructural characterization of whole hydrosalpinx from infertile Chinese women显示文摘 | Louis Chukwuemeka Ajonuma Ernest Hung Yu Ng Lin Nga Chan Pak Ham Chow Lai Sin Kung Annie Nga Yin Cheung Lok Sze Ho Christine Briton-Jones Ingrid H. Lok Christopher J. Haines Hsiao Chang Chan | 2005 | Cell Biology International2005，，10： | 1 |
| 6 | Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis显示文摘 | Y. M. Dennis Lo Mark S.C. Tein Tze K. Lau Christopher J. Haines Tse N. Leung Priscilla M.K. Poon James S. Wainscoat Philip J. Johnson Allan M.Z. Chang N. Magnus Hjelm | 1998 | The American Journal of Human Genetics1998，，4： | 1 |
| 7 | Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis显示文摘 | Y. M. Dennis Lo Mark S.C. Tein Tze K. Lau Christopher J. Haines Tse N. Leung Priscilla M.K. Poon James S. Wainscoat Philip J. Johnson Allan M.Z. Chang N. Magnus Hjelm | 1998 | The American Journal of Human Genetics1998，，4： | 1 |
| 8 | Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis显示文摘 | Y. M. Dennis Lo Mark S.C. Tein Tze K. Lau Christopher J. Haines Tse N. Leung Priscilla M.K. Poon James S. Wainscoat Philip J. Johnson Allan M.Z. Chang N. Magnus Hjelm | 1998 | The American Journal of Human Genetics1998，，4： | 1 |
| 9 | Evaluation of Drought Indices Based on Thermal Remote Sensing of Evapotranspiration over the Continental United States显示文摘 | Anderson Martha C Hain Christopher Wardlow Brian Pimstein Agustin Mecikalski John R Kustas William P | 2011 | Journal of Climate2011，，8： | 1 |
| 10 | Hepatitis B infection and outcomes of in vitro fertilization and embryo transfer treatment显示文摘 | Po Mui Lam Sik Hung Suen Terence Tzu Lao Lai Ping Cheung Tak Yeung Leung Christopher Haines | 2010 | Fertility and Sterility2010，，2： | 1 |
| 11 | C-kit and its related genes in spermatogonial differentiation显示文摘 | Lei Zhang Jiangjing Tang Christopher J Haines | | 0，，03： | 1 |
| 12 | The effect of exogenous estradiol treatment on the mRNA expression of vascular endothelial growth factor and its receptors in cultured human oviduct mucosal cells显示文摘 | Po Mui Lam M.D. Lai See Po Lai Ping Cheung Christopher Haines | 2005 | Journal of Assisted Reproduction and Genetics2005，，6： | 1 |
| 13 | A comparison of the psychologic impact and client satisfaction of surgical treatment with medical treatment of spontaneous abortion: A randomized controlled trial显示文摘 | Dominic T.S. Lee L.P. Cheung Christopher J. Haines Kathy P.M. Chan Tony K.H. Chung | 2001 | American Journal of Obstetrics and Gynecology2001，，4： | 1 |
| 14 | Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse显示文摘瞄准:为了决定 t 复杂的睾丸的可能的角色,表示了基因 5 (Tctex 5 ) 在精子上工作, mRNA 的全身的顺序在在野类型的正常和无菌的 t-haplotype 异种老鼠之间的睾丸被学习并且比较。方法:我们使用了 cDNA 结束,北污点和分析从睾丸孤立的 Tctex5 mRNAs 的完整的长度的反向的抄写聚合酶链反应的快速的扩大野类型并且 t-haplotype 老鼠。反向的抄写聚合酶链反应习惯于半份量上在野类型的鼠标在 16 纸巾和 9.5 个天阶段胚胎比较 Tctex 5 抄本的表示。电子翻译被使用估计氨基酸序列。结果:长的和 Tctex5 mRNA 的一个短抄本在老鼠睾丸被发现野类型(Tctex5 long-+ 和 Tctex5 short-+) 和 t-haplotype (Tctex5 long-t 和 Tctex5 short-t ) 老鼠分别地。仅仅在睾丸被提高, Tctex5 long-t 让 17 在 1 个区域上把变化和一 15-bp-deletion 指向前,与 Tctex5 long-+, 而 Tctex5 short-t 类似于 Tctex5 short-+ 。在二个模型的 Tctex5 mRNAs 的短 isoforms 编码了一模一样的肽,而是长 isoforms。估计的肽由 Tctex5 long-t 在 phosphorylation 和 PP1 绑定的通常认为的地点上有重要变化。结论:我们证实发生在 t-haplotype 老鼠的 Tctex5 长抄本的变化为正常精子功能是重要的,而 Tctex5 的短抄本可能在不同纸巾之中有保存功能。 | Yibing Han Xue-Xiong Song Huai-Liang Feng Che-Kwok Cheung Po-Mui Lam Chi-Chiu Wang Christophe John Haines | 2008 | Asian Journal of Andrology2008，10，2： | 1 |
| 15 | In, proving communication with bedside vidieo roundings 显示文摘 | Peachy B Hain Christopher S | 2009 | Ameirica Journal of Nurisng2009，109，11： | 1 |
| 16 | Prevalence of menopausal symptoms in different ethnic groups of Asian women and responsiveness to therapy with three doses of conjugated estrogens /medroxyprogesterone acetate:The Pan-Asia menopause(PAM) study显示文摘 | Christopher J Haines Shu Min Xing | 2005 | Maturitas2005，，52： | 1 |
| 17 | Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells显示文摘 | Christopher D. Pritchard Jonathan R. Slotkin Dou Yu Haining Dai Matthew S. Lawrence Roderick T. Bronson Francis M. Reynolds Yang D. Teng Eric J. Woodard Robert S. Langer | 2010 | Journal of Neuroscience Methods2010，，： | 1 |
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